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11. 发明申请

US20090054475A1 HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译：用于治疗糖尿病和代谢障碍的异位受体激动剂
公开(公告)号：US20090054475A1
公开(公告)日：2009-02-26
申请号：US11964461
申请日：2007-12-26
申请人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： A61K31/506 , C07D401/04 , C07D417/14 , A61P3/10 , A61P3/00 , A61P3/08 , A61K31/4523
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

12. 发明申请

US20060058301A1 Modulators of PPAR and methods of their preparation 失效
公开(公告)号：US20060058301A1
公开(公告)日：2006-03-16
申请号：US11202963
申请日：2005-08-11
申请人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
发明人： Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine Gregoire , Vera Rakhmanova
IPC分类号： A61K31/4965 , A61K31/50 , A61K31/506 , A61K31/53 , C07D403/02
CPC分类号： C07D263/57 , C07D249/06 , C07D249/20 , C07D403/12 , C07D409/10
摘要： The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.

13. 发明授权

US06962970B2 Glycopeptide derivatives and pharmaceutical compositions containing the same 有权
标题翻译：糖肽衍生物和含有它们的药物组合物
公开(公告)号：US06962970B2
公开(公告)日：2005-11-08
申请号：US10092088
申请日：2002-03-06
申请人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
发明人： J. Kevin Judice , Paul Ross Fatheree , Bernice M. T. Lam , Michael R. Leadbetter , Martin S. Linsell , YongQi Mu , Sean Gary Trapp , Guang Yang , Yan Zhu
IPC分类号： A61K38/00 , A61K20060101 , A61K38/14 , A61P31/04 , C07K20060101 , C07K7/06 , C07K9/00 , C07K7/50
CPC分类号： C07K9/008 , A61K38/00 , C07K7/06
摘要： Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: —Ra—Y—Rb—(Z)x where Ra, Rb, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
摘要翻译：公开了具有至少一个下式的取代基的糖肽化合物的衍生物：<？in-line-formula description =“In-line Formulas”end =“lead”？> - R < （Z） <？in-line-formula description =“In-line Formulas”end =“tail”？>其中R ^a

14. 发明授权

US06779583B1 Die casting process incorporating iterative process parameter adjustments 有权
标题翻译：压铸过程包括迭代过程参数调整
公开(公告)号：US06779583B1
公开(公告)日：2004-08-24
申请号：US10208106
申请日：2002-07-30
申请人： Arnie Fulton , Yan Zhu , Michael Bomar
发明人： Arnie Fulton , Yan Zhu , Michael Bomar
IPC分类号： B22D4600
CPC分类号： B22D46/00 , B22D17/2245 , B22D17/32
摘要： A die casting process uses information derived from analysis of a prior casting to modify the process producing a subsequent casting. An aluminum alloy casting is manufactured at a first location. During the manufacture thereof, plural physical parameters are measured and recorded in an entry in memory. Further during the manufacture thereof, the casting is marked with a unique identifier which is stored, with the plural physical parameters, in the entry. The castings are then shipped to a second location, remotely located relative to the first location, for chrome plating. The chrome plated castings are examined for defects and, using the unique identifier on the casting, the casting is associated with the entry containing the physical parameters under which it was manufactured. The physical parameters may then be adjusted so that the subsequent castings are manufactured under conditions less likely to produce defects.
摘要翻译：压铸过程使用从现有铸件的分析得到的信息来修改产生后续铸件的工艺。在第一个位置制造铝合金铸件。在其制造过程中，测量多个物理参数并将其记录在存储器中的条目中。此外，在其制造过程中，铸件标有唯一的标识符，其具有多个物理参数存储在入口中。然后将铸件运送到相对于第一位置远程定位的第二位置，用于镀铬。检查镀铬铸件是否存在缺陷，并使用铸件上的唯一标识符，铸件与包含其制造的物理参数的条目相关联。然后可以调整物理参数，使得随后的铸件在不太可能产生缺陷的条件下制造。

15. 发明授权

US08975258B2 Heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译：用于治疗糖尿病和代谢紊乱的杂环受体激动剂
公开(公告)号：US08975258B2
公开(公告)日：2015-03-10
申请号：US13612451
申请日：2012-09-12
申请人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edward Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jiangao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： A61K31/50 , C07D413/04 , C07D401/04 , C07D401/14 , C07D417/14 , C07D413/14 , C07D417/04
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

16. 发明申请

US20140024830A1 HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS 有权
标题翻译：用于治疗糖尿病和代谢障碍的异位受体激动剂
公开(公告)号：US20140024830A1
公开(公告)日：2014-01-23
申请号：US13612451
申请日：2012-09-12
申请人： Xin Chen , Peng Cheng , L. Edwards Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jaingao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
发明人： Xin Chen , Peng Cheng , L. Edwards Clemens , Jeffrey D. Johnson , Jingyuan Ma , Alison Murphy , Imad Nashashibi , Christopher J. Rabbat , Jaingao Song , Maria E. Wilson , Yan Zhu , Zuchun Zhao
IPC分类号： C07D413/04 , C07D413/14
CPC分类号： A61K31/506 , A61K31/454 , C07D277/42 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of the invention are orally active.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。本发明的化合物是口服活性的。

17. 发明授权

US08434544B2 Die casting process incorporating computerized pattern recognition techniques 有权
标题翻译：包含计算机化模式识别技术的压铸工艺
公开(公告)号：US08434544B2
公开(公告)日：2013-05-07
申请号：US13442628
申请日：2012-04-09
申请人： Arnie Fulton , Yan Zhu , Michael Bomar
发明人： Arnie Fulton , Yan Zhu , Michael Bomar
IPC分类号： B22D46/00
CPC分类号： B22D17/32 , B22D46/00
摘要： A die casting process using pattern recognition techniques to identify those die castings manufactured under conditions likely to produce a die casting which would subsequently prove unacceptable for use. By promptly identifying such die castings, they may be discarded before being shipped to a remote facility for further processing. As a result, the rejection rate of die castings at the remote facility may be reduced and the raw materials used to form the discarded die castings may be more readily recycled.
摘要翻译：使用模式识别技术的压铸方法来识别在可能产生压铸件的条件下制造的那些压铸件，随后将被证明是不可接受的。通过及时识别这种压铸件，在运送到远程设备进行进一步处理之前，可将其丢弃。结果，可以减少远程设备的压铸件的排出率，并且用于形成废弃压铸件的原材料可以更容易地再循环。

18. 发明授权

US08344931B2 N-bits successive approximation register analog-to-digital converting circuit 有权
标题翻译： N位逐次逼近寄存器模数转换电路
公开(公告)号：US08344931B2
公开(公告)日：2013-01-01
申请号：US13150508
申请日：2011-06-01
申请人： Yan Zhu , Chi-Hang Chan , U-Fat Chio , Sai-Weng Sin , Seng-Pan U , Rui Paulo Da Silva Martins , Franco Maloberti
发明人： Yan Zhu , Chi-Hang Chan , U-Fat Chio , Sai-Weng Sin , Seng-Pan U , Rui Paulo Da Silva Martins , Franco Maloberti
IPC分类号： H03M1/12
CPC分类号： H03M1/002 , H03M1/466
摘要： The present invention provides an n-bits successive approximation register (SAR) analog-to-digital converting (ADC) circuit, comprising: an n-bits SAR control logic, a p-type capacitor network including a DACp array and a sampling capacitor CSp, an n-type capacitor network including a DACn array and a sampling capacitor CSn; and a comparator for comparing outputs from the p-type capacitor network and the n-type capacitor network, wherein a power supply and ground are directly connected to the p-type capacitor network and the n-type capacitor network without using reference voltages produced by a reference voltage generator. The n-bits SAR control logic comprises n shift registers, n bit registers, and a switching logic. The comparator comprises a first pre-amplifier, a second pre-amplifier and a dynamic latch. Alternative, the comparator comprises a four-input pre-amplifier and a dynamic latch.
摘要翻译：本发明提供一种n位逐次逼近寄存器（SAR）模数转换（ADC）电路，包括：n位SAR控制逻辑，包括DACp阵列和采样电容器CSp的p型电容器网络包括DACn阵列和采样电容器CSn的n型电容器网络; 以及用于比较来自p型电容器网络和n型电容器网络的输出的比较器，其中电源和接地直接连接到p型电容器网络和n型电容器网络，而不使用由p型电容器网络和n型电容器网络产生的参考电压参考电压发生器。 n位SAR控制逻辑包括n个移位寄存器，n个位寄存器和一个开关逻辑。比较器包括第一前置放大器，第二前置放大器和动态锁存器。替代方案，比较器包括四输入前置放大器和动态锁存器。

19. 发明授权

US08183381B2 N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders 有权
标题翻译：用于治疗糖尿病和代谢紊乱的N-连接的杂环受体激动剂
公开(公告)号：US08183381B2
公开(公告)日：2012-05-22
申请号：US12171209
申请日：2008-07-10
申请人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
发明人： Jingyuan Ma , Christopher J. Rabbat , Jiangao Song , Xin Chen , Imad Nashashibi , Zuchun Zhao , Aaron Novack , Dong Fang Shi , Peng Cheng , Yan Zhu , Alison Murphy
IPC分类号： C07D401/00
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14
摘要： Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
摘要翻译：提供了化合物和方法用于治疗特别是II型糖尿病和与血糖控制不良相关的其它疾病。

20. 发明授权

US08167022B2 Die casting process incorporating computerized pattern recognition techniques 有权
标题翻译：包含计算机化模式识别技术的压铸工艺
公开(公告)号：US08167022B2
公开(公告)日：2012-05-01
申请号：US13100778
申请日：2011-05-04
申请人： Arnie Fulton , Yan Zhu , Michael Bomar
发明人： Arnie Fulton , Yan Zhu , Michael Bomar
IPC分类号： B22D46/00
CPC分类号： B22D17/32 , B22D46/00
摘要： A die casting process using pattern recognition techniques to identify those die castings manufactured under conditions likely to produce a die casting which would subsequently prove unacceptable for use. By promptly identifying such die castings, they may be discarded before being shipped to a remote facility for further processing. As a result, the rejection rate of die castings at the remote facility may be reduced and the raw materials used to form the discarded die castings may be more readily recycled.
摘要翻译：使用模式识别技术的压铸方法来识别在可能产生压铸件的条件下制造的那些压铸件，随后将被证明是不可接受的。通过及时识别这种压铸件，在运送到远程设备进行进一步处理之前，可将其丢弃。结果，可以减少远程设备的压铸件的排出率，并且用于形成废弃压铸件的原材料可以更容易地再循环。

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