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91. 发明授权

US5545645A Heterocyclic derivatives in the treatment of ischaemia and related diseases 失效
标题翻译：杂环衍生物治疗局部缺血及相关疾病
公开(公告)号：US5545645A
公开(公告)日：1996-08-13
申请号：US401486
申请日：1995-03-09
申请人： Jean-Claude Pascal , Gary McCort , Dominique Blondet , Fran.cedilla.oise Gellibert
发明人： Jean-Claude Pascal , Gary McCort , Dominique Blondet , Fran.cedilla.oise Gellibert
IPC分类号： C07D295/02 , A61K31/135 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/435 , A61K31/443 , A61K31/445 , A61K31/451 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/02 , A61P25/28 , C07C209/04 , C07C209/50 , C07C211/27 , C07C211/29 , C07C217/62 , C07D207/32 , C07D207/333 , C07D207/335 , C07D211/10 , C07D211/46 , C07D211/54 , C07D211/58 , C07D277/22 , C07D295/03 , C07D295/06 , C07D295/073 , C07D295/08 , C07D295/096 , C07D295/135 , C07D307/46 , C07D307/52 , C07D333/20 , C07D333/22 , C07D405/06 , C07D401/06 , C07D409/06
CPC分类号： C07D207/333 , C07D207/335 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/135 , C07D307/46 , C07D307/52 , C07D333/20 , C07D333/22
摘要： Compounds of the formula: ##STR1## wherein: m is 0 or 1;R.sup.1 is hydrogen, hydroxy, or lower alkyl;R.sup.2 is hydrogen, or lower alkyl;R.sup.3 is ##STR2## or R.sup.2 and R.sup.3 taken together with the nitrogen atom to which they are attached represent a group of the formula: ##STR3## wherein: n is 0 or 1;p is 0, 1, 2 or 3;q is 0 or 1;R.sup.4 is hydrogen, lower alkyl, cycloalkyl, or optionally substituted phenyl;R.sup.5 is optionally substituted phenyl;X is (CH.sub.2).sub.p, or 4-piperidin-1-yl;Y is CH, CH--O--, CH--S--, or nitrogen;Z is CH.sub.2, NH, sulfur, or oxygen; andA is a substituted furanyl group.
摘要翻译：下式的化合物：其中：m为0或1; R1是氢，羟基或低级烷基; R2是氢或低级烷基; 或者R 3和R 3与它们所连接的氮原子一起表示下式的基团：其中n为0或1; p为0,1,2或3; q为0或1; R4是氢，低级烷基，环烷基或任选取代的苯基; R5是任选取代的苯基; X是（CH 2）p或4-哌啶-1-基; Y是CH，CH-O-，CH-S-或氮; Z是CH 2，NH，硫或氧; A是取代的呋喃基。

92. 发明授权

US5208238A Agents for potentiating the effects of antitumor agents and combating multiple drug resistance 失效
标题翻译：用于增强抗肿瘤剂作用和抵抗多种耐药性的药剂
公开(公告)号：US5208238A
公开(公告)日：1993-05-04
申请号：US896305
申请日：1992-06-10
申请人： Ann C. King
发明人： Ann C. King
IPC分类号： A61K31/335 , A61K31/40 , A61K31/44 , A61K31/495 , A61K31/55 , C07D213/55 , C07D213/56 , C07D295/073 , C07D295/096 , C07D295/155 , C07D313/12
CPC分类号： C07D295/073 , A61K31/335 , A61K31/40 , A61K31/44 , A61K31/495 , A61K31/55 , C07D213/55 , C07D213/56 , C07D295/096 , C07D295/155 , C07D313/12
摘要： Potentiating agents which enhance the efficacy of antineoplastic agents are disclosed. The potentiating agents disclosed are 2-(aminoethylamino) pyridines such as (E)-3-(6-(N-(2-Dimethylaminoethyl)-4-methoxybenzylamino)-2-pyridyl)acrylic acid.
摘要翻译：公开了增强抗肿瘤剂功效的增效剂。公开的增效剂是2-（氨基乙基氨基）吡啶如（E）-3-（6-（N-（2-二甲基氨基乙基）-4-甲氧基苄基氨基）-2-吡啶基）丙酸。

93. 发明授权

US5079245A 2-trifluoromethyl-7-substitute-6,7,8,9-tetrahydro-[5H]-benzocycloheptenes 失效
标题翻译： 2-三氟甲基-7-取代基-6,7,8,9-四氢 - （5H） - 苄氧基羰基
公开(公告)号：US5079245A
公开(公告)日：1992-01-07
申请号：US375591
申请日：1989-07-05
申请人： Michel Wierzbicki , Pierre Hugon , Jacques Duhault , Francoise Lacour
发明人： Michel Wierzbicki , Pierre Hugon , Jacques Duhault , Francoise Lacour
IPC分类号： A61K31/045 , A61K31/12 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/275 , A61K31/415 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P9/10 , C07C29/38 , C07C35/23 , C07C45/00 , C07C49/697 , C07C67/00 , C07C209/00 , C07C209/40 , C07C209/48 , C07C209/50 , C07C209/52 , C07C209/62 , C07C211/30 , C07C211/42 , C07C211/52 , C07C215/08 , C07C215/42 , C07C215/44 , C07C219/14 , C07C223/02 , C07C229/14 , C07C231/06 , C07C231/10 , C07C233/13 , C07C233/14 , C07C233/36 , C07C233/66 , C07C241/00 , C07C251/04 , C07C251/18 , C07C251/20 , C07C251/24 , C07D211/18 , C07D233/04 , C07D295/06 , C07D295/073 , C07D521/00
CPC分类号： C07D295/073 , C07C211/30 , C07C211/42 , C07C215/08 , C07C215/44 , C07C219/14 , C07C229/14 , C07C233/14 , C07C233/36 , C07C251/18 , C07D233/04 , C07C2102/12
摘要： The compounds 2-trifluoromethyl-7-substituted-6,7,8,9-tetrahydro-[5H]-benzocycloheptenes are disclosed and disclosed to be useful in the treatment of metabolic illnesses such as diabetes, obesity, and their complications. A perferred compound is 2-trifluoromethyl-7-amino-6,7,8,9-tetrahydro-[5H-benzocycloheptane.
摘要翻译：公开和公开了化合物2-三氟甲基-7-取代-6,7,8,9-四氢 - [5H] - 苯并环庚烯，可用于治疗代谢疾病如糖尿病，肥胖及其并发症。延迟化合物是2-三氟甲基-7-氨基-6,7,8,9-四氢 - [5H-苯并环庚烷。

94. 发明授权

US5047432A Arylcyclobutylmethylamine therapeutic agents 失效
标题翻译：芳环丁基甲胺治疗剂
公开(公告)号：US5047432A
公开(公告)日：1991-09-10
申请号：US541174
申请日：1990-06-20
申请人： John R. Housley , James E. Jeffery , David N. Johnston , Bruce J. Sargent
发明人： John R. Housley , James E. Jeffery , David N. Johnston , Bruce J. Sargent
IPC分类号： C07D307/52 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/22 , A61K31/33 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/535 , A61K31/5375 , A61P25/24 , A61P25/26 , C07C45/63 , C07C49/567 , C07C67/00 , C07C213/00 , C07C215/38 , C07C217/48 , C07C217/74 , C07C219/22 , C07C225/18 , C07C231/00 , C07C231/12 , C07C235/06 , C07C313/00 , C07C317/28 , C07C323/29 , C07D211/14 , C07D211/30 , C07D211/70 , C07D213/30 , C07D295/073 , C07D295/08 , C07D295/084 , C07D295/10 , C07D295/13 , C07D295/145 , C07D295/185 , C07D317/28 , C07D319/06
CPC分类号： C07D213/30 , C07C45/63 , C07C49/567 , C07D211/70 , C07D295/073 , C07D295/092 , C07D295/13 , C07D295/145 , C07D295/185 , C07D317/28
摘要： Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof; in which R.sub.1 and R.sub.2, which are the same or different, are H or an optionally substituted hydrocarbon group or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring;R.sub.3 is an optionally substituted aromatic hydrocarbon group; andR.sub.4 is a hydrocarbon group containing at least one substituent selected from the group consisting of hydroxy and acylated derivatives thereof, optionally substituted alkoxy groups, optionally substituted cycloalkyloxy groups, optionally substituted alkylenedioxy groups, oxo and groups of formula S(O).sub.p R.sub.5 in which p is 0, 1 or 2 and R.sub.5 is an alkyl group, said hydrocarbon group being optionally substituted by additional substituents,are useful in the treatment of depression.

95. 发明授权

US4950671A Substituted 2-propenyl derivatives of pyridine 失效
标题翻译：吡啶的取代的2-丙烯基衍生物
公开(公告)号：US4950671A
公开(公告)日：1990-08-21
申请号：US321028
申请日：1989-03-09
申请人： Hoi Kiong Lai , Robert A. Davis
发明人： Hoi Kiong Lai , Robert A. Davis
IPC分类号： C07D209/08 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/42 , A01N43/84 , C07D207/06 , C07D211/14 , C07D211/18 , C07D211/22 , C07D215/06 , C07D217/02 , C07D265/30 , C07D295/02 , C07D295/03 , C07D295/06 , C07D295/073 , C07D295/08 , C07D295/096
CPC分类号： C07D295/03 , A01N43/38 , A01N43/40 , A01N43/42 , A01N43/84 , C07D209/08 , C07D215/06 , C07D295/073 , C07D295/096
摘要： A heterocyclic compound having the structural formula ##STR1## where R is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.6 cycloalkyl, trifluoromethyl, phenyl, substituted phenyl, phenoxy, substituted phenoxy, benzyl or substituted benzyl; and R.sup.1 is at least a partially saturated monocyclic or bicyclic heterocycle of nitrogen which may be substituted with lower alkyl and physiologically acceptable salts thereof is disclosed. A process for forming this compound which involves the reaction of an amine of the formula HR.sup.1 where R.sup.1 has the meanings given above with a substituted 2-propenyl halide having the structural formula ##STR2## where R has the meanings given above; and X is a halogen atom is described. The invention embodies the above-mentioned novel 2-propenyl halide utilized as an intermediate in the formation of the heterocyclic compound of this invention. A method ofcontrolling phytopathogenic fungi by applying a fungicidally effective amount of the heterocyclic compound of the present invention to the locus under attack by said fungi is also taught. Finally, a fungicidally composition comprising the heterocyclic compound of the present invention and a suitable carrier therefor is set forth.
摘要翻译：其中R是C1-C8烷基，C3-C6环烷基，三氟甲基，苯基，取代的苯基，苯氧基，取代的苯氧基，苄基或取代的苄基的结构式的杂环化合物。并且R 1是至少部分饱和的单环或双环氮杂环，其可被低级烷基和其生理上可接受的盐所取代。形成该化合物的方法，其涉及式为HR1的胺，其中R1具有上述含义的结构式为：其中R具有上述含义的取代的2-丙烯基卤化物; 并且X是卤素原子。本发明体现了用作本发明的杂环化合物形成中间体的上述新型2-丙烯基卤化物。还教导了通过将杀真菌有效量的本发明的杂环化合物施用于被所述真菌攻击的场所来控制植物致病真菌的方法。最后，提出了包含本发明的杂环化合物和其合适的载体的杀真菌组合物。

96. 发明授权

US4948796A Piperazine derivative or its salt, process for producing the same and pharmaceutical composition comprising the same as active ingredient 失效
标题翻译：哌嗪衍生物或其盐，其制备方法和包含其作为活性成分的药物组合物
公开(公告)号：US4948796A
公开(公告)日：1990-08-14
申请号：US316174
申请日：1989-02-27
申请人： Toru Hiraiwa , Kenji Takeda , Joji Nakano , Mineichi Sudani , Kunikazu Furuhata , Makoto Takata , Hiroyo Kawafuchi , Isao Watanabe
发明人： Toru Hiraiwa , Kenji Takeda , Joji Nakano , Mineichi Sudani , Kunikazu Furuhata , Makoto Takata , Hiroyo Kawafuchi , Isao Watanabe
IPC分类号： A61K31/00 , A61K31/495 , A61P9/00 , A61P9/08 , C07D20060101 , C07D207/26 , C07D207/27 , C07D213/26 , C07D215/12 , C07D221/16 , C07D233/54 , C07D235/08 , C07D271/10 , C07D271/12 , C07D295/04 , C07D295/06 , C07D295/073 , C07D295/096 , C07D295/135 , C07D295/155 , C07D313/12 , C07D333/54 , C07D337/12 , C07D401/00 , C07D401/12 , C07D403/06 , C07D405/00 , C07D405/12 , C07D409/00 , C07D409/12 , C07D411/12 , C07D413/12 , C07D417/00 , C07D417/12 , C07D491/04 , C07D491/044 , C07D491/052 , C07D491/14 , C07D495/04 , C07D495/14 , C07D521/00 , C07F7/18
CPC分类号： C07D207/27 , C07D213/26 , C07D215/12 , C07D221/16 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/08 , C07D249/08 , C07D271/10 , C07D271/12 , C07D295/073 , C07D295/096 , C07D295/135 , C07D295/155 , C07D313/12 , C07D333/54 , C07D337/12 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/04 , C07D495/04 , C07F7/1856
摘要： A piperazine derivative represented by the following formula or a salt thereof: ##STR1## which is useful for curing cerebro-vascular disease and post-cerebro-vascular disease.
摘要翻译：由下式表示的哌嗪衍生物或其盐：，其可用于治疗脑血管疾病和脑血管疾病。

97. 发明授权

US4925879A Arylcyclobutylmethylamines 失效
标题翻译：芳环丁基甲胺
公开(公告)号：US4925879A
公开(公告)日：1990-05-15
申请号：US227869
申请日：1988-08-01
申请人： John R. Housley , James E. Jeffery , David N. Johnston , Bruce J. Sargent
发明人： John R. Housley , James E. Jeffery , David N. Johnston , Bruce J. Sargent
IPC分类号： C07D307/52 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/215 , A61K31/22 , A61K31/33 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/535 , A61K31/5375 , A61P25/24 , A61P25/26 , C07C45/63 , C07C49/567 , C07C67/00 , C07C213/00 , C07C215/38 , C07C217/48 , C07C217/74 , C07C219/22 , C07C225/18 , C07C231/00 , C07C231/12 , C07C235/06 , C07C313/00 , C07C317/28 , C07C323/29 , C07D211/14 , C07D211/30 , C07D211/70 , C07D213/30 , C07D295/073 , C07D295/08 , C07D295/084 , C07D295/10 , C07D295/13 , C07D295/145 , C07D295/185 , C07D317/28 , C07D319/06
CPC分类号： C07D213/30 , C07C45/63 , C07C49/567 , C07D211/70 , C07D295/073 , C07D295/092 , C07D295/13 , C07D295/145 , C07D295/185 , C07D317/28
摘要： Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof; in which R.sub.1 and R.sub.2, which are the same or different, are H or an optionally substituted hydrocarbon group or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring;R.sub.3 is an optionally substituted aromatic hydrocarbon group; andR.sub.4 is a hydrocarbon group containing at least one substituent selected from the group consisting of hydroxy and acylated derivatives thereof, optionally substituted alkoxy groups, optionally substituted cycloalkyloxy groups, optionally substituted alkylenedioxy groups, oxo and groups of formula S(O).sub.p R.sub.5 in which p is 0, 1 or 2 and R.sub.5 is an alkyl group, said hydrocarbon group being optionally substituted by additional substituents,are useful in the treatment of depression.
摘要翻译：式I化合物及其药学上可接受的盐; 其中相同或不同的R 1和R 2为H或任选取代的烃基或R 1和R 2与它们所连接的氮原子一起形成任选取代的杂环; R3是任选取代的芳族烃基; 并且R 4是含有至少一个选自羟基和其酰化衍生物，任选取代的烷氧基，任选取代的环烷氧基，任选取代的亚烷基二氧基，氧代和式S（O）p R 5基团的取代基的烃基，其中 p为0,1或2，R5为烷基，所述烃基任选被其它取代基取代，可用于治疗抑郁症。

98. 发明授权

US4845221A Serotonergic substituted piperazinyl tetralins 失效
标题翻译：血清素能取代哌嗪基四氢化萘
公开(公告)号：US4845221A
公开(公告)日：1989-07-04
申请号：US181842
申请日：1988-04-15
申请人： Gary P. Stack , Edward J. Podlesny
发明人： Gary P. Stack , Edward J. Podlesny
IPC分类号： C07D239/42 , C07D241/20 , C07D295/073 , C07D295/096
CPC分类号： C07D239/42 , C07D241/20 , C07D295/073 , C07D295/096
摘要： The compounds ##STR1## in which R.sub.1 is hydroxy, alkoxy of 1 to 6 carbon atoms, amino, alkylamino of 1 to 6 carbon atoms, dialkylamino where each alkyl substituent contains 1 to 6 carbon atoms, or alkanoylamino of 2 to 6 carbon atoms;R.sub.2 is 3-trifluoromethylphenyl, 3-halophenyl, 2-pyrimidinyl, halopyrimidin-2-yl, 2-pyrazinyl or halopyrazin-2-yl; andn is one of the integers 1 or 2;or a pharmaceutically acceptable salt thereof, are selective serotonergic agents useful in the treatment of depression and/or anxiety, as well as related sexual dysfunctions and appetite disorders.
摘要翻译：其中R 1是羟基，1至6个碳原子的烷氧基，氨基，1至6个碳原子的烷基氨基，其中每个烷基取代基含有1至6个碳原子的二烷基氨基，或2至6个碳原子的烷酰基氨基的化合物＆lt; IMAGE＆gt; R2是3-三氟甲基苯基，3-卤代苯基，2-嘧啶基，卤代嘧啶-2-基，2-吡嗪基或卤代吡嗪-2-基; 并且n是整数1或2之一; 或其药学上可接受的盐是用于治疗抑郁症和/或焦虑症以及相关的性功能障碍和食欲障碍的选择性5-羟色胺能药物。

99. 发明授权

US4814352A Therapeutic agents 失效
标题翻译：治疗剂
公开(公告)号：US4814352A
公开(公告)日：1989-03-21
申请号：US44604
申请日：1987-05-01
申请人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
发明人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
IPC分类号： C07D295/06 , A01N33/02 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/40 , A61K31/435 , A61K31/495 , A61P25/24 , A61P25/26 , C07C29/147 , C07C33/50 , C07C45/00 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07C67/00 , C07C209/00 , C07C209/28 , C07C209/40 , C07C209/48 , C07C209/52 , C07C209/56 , C07C209/58 , C07C211/25 , C07C211/26 , C07C213/00 , C07C217/74 , C07C231/00 , C07C231/02 , C07C231/08 , C07C231/10 , C07C231/12 , C07C233/03 , C07C233/05 , C07C233/13 , C07C233/18 , C07C313/00 , C07C323/32 , C07D207/06 , C07D211/70 , C07D295/073 , C07D295/185
CPC分类号： C07D295/185 , C07C255/00 , C07C29/147 , C07C33/50 , C07C45/004 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07D207/06 , C07D211/70 , C07D295/073 , C07C2101/04
摘要： Compounds of formula I ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, formyl, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.
摘要翻译：式I的化合物其中R 1为C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-7环烷基，环烷基烷基或任选取代的苯基; R2是H或C1-3烷基; R 3和/或R 4是H，甲酰基，C 1-3烷基，C 3-6烯基，C 3-6炔基，C 3-7环烷基或R 3和R 4与氮原子一起形成杂环体系; R 5和/或R 6是H，卤素，CF 3，C 1-3烷基，C 1-3烷氧基，C 1-3烷硫基或R 5和R 6与它们所连接的碳原子一起形成第二苯环，治疗抑郁症。公开了制备式I化合物的药物组合物和方法。

100. 发明授权

US4792553A Diene derivatives and vasodilators containing the same 失效
标题翻译：二烯衍生物和含有相同的血管扩张剂
公开(公告)号：US4792553A
公开(公告)日：1988-12-20
申请号：US10477
申请日：1987-02-03
申请人： Shin Hattori , Makoto Takai , Toshio Wakabayashi , Yasusi Suwabe , Syozo Miyaoka
发明人： Shin Hattori , Makoto Takai , Toshio Wakabayashi , Yasusi Suwabe , Syozo Miyaoka
IPC分类号： A61K31/495 , A61P9/08 , A61P9/10 , C07D295/02 , C07D295/03 , C07D295/06 , C07D295/073 , C07D295/08 , C07D295/096
CPC分类号： C07D295/03 , C07D295/073 , C07D295/096
摘要： Novel dienyl derivatives are disclosed. As examples of said diene derivative are mentioned 1-benzhydryl-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(3,4,5-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-(2,4-dimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4'-difluorobenzhydryl)-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine and the like. These dienyl derivatives are useful as vasodilators.
摘要翻译：公开了新的二烯基衍生物。作为所述二烯衍生物的实例，提及1-二苯甲基-4-（5-苯基-2,4-戊二烯基）哌嗪，1-（4,4'-二氟二苯甲基）-4-（5-苯基-2,4-戊二烯基））哌嗪，1-二苯甲基-4-（5-（3,4,5-三甲氧基苯基）-2,4-戊二烯基）哌嗪，1-（4,4'-二氟二苯甲基）-4-（5-（2,4 -1-（4,4'-二氟二苯甲基） - 哌嗪，1-二苯甲基-4-（5- 4-（5-（2,3,4-三甲氧基苯基）-2,4-戊二烯基）哌嗪等。这些二烯基衍生物可用作血管扩张剂。

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