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1. 发明授权

US09121049B2 Pharmaceutical composition for elevating radio-sensitivity of cancer cells, pharmaceutical composition for detecting cancer cells with radio-sensitivity, and detection method thereof 有权
标题翻译：用于提高癌细胞的放射敏感性的药物组合物，用于检测具有放射敏感性的癌细胞的药物组合物及其检测方法
公开(公告)号：US09121049B2
公开(公告)日：2015-09-01
申请号：US13628306
申请日：2012-09-27
申请人： Dar-Bin Shieh , Hai-Wen Chen , Chia-Chun Chen , Ping-Ching Wu
发明人： Dar-Bin Shieh , Hai-Wen Chen , Chia-Chun Chen , Ping-Ching Wu
IPC分类号： G01N33/574 , C12Q1/04
CPC分类号： C12N13/00 , C12Q1/04 , G01N33/574 , G01N33/57423 , G01N2800/52
摘要： The present invention relates to a pharmaceutical composition for elevating radiation-sensitivity of cancer cells, which comprises: a nanoparticle containing with a first element, which is iron, copper, or the combination thereof; and a pharmaceutically acceptable carrier, wherein the nanoparticle is a metal nanoparticle, an alloy nanoparticle, or a metal nanoparticle with core-shell structure, and the size of the nanoparticle is under a controllable range of 3 nm to 150 nm. In addition, the present invention provides a detection method to detect radiation-sensitivity of the cancer cells through different modalities such as CT or MRI due to its native high CT number and magnetic property. Furthermore, the present invention provides a pharmaceutical composition for elevating radiation-sensitivity of the cancer cells through preferential uptake of the nanoparticle, in order to enhance the radiation-sensitivity of the cancer cells and improve the efficiency of radiation therapy to the cancer cells.
摘要翻译：本发明涉及一种用于提高癌细胞的放射敏感性的药物组合物，其包含：含有第一元素的纳米颗粒，其为铁，铜或其组合; 和药学上可接受的载体，其中所述纳米颗粒是金属纳米颗粒，合金纳米颗粒或具有核 - 壳结构的金属纳米颗粒，并且所述纳米颗粒的尺寸在3nm至150nm的可控范围内。此外，本发明提供了一种检测方法，由于其天然的高CT数和磁特性，通过CT或MRI等不同的方式检测癌细胞的放射敏感性。此外，本发明提供了一种用于通过优先吸收纳米颗粒提高癌细胞的辐射敏感性的药物组合物，以增强癌细胞的辐射敏感性并提高对癌细胞的放射疗法的效率。

2. 发明授权

US08137839B2 Alloy powder for electrode and method for producing same 有权
标题翻译：电极用合金粉末及其制造方法
公开(公告)号：US08137839B2
公开(公告)日：2012-03-20
申请号：US12063015
申请日：2006-09-14
申请人： Hideaki Ohyama , Kyoko Nakatsuji , Yoshitaka Dansui , Shinichi Orimo , Yuko Nakamori , Hai-Wen Li , Kazutaka Ikeda
发明人： Hideaki Ohyama , Kyoko Nakatsuji , Yoshitaka Dansui , Shinichi Orimo , Yuko Nakamori , Hai-Wen Li , Kazutaka Ikeda
IPC分类号： H01M4/58 , C22C19/03 , B22F9/16
CPC分类号： H01M4/383 , B22F1/0018 , B22F9/04 , B22F2009/041 , B22F2009/043 , B82Y25/00 , B82Y30/00 , C01B3/0057 , C22C1/00 , C22C1/0441 , C22C19/03 , C22C19/058 , C22C28/00 , H01F1/0045 , H01M4/02 , H01M4/385 , H01M4/463 , H01M10/345 , H01M2004/021 , Y02E60/124 , Y02E60/327 , Y02P70/54 , Y10T428/12181
摘要： An electrode alloy powder includes a hydrogen storage alloy and magnetic material clusters. The hydrogen storage alloy contains 20 to 70 wt % of Ni. The magnetic material clusters contain metal nickel, and have an average cluster size of 8 to 10 nm. A method for producing the electrode alloy powder includes an activation step of allowing a raw material powder including a hydrogen storage alloy to be in contact with an aqueous solution containing A wt % of sodium hydroxide and held at 100° C. or greater for B minutes. A and B satisfy 2410≦A×B≦2800.
摘要翻译：电极合金粉末包括储氢合金和磁性材料簇。储氢合金含有20〜70重量％的Ni。磁性材料簇含有金属镍，平均簇尺寸为8〜10nm。电极合金粉末的制造方法包括使包含储氢合金的原料粉末与含有A重量％的氢氧化钠的水溶液接触并保持在100℃以上B分钟的活化工序。 A和B满足2410＆nlE; A×B＆nlE; 2800。

3. 发明授权

US07978880B2 Continuous extended range image processing 有权
公开(公告)号：US07978880B2
公开(公告)日：2011-07-12
申请号：US12817417
申请日：2010-06-17
申请人： Gene D. Tener , Barry Mattox , Jennifer K. Park , John Cowan , William R. Herzog , Hai-Wen Chen , James P. Kane, III , David J. Huber , Timothy Alderson
发明人： Gene D. Tener , Barry Mattox , Jennifer K. Park , John Cowan , William R. Herzog , Hai-Wen Chen , James P. Kane, III , David J. Huber , Timothy Alderson
IPC分类号： G06K9/00 , G06K9/32
CPC分类号： G06T3/4038 , G06T7/337 , G06T2200/32
摘要： Methods and systems for image processing are provided. A method for processing images of a scene includes receiving image data of a reference and a current frame; generating N motion vectors that describe motion of the image data within the scene by computing a correlation function on the reference and current frames at each of N registration points; registering the current frame based on the N motion vectors to produce a registered current frame; and updating the image data of the scene based on the registered current frame. Optionally, registered frames may be oversampled. Techniques for generating the N motion vectors according to roll, zoom, shift and optical flow calculations, updating image data of the scene according to switched and intermediate integration approaches, re-introducing smoothed motion into image data of the scene, re-initializing the process, and processing images of a scene and moving target within the scene are provided.

4. 发明授权

US07742620B2 Target detection improvements using temporal integrations and spatial fusion 失效
标题翻译：使用时间整合和空间融合的目标检测改进
公开(公告)号：US07742620B2
公开(公告)日：2010-06-22
申请号：US10555104
申请日：2004-03-18
申请人： Hai-Wen Chen , Teresa L. Olson , Surachai Sutha
发明人： Hai-Wen Chen , Teresa L. Olson , Surachai Sutha
IPC分类号： G06K9/00
CPC分类号： G06K9/3241 , G06K9/6289 , G06K9/6293
摘要： A method for identifying potential targets as far away as possible is disclosed. In a simple background scene such as a blue sky, a target may be recognized from a relatively long distance, but for some high clutter situations such as mountains and cities, the detection range is severely reduced. The background clutter may also be non-stationary further complicating the detection of a target. To solve these problems, target detection (recognition) of the present invention is based upon temporal fusion (integration) of sensor data using pre-detection or post-detection integration techniques, instead of using the prior art technique of fusing data from only a single time frame. Also disclosed are double-thresholding and reversed-thresholding techniques which further enhance target detection and avoid the shortcomings of the traditional constant false alarm rate (CFAR) thresholding technique. The present invention further discloses improved spatial fusion techniques for target detection (recognition) employing multiple sensors instead of employing the more conventional single sensor techniques. If spatial fusion is implemented with more than three sensors, then target detection can be enhanced by also using post-detection techniques. Moreover, since the pre-detection and the post-detection technique are complementary to each other, a combination of these two integration techniques will further improve target detection (recognition) performance.
摘要翻译：公开了一种尽可能远地识别潜在目标的方法。在诸如蓝天的简单的背景场景中，可以从较长的距离识别目标，但是对于诸如山脉和城市的一些高杂波情况，检测范围被严重降低。背景杂波也可能是非平稳的，进一步使目标的检测复杂化。为了解决这些问题，本发明的目标检测（识别）基于使用预检测或检测后集成技术的传感器数据的时间融合（集成），而不是使用现有技术来仅将来自单个大体时间。还公开了双阈值和反向阈值技术，其进一步增强目标检测并避免传统的恒定误报率（CFAR）阈值技术的缺点。本发明还公开了使用多个传感器的目标检测（识别）的改进的空间融合技术，而不是采用更传统的单传感器技术。如果使用三个以上的传感器实现空间融合，则可以通过使用后检测技术来增强目标检测。此外，由于预检测和后检测技术彼此互补，这两种集成技术的组合将进一步改善目标检测（识别）性能。

5. 发明申请

US20060257358A1 Suspension of calcium phosphate particulates for local delivery of therapeutic agents 审中-公开
标题翻译：用于局部递送治疗剂的磷酸钙颗粒的悬浮液
公开(公告)号：US20060257358A1
公开(公告)日：2006-11-16
申请号：US11129249
申请日：2005-05-13
申请人： Hai Wen , Panjian Li
发明人： Hai Wen , Panjian Li
IPC分类号： A61K38/19 , A61K38/18 , A61K38/17 , A61K39/395 , A61K33/42
CPC分类号： A61K9/0021 , A61K33/42 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods for preparing and using porous, crystalline biomimetic bioactive compositions of calcium phosphate with at least one therapeutic agent. The bioactive composition has strong adsorption properties for therapeutic agents which adsorb to the calcium phosphate with a high affinity. The bioactive composition also provides a sustained release implant that can be used for localized delivery of therapeutic agents. This localized delivery of therapeutic agents, promotes repair, healing, or regeneration of hard and soft tissues.
摘要翻译：本文公开了制备和使用具有至少一种治疗剂的磷酸钙的多孔，结晶仿生生物活性组合物的方法。该生物活性组合物对于以高亲和力吸附在磷酸钙上的治疗剂具有很强的吸附性能。生物活性组合物还提供可用于治疗剂的局部递送的持续释放植入物。这种治疗剂的局部递送，促进硬组织和软组织的修复，愈合或再生。

6. 发明申请

US20060082490A1 Method and system for data fusion using spatial and temporal diversity between sensors 有权
公开(公告)号：US20060082490A1
公开(公告)日：2006-04-20
申请号：US11129395
申请日：2005-05-16
申请人： Hai-Wen Chen , Teresa Olson
发明人： Hai-Wen Chen , Teresa Olson
IPC分类号： G01S13/86
CPC分类号： G06K9/3241 , G06K9/6288 , G06K9/6289 , G06K9/6293 , G06T5/009 , G06T5/40 , G06T2207/10048
摘要： A method and system provide a multi-sensor data fusion system capable of adaptively weighting the contributions from each one of a plurality of sensors using a plurality of data fusion methods. During a predetermined tracking period, the system receives data from each individual sensor and each data fusion method is performed to determine a plurality of reliability functions for the system based on combining each sensor reliability function which are individually weighted based on the S/N (signal-to-noise) ratio for the received data from each sensor, and a comparison of predetermined sensor operation characteristics for each sensor and a best performing (most reliable) sensor. The system may dynamically select to use one or a predetermined combination of the generated reliability functions as the current (best) reliability function which provides a confidence level for the multi-sensor system relating to the correct classification (recognition) of targets and decoys.

7. 发明申请

US20050196519A1 Apparatus for producing a biomimetic coating on a medical implant 审中-公开
标题翻译：用于在医疗植入物上生产仿生涂层的装置
公开(公告)号：US20050196519A1
公开(公告)日：2005-09-08
申请号：US10795758
申请日：2004-03-08
申请人： Panjian Li , Elizabeth Hippensteel , Hai Wen , Ronald Konkle
发明人： Panjian Li , Elizabeth Hippensteel , Hai Wen , Ronald Konkle
IPC分类号： A61C8/00 , A61F2/00 , A61F2/28 , A61F2/30 , B05C3/00 , B05C3/109 , A61L2/00 , B05D3/00
CPC分类号： B05C3/005 , A61C8/0012 , A61F2/28 , A61F2/30767 , A61F2/3094 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/00095 , A61F2310/00131 , A61F2310/00179 , B05C3/109
摘要： An apparatus for producing a biomimetic coating on an implantable article is provided. The apparatus includes an outer reactor for containing a biomimetic coating solution and an inner reactor arranged within the outer reactor. The inner reactor is smaller than the outer reactor so as to define a space between the inner and outer reactors. The apparatus also includes a pump system for circulating the biomimetic coating solution. The pump system is arranged to operate in the space between the inner and outer reactors. The inner reactor includes a flow control system that is selectively operable to control the flow of biomimetic coating solution between the outer and inner reactors.
摘要翻译：提供了一种用于在可植入制品上生产仿生涂层的装置。该装置包括用于容纳仿生涂层溶液的外反应器和布置在外反应器内的内反应器。内反应器小于外反应器，以便在内反应器和外反应器之间限定空间。该装置还包括用于循环仿生涂层溶液的泵系统。泵系统布置成在内反应器和外反应器之间的空间中操作。内反应器包括流量控制系统，其可选择性地操作以控制外反应器和内反应器之间的仿生涂层溶液的流动。

8. 发明授权

US06909997B2 Method and system for data fusion using spatial and temporal diversity between sensors 有权
标题翻译：使用传感器之间的空间和时间分集的数据融合方法和系统
公开(公告)号：US06909997B2
公开(公告)日：2005-06-21
申请号：US10395269
申请日：2003-03-25
申请人： Hai-Wen Chen , Teresa L. Olson
发明人： Hai-Wen Chen , Teresa L. Olson
IPC分类号： G01S13/86 , G06F17/40 , G06F19/00 , G06K9/32 , G06K9/62 , G06T1/00 , G06T5/40 , H04B17/00 , H04J3/00
CPC分类号： G06K9/3241 , G06K9/6288 , G06K9/6289 , G06K9/6293 , G06T5/009 , G06T5/40 , G06T2207/10048
摘要： A method and system provide a multi-sensor data fusion system capable of adaptively weighting the contributions from each one of a plurality of sensors using a plurality of data fusion methods. During a predetermined tracking period, the system receives data from each individual sensor and each data fusion method is performed to determine a plurality of reliability functions for the system based on combining each sensor reliability function which are individually weighted based on the S/N (signal-to-noise) ratio for the received data from each sensor, and a comparison of predetermined sensor operation characteristics for each sensor and a best performing (most reliable) sensor. The system may dynamically select to use one or a predetermined combination of the generated reliability functions as the current (best) reliability function which provides a confidence level for the multi-sensor system relating to the correct classification (recognition) of targets and decoys.
摘要翻译：一种方法和系统提供一种多传感器数据融合系统，其能够使用多种数据融合方法自适应地对来自多个传感器中的每一个的贡献进行加权。在预定的跟踪期间，系统从每个单独的传感器接收数据，并且执行每个数据融合方法，以便基于基于S / N（信号）单独加权的每个传感器可靠性函数来组合系统的多个可靠性函数对于每个传感器的接收数据的比较，以及每个传感器和最佳性能（最可靠）传感器的预定传感器操作特性的比较。该系统可以动态地选择使用所生成的可靠性函数中的一个或预定组合作为当前（最佳）可靠性函数，该功能为与针对和诱饵的正确分类（识别）相关的多传感器系统提供置信度。

9. 发明授权

US06897446B2 Method and system for target detection using an infra-red sensor 失效
标题翻译：使用红外传感器进行目标检测的方法和系统
公开(公告)号：US06897446B2
公开(公告)日：2005-05-24
申请号：US10395264
申请日：2003-03-25
申请人： Hai-Wen Chen , Steven R. Frey, Jr. , Teresa L. Olson
发明人： Hai-Wen Chen , Steven R. Frey, Jr. , Teresa L. Olson
IPC分类号： G01S13/86 , G06F17/40 , G06F19/00 , G06K9/32 , G06K9/62 , G06T1/00 , G06T5/40 , H04B17/00 , H04J3/00
CPC分类号： G06K9/3241 , G06K9/6288 , G06K9/6289 , G06K9/6293 , G06T5/009 , G06T5/40 , G06T2207/10048
摘要： A target detection and tracking system provides dynamic changing of the integration time (IT) for the system IR sensor within a discrete set of values to maintain a high sensor sensitivity. The system changes the integration time to the same or a different sensor integration time within the discrete set based on the image data output from the sensor satisfying pre-determined system parameter thresholds. The system includes an IT-related saturation prediction function allowing the system to avoid unnecessary system saturation when determining whether an IT change should be made. The tracking portion of the system provides tracking feedback allowing target objects with a low sensor signature to be detected without being obscured by nearby uninterested objects that produce system saturation.
摘要翻译：目标检测和跟踪系统提供系统红外传感器在一组离散值内的积分时间（IT）的动态变化，以保持较高的传感器灵敏度。基于从满足预定系统参数阈值的传感器输出的图像数据，系统将积分时间改变为离散组内相同或不同的传感器积分时间。该系统包括IT相关的饱和预测功能，允许系统在确定是否应进行IT更改时避免不必要的系统饱和。系统的跟踪部分提供跟踪反馈，允许检测到具有低传感器签名的目标对象，而不会被产生系统饱和的附近不感兴趣的对象遮蔽。

10. 发明授权

US06393137B1 Multi-resolution object classification method employing kinematic features and system therefor 有权
标题翻译：使用运动特征的多分辨率对象分类方法及其系统
公开(公告)号：US06393137B1
公开(公告)日：2002-05-21
申请号：US09335427
申请日：1999-06-17
申请人： Hai-Wen Chen , Harry A. Schmitt , Jack G. Riddle
发明人： Hai-Wen Chen , Harry A. Schmitt , Jack G. Riddle
IPC分类号： G06K900
CPC分类号： G06K9/522
摘要： A multi-resolution feature extraction method and apparatus. In the illustrative embodiment, the feature extractor includes circuitry for receiving and transforming a time variant data signal into a multi-resolution data signal. The multi-resolution data signal is compared to each of a plurality of object templates. The system then generates a feature vector based on a correlation of the multi-resolution data signal to one of the object templates. The multi-resolution feature extraction method employs object templates formed by transforming time variant image data for each of a plurality of objects into a respective multi-resolution template and averaging all templates for each respective object. The method includes steps for transforming an incoming time variant data signal into a multi-resolution data signal, comparing the multi-resolution data signal to each of the object templates, and generating a feature vector when the multi-resolution data signal correlates to one of the object templates. In a more specific implementation, the method further includes the steps of calculating a confusion matrix (CM), classifying the feature vectors as one of the objects to thereby produce classified objects responsive to the CM, and selecting a target from the classified objects. A multi-resolution feature extractor according to the present invention employs object templates formed by transforming time variant image data for each of a plurality of objects into a respective multi-resolution template and averaging all templates for each respective object to thereby generate object templates.
摘要翻译：一种多分辨率特征提取方法和装置。在说明性实施例中，特征提取器包括用于接收时变数据信号并将其变换为多分辨率数据信号的电路。将多分辨率数据信号与多个对象模板中的每一个进行比较。然后，系统基于多分辨率数据信号与对象模板之一的相关性生成特征向量。多分辨率特征提取方法使用通过将多个对象中的每一个的时间变量图像数据变换为相应的多分辨率模板而形成的对象模板，并对每个相应对象的所有模板进行平均。该方法包括以下步骤：将输入时变数据信号变换为多分辨率数据信号，将多分辨率数据信号与每个对象模板进行比较，以及当多分辨率数据信号与对象模板。在更具体的实现中，该方法还包括以下步骤：计算混淆矩阵（CM），将特征向量分类为对象之一，从而响应于CM产生分类对象，并从分类对象中选择目标。根据本发明的多分辨率特征提取器采用通过将多个对象中的每一个的时间变量图像数据变换为相应的多分辨率模板而形成的对象模板，并对每个相应对象的所有模板进行平均，从而生成对象模板。

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