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1. 发明授权

US12006352B2 Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains 有权
公开(公告)号：US12006352B2
公开(公告)日：2024-06-11
申请号：US16823412
申请日：2020-03-19
申请人： Ablynx N.V. , Sanofi
发明人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
IPC分类号： C07K16/00 , C07K16/18 , A61K39/00 , A61K39/395 , C07K16/28 , C07K16/42 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： C07K16/00 , C07K16/18 , A61K39/39533 , A61K2039/505 , C07K16/28 , C07K16/2875 , C07K16/42 , C07K16/4283 , C07K2317/22 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/567 , C07K2317/569 , C07K2317/92 , C07K2317/94 , C07K2319/30 , G01N33/5306 , G01N33/54393 , G01N33/6854 , G01N33/6857
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal;—methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal;—modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

2. 发明授权

US11753465B2 Nucleic acids encoding polypeptides against IL-23 有权
公开(公告)号：US11753465B2
公开(公告)日：2023-09-12
申请号：US17188158
申请日：2021-03-01
申请人： Ablynx N.V. , Sanofi
发明人： Marie-Ange Buyse
IPC分类号： C07K16/24 , A61P35/00 , C07K16/42 , A61P31/00
CPC分类号： C07K16/244 , A61P35/00 , A61P31/00 , C07K16/4208 , C07K2317/22 , C07K2317/34 , C07K2317/56 , C07K2317/569
摘要： The present invention relates to amino acid sequences that are directed against interleukin 23 (IL-23). The amino acid sequences of the present invention comprise two NANOBODY® molecules against IL-23 and one NANOBODY® molecule against serum albumin, linked by two linkers. In particular, the invention relates to the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 3 (listed in Table 1 and FIG. 1) (also referred to herein as “anti-IL 23 polypeptides of the invention”).

3. 发明授权

US11708404B2 Immunoglobulin variable domains 有权
公开(公告)号：US11708404B2
公开(公告)日：2023-07-25
申请号：US17719496
申请日：2022-04-13
申请人： Ablynx N.V. , Sanofi
发明人： Marie-Ange Buyse , Carlo Boutton
IPC分类号： C07K16/18 , C07K16/00 , C07K16/28 , C07K16/42 , C07K16/32 , C07K16/30 , C07K16/24
CPC分类号： C07K16/18 , C07K16/00 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/28 , C07K16/2863 , C07K16/2866 , C07K16/2875 , C07K16/30 , C07K16/32 , C07K16/42 , C07K16/4291 , C07K2317/22 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2319/00 , C07K2319/31
摘要： VH domain, in which: (i) the amino acid residue at position 112 is one of K or Q; and/or (ii) the amino acid residue at position 89 is T; and/or (iii) the amino acid residue at position 89 is L and the amino acid residue at position 110 is one of K or Q; and (iv) in each of cases (i) to (iii), the amino acid at position 11 is preferably V; and in which said VH domain contains a C-terminal extension (X)n, in which n is 1 to 10, preferably 1 to 5, such as 1, 2, 3, 4 or 5 (and preferably 1 or 2, such as 1); and each X is an (preferably naturally occurring) amino acid residue that is independently chosen, and preferably independently chosen from the group consisting of alanine (A), glycine (G), valine (V), leucine (L) or isoleucine (I).

4. 发明申请

US20220332807A1 IMMUNOGLOBULIN VARIABLE DOMAINS 有权
公开(公告)号：US20220332807A1
公开(公告)日：2022-10-20
申请号：US17704063
申请日：2022-03-25
申请人： Ablynx N.V. , Sanofi
发明人： Marie-Ange Buyse , Carlo Boutton
IPC分类号： C07K16/18 , C07K16/00 , C07K16/28 , C07K16/42 , C07K16/32 , C07K16/30 , C07K16/24
摘要： VH domain, in which: (i) the amino acid residue at position 112 is one of K or Q; and/or (ii) the amino acid residue at position 89 is T; and/or (iii) the amino acid residue at position 89 is L and the amino acid residue at position 110 is one of K or Q; and (iv) in each of cases (i) to (iii), the amino acid at position 11 is preferably V; and in which said VH domain contains a C-terminal extension (X)n, in which n is 1 to 10, preferably 1 to 5, such as 1, 2, 3, 4 or 5 (and preferably 1 or 2, such as 1); and each X is an (preferably naturally occurring) amino acid residue that is independently chosen, and preferably independently chosen from the group consisting of alanine (A), glycine (G), valine (V), leucine (L) or isoleucine (I).

5. 发明申请

US20220298227A9 TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS 有权
公开(公告)号：US20220298227A9
公开(公告)日：2022-09-22
申请号：US17408893
申请日：2021-08-23
申请人： Ablynx N.V.
发明人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Néotère Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
IPC分类号： C07K16/00 , C07K16/18
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.

6. 发明申请

US20210269514A1 IMMUNOGLOBULIN VARIABLE DOMAINS 有权
公开(公告)号：US20210269514A1
公开(公告)日：2021-09-02
申请号：US17215039
申请日：2021-03-29
申请人： Ablynx N.V.
发明人： Marie-Ange Buyse , Carlo Boutton
IPC分类号： C07K16/18 , C07K16/00 , C07K16/28 , C07K16/42 , C07K16/32 , C07K16/30 , C07K16/24
摘要： VH domain, in which: (i) the amino acid residue at position 112 is one of K or Q; and/or (ii) the amino acid residue at position 89 is T; and/or (iii) the amino acid residue at position 89 is L and the amino acid residue at position 110 is one of K or Q; and (iv) in each of cases (i) to (iii), the amino acid at position 11 is preferably V; and in which said VH domain contains a C-terminal extension (X)n, in which n is 1 to 10, preferably 1 to 5, such as 1, 2, 3, 4 or 5 (and preferably 1 or 2, such as 1); and each X is an (preferably naturally occurring) amino acid residue that is independently chosen, and preferably independently chosen from the group consisting of alanine (A), glycine (G), valine (V), leucine (L) or isoleucine (I).

7. 发明申请

US20210188967A1 POLYPEPTIDES AGAINST IL-23 有权
公开(公告)号：US20210188967A1
公开(公告)日：2021-06-24
申请号：US17188158
申请日：2021-03-01
申请人： Ablynx N.V.
发明人： Marie-Ange Buyse
IPC分类号： C07K16/24 , C07K16/42 , A61P35/00
摘要： The present invention relates to amino acid sequences that are directed against IL-23. The amino acid sequences of the present invention comprise two Nanobodies against IL-23 and one Nanobody against serum albumin, linked by two linkers (9GS linkers). In particular, the invention relates to the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 3 (listed in Table 1 and FIG. 1) (also referred to herein as “anti-IL 23 polypeptides of the invention”).

8. 发明授权

US10875918B2 P2X7 receptor binders and polypeptides comprising the same 有权
公开(公告)号：US10875918B2
公开(公告)日：2020-12-29
申请号：US15775266
申请日：2016-11-11
申请人： Ablynx N.V.
发明人： Marie-Ange Buyse , Catelijne Stortelers
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/28 , C07K2317/22 , C07K2317/24 , C07K2317/567 , C07K2317/569 , C07K2317/76 , C07K2317/94
摘要： The present invention relates to amino acid sequences and polypeptides binding to the P2X7 receptor. In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as “ISV's” or “ISVD's”) binding to the P2X7 receptor, as well as to proteins, polypeptides and other constructs, compounds, molecules or 5 chemical entities that comprise such ISVD's.

9. 发明申请

US20170267752A1 TNF BINDERS 审中-公开
公开(公告)号：US20170267752A1
公开(公告)日：2017-09-21
申请号：US15501011
申请日：2016-11-14
申请人： Ablynx N.V.
发明人： Marie-Ange Buyse , Joachim Boucneau , Peter Casteels , Gino Van Heeke
IPC分类号： C07K16/24
摘要： The present invention relates to amino acid sequences, compounds and polypeptides binding to tumor necrosis factor alpha (“TNF” or “TNF-alpha”). In particular, the present invention relates to improved heavy-chain immunoglobulin single variable domains (also referred to herein as “ISV's” or “ISVDs”) binding to tumor necrosis factor alpha, as well as to proteins, polypeptides and other constructs, compounds, molecules or chemical entities that comprise such ISVDs, collectively TNF binders. Other aspects, embodiments, features, uses and advantages of the invention will be clear to the skilled person based on the disclosure herein.

10. 发明申请

US20140205597A1 TECHNIQUES FOR PREDICTING, DETECTING AND REDUCING ASPECIFIC PROTEIN INTERFERENCE IN ASSAYS INVOLVING IMMUNOGLOBULIN SINGLE VARIABLE DOMAINS 审中-公开
标题翻译：涉及免疫球蛋白单个可变区域的测定中预测，检测和降低相关蛋白质干扰的技术
公开(公告)号：US20140205597A1
公开(公告)日：2014-07-24
申请号：US14138863
申请日：2013-12-23
申请人： Ablynx N.V.
发明人： Judith Baumeister , Marie-Paule Lucienne Armanda Bouche , Carlo Boutton , Marie-Ange Buyse , Veerle Snoeck , Stephanie Staelens , Bruno Dombrecht , Peter Schotte , Cedric Jozef Neotere Ververken , Gerald Beste , Guy Hermans , Soren Steffensen , Alexander Szyroki , Tinneke Denayer
IPC分类号： G01N33/68 , C07K16/18
CPC分类号： G01N33/6857 , A61K2039/505 , C07K16/18 , C07K16/2863 , C07K16/4258 , C07K2317/22 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： This invention provides, and in certain specific but non-limiting aspects relates to: assays that can be used to predict whether a given ISV will be subject to protein interference as described herein and/or give rise to an (aspecific) signal in such an assay (such as for example in an ADA immunoassay). Such predictive assays could for example be used to test whether a given ISV could have a tendency to give rise to such protein interference and/or such a signal; to select ISV's that are not or less prone to such protein interference or to giving such a signal; as an assay or test that can be used to test whether certain modification(s) to an ISV will (fully or partially) reduce its tendency to give rise to such interference or such a signal; and/or as an assay or test that can be used to guide modification or improvement of an ISV so as to reduce its tendency to give rise to such protein interference or signal; methods for modifying and/or improving ISV's to as to remove or reduce their tendency to give rise to such protein interference or such a signal; modifications that can be introduced into an ISV that remove or reduce its tendency to give rise to such protein interference or such a signal; ISV's that have been specifically selected (for example, using the assay(s) described herein) to have no or low(er)/reduced tendency to give rise to such protein interference or such a signal; modified and/or improved ISV's that have no or a low(er)/reduced tendency to give rise to such protein interference or such a signal.
摘要翻译：本发明提供并且在某些特定但非限制性方面涉及：可用于预测给定ISV是否将如本文所述受到蛋白质干扰和/或产生（特异性）信号的测定法测定（例如在ADA免疫测定中）。这样的预测测定可以例如用于测试给定的ISV是否可能具有引起这种蛋白质干扰和/或这种信号的倾向; 选择不是或不太容易发生蛋白质干扰的ISV或给出这样的信号; 作为可用于测试对ISV的某些修改（完全或部分）是否降低其引起这种干扰或这种信号的趋势的测定或测试; 和/或作为可用于指导ISV的修饰或改进的测定或测试，以便减少引起这种蛋白质干扰或信号的趋势; 修改和/或改善ISV以消除或减少其引起这种蛋白质干扰或这种信号的趋势的方法; 可以引入到ISV中的修饰，其可以去除或减少引起这种蛋白质干扰或这种信号的趋势; 已经特别选择的ISV（例如，使用本文所述的测定）具有没有或低（呃）/降低的趋势导致这种蛋白质干扰或这种信号; 修饰和/或改进的ISV，其没有或低（呃）/降低的趋势引起这种蛋白质干扰或这种信号。

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