会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 31. 发明授权
    • Polyalkylene glycol derivative and process for producing same
    • 聚亚烷基二醇衍生物及其制备方法
    • US08569444B2
    • 2013-10-29
    • US13128470
    • 2009-11-11
    • Ken-ichiro NakamotoChika ItohShuichi YoshimuraTsuyoshi Takehana
    • Ken-ichiro NakamotoChika ItohShuichi YoshimuraTsuyoshi Takehana
    • C08G59/68C08G65/34C08G59/00C08G65/00
    • C08G65/2648C08G65/2696
    • A process for producing a polyalkylene glycol derivative having such high molecular weight and purity that the derivative can be used in pharmaceutical applications, which produces a polyalkylene glycol derivative of the formula (X) by steps (A), (B), (C) and (D), wherein R is as defined: R—(OA)nOH  (X) (step (A)) 5 to 50% by mol of an alkali catalyst is added to a compound represented by the formula (Y), wherein R is as defined: R—OH  (Y) (step (B)) an alkylene oxide having 2 to 4 carbon atoms is reacted under a condition of 50 to 130° C. until the average number of moles of an oxyalkylene group OA added reaches the range of 5 to 500 to obtain a polyalkylene glycol derivative; (step (C)) 10 to 5000% by mass of a hydrocarbon solvent is added to the derivative of the step (B) to dilute it, and remaining water is removed by azeotropy; and (step (D)) the derivative of the step (B) is reacted with an alkylene oxide having 2 to 4 carbon atoms under a condition of 50 to 130° C. until the average number of moles of the oxyalkylene group (OA) reaches the range of 600 to 2000.
    • 一种制备具有如此高分子量和纯度的聚亚烷基二醇衍生物的方法,该衍生物可用于药物应用,其通过步骤(A),(B),(C)产生式(X)的聚亚烷基二醇衍生物, 和(D),其中R定义如下:R-(OA)nOH(X)(步骤(A))将5〜50摩尔碱性催化剂加入到式(Y)表示的化合物中,其中 R定义如下:R-OH(Y)(步骤(B))将具有2至4个碳原子的烯化氧在50至130℃的条件下反应,直到加入的氧化烯基OA的平均摩尔数 达到5〜500的范围,得到聚亚烷基二醇衍生物; (步骤(C))将10〜5000质量%的烃类溶剂加入步骤(B)的衍生物中以稀释,并通过共沸除去剩余的水; 和(步骤(D)),使步骤(B)的衍生物在50至130℃的条件下与具有2至4个碳原子的烯化氧反应,直到氧化烯基(OA)的平均摩尔数 达到600〜2000的范围。
    • 33. 发明授权
    • Epoxy resin compositions and process for preparing them
    • 环氧树脂组合物及其制备方法
    • US08399596B2
    • 2013-03-19
    • US12518175
    • 2007-11-30
    • Michael HenningsenLars Wittenbecher
    • Michael HenningsenLars Wittenbecher
    • C08G59/00
    • C07D301/28C07D303/28C08G59/24
    • The preparation of epoxy resin compositions which comprise glycidyl ethers comprising cyclohexyl groups and have a low oligomer content is carried out by distillation of compositions which are obtainable by ring hydrogenation of compounds of the general formula (I) where —X— is —CR2—, —CO—, —O, —S—, —SO2—, the radicals R are each, independently of one another, H, C1-6-alkyl, C3-6-cycloalkyl, in which one or more H atoms can be replaced by halogen, the radicals R′ are each, independently of one another, C1-4-alkyl, halogen, the indices n are each, independently of one another, 0, 1, 2 or 3, and subsequent reaction of the hydroxyl groups with epichlorohydrin, in thin film evaporators or short path evaporators at a temperature in the range from 150 to 270° C. and a pressure in the range from 0.001 to 1 mbar.
    • 包含环己基并且具有低低聚物含量的缩水甘油醚的环氧树脂组合物的制备通过蒸馏可通过环化氢化通式(I)的化合物获得的组合物进行,其中-X-为-CR 2 - -CO - , - O - , - S - , - SO 2 - ,基团R各自独立地为氢,C 1-6 - 烷基,C 3-6 - 环烷基,其中一个或多个H原子可以被替换 通过卤素,基团R'各自独立地为C 1-4 - 烷基,卤素,指数n各自彼此独立地为0,1,2或3,随后羟基与 表氯醇,薄膜蒸发器或短程蒸发器,温度范围为150至270℃,压力范围为0.001至1毫巴。