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1. 发明授权

US09044529B2 Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether 有权
标题翻译：水凝胶组织粘合剂由胺化多糖和醛官能化的多臂聚醚形成
公开(公告)号：US09044529B2
公开(公告)日：2015-06-02
申请号：US13129617
申请日：2009-08-31
申请人： Helen S. M. Lu , Steven Willis Shuey
发明人： Helen S. M. Lu , Steven Willis Shuey
IPC分类号： A61L24/04 , A61L24/00 , A61L24/08 , A61K47/36 , A61K47/34 , A61L26/00
CPC分类号： A61L24/043 , A61K47/34 , A61K47/36 , A61L24/0031 , A61L24/046 , A61L24/08 , A61L26/0019 , A61L26/0023 , C08L71/02
摘要： A hydrogel tissue adhesive formed by reacting an aminated polysaccharide with a water-dispersible, aldehyde-functionalized multi-arm polyether is described. The hydrogel tissue adhesive may be useful as a general tissue adhesive and sealant for medical and veterinary applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions. Additionally, due to the presence of the aminated polysaccharide, the hydrogel tissue adhesive may also promote wound healing and blood coagulation, and provide antimicrobial properties.
摘要翻译：描述了通过使胺化多糖与水分散性醛官能化的多臂聚醚反应形成的水凝胶组织粘合剂。水凝胶组织粘合剂可用作用于医疗和兽医应用的一般组织粘合剂和密封剂，例如在内部手术过程中的伤口闭合，补充或替换缝合线或缝钉，例如肠吻合和血管吻合，组织修复，眼科手术，药物递送，并防止手术后粘连。此外，由于存在胺化多糖，水凝胶组织粘合剂也可促进伤口愈合和凝血，并提供抗微生物性质。

2. 发明申请

US20100015231A1 LOW SWELL, LONG-LIVED HYDROGEL SEALANT 审中-公开
标题翻译： LOW SWELL，长寿命密封胶
公开(公告)号：US20100015231A1
公开(公告)日：2010-01-21
申请号：US12497729
申请日：2009-07-06
申请人： Helen S. M. LU
发明人： Helen S. M. LU
IPC分类号： A61K9/10
CPC分类号： A61L24/08 , A61K9/0024 , A61K9/0051 , A61K47/36
摘要： A low swell, long-lived hydrogel sealant formed by reacting a highly oxidized polysaccharide containing aldehyde groups with a multi-arm amine is described. The hydrogel sealant may be particularly suitable for applications requiring low swell and slow degradation, for example, ophthalmic applications such as sealing wounds resulting from trauma such as corneal lacerations, or from surgical procedures such as vitrectomy procedures, cataract surgery, LASIK surgery, glaucoma surgery, and corneal transplants; neurosurgery applications, such as sealing the dura; and as a plug to seal a fistula or the punctum. The low swell, long-lived hydrogel sealant may also be useful as a tissue sealant and adhesive, and as an anti-adhesion barrier.
摘要翻译：描述了通过使含有醛基的高度氧化的多糖与多臂胺反应形成的低溶胀，长寿命的水凝胶密封剂。水凝胶密封剂可以特别适用于需要低溶胀和缓慢降解的应用，例如眼科应用，例如由诸如角膜撕裂等创伤引起的伤口，或外科手术如玻璃体切除术，白内障手术，LASIK手术，青光眼手术，角膜移植; 神经外科应用如密封硬脑膜; 并用作密封瘘管或泪点的塞子。低膨胀，长寿命的水凝胶密封剂也可用作组织密封剂和粘合剂，以及作为抗粘连屏障。

3. 发明授权

US07601361B2 Process for providing antimicrobial surfaces 失效
标题翻译：提供抗菌表面的方法
公开(公告)号：US07601361B2
公开(公告)日：2009-10-13
申请号：US11242395
申请日：2005-10-03
申请人： Helen S. M. Lu , John S. Chapman , Albert Gordon Anderson
发明人： Helen S. M. Lu , John S. Chapman , Albert Gordon Anderson
IPC分类号： A61K9/00 , A61F13/00 , A61K38/16 , A61K38/10
CPC分类号： C09D5/14 , A61K38/10 , A61K38/16 , A61L29/048 , A61L29/08 , A61L29/16 , A61L31/047 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/606
摘要： Processes for providing durable antimicrobial surfaces are disclosed that comprise treating a polymer substrate surface with formaldehyde followed by treatment with an antimicrobial peptide. Further embodiments include articles, including medical devices, characterized by a durable antimicrobial surface provided by the processes of the invention.
摘要翻译：公开了用于提供耐久性抗微生物表面的方法，其包括用甲醛处理聚合物底物表面，然后用抗微生物肽处理。其它实施方案包括包括医疗装置的制品，其特征在于由本发明的方法提供的耐久的抗微生物表面。

4. 发明申请

US20090087466A1 PROCESS FOR PROVIDING ANTIMICROBIAL SURFACES 审中-公开
标题翻译：提供抗微生物表面的方法
公开(公告)号：US20090087466A1
公开(公告)日：2009-04-02
申请号：US12261448
申请日：2008-10-30
申请人： Helen S. M. Lu , John S. Chapman , Albert Gordon Anderson
发明人： Helen S. M. Lu , John S. Chapman , Albert Gordon Anderson
IPC分类号： A01N25/34 , A01N37/18 , A01P1/00
CPC分类号： C09D5/14 , A61K38/10 , A61K38/16 , A61L29/048 , A61L29/08 , A61L29/16 , A61L31/047 , A61L31/08 , A61L31/16 , A61L2300/25 , A61L2300/404 , A61L2300/606
摘要： Processes for providing durable antimicrobial surfaces are disclosed that comprise treating a polymer substrate surface with formaldehyde followed by treatment with an antimicrobial peptide. Further embodiments include articles, including medical devices, characterized by a durable antimicrobial surface provided by the processes of the invention.
摘要翻译：公开了用于提供耐久性抗微生物表面的方法，其包括用甲醛处理聚合物底物表面，然后用抗微生物肽处理。其它实施方案包括包括医疗装置的制品，其特征在于由本发明的方法提供的耐久的抗微生物表面。

5. 发明授权

US06737539B2 Phosphonite ligands and their use in hydrocyanation 失效
标题翻译：膦酸酯配体及其在氢氰化中的应用
公开(公告)号：US06737539B2
公开(公告)日：2004-05-18
申请号：US10454074
申请日：2003-06-04
申请人： Christian P. Lenges , Helen S. M. Lu , Joachim C. Ritter
发明人： Christian P. Lenges , Helen S. M. Lu , Joachim C. Ritter
IPC分类号： C07C25310
CPC分类号： C07C253/30 , C07C253/10 , C07C255/04 , C07C255/07
摘要： Disclosed herein are processes for hydrocyanation and isomerization of olefins by using at least one multidentate phosphonite ligands, including organometallic phosphonite ligands with a Group VIII metal or Group VIII metal compound, and optionally, a Lewis acid promoter.
摘要翻译：本文公开了通过使用至少一个多齿膦酸酯配体，包括具有VIII族金属或VIII族金属化合物的有机金属亚膦酸盐配体和任选的路易斯酸启动子来氢化氰化和异构化烯烃的方法。

6. 发明申请

US20120285930A1 PRINTING FORM AND PROCESS FOR PREPARING THE PRINTING FORM WITH CURABLE COMPOSITION HAVING EPOXY NOVOLAC RESIN 审中-公开
标题翻译：印刷形式和制备具有环氧氯酚树脂的可固化组合物的印刷方法
公开(公告)号：US20120285930A1
公开(公告)日：2012-11-15
申请号：US13469337
申请日：2012-05-11
申请人： Douglas J. Adelman , Cara L. Blankenbicker , Andrew P. Davis , Barbara B. Fones , Helen S. M. Lu , Mark E. Wagman
发明人： Douglas J. Adelman , Cara L. Blankenbicker , Andrew P. Davis , Barbara B. Fones , Helen S. M. Lu , Mark E. Wagman
IPC分类号： B29C59/16 , B05C21/00 , B05D5/00
CPC分类号： B41N1/22 , B41C1/045 , B41C1/05 , B41N1/06 , B41N1/12 , C08G59/08 , C08G59/5006 , C08L63/04
摘要： The invention pertains to a printing form and a process for preparing the printing form from a curable composition that includes an epoxy novolac resin having an epoxide equivalent weight of 156 to 300 g/equivalent, and an amine curing agent selected from primary amines and secondary amines, the agent having an amine equivalent weight of less than or equal to 60 g/equivalent. The process includes applying the curable composition to a supporting substrate to form a layer, curing the layer at one or more temperatures in a temperature range, and engraving to form at least one cell in the cured layer. The process prepares printing forms, particularly gravure printing forms, having a cured resin composition layer that is engravable, resistant to solvent inks and to mechanical wear, and capable of printing gravure-quality images.
摘要翻译：本发明涉及一种印刷形式和从包含环氧当量为156-300g /当量的环氧酚醛清漆树脂和选自伯胺和仲胺的胺固化剂的可固化组合物制备印刷形式的方法该胺的当量重量小于或等于60g /当量。该方法包括将可固化组合物施加到支撑基底以形成层，在一个或多个温度范围内固化该层，并雕刻以在固化层中形成至少一个电池。该方法制备具有可雕刻，耐溶剂油墨和机械磨损的固化树脂组合物层并且能够印刷凹版印刷图像的印刷形式，特别是凹版印刷形式。

7. 发明授权

US08039681B2 Functionalized carbon materials 失效
标题翻译：官能化碳材料
公开(公告)号：US08039681B2
公开(公告)日：2011-10-18
申请号：US11205452
申请日：2005-08-17
申请人： Paul J. Krusic , Clarence G. Law , Helen S. M. Lu , Zhen-Yu Yang , Jocelyn Hicks Garner
发明人： Paul J. Krusic , Clarence G. Law , Helen S. M. Lu , Zhen-Yu Yang , Jocelyn Hicks Garner
IPC分类号： C07C22/00 , C07C19/08 , H01M8/10
CPC分类号： C09C1/48 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174 , C01B2202/28 , C01P2002/88 , C01P2004/13 , C07C23/46 , C07C309/10 , C07C2604/00 , C09C1/56 , C09C1/565 , Y10S977/738
摘要： This invention relates to carbon materials, such as a fullerene molecule or a curved carbon nanostructure, that are functionalized by addition chemistry performed on surface C—C double bond.
摘要翻译：本发明涉及通过在表面C-C双键上进行的加成化学官能化的碳材料，例如富勒烯分子或弯曲碳纳米结构。

8. 发明授权

US07732018B2 Durable coating compositions containing novel aspartic amine compounds 有权
标题翻译：含有新型天冬氨酸胺化合物的耐久涂料组合物
公开(公告)号：US07732018B2
公开(公告)日：2010-06-08
申请号：US11303083
申请日：2005-12-14
申请人： Christian Peter Lenges , Domenic J. Barsotti , Robert John Barsotti , Kalindi Dogra , Helen S. M. Lu , Stefan Reinartz
发明人： Christian Peter Lenges , Domenic J. Barsotti , Robert John Barsotti , Kalindi Dogra , Helen S. M. Lu , Stefan Reinartz
IPC分类号： C08F218/04 , B32B27/26 , B05D1/36
CPC分类号： C08F220/04 , C08F222/02 , Y10T428/31551
摘要： A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula (I) including isomers and mixtures of isomers thereof: wherein R, R1, R2, X, Y, Z, m, n, p, q, r and s are described in the specification and a two component composition formulated with the above constituents and substrates, such as, automotive and truck bodies and parts coated with the novel composition and novel amine and/or hydroxy amine compounds are also part of the invention.
摘要翻译：一种涂料组合物，其包含a。多异氰酸酯交联剂; b。具有至少一种具有下列通式（I）的化合物的异氰酸酯反应性组分，包括异构体及其异构体的混合物：其中R，R1，R2，X，Y，Z，m，n，p，q，r和s分别为在本说明书中描述的两组分组合物和由上述组分配制的双组分组合物和底物，例如汽车和卡车体以及涂有新组合物和新型胺和/或羟基胺化合物的部分也是本发明的一部分。

9. 发明授权

US07550430B2 Cationic antimicrobial peptides and compositions 有权
标题翻译：阳离子抗菌肽和组合物
公开(公告)号：US07550430B2
公开(公告)日：2009-06-23
申请号：US10920548
申请日：2004-08-18
申请人： Sharon J. Keeler , Helen S. M. Lu
发明人： Sharon J. Keeler , Helen S. M. Lu
IPC分类号： A61K38/00 , A61K38/12
CPC分类号： A61K38/00 , Y02P20/55
摘要： The invention described herein relates to compositions of novel antimicrobial peptides. The peptides of the present invention exhibit high antibacterial activity and low hemolytic activity. The invention further provides compositions comprising these antimicrobial peptides and methods of use thereof for killing, reducing the growth of, or preventing the growth of microorganisms. The invention also provides antimicrobial substrates and articles comprising the peptides of the present invention.
摘要翻译：本文描述的本发明涉及新型抗微生物肽的组合物。本发明的肽具有高抗菌活性和低溶血活性。本发明还提供包含这些抗微生物肽的组合物及其用于杀死，减少生长或防止微生物生长的方法。本发明还提供了包含本发明的肽的抗微生物底物和制品。

10. 发明授权

US06846945B2 Phosphonite ligands and their use in hydrocyanation 有权
标题翻译：膦酸酯配体及其在氢氰化中的应用
公开(公告)号：US06846945B2
公开(公告)日：2005-01-25
申请号：US10454024
申请日：2003-06-04
申请人： Christian P. Lenges , Helen S. M. Lu , Joachim C. Ritter
发明人： Christian P. Lenges , Helen S. M. Lu , Joachim C. Ritter
IPC分类号： C07C253/10 , C07C253/30 , C07C255/04 , C07C255/07 , C07C253/00
CPC分类号： C07C253/30 , C07C253/10 , C07C255/04 , C07C255/07
摘要： Disclosed herein are processes for hydrocyanation and isomerization of olefins by using at least one multidentate phosphonite ligands, including organometallic phosphonite ligands with a Group VIII metal or Group VIII metal compound, and optionally, a Lewis acid promoter.
摘要翻译：本文公开了通过使用至少一个多齿膦酸酯配体，包括具有VIII族金属或VIII族金属化合物的有机金属亚膦酸盐配体和任选的路易斯酸启动子来氢化氰化和异构化烯烃的方法。

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