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1. 发明申请

US20090028168A1 Modem relay over packed based network 审中-公开
标题翻译：调制解调器中继基于打包的网络
公开(公告)号：US20090028168A1
公开(公告)日：2009-01-29
申请号：US12221154
申请日：2008-07-30
申请人： Oren Somekh , Abraham Fisher , Udi Dahan , Gil Graiber
发明人： Oren Somekh , Abraham Fisher , Udi Dahan , Gil Graiber
IPC分类号： H04L12/66
CPC分类号： H04L12/5692 , H04L12/2859 , H04L12/2898 , H04L12/4604 , H04L12/4633 , H04L29/06 , H04L69/16 , H04L69/164 , H04L69/165 , H04L69/169 , H04L69/24 , H04N1/001 , H04N1/00209 , H04N2201/0024 , H04N2201/0025 , H04N2201/0039 , H04N2201/0086 , H04N2201/0093
摘要： A method of performing a negotiation session on a modem connection. The method includes receiving a plurality of negotiation signals from the source modem, by a first gateway, forwarding at least some of the received negotiation signals from the first gateway to a second gateway, over a packet based network, receiving, by the first gateway, responses to the forwarded negotiation signals from the second gateway, forwarding the responses from the second gateway to the source modem, by the first gateway, and transmitting from the first gateway to the source modem, response signals to at least some of the received negotiation signals, without receiving a response to the at least some of the signals from the second gateway.
摘要翻译：一种在调制解调器连接上执行协商会话的方法。该方法包括：通过第一网关从源调制解调器接收多个协商信号，通过基于分组的网络将接收到的协商信号中的至少一些从第一网关转发到第二网关，由第一网关接收，对来自第二网关的转发的协商信号的响应，由第一网关将来自第二网关的响应转发到源调制解调器，以及从第一网关向源调制解调器发送响应信号到至少一些所接收的协商信号，而没有接收到来自第二网关的至少一些信号的响应。

2. 发明授权

US07424003B2 Multi-parameter scheduling in communication systems 有权
标题翻译：通信系统中的多参数调度
公开(公告)号：US07424003B2
公开(公告)日：2008-09-09
申请号：US10796511
申请日：2004-03-08
申请人： Abraham Fisher , Gil Graiber
发明人： Abraham Fisher , Gil Graiber
IPC分类号： H04B7/212
CPC分类号： H04L47/56 , H04L47/6275
摘要： A method of scheduling the handling of communication channels by a processor assigned to handle a plurality of channels. The method includes determining for each channel, handled by the processor, a target time by which time it should receive processing, selecting one or more of the assigned channels whose data is to be handled next, based on the target times of the channels and when more than one channel is selected, choosing for handling before other channels, at least one of the selected channels based on a consideration directed at minimizing the average processing time of the channels.
摘要翻译：一种通过分配给处理多个信道的处理器调度对通信信道的处理的方法。该方法包括：确定由处理器处理的每个信道，基于该信道的目标时间，何时应该接收处理的目标时间，以及下一个处理其数据要被处理的一个或多个所分配的信道选择多于一个信道，基于针对最小化信道的平均处理时间的考虑，选择在其它信道之前处理所选择的信道中的至少一个。

3. 发明授权

US07049321B2 Methods and pharmaceutical compositions for treatment of central and peripheral nervous system disorders and compounds useful therefor 失效
标题翻译：用于治疗中枢和周围神经系统疾病的方法和药物组合物及其有用的化合物
公开(公告)号：US07049321B2
公开(公告)日：2006-05-23
申请号：US10429277
申请日：2003-05-02
申请人： Abraham Fisher , Nira Bar-Ner , Yishai Karton
发明人： Abraham Fisher , Nira Bar-Ner , Yishai Karton
IPC分类号： A61K31/438 , C07D417/04
CPC分类号： C07D513/10 , C07B2200/05 , C07D471/10 , C07D491/10
摘要： There are provided methods for the treatment of diseases involving dysfunction of the peripheral and central nervous system comprising administering one or more Spiro compounds. Also provided and pharmaceutical compositions useful in such methods, compounds for use in the preparation of such pharmaceutical compositions, processes for preparing compounds useful in the practice of such methods, and some novel such compounds per se.
摘要翻译：提供了治疗涉及周围和中枢神经系统功能障碍的疾病的方法，包括施用一种或多种螺环化合物。还提供了可用于这些方法的药物组合物，用于制备这种药物组合物的化合物，用于制备用于实施这些方法的化合物的方法，以及一些新的这类化合物本身。

4. 发明申请

US20110281903A1 BICYCLIC HETEROCYCLIC SPIRO COMPOUNDS 有权
标题翻译：双相杂环磷脂化合物
公开(公告)号：US20110281903A1
公开(公告)日：2011-11-17
申请号：US13146209
申请日：2010-01-26
申请人： Abraham Fisher , Nira Bar-Ner , Victoria Nachum
发明人： Abraham Fisher , Nira Bar-Ner , Victoria Nachum
IPC分类号： A61K31/438 , C07D498/10 , A61P3/10 , C07D495/10 , C07D493/10 , A61P25/28 , C07D513/10 , C07D491/20
CPC分类号： C07D498/10 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/10
摘要： There are disclosed bicyclic heterocyclic spiro compounds; pharmaceutical compositions comprising these compounds; and methods for the treatment in a mammal of diseases and conditions which are susceptible to modulation of the M1 muscarinic receptor, including Alzheimer's disease, insulin resistance syndrome and type 2 diabetes. Other embodiments are also disclosed.
摘要翻译：公开了双环杂环螺环化合物; 包含这些化合物的药物组合物; 以及用于在哺乳动物中治疗易于调节M1毒蕈碱受体（包括阿尔茨海默病，胰岛素抵抗综合征和2型糖尿病）的疾病和病症的方法。还公开了其他实施例。

5. 发明授权

US07991940B2 Communication processor board 有权
标题翻译：通讯处理板
公开(公告)号：US07991940B2
公开(公告)日：2011-08-02
申请号：US11989438
申请日：2005-07-25
申请人： Daniel Frydman , Abraham Fisher
发明人： Daniel Frydman , Abraham Fisher
IPC分类号： G06F13/20
CPC分类号： H04L69/12 , H04L69/08
摘要： A signal processing board including a resource board substrate, an external interface on the board substrate, adapted to receive signals for processing, at least one slot adapted to receive a plug-in module with at least one processor thereon and an interface unit adapted to at least participate in converting signals exchanged between the external interface and a processor on a module received by the slot, between a format of signals received by the external interface and a signal format of the processor. The interface unit is suitable to at least participate in the conversion for a plurality of types of processors that differ in the format in which they transmit or receive signals.
摘要翻译：一种信号处理板，包括资源板基板，板基板上的外部接口，适于接收用于处理的信号，适于接收具有至少一个处理器的插件模块的至少一个插槽和适于最少参与在由外部接口接收的信号的格式与处理器的信号格式之间转换在外部接口与由时隙接收的模块上的处理器之间交换的信号。接口单元适合于至少参与其发送或接收信号格式不同的多种类型的处理器的转换。

6. 发明授权

US5106831A Pharmaceutical composition comprising a spiro oxathiolon/quinuclidine and method of treating senile dementia 失效
标题翻译：包含螺恶唑硫酮/奎宁环的药物组合物和治疗老年痴呆的方法
公开(公告)号：US5106831A
公开(公告)日：1992-04-21
申请号：US599977
申请日：1990-10-19
申请人： Abraham Fisher , Ishai Karton , Eliahu Heldman , Yona Grunfeld , Aharon Levy
发明人： Abraham Fisher , Ishai Karton , Eliahu Heldman , Yona Grunfeld , Aharon Levy
IPC分类号： C07D497/20
CPC分类号： C07D497/20
摘要： A pharmaceutical composition is disclosed comprising (-)-cis-2-methylspiro(1,3-oxathiolan-5,3')quinuclidine, and/or the pharmaceutically compatible acid addition salts thereof, together with at least one of physostigmine, tetrahydroaminoacridine, choline, lecithin, piracetam, aniracetam, pramiracetam, oxiracetam, 4-aminopyridine, 3,4-diaminopyridine, somatostatin, pirenzepine, N-methylatropine, N-butylscopolamine, scopolamine, clonidine, quanfamicine and Nerve Growth Factor. Also disclosed is a method for treating senile dementia of Alzheimer's type, which comprises coadministering to a patient in need thereof an effective dose of the spiro compound together with at least one other compound selected from those listed above.
摘要翻译：公开了一种药物组合物，其包含（ - ） - 顺式-2-甲基螺旋（1,3-氧硫杂环戊烷-5,3'）奎宁环和/或其药学上相容的酸加成盐，以及至少一种毒扁豆素，四氢氨基吖啶，胆碱，卵磷脂，吡拉西坦，阿拉西坦，普拉西坦，奥拉西坦，4-氨基吡啶，3,4-二氨基吡啶，生长抑素，哌仑西平，N-甲基阿托品，N-丁基东莨菪碱，东莨菪碱，可乐定，喹唑啉和神经生长因子。还公开了一种治疗阿尔茨海默氏型老年痴呆症的方法，其包括将有效剂量的螺环化合物与选自上述列举的至少一种其它化合物共同施用于有需要的患者。

7. 发明授权

US4900830A Process for labelling sulfur-containing compounds 失效
标题翻译：含硫化合物标记方法
公开(公告)号：US4900830A
公开(公告)日：1990-02-13
申请号：US114479
申请日：1987-10-28
申请人： Abraham Fisher , Ishai Karton
发明人： Abraham Fisher , Ishai Karton
IPC分类号： C07D497/20
CPC分类号： C07D497/20
摘要： The invention thus provides a process for obtaining the preferential replacement by isotopes, of at least one of the hydrogen atoms selected from the group consisting of those attached to the .alpha.- or .alpha.'-carbon atoms in a compound containing the structural moiety (I) ##STR1## which comprises the steps of oxidizing the compound to the corresponding sulfoxide or sulfone which contains the corresponding structural moiety (II) ##STR2## wherein in the sulfoxide n is 1 and in the sulfone n is 2, effecting the isotopic replacement by a known method of said at least one hydrogen atom, and reducing the resultant isotope-labelled sulfoxide or sulfone to the correspondingly labelled compound containing the structural moiety (I).
摘要翻译：因此，本发明提供了一种通过同位素获得优先置换的方法，该方法中至少一个氢原子选自与含有结构部分（I）的化合物中的α-或α-碳原子连接的氢原子，其包括将化合物氧化成相应的亚砜或砜的步骤，所述亚砜或砜包含相应的结构部分（II），其中在亚砜中n为1，在砜中n为2，通过所述至少一个氢原子的已知方法实现同位素替代，并将所得到的同位素标记的亚砜或砜还原成含有结构部分（I）的相应标记的化合物。

8. 发明授权

US4855290A Derivatives of quinuclidine 失效
标题翻译：奎宁环的衍生物
公开(公告)号：US4855290A
公开(公告)日：1989-08-08
申请号：US853404
申请日：1986-04-18
申请人： Abraham Fisher , Ishai Karton , Eliahu Heldman , Aharon Levy , Yona Grunfeld
发明人： Abraham Fisher , Ishai Karton , Eliahu Heldman , Aharon Levy , Yona Grunfeld
IPC分类号： A61K31/435 , A61K38/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/26 , A61P25/28 , C07D327/00 , C07D453/02 , C07D497/20
CPC分类号： C07D453/02
摘要： Quinuclidine derivatives having the general formula (I) ##STR1## and geometrical isomers, enantiomers, diastereoisomers, racemates and/or acid addition salts thereof, wherein Z represents the group >CR.sup.1 R.sup.2 or two hydrogen atoms; and R.sup.1 and R.sup.2, which may be identical or different, are each alkyl, cyclopentyl, cyclohexyl, aryl, or diarylmethylol, or alkyl which is substituted by one or more aryl groups, or one of R.sup.1 and R.sup.2 may be hydrogen.
摘要翻译：具有通式（I）的奎宁环衍生物及其几何异构体，对映异构体，非对映异构体，外消旋体和/或其酸加成盐，其中Z表示基团> CR1R2或两个氢原子; R 1和R 2可以相同或不同，分别为烷基，环戊基，环己基，芳基或二芳基羟甲基，或被一个或多个芳基取代的烷基，或者R 1和R 2之一可以是氢。

9. 发明授权

US4788063A Drug delivery system 失效
标题翻译：药物输送系统
公开(公告)号：US4788063A
公开(公告)日：1988-11-29
申请号：US760609
申请日：1985-07-30
申请人： Abraham Fisher , Drora Levy , Michael Y. Spiegelstein , Jacob Grunwald , Aharon Levy , Moshe Kushnir
发明人： Abraham Fisher , Drora Levy , Michael Y. Spiegelstein , Jacob Grunwald , Aharon Levy , Moshe Kushnir
IPC分类号： A61K9/70 , A61K45/08 , A61K47/12 , A61F13/02
CPC分类号： A61K9/7084 , A61K47/12
摘要： There is provided a composition for the transdermal application of basic drugs which have a high specific activity. The drug is provided in combination with a fatty acid having a low molecular weight. Amongst others, the delivery system is suited for cholinergic and anticholinergic basic drugs. The compositions can be supported by a pad, bandage or the like. It is one of the advantages of the compositions of the invention that a prolonged effect can be obtained, with an essentially constant therapeutic level of the active ingredient.
摘要翻译：提供了具有高比活性的经皮施用基础药物的组合物。药物与低分子量的脂肪酸组合提供。其中，输送系统适用于胆碱能和抗胆碱能药物。组合物可以由垫，绷带等支撑。本发明组合物的优点之一是可以获得延长的效果，具有基本上恒定的治疗水平的活性成分。

10. 发明授权

US4226996A Novel heterocyclic compounds and pharmaceutical composition containing them 失效
标题翻译：新型杂环化合物和含有它们的药物组合物
公开(公告)号：US4226996A
公开(公告)日：1980-10-07
申请号：US953514
申请日：1978-10-23
申请人： Sasson Cohen , Abraham Fisher
发明人： Sasson Cohen , Abraham Fisher
IPC分类号： C07D453/02 , C07D491/04 , C07D491/08
CPC分类号： C07D453/02
摘要： The invention relates to the production of compounds of the general formula: ##STR1## wherein X is selected from the group consisting of oxygen, CH.sub.2 and CH radicals, and when X designates oxygen, R designates alkyl, isoalkyl, aralkyl, and substituted aralkyl groups and when X designates CH.sub.2 then R designates alkyl, phenyl or substituted phenyl group, and A-B is a single bond, and when X designates CH.sub.2, R designates alkyl, phenyl or substituted phenyl groups and A-B is a double bond; and physiologically acceptable salts of these, and pharmaceutical compositions containing the same as active ingredient.
摘要翻译：本发明涉及以下通式的化合物的制备：其中X选自氧，CH 2和CH自由基，当X表示氧时，R表示烷基，异烷基，芳烷基和取代的芳烷基当X表示CH2时，R表示烷基，苯基或取代的苯基，AB表示单键，当X表示CH2时，R表示烷基，苯基或取代的苯基，AB表示双键; 和这些的生理上可接受的盐，以及含有与活性成分相同的药物组合物。

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