Document	Document Title
US09399115B2	Catheters with enhanced flexibility and associated devices, systems, and methods A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.
US09399104B2	Respiration system for an anesthesia apparatus A respiration system includes a patient connection (1), an inspiratory branch (3), an expiratory branch (13), a rebreathing line (99), a reservoir (25), a CO2 absorber (29), a radial compressor respiration drive (33), a fresh gas supply unit (51), an oxygen flushing device (55), connected to the rebreathing line, a pressure sensor (31) and an actuatable control valve (21), arranged in the rebreathing line between a second end (17) of the expiratory branch and the CO2 absorber. The compressor, oxygen flushing device and fresh gas supply unit are arranged in the rebreathing line between the CO2 absorber and a second end (7) of the inspiration branch. The compressor inlet points towards the CO2 absorber and the outlet points towards the second end of the inspiratory branch. The pressure sensor is arranged in the rebreathing line between the compressor and the second end of the inspiratory branch.
US09399098B2	Flushing medical devices Syringes and flushing medical devices are generally discussed herein for withdrawing, injecting, or instilling fluids. More particularly, syringe tips and flushing tip adaptors with multiple flow channels are discussed for flushing vascular access devices. The tips have cut-outs that are located and sized to produce a relatively wider flow profile than a typical syringe tip with a single central lumen to facilitate flushing the vascular access devices.
US09399087B2	Implantable materials having engineered surfaces comprising a pattern of features and method of making same Implantable materials having defined patterns of affinity regions for binding endothelial cells and providing for directed endothelial cell migration across the surface of the material. The affinity regions include photochemically altered regions of a material surface and physical members patterned on the material surface that exhibit a greater affinity for endothelial cell binding and migration than the remaining regions of the material surface.
US09399084B2	Crosslinked human or animal tissue products and their methods of manufacture and use Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
US09399076B2	Optical sensor for in vivo detection of analyte A sensor for the in vivo detection of glucose comprises:components of an assay for glucose, a readout of which is a detectable optical signal which can be interrogated transcutaneously by external optical means when the sensor is implanted in vivo; anda shell of biodegradable material encapsulating the assay components while allowing analyte to contact the assay components, wherein the biodegradable material comprises a co-polymer having hydrophobic and hydrophilic units.A method of preparing such a sensor preferably comprises coacervation, solvent evaporation and/or extraction, spray drying, spray coating, spray chilling, rotary disk atomisation, fluid bed coating, coextrusion and/or pan coating.A method of detecting glucose using such a sensor suitably comprises implantation of the sensor into the skin of a mammal, transdermal detection or measurement of glucose using external optical means and degradation of the biodegradable material.
US09399074B2	Antibodies specific for trop-2 and their uses The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies, antibody encoding nucleic acids, and methods of obtaining such antibodies. The invention further relates to therapeutic methods for use of these antibodies and Trop-2 antibody conjugates for the treatment of a condition associated with Trop-2 expression (e.g., cancer), such as colon, esophageal, gastric, head and neck, lung, ovarian, or pancreatic cancer.
US09399073B2	Pyrrolobenzodiazepines A compound with the formula (I), wherein: R2 is of formula (II), where X is selected from the group comprising: OH, SH, CO2H, COH, N═C═O, NHNH2, CONHNH2, formula (A), formula (B), NHRN, wherein RN is selected from the group comprising H and C1-4 alkyl; RC1, RC2 and RC3 are independently selected from H and unsubstituted C1-2 alkyl; and either: R12 is selected from the group consisting of: (ia) C5-10 aryl group, optionally substituted by one or more substituents selected from the group comprising: halo, nitro, cyano, ether, C1-7 alkyl, C3-7 heterocyclyl and bis-oxy-C1-3 alkylene; (ib) C1-5 saturated aliphatic alkyl; (ic) C3-6 saturated cycloalkyl; (id) formula (C), wherein each of R21, R22 and R23 are independently selected from H, C1-3 saturated alkyl, C2-3 alkenyl, C2-3 alkynyl and cyclopropyl, where the total number of carbon atoms in the R12 group is no more than 5; (ie) formula (D), wherein one of R25a and R25b is H and the other is selected from: phenyl, which phenyl is optionally substituted by a group selected from halo, methyl, methoxy; pyridyl; and thiophenyl; and (if) formula (E), where R24 is selected from: H; C1-3 saturated alkyl; C2-3 alkenyl; C2-3 alkynyl; cyclopropyl; phenyl, which phenyl is optionally substituted by a group selected from halo, methyl, methoxy; pyridyl; and thiophenyl; R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR′, nitro, Me3Sn and halo; where R and R′ are independently selected from optionally substituted C1-12 alkyl, C3-20 heterocyclyl and C5-20 aryl groups; R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NHRR′, nitro, Me3Sn and halo; either: (a) R10 is H, and R11 is OH, ORA, where RA is C1-4 alkyl; (b) R10 and R11 form a nitrogen-carbon double bond between the nitrogen and carbon atoms to which they are bound; or (c) R10 is H and R11 is SOzM, where z is 2 or 3 and M is a monovalent pharmaceutically acceptable cation; R″ is a C3-12 alkylene group, which chain may be interrupted by one or more heteroatoms, and/or aromatic rings; Y and Y′ are selected from O, S, or NH; R6′, R7′, R9′ are selected from the same groups as R6, R7 and R9 respectively and R10′ and R11′ are the same as R10 and R11, wherein if R11 and R11′ are SOzM, M may represent a divalent pharmaceutically acceptable cation.
US09399069B2	17-Hydroxyprogesterone ester containing oral compositions and related methods The present invention provides for bioavailable oral dosage forms containing esters of 17-hydroxyprogesterone as well as related methods. The oral dosage forms can be formulated for pregnancy support and can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. In another embodiment, a pharmaceutically acceptable oral dosage form for pregnancy support is provided. The pharmaceutically acceptable oral dosage can include a therapeutically effective amount of an ester of 17-hydroxyprogesterone and a pharmaceutically acceptable carrier. The oral dosage form can, when measured using a USP Type-II dissolution apparatus in 900 mL of deionized water with 0.5 (w/v) of sodium lauryl sulfate at 50 RPM at 37° C., release at least 20 wt % of the dose of the ester of 17-hydroxyprogesterone after 60 minutes, or in the alternative release at least 20 wt % more after 60 minutes than an equivalently dosed oral dosage form without the carrier.
US09399066B2	Process for making compositions comprising sphingosine 1 phosphate (S1P) receptor modulators The present invention relates to stable compositions comprising a sphingosine 1 phosphate (S1P) receptor modulator, suitable for use as a dosage form. The S1P receptor modulators are typically sphingosine analogues, such as 2-substituted 2-amino-propane-1,3-diol or 2-amino-propanol derivatives, e.g. a compound comprising a group of formula Y.
US09399060B2	Multivalent pneumococcal polysaccharide-protein conjugate composition An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
US09399057B2	Salmonella vaccine The present invention relates to novel Salmonella mutants, to a process for producing same and to vaccines containing same, wherein said Salmonella mutants are characterized in that they elicit a humoral response that can be distinguished from the humoral response elicited by the wild type strains. It is accordingly an object of the present invention to provide the use of said Salmonella mutants as serological marker strains in the vaccination of animals, in particular mammals and birds, more in particular cattle, poultry and pigs. The serological marker vaccine is of special value in animal farming and provides a (long-lasting) immunization against a wide range of Salmonella strains. The novel mutants are non-reverting and can be used for the efficient immunization of mammals and birds.
US09399056B2	Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
US09399048B2	Lactic acid bacteria and its applications in immunomodulation and anti-inflammation The invention provides a new lactic acid bacteria (LAB) strain with immunomodulatory and anti-inflammatory activity and a composition containing and method using the same. The LAB of the invention can be administrated for modulating an immune response in order to restore or prevent metabolic disorders caused by obesity or chronic inflammation.
US09399047B2	Composition and method to alleviate joint pain using phospholipids and roe extract A dietary supplement composition and associated method has its composition formulated in a therapeutic amount to treat and alleviate symptoms of joint pain in a person having joint pain. The composition includes astaxanthin, low molecular weight hyaluronic acid or sodium hyaluronate (hyaluronan) having a molecular weight of 0.5 to 300 kilodaltons (kDa), and a phospholipid rich egg roe extract having phospholipid bound EPA and DHA admixed with seed and/or fish oil having an ALA to LA ratio of 1:1 to 6:1 and in an oral dosage form.
US09399044B2	Antimicrobial cationic polyamines Antimicrobial, non-hemolytic cationic polyamines were prepared by treating partially N-acylated polyethylenimines and/or partially oxidized polyethylenimines with a protic acid. The cationic polyamines can have a linear or branched polyethylenimine backbone structure. Preferably, the cationic polyamines comprise pendant urea groups, which can be introduced via a cyclic carbonate comprising a pendant urea group. The cationic polyamines can be active against a tuberculosis mycobacterium at low concentration. The cationic polyamines are also effective against Gram-negative Escherichia coli and Pseudomonas aeruginosa, Gram-positive Staphylococcus aureus, and fungus Candida albicans in solution and in the form of a film.
US09399033B2	Oligomer-containing pyrrolidine compounds The invention relates to (among other things) oligomer-containing pyrrolidine compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits one or more advantages over corresponding compounds lacking the oligomer.
US09399026B2	Methods for alleviating statin myopathy Disclosed herein are methods and compositions for alleviating side effects of statin administration, such as myopathic or myalgic side effects, short-term memory loss, abnormal liver function, glucose intolerance, hyperglycemia, increased risk for diabetes, or cumulative trauma disorder, comprising administration of β-hydroxy β-methylbutyrate (HMB) to an individual taking a statin. Also disclosed are methods and compositions for alleviating acute rhabdomyolysis comprising administration of HMB. The disclosure further provides uses of HMB in combination with a statin to alleviate side effects of statin administration.
US09399017B2	Peptide pharmaceutical for oral delivery Acid-containing oral pharmaceutical compositions are provided wherein the pharmaceutical active agents are peptide compounds (i.e., those that include a plurality of amino acids and at least one peptide bond in their molecular structures). Certain barrier layers and/or particulate coated acid are used to reduce any adverse interactions that might otherwise occur between the acid of the compositions and other components of the composition. Use of these barrier layers and/or use of particulate coated acid is believed to promote a more simultaneous release of the components of the composition than is achieved by prior art acid-protection techniques, thus enhancing, and making more consistent, the bioavailability of the active peptide compounds.
US09399015B2	Method for making nanolipidic particles Nanolipidic Particles (NLPs) having average mean diameters of 1 nm to 20 nm are made from a precursor solution. NLPs can be loaded with a desired passenger molecule. Assemblies of these particles, called NLP assemblies, result in a vehicle population of a desired size. Single application or multifunction NLP assemblies are made from the loaded NLPs and range in size from about 30 nm to about 200 nm. A method of using preloaded NLPs to make larger carrier vehicles or a mixed population provides increased encapsulation efficiency. NLPs have application in the cosmetics, pharmaceutical, and food and beverage industries.
US09399009B1	Composition and method of treating skin conditions The present invention is a composition and method of treatment for skin disorders, conditions, and severe skin dryness in general through topical systematic and periodic application of a formulation that generally may include salicylic acid, glycolic acid, urea, dimethyl isosorbide, ethoxydiglycol, barrier repair agents, anti-irritants, humectants, and also has an acidic pH formulation.
US09399003B2	Broad spectrum root canal filing composition for endodontric usage Disclosed is dental root canal filling (intracanal medicament) compositions that are effective against resistant root canal infections caused by Enterococcus faecalis and Vancomycin-resistant Enterococci.
US09399002B2	Gripping member of a bag for pharmaceutical products A bag for pharmaceutical products is gripped by a gripping member provided with two jaws movable between a gripping position and a releasing position of the bag, with a recess obtained between the two jaws to accommodate therein at least one duct to access the content of the bag, and with a support pin protruding into the recess to allow the access duct to be folded from a substantially rectilinear, initial configuration to a final configuration, where the access duct is folded about the support element itself.
US09398999B2	CPR chest compression monitor and method of use A chest compressions monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest compression indication signals directing a chest compression force being applied to the chest and a frequency of such compressions.
US09398987B2	Method of printing graphics on absorbent-articles Absorbent articles having graphics disposed upon them and methods of printing graphics. The graphics are suitable for or actually embodied in fabric and may be visually coordinated to clothing. The clothing may be an article of clothing and/or a line of clothing.
US09398983B2	Matrix-construction padded absorbing article and making method therefor An absorbing article with a pad having a matrix construction comprises a water impermeable first main sheet, a substantially water permeable second sheet and an absorbing pad member arranged between the first and second sheets, the absorbing pad member having an absorbing layer including a flexible matrix made of cotton fibers and superabsorbing polymer fibers, the cotton fibers of the pad matrix having a random three-axis orientation and do not have a preferred X-Y orientation.
US09398982B2	Device for use in endoluminal vacuum therapy The device (10, 36, 38, 42, 68) applies a negative pressure to an endoluminal surface in the body of a patient to facilitate healing of a wound in the endoluminal surface. The device comprises a flexible porous element (14) with a peripheral outer face (32) for contact with the wound, the outer face being defined between opposite proximal and distal ends of the porous element. A suction tube (30) for being connected to a suction source externally of the patient's body is provided in fluid communication with the porous element to apply a negative pressure to the wound via the outer face (32) of the porous element (14) upon operation of the suction source. The porous element (14) has at least one through passageway (16) extending from its proximal end to its distal end for passage of bodily substances of the patient through the porous element. The device can also include a drainage tube (22) for collection and drainage of the bodily substances from the patient, wherein the drainage tube is received in the through passageway of the porous element. The device is particularly suitable for assisted healing of anastomotic wounds but its use is not limited thereto.
US09398979B2	Dimensional compensator for use with a patient interface An apparatus and method are provided for performing ocular laser surgery using a patient interface having a posterior contact surface that may include surface irregularities that were generated during manufacturing of the patient interface. A beam delivery system having a focusing lens, scanning subsystem and adaptive optic (e.g. deformable mirror) is provided for guiding the surgical laser beam through the patient interface and to a desired focal spot location. An optical detector generates image data representing the posterior patient interface surface which is then processed by a computer system to identify surface irregularities by comparing the image data to a reference surface or axis. In particular, a surface irregularity can be identified as having a z-axis component; a tilt component and a surface profile component. Each irregularity component can be compensated separately by sending an adjustment signal to one of the beam delivery system components.
US09398973B1	Abdominal splint and back support wrap Disclosed is a abdominal splinting device to stabilize and support a woman's abdomen during pregnancy and to be used in treatment of diastasis recti in postnatal women. The abdominal splinting device has a back support panel with a central region and opposing first and second side regions, and arms extending from the side regions, where the arms each have a length sufficient to contact the opposite side region when wrapped about a human's trunk region. Also disclosed is a method of treating diastasis recti using the abdominal splinting device. The method includes the steps of providing a abdominal splinting device, centering the abdominal splinting device about a user's torso, applying manual traction to the user's rectus abdominis to bring the two opposing halves of the rectus abdominis near to each other, affixing the arms to the back support panel, and instructing the user to perform abdominal strengthening exercises.
US09398972B2	Posture correction girdle and the method of correcting spinal deformity A posture correction girdle comprises a body wrapping shell, a plurality of pockets and a plurality of paddings is disclosed. The paddings are configured to be inserted into pockets at predetermined positions. Thereby, when the posture correction girdle is worn by the user, pressure is exerted onto a corresponding predetermined section of the user's spine for posture correction purpose. The posture correction girdle further comprises a pair of elastic shoulder straps, an elastic waist strap and a plurality of elongated bones to provide additional support to the user's spine. A micro-system comprising a processor, an output device and a plurality of sensors can also be embedded into the posture correction girdle to provide information regarding the efficiency of the posture correction girdle and the progression of the treatment. Such information is provided to the users using the output device.
US09398971B2	Hinge for an orthopedic brace A hinge for an orthopedic brace includes: a pivot shaft; a lower leg plate pivoted to the pivot shaft; an upper leg plate; a catch plate having a toothed peripheral edge; and two position adjusting units, each of which includes a rotatable limiting seat, a limiting pin, and a slider body. The rotatable limiting seat defines a housing chamber therein, and is formed with a wall slot. The slider body is slidably disposed in the housing chamber. The limiting pin extends from the slider body through the wall slot for engaging and disengaging the toothed peripheral edge. The catch plate is formed with a guiding groove. The rotatable limiting seat has a tongue protruding into the guiding groove.
US09398970B1	Rooster boot ankle foot orthosis The Rooster Boot is a lightweight therapeutic ankle foot orthosis designed for increasing the range of motion and correcting alignment of the foot and ankle. The dynamic orthosis creates a variable load stretch at the ankle to prevent contracture and shortening of the heel cord. The orthosis is utilized during rest, sleep, and weight bearing therapy. This dynamic design has been of particular benefit to children with spasticity or weakening muscles, as evidenced in cerebral palsy.
US09398968B2	Method and device for loading medical appliance with drugs and/or polymers A method for loading a medical appliance with a medicament and/or a polymer is disclosed, the medical appliance comprising one or more grooves or holes loaded with the medicament and/or polymer. The method comprising the steps of: 1) capturing an image of the grooves or holes of the medical appliance, wherein the image contains at least one complete pattern of the grooves or holes; 2) performing digital image processing on the captured image to obtain the pattern of the grooves or holes; 3) calculating a central position of the pattern of the grooves or holes, and determining an actual central position of the grooves or holes based on the central position; 4) adjusting a relative position of a loading device to the medical appliance to align an outlet of the loading device with the actual central position of the grooves or holes; and 5) opening the outlet of the loading device to load the grooves or holes. A device for loading a medical appliance with a medicament and/or a polymer is further disclosed.
US09398964B2	Device for securing a prosthesis to the internal wall of a body lumen There is provided a device to secure a prosthesis, such as a stent graft, to the internal wall of a body lumen. The device is formed from two elongate elements each comprising a central portion with at least one arm extending therefrom. The central portions of the elements abut. Optionally, the central portions are joined together, optionally by a joining element which can act as a hinge. The terminal end of each arm can be shaped for engagement with the inner surface of the body lumen. The device is reversibly interchangeable between a first folded configuration and a second deployed or open configuration. The device is preferably attached to the sleeve of a stent graft independent of the stents which are preferably ring stents. A stent graft comprising the device is also described.
US09398958B2	Knee prosthesis Tibial inserts and tibial femoral systems are provided for improved knee reconstruction systems. External rotation of a knee joint implant is enhanced by modifications to the post, providing a recess that allows clearance of the post against the corners of a box wall within the femoral component. The rotation provides for a more natural knee joint motion of the implant. The depth, size, and location of the post relief may be modified for certain applications to provide both improved rotational motion and constraint against undesirable motion of the knee.
US09398955B2	Artificial joint components including mechanized synovial fluid deflecting structures and particle retaining structures Prosthetic artificial joints are described, including hip, knee and shoulder joints. In some embodiments, an artificial joint prosthesis includes: a bone-facing surface of a artificial joint prosthesis, the bone-facing surface configured to face a bone-prosthesis interface in vivo; a non-contact surface of the artificial joint prosthesis, the non-contact surface adjacent to the bone-facing surface of the artificial joint prosthesis; at least one fluid deflection structure positioned adjacent to the non-contact surface, the fluid deflection structure positioned to deflect synovial fluid away from the bone-prosthesis interface in vivo; a mechanism attached to the fluid deflection structure, the mechanism operable to move the fluid deflection structure to direct synovial fluid away from the bone-prosthesis interface in vivo; and at least one particle retaining structure positioned to contact the directed flow of synovial fluid and configured to retain non-physiological particles present within the synovial fluid.
US09398952B2	Planar zone in prosthetic heart valve leaflet Described embodiments are directed toward prosthetic valves having leaflets of a particular shape that improves bending character without requiring a long length valve. In accordance with an embodiment, a prosthetic valve comprises a leaflet frame, a plurality of leaflets coupled to the leaflet frame, where each leaflet has a free edge and a base. Each leaflet has a planar zone in a central portion, wherein the planar zone is substantially planar. The planar zone defines a shape having an area, wherein the area is larger nearer the base than the free edge.
US09398949B2	Intraocular lens system A multi-component intraocular lens implanted in an optical system of a human eye, includes one or more removable components. One component acts as a base lens and another component acts as the front lens. A front lens formed from two integral optical portions may be milled with tabs to establish an axial orientation of the front lens. The front lens may have a different diameter than the base lens. The base lens may have sharp or angled edges and the front lens may have rounded edges. Non-optical portions of the intraocular lens system may be manufactured from a material that is capable of releasing a pharmacological agent. A flange may be fused with the base lens to allow the front lens to engage with the base lens.
US09398943B2	Ventral hernia repair with barbed suture The present disclosure is directed to a method and system for the repair of ventral hernias. The method includes the steps of providing a needle; providing a barbed suture having a distal end attached to the needle; providing a surgical mesh; rolling the surgical mesh, the barbed suture, and the needle to form a rolled mesh having the needle oriented substantially parallel to a longitudinal axis of the rolled mesh; transferring the rolled mesh into a body cavity via a laparoscopic device; unrolling and laying the surgical mesh under a ventral hernia in an abdominal wall; threading the needle and barbed suture through the surgical mesh and the abdominal wall; and trimming the barbed suture.
US09398933B2	Methods for improving drug efficacy including a combination of drug administration and nerve modulation The present disclosure provides methods for improving drug efficacy in a patient having an obstructed airway in a lung. Such methods modulate nerve activity in the autonomic nervous system of a patient to reduce obstruction of an airway in a lung of the patient prior to administering a drug to the patient. These methods are especially useful in improving efficacies of bronchodilators in treating obstructive lung diseases, such as chronic obstructive pulmonary disease.
US09398929B2	Pin impactor A multi-pin pin impactor and method of use are described. The pin impactor includes a body which can be held by a user and manipulated to re-position the pin impactor during use. First and second pin holders are attached to the body and each include a pin release mechanism effective to releasably retain a pin within the pin holder. An impaction can have a force applied to apply a driving force to a one of the pins. In use, a first pin held by the pin impactor is introduced into an aperture in a surgical instrument mounted on a bone. A force is applied to the pin impactor to drive the first pin into the bone. The orientation or position of the pin impactor is changed to introduce a second pin held by the pin impactor into a second aperture in the surgical instrument without re-loading the pin impactor and a force is applied to the pin impactor to drive the second pin into the bone.
US09398924B2	Hybrid cannula and methods for manufacturing the same A hybrid cannula may comprise a rigid portion overmolded with a flexible portion. The rigid portion at its proximal end may comprise a rigid flange for preventing the proximal end of the hybrid cannula from being pushed through the portal. The flexible portion may comprise a dam within the passage of the hybrid cannula, the dam defining interior spaces thereof between the proximal and distal ends of the hybrid cannula. The flexible portion's distal end may comprise a variety of features extending therefrom, including a flange and/or a cannulated tip. The flexible portion's proximal end may further comprise a membrane to prevent liquid from projecting during insertion of a tool into the dam and/or removal of the tool from the dam. The hybrid cannula can be useful in minimally invasive surgical procedures, including arthroscopic and endoscopic surgeries.
US09398922B2	Targeting set for MRI biopsy device with probe holster support A support assembly is configured to support a biopsy device. The biopsy device has a probe portion coupled with a holster portion. The probe portion may have an integral or removable needle. The holster portion has a mounting recess and a pair of distally extending mounting arms. The support assembly comprises a cradle and a mount. The cradle has a rail that complements the mounting recess of the holster portion. The mount is configured to move longitudinally along the rail. The mount has a pair of recesses that complement the pair of distally extending mounting arms of the holster portion. A cannula support member may be located at the distal end of the cradle. The cradle, mount, and cannula support may collectively support and stabilize the biopsy device in a rigid fashion. The cradle may be coupled with a targeting assembly such as a grid or pedestal.
US09398910B2	Method for providing surgical access One embodiment is directed to a method for providing surgical access across a wall of a tissue structure, comprising: advancing a helical needle into the wall of the tissue structure such that the needle pulls an intercoupled suture member across the wall to form a deployed suture pattern, the deployed suture pattern being characterized in that: the portion of the suture member encapsulated by the wall of the tissue structure is substantially helical in formation and represents a number of helical loops that is greater than about one helical loop, and is less than about three helical loops; portions of the suture member on either side of the wall are in a slack configuration such that tension in the suture member arising from the encapsulated portion pulls in additional length from the slack configuration on either side of the wall to accommodate expansion of the substantially helical encapsulated portion.
US09398905B2	Circular needle applier with offset needle and carrier tracks A surgical suturing device comprises an arced needle track. An arced needle is positioned in the needle track, the needle having a leading end, a trailing end, a medial face, and a lateral face. A length of suture is connected to the needle. An arced carrier track is spaced from the needle track. A reciprocating needle driver has a carrier positioned in the carrier track and a driver positioned in the needle track and is operative to engage and move the needle in the needle track. A transmission is operative to reciprocate the carrier in the carrier track.
US09398895B2	Method apparatus and system for enhancing needle visualization in medical ultrasound imaging The present invention discloses a method, apparatus and system for enhancing needle visualization in ultrasound imaging, said method comprising: a setting step for setting a scanning depth corresponding to a depth of a part or tissue target in a patient's body; and a determining step for automatically determining a needle frame steering angle and an ultrasound working frequency for needle frame collection based on the scanning depth. In the embodiments of the present invention, the needle frame steering angle and ultrasound working frequency for needle frame collection and the filter kernel for enhancing edge filtering of the collected needle frame are both dependent upon the scanning depth, and thereby can achieve enhancing needle visualization in ultrasound imaging for scanning at different depths without participation of the user or extra change of hardware.
US09398894B2	Removable cassette for articular injection system Systems for injecting fluids and/or other materials into a targeted anatomical location, in particular, an intra-articular space, include a handpiece assembly having a proximal end and a distal end, a needle extending from the distal end of the handpiece assembly, a fluid delivery module comprising a cassette and a fluid transfer device. A conduit is generally configured to place the fluid delivery module in fluid communication with the handpiece assembly. Medications, formulations and/or other fluids or materials contained within vials that are secured to the fluid delivery module can be selectively delivered into an anatomy through a needle located at the distal end of the handpiece assembly. In some embodiments, ultrasound or other imaging technologies can be used to locate a joint or other targeted anatomical location.
US09398893B2	System and method for diagnostic vector classification support The diagnostic vector classification support system and method disclosed herein may both reduce the time and effort required to train radiologists to interpret medical images, and provide a decision support system for trained radiologists who, regardless of training, have the potential to miss relevant findings. In an embodiment, a morphological image is used to identify a zone of interest in a co-registered functional image. An operator's grading of a feature at least partially contained within the zone of interest is compared to one or more computer-generated grades for the feature. Where the operator and computer-generated grades differ, diagnostic support can be provided such as displaying additional images, revising the zone of interest, annotating one or more displayed images, displaying a computer-generated feature grade, among other possibilities disclosed herein.
US09398892B2	Device and method for a trackable ultrasound The invention provides a method for adjusting the calibration of a tracked ultrasound device using the measured difference between two sets of fiducial markings in two relative positions of a tracker and an scan head of the device. The invention also provides a trackable ultrasound device that enables repeatable attachment of a tracker to a scan head, thus preserving an initial calibration between the tracker and the scan head. Furthermore, the invention provides a calibration jig that can be used to repeatably attach a tracker to an ultrasound scan head or to measure the difference between two relative positions of a tracker and a scan head.
US09398887B2	Radiation imaging control apparatus, method of controlling radiation imaging control apparatus, medical imaging apparatus, medical image display method, and storage medium A medical imaging apparatus which captures a medical image based on imaging technique information includes a display control unit which displays thumbnails of medical images captured based on imaging technique information in a first area on a display window, displays a thumbnail of a different-inspection image retrieved based on the imaging technique information in a second area, and displays, in a third area, a medical image corresponding to a selected thumbnail of the thumbnails displayed in the first area.
US09398877B2	Method and device for optical imaging of a turbid medium Disclosed is a method and a device for optical imaging of a turbid medium. This method comprises a reference measurement of reference intensities of light emanating from the turbid medium at a reference blood oxygen saturation (SaO2) in the turbid medium and a reference imaging step for reconstructing a reference image of the turbid medium from the measured reference intensities. Furthermore the method comprises a contrast measurement of the contrast intensity of the light emanating from the turbid medium at a contrast blood oxygen saturation (SaO2) level in the turbid medium and a contrast imaging step for reconstructing a contrast image of the turbid medium from the measured contrast intensities. A comparison is made between the contrast image to the reference image of the turbid medium.
US09398865B2	Endobronchial tube apparatus Concepts presented herein include an apparatus for monitoring EMG signals of a patient's laryngeal muscles. The apparatus includes an endobronchial tube having an exterior surface and two lumens for providing ventilation. Conductive ink electrodes are formed on the exterior surface of the endobronchial tube. The conductive ink electrodes are configured to receive the EMG signals from the laryngeal muscles when the endotracheal tube is placed in a trachea of the patient. At least one conductor is coupled to the conductive ink electrodes and is configured to carry the EMG signals received by the conductive ink electrodes to a processing apparatus.
US09398863B2	Detection of anomalies in measurement of level of hypnosis The invention relates to detection of anomalies related to a measurement of the hypnotic level of a subject. In order to detect when a measure indicative of the hypnotic level of a subject is anomalous either due to a medical reason or due to an interference, the measure is monitored and state information indicative of the activity of the autonomous nervous system of the subject and drug effect information indicative of the hypnotic drug effect in the subject are employed to check whether the measure fulfills a predetermined consistency condition requiring that the measure changes consistently with at least one of the drug effect information and the state information. An anomaly, indicative of an abnormal change in the measure, is detected when the measure fails to fulfill the predetermined consistency condition.
US09398854B2	System with a monitoring device that monitors individual activities, behaviors or habit information and communicates with a database with corresponding individual base information for comparison A system is provided for obtaining monitored information about an individual and provide the individual with feedback. A monitoring device has one or more sensors that detect or measure individual information selected from of at least one of, an individual's activities, behaviors and habit information, and an individual's health. The monitoring device includes ID circuitry with an ID storage that contains a unique individual ID, a communication system which reads and transmits the unique individual ID from the ID storage, a power source and a pathway system. A telemetry system is in communication with the monitoring device. The telemetry system has a database that includes base individual information selected from at least one of, individual physiological information, information that is indicative of the individual's activities, data indicative of one or more contextual parameters of the individual and information regarding a degree to which an individual has followed a routine.
US09398840B2	Endoscope with variable direction of view An endoscope with a variable direction of view is provided, which includes an endoscope shaft and imaging optics arranged inside the endoscope shaft. These image an object located before the distal end of the endoscope and produce an image of the object in the proximal area of the endoscope in which a field stop is arranged. The produced image is larger than the field stop. In the proximal area of the endoscope an image module is arranged with which the relative position between the produced image and the field stop can be changed for changing the section of the produced image visible after the field stop in order to change the direction of view of the endoscope.
US09398831B2	Food pusher for food processor A food pusher for a food processor is provided. The food pusher includes a first member configured to be slidably received in a feed tube of a food processor, and a second member slidably received in the first member. The second member includes a valve positioned at the bottom thereof that is configured to open when the second member is fully inserted into the first member to release the liquid contents of the second member.
US09398826B2	Infusion unit for drinks with hydraulic closing system The infusion unit (3) comprises a moving element (9) with a seat (15) for ingredients for making said beverages, forming an infusion chamber (15) and shifting from a position for charging the ingredients to an infusion position, wherein the seat is between a hot water dispensing device (41) and a beverage outlet nozzle (35) opposite one another. The hot water dispensing device (41) comprises a cylinder-piston actuator (43, 47) fed by a first conduit (48) of water under pressure that controls a closing movement of the dispensing device (41) towards the seat (15) in infusion position. Moreover, the piston (47) of the actuator is associated to a conduit (57) of hot water under pressure. The piston exhibits a feeding chamber (55) of the hot water under pressure with an outlet port on a closing surface (53A) of the infusion chamber.
US09398822B2	Reclosable container A container (1) having a lower part (2) and a lid (3) which covers the lower part (3), wherein the lid (3) has a closure (4) that can be moved from a first position into at least one further position, wherein the lower part (3) is fully closed by a covering (5), and the closure (4) is configured such that at least one opening (13) is realized in the covering (5) when the closure (4) is moved from the first position into the at least one further position. Further movement of the closure (4) to a third position exposes the at least one opening (13), allowing access to a medium stored in the container (1).
US09398820B2	Manikin stretch joint Joints are provided for connecting first and second manikin parts. The joints can be partially opened like a clamshell by pivoting the parts on a point on the joint interface. They include first and second joint assemblies attached to the first and second manikin parts respectively. The joint assemblies comprise a stretch element such as a spring or an elastomeric cord, and are capable of detachably engaging with each other. The joints can rotate in a primary rotational direction, for example to move a detachable manikin leg closer to the other manikin leg so that the manikin can quickly and easily be dressed in a pair of slacks. Rotation in a secondary direction is also provided to enable the manikins to be easily assembled by customers so that the manikin parts can be shipped separately. Components and methods of making and using the joints are also provided.
US09398819B2	Basket structure with hooks A basket may include a basket frame, a hook assembly and a bottom. The basket frame has a meshed unit, and an upper board and lower board extending from the meshed unit. The upper board has a side frame with reversed U shape, and the lower board has an L-shaped portion. The basket frame is made in one piece to avoid soldering, which would decrease the structural strength of the basket. Also, the upper board has a side frame with reversed U shape and the lower board has an L-shaped portion to enhance the structural strength of the basket frame, so the bottom can sustain heavier objects. Furthermore, the basket frame and the bottom are all meshed, the objects are unlikely to fall out from the basket.
US09398816B2	Upper body garment with infant pouch An upper body garment for supporting an infant adjacent the chest and upper belly of a wearer that includes a tubular garment body made from a stretchable fabric and comprising a front panel and a back panel, one or more breast panels extending from a top portion of the back panel and over the shoulders of the wearer; and a pouch panel extending from a lower portion of the breast panels. The pouch panel is secured along a U-shaped seam to an inside surface of the front panel to form a pouch with a top opening proximate the lower portion of the breast panels. The stretchable fabric is a two-way stretchable fabric with an increased capability for elastic expansion within a substantially horizontal plane when the wearer is in an upright position.
US09398815B2	Cot A cot is provided that has a frame having a shape of a continuous loop. The frame bounds an interior area of the loop and the interior area is covered by a fabric covering. The frame includes an outer perimeter. At least two legs are mounted to the frame and each leg includes a foot portion. The at least two legs are positioned to support the frame above a horizontal floor surface with the foot portions of each leg in contact with the floor surface. Also, each leg extends outwardly and downwardly from the frame such that the foot portions are positioned outwardly of the outer perimeter of the frame in both vertical and horizontal directions.
US09398800B2	Cosmetic application device This cosmetic application device (1) includes an application tool (2) and a container (3), the application tool (2) being insertable into and removable from the container (3) through an opening (33) of the container (3). When the application tool (2) is tilted in a state where the fixation between the lid body (23) of the application tool (2) and the mouth/neck section (32) of the container (3) has been released and the lower end section (23d) of the lid body (23) is located at a position within the height-wise length of the mouth/neck section (32), the front end of the application section (21) of the application tool (2) is made to contact an inner wall in the vicinity of the bottom section of the containing section (31) of the container (3).
US09398799B2	Double-layered screen cap of a cosmetics container A double-layered screen cap of a cosmetics container includes a lower cap and an upper cap pivotally connected together by a connecting unit. The lower cap is bored with a plurality of insert holes, and the upper cap is provided with a plurality of projections corresponding with the insert holes. Thus, when the upper cap is covered on the lower cap, the projections of the upper cap will be respectively and correspondingly inserted in the insert holes of the lower cap to hermetically seal the insert holes for restrictedly positioning the cosmetic material in the cosmetics container, able to prevent the cosmetic material from leaking out of the cosmetics container.
US09398798B2	Nail art device, system, and method using UV light The nail art device having a control unit; a holder; a display panel that displays a predetermined selected pattern through the control of the control unit; and a UV irradiation unit that irradiates the display panel with UV rays is provided. When a finger, to the nail of which polish having a UV-reactive component has been applied, is placed in the holder, the polish applied to the nail reacts with the UV rays which are transmitted through the display panel where the selected pattern is displayed to form a nail pattern.
US09398796B2	Hair styling device A hair styling device that has a rotating cylinder extending from a body that may be easily grasped by hand. The device allows the cylinder to rotate relative to the body, which remains stationary in the hand of a user. The cylinder has a clamp for clamping hair to the cylinder. The clamp rotates with the cylinder and is used to wind hair up the cylinder while the user holds the body of the device. The direction of rotation of the cylinder may be changed as desired by the user. The ability of a user to rotate the cylinder without rotating the entire device manually eliminates twisting the cord due to turning the entire device as is done with traditional curling irons. Buttons on the device select the direction of rotation of the cylinder.
US09398781B1	Headgear appliance mounting and retention system A headgear appliance mounting and retention system is provided. The system utilizing specially designed clips that include at least two small clips and at least one large clip. The clips are attachable to headgear, particularly protective headgear, headwear or helmets such as, but not limited to, helmets worn by firefighters, utility workers, industrial/construction workers, or the like. The small clips are configured to receive and retain a strap of an accessory and the large clip is configured to simultaneously receive and retain straps of multiple accessories.
US09398779B2	Articles of apparel incorporating cushioning elements and methods of manufacturing the articles of apparel A method of making articles of apparel that include a base layer having a first surface and an opposite second surface. The base layer is associated with a thermoplastic polymer element, then an aperture is formed through the base layer and the thermoplastic polymer element. A cushioning elements that may have a first material layer, a second material layer, and a plurality of foam components is positioned proximate the aperture. The first material layer and the second material layer are bonded to the second surface of the base layer. The foam components are located between and secured to the first material layer and the second material layer. In addition, the foam components are positioned to correspond with a location of the aperture.
US09398763B2	Two-speed fishing reel The present invention relates to a two-speed fishing reel which allows the choice of a higher or lower speed when reeling in or pulling out the fishing line, while keeping constant the rotation speed of the handle driving the reel operation.That is possible because the fishing reel features two kinematic chains, which, by means of a knob, allow choosing one or the other, and due to the diameter and number of cogs of each one of the gears of these kinematic chains, the rotation speed of the rotor increases or decreases, at the same rotation speed of the handle.
US09398760B2	Fish farming plant, module, method and use A fish farming plant is adapted for floating in free water. The plant comprises a substantially vertical inlet pipe and a corresponding outlet pipe for taking in and discharging water, respectively, at a water depth having the desired water quality at a depth (h). A substantially horizontal residential compartment of an accommodation assembly has an inlet end and an outlet end. Lattices are provided at the inlet end and the outlet end. Also provided at the ends are angled end sections for connecting the inlet pipe, outlet pipe, and the residential compartment. The plant also comprises at least one arrangement for providing water flow through the residential compartment. A module for a residential compartment of a fish farming plant, a method for manufacturing an accommodation assembly, use of such a fish farming plant for smolt, as well as a method for emptying such a fish farming plant are also provided.
US09398759B2	Indexing system for an in ovo injection apparatus, and associated method An indexing system for an in ovo injection apparatus is provided. Such an indexing system provides a positioning scheme for an egg carrier carrying a plurality of avian eggs to an injection assembly for injection thereof. The indexing system includes an initial stop provided to abut the trailing end of the egg carrier to form a first egg carrier position such that a first subset of the plurality of avian eggs is injected. An intermediate stop is provided to abut the trailing end of the egg carrier to form a second egg carrier position such that a second subset of the plurality of avian eggs is injected. An associated method is also provided.
US09398757B2	Laboratory animal stimulatory enrichment product A puck formed from compressed paper strips is provided that has utility as an animal entertainment device and nest building material. The paper strips include at least one ply of fibrous material, and may be treated with adjuvants illustratively including flavorants, fragrances, dyes, and odor suppressants. The unfolding and deconstruction of the puck into constituent paper strips by an animal provides the animal with a degree of mental stimulation and nest construction for thermal regulation, and it is noted that animal food consumption and health are generally improved by alleviating behaviors associated with cage confinement. The pre-measured quantum of material in an inventive puck affords a benefit to the caregiver in that the product is simply placed in the cage without resort to measuring and thereby saving time and precluding spillage of separated materials. The puck is particularly beneficial to rodents and especially mice.
US09398752B2	Lettuce cultivar fusion A lettuce cultivar, designated Fusion, is disclosed. The invention relates to the seeds of lettuce cultivar Fusion, to the plants of lettuce cultivar Fusion and to methods for producing a lettuce plant by crossing the cultivar Fusion with itself or another lettuce cultivar. The invention further relates to methods for producing a lettuce plant containing in its genetic material one or more transgenes and to the transgenic lettuce plants and plant parts produced by those methods. This invention also relates to lettuce cultivars or breeding cultivars and plant parts derived from lettuce cultivar Fusion, to methods for producing other lettuce cultivars, lines or plant parts derived from lettuce cultivar Fusion and to the lettuce plants, varieties, and their parts derived from the use of those methods. The invention further relates to hybrid lettuce seeds, plants, and plant parts produced by crossing cultivar Fusion with another lettuce cultivar.
US09398750B2	Rice cultivar LaKast A rice cultivar designated LaKast is disclosed. The invention relates to the seeds of rice cultivar LaKast, to the plants of rice cultivar LaKast, to plant parts of rice cultivar LaKast, and to methods for producing a rice plant produced by crossing rice cultivar LaKast with itself or with another rice variety. The invention also relates to methods for producing a rice plant containing in its genetic material one or more transgenes and to the transgenic rice plants and plant parts produced by those methods. This invention also relates to rice cultivars, or breeding cultivars, and plant parts derived from rice cultivar LaKast, to methods for producing other rice cultivars, lines or plant parts derived from rice cultivar LaKast, and to the rice plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid rice seeds, plants, and plant parts produced by crossing rice cultivar LaKast with another rice cultivar.

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