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1. 发明授权

US06479032B1 Calcitonin receptor binding reagents 失效
标题翻译：降钙素受体结合试剂
公开(公告)号：US06479032B1
公开(公告)日：2002-11-12
申请号：US09553493
申请日：2000-04-20
申请人： Richard T. Dean , Larry R. Bush , Daniel A. Pearson , John Lister-James
发明人： Richard T. Dean , Larry R. Bush , Daniel A. Pearson , John Lister-James
IPC分类号： A61K5100
CPC分类号： C07K14/585 , A61K38/00
摘要： This invention relates to calcitonin receptor binding reagents comprising compounds which are covalently linked to a radiometal chelator. The invention is embodied as calcitonin receptor binding peptide derivatives and analogues of calcitonin which may be radiolabeled with a suitable isotope and used as radiodiagnostic or radiotherapeutic agents. Methods and kits for making, radiolabeling and using such reagents diagnostically and therapeutically in a mammalian body are also provided.
摘要翻译：本发明涉及包含与放射性金属螯合剂共价连接的化合物的降钙素受体结合试剂。本发明体现为降钙素受体结合肽衍生物和降钙素类似物，其可以用合适的同位素放射标记并用作放射诊断或放射治疗剂。还提供了用于在哺乳动物身体中诊断和治疗地制备，放射性标记和使用这些试剂的方法和试剂盒。

2. 发明授权

US6086850A Calcitonin receptor binding reagents 失效
公开(公告)号：US6086850A
公开(公告)日：2000-07-11
申请号：US71090
申请日：1998-05-01
申请人： Richard T. Dean , Larry R. Bush , Daniel A. Pearson , John Lister-James
发明人： Richard T. Dean , Larry R. Bush , Daniel A. Pearson , John Lister-James
IPC分类号： A61K51/00 , A61K38/00 , A61K38/23 , A61K49/00 , A61K51/08 , A61P35/00 , C07B59/00 , C07K14/585 , A61M36/14
CPC分类号： C07K14/585 , A61K38/00
摘要： This invention relates to calcitonin receptor binding reagents comprising compounds which are covalently linked to a radiometal chelator. The invention is embodied as calcitonin receptor binding peptide derivatives and analogues of calcitonin which may be radiolabeled with a suitable isotope and used as radiodiagnostic or radiotherapeutic agents. Methods and kits for making, radiolabeling and using such reagents diagnostically and therapeutically in a mammalian body are also provided.

3. 发明申请

US20100190861A1 CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS 有权
标题翻译：环丙基胺作为单胺类复制抑制剂
公开(公告)号：US20100190861A1
公开(公告)日：2010-07-29
申请号：US12688474
申请日：2010-01-15
申请人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campbell
发明人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campbell
IPC分类号： A61K31/135 , C07C211/15 , C07C215/48 , A61P25/00 , A61P25/24
CPC分类号： C07D333/20 , C07C211/17 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D207/06 , C07D207/08 , C07D211/14 , C07D211/16 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
摘要翻译：本发明涉及新的环己胺衍生物及其在治疗和/或预防中枢神经系统（CNS）障碍如抑郁，焦虑，精神分裂症和睡眠障碍中的用途及其合成方法。本发明还涉及含有本发明化合物的药物组合物，以及抑制内源性单胺如从突触间隙中再摄取多巴胺，5-羟色胺和去甲肾上腺素以及调节一种或多种单胺转运蛋白的方法。

4. 发明授权

US08877975B2 Cycloalkylamines as monoamine reuptake inhibitors 有权
标题翻译：环烷基胺作为单胺再摄取抑制剂
公开(公告)号：US08877975B2
公开(公告)日：2014-11-04
申请号：US12688474
申请日：2010-01-15
申请人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campbell
发明人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Jianguo Ma , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , John E. Campbell
IPC分类号： C07C211/17 , A61K31/137 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07D207/06 , C07D207/08 , C07D211/14 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D333/20 , C07D491/056
CPC分类号： C07D333/20 , C07C211/17 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D207/06 , C07D207/08 , C07D211/14 , C07D211/16 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.
摘要翻译：本发明涉及新的环己胺衍生物及其在治疗和/或预防中枢神经系统（CNS）障碍如抑郁，焦虑，精神分裂症和睡眠障碍中的用途及其合成方法。本发明还涉及含有本发明化合物的药物组合物，以及抑制内源性单胺如从突触间隙中再摄取多巴胺，5-羟色胺和去甲肾上腺素以及调节一种或多种单胺转运蛋白的方法。

5. 发明授权

US06509001B1 Calcitonin receptor binding reagents 失效
标题翻译：降钙素受体结合试剂
公开(公告)号：US06509001B1
公开(公告)日：2003-01-21
申请号：US09553494
申请日：2000-04-20
申请人： Richard T. Dean , Larry R. Bush , Daniel A. Pearson , John Lister-James
发明人： Richard T. Dean , Larry R. Bush , Daniel A. Pearson , John Lister-James
IPC分类号： A61K5100
CPC分类号： C07K14/585 , A61K38/00
摘要： This invention relates to calcitonin receptor binding reagents Comprising Compounds which are Covalently linked to a radiometal chelator. The invention is embodied as calcitonin receptor binding peptide derivatives and analogues of calcitonin which may be radiolabeled with a suitable isotope and used as radiodiagnostic or radiotherapeutic agents. Methods and kits for making, radiolabeling and using such reagents diagnostically and therapeutically in a mammalian body are also provided.
摘要翻译：本发明涉及包含与放射性金属螯合剂共价连接的化合物的降钙素受体结合试剂。本发明体现为降钙素受体结合肽衍生物和降钙素类似物，其可以用合适的同位素放射标记并用作放射诊断或放射治疗剂。还提供了用于在哺乳动物身体中诊断和治疗地制备，放射性标记和使用这些试剂的方法和试剂盒。

6. 发明授权

US6083480A Calcitonin receptor binding reagents 失效
标题翻译：降钙素受体结合试剂
公开(公告)号：US6083480A
公开(公告)日：2000-07-04
申请号：US847007
申请日：1997-05-01
申请人： Richard T. Dean , Larry R. Bush , Daniel A. Pearson , John Lister-James
发明人： Richard T. Dean , Larry R. Bush , Daniel A. Pearson , John Lister-James
IPC分类号： A61K51/00 , A61K38/00 , A61K38/23 , A61K49/00 , A61K51/08 , A61P35/00 , C07B59/00 , C07K14/585 , A61M36/14
CPC分类号： C07K14/585 , A61K38/00
摘要： This invention relates to radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic and radiotherapeutic agents. Specifically, the invention relates to calcitonin receptor binding compounds, preferably peptides, derivatives and analogues of calcitonin, and embodiments of such compounds radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such compounds, particularly peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to calcitonin receptor binding peptide derivatives and analogues of calcitonin radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to calcitonin receptor binding peptide derivatives and analogues of calcitonin radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents. Methods and kits for making, radiolabeling and using such peptides diagnostically and therapeutically in a mammalian body are also provided.
摘要翻译：本发明涉及放射治疗试剂和肽，放射诊断试剂和肽，以及用于产生标记的放射诊断和放射治疗剂的方法。具体地，本发明涉及降钙素受体结合化合物，优选降钙素的肽，衍生物和类似物，以及用放射性同位素放射性标记的这种化合物的实施方案，以及用于制备，放射性标记和使用这些化合物的方法和试剂盒，特别是用于放射诊断和放射治疗目的。本发明具体涉及降钙素受体结合肽衍生物和用锝-99m放射性标记的降钙素的类似物及其用作闪烁照相成像剂。本发明还具体涉及降钙素受体结合肽衍生物和放射性标记的细胞毒性放射性同位素如铼-186（186Re）和铼-188（188Re）用作放射治疗剂的降钙素的类似物。还提供了用于在哺乳动物体内制造，放射性标记和诊断和治疗上使用这些肽的方法和试剂盒。

7. 发明授权

US5951981A Thrombolytic agents with antithrombotic activity 失效
标题翻译：具有抗血栓活性的溶血剂
公开(公告)号：US5951981A
公开(公告)日：1999-09-14
申请号：US753781
申请日：1996-12-02
申请人： Francis S. Markland, Jr. , Larry R. Bush , Stephen Swenson , Eladio Flores Sanchez
发明人： Francis S. Markland, Jr. , Larry R. Bush , Stephen Swenson , Eladio Flores Sanchez
IPC分类号： A61K47/48 , A61K51/08 , A61P7/02 , C12N9/64 , A61K38/54 , A61K38/46 , C12N9/48 , C12N9/96
CPC分类号： A61K47/48246 , A61K47/48023 , C12N9/6418
摘要： This invention provides thrombolytic agents and methods for making and using thrombolytic agents. Specifically, the invention provides thrombolytic agents comprising a thrombolytic proteinase and a specific binding peptide that specifically binds at the site of blood clots and thrombi in vivo. The invention particularly provides chemically crosslinked conjugates of a thrombolytic proteinase and a plurality of specific binding peptide. Methods for producing such chemically crosslinked conjugates and methods for using such conjugates for eliminating thrombi in vivo to alleviate pathological conditions caused thereby are also provided. The preferred thrombolytic proteinase in the conjugate is fibrolase obtainable from Agkistrodon contortrix confortrix venom.
摘要翻译：本发明提供血栓溶解剂和制造和使用溶栓剂的方法。具体地，本发明提供溶栓剂，其包含在体内血凝块和血栓位置上特异性结合的溶血栓素蛋白酶和特异性结合肽。本发明特别提供了溶栓酶蛋白酶和多种特异性结合肽的化学交联的缀合物。还提供了生产这种化学交联共轭物的方法和使用这种缀合物消除体内血栓以减轻由此引起的病理状况的方法。缀合物中优选的血栓溶解蛋白酶是可从腱蛇毒混合液中获得的纤维素酶。

8. 发明申请

US20180230120A1 CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS 审中-公开
公开(公告)号：US20180230120A1
公开(公告)日：2018-08-16
申请号：US15836261
申请日：2017-12-08
申请人： Liming SHAO , Fengjiang WANG , Scott Christopher MALCOLM , Michael Charles HEWITT , Larry R. BUSH , Jianguo MA , Mark A. VARNEY , Una CAMPBELL , Sharon Rae ENGEL , Larry Wendell HARDY , Patrick KOCH , John E. CAMPELL
发明人： Liming SHAO , Fengjiang WANG , Scott Christopher MALCOLM , Michael Charles HEWITT , Larry R. BUSH , Jianguo MA , Mark A. VARNEY , Una CAMPBELL , Sharon Rae ENGEL , Larry Wendell HARDY , Patrick KOCH , John E. CAMPELL
IPC分类号： C07D333/20 , C07C211/17 , C07C211/29 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07D207/06 , C07D207/08 , C07D211/14 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056 , C07D211/16 , C07C211/40
CPC分类号： C07D333/20 , C07C211/17 , C07C211/29 , C07C211/40 , C07C215/42 , C07C215/44 , C07C217/52 , C07C217/74 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07D207/06 , C07D207/08 , C07D211/14 , C07D211/16 , C07D265/14 , C07D277/28 , C07D295/06 , C07D307/52 , C07D317/58 , C07D317/72 , C07D319/06 , C07D491/056
摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

9. 发明授权

US08053603B2 Tetralone-based monoamine reuptake inhibitors 有权
标题翻译：基于四氢萘酮的单胺再摄取抑制剂
公开(公告)号：US08053603B2
公开(公告)日：2011-11-08
申请号：US11643190
申请日：2006-12-21
申请人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , Jianguo Ma
发明人： Liming Shao , Fengjiang Wang , Scott Christopher Malcolm , Michael Charles Hewitt , Larry R. Bush , Mark A. Varney , Una Campbell , Sharon Rae Engel , Larry Wendell Hardy , Patrick Koch , Jianguo Ma
IPC分类号： C07C211/42 , A61K31/133 , A61K31/135
CPC分类号： C07C211/40 , C07C17/16 , C07C17/35 , C07C45/38 , C07C45/52 , C07C45/63 , C07C45/67 , C07C45/68 , C07C45/74 , C07C211/29 , C07C211/30 , C07C211/42 , C07C215/44 , C07C217/74 , C07C2601/14 , C07C2602/10 , C07D215/12 , C07C25/22 , C07C22/04 , C07C47/453 , C07C49/67 , C07C49/697 , C07C49/255 , C07C49/755 , C07C49/683
摘要： The invention relates to novel tetralone based amines and their use in the treatment of central nervous system (CNS) disorders, such as depression, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease. The invention further relates to pharmaceutical compositions containing the compounds and compositions of the invention as well as methods of inhibiting reuptake of one or more monoamine, such as such as dopamine and norepinephrine, from the synaptic cleft, and methods of modulating one or more monoamine transporter.
摘要翻译：本发明涉及新的四氢萘酮类胺及其用于治疗中枢神经系统（CNS）障碍，例如抑郁症，注意缺陷多动障碍（ADHD）和帕金森病。本发明还涉及含有本发明化合物和组合物的药物组合物以及抑制一种或多种单胺（例如多巴胺和去甲肾上腺素）从突触裂缝再摄取的方法，以及调节一种或多种单胺转运蛋白的方法。

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