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1. 发明授权

US11668653B2 Raman-based immunoassay systems and methods 有权
公开(公告)号：US11668653B2
公开(公告)日：2023-06-06
申请号：US15776649
申请日：2016-11-16
申请人： ChemImage Corporation
发明人： Patrick Treado , Shona Stewart , Aaron Smith , Heather Gomer
IPC分类号： G01N21/65 , G01J3/44 , G01N21/17 , G01J3/02 , G01J3/28 , G16H50/20 , G01N33/53
CPC分类号： G01N21/65 , G01J3/0218 , G01J3/0291 , G01J3/2823 , G01J3/44 , G01N21/17 , G01N33/53 , G16H50/20 , G01N2201/0833 , G01N2800/50 , G01N2800/52 , G01N2800/56 , G01N2800/60
摘要： This disclosure is directed to systems and methods for fusing Raman data with biomarker data to identify a disease and/or the progression of the disease. The system disclosed herein may include an illumination source for generating interacted photons from a biological sample and a detector for detecting the interacted photons to generate a Raman data set. A processor is included to fuse the Raman data set with a biomarker data set to identify a disease and/or a disease progression. The instant disclosure further includes a method comprising illuminating a biological sample to generate interacted photons, and detecting the interacted photons to generate a Raman data set. A biomarker data set is obtained from the biological sample, and the Raman data set is fused with the biomarker data set to generate an index score. The index score correlates with one or more of a disease and a disease progression.

2. 发明授权

US10779713B2 Molecular chemical imaging endoscopic imaging systems 有权
公开(公告)号：US10779713B2
公开(公告)日：2020-09-22
申请号：US15932435
申请日：2015-12-09
申请人： ChemImage Corporation
发明人： Patrick Treado , Matthew Nelson , Shona Stewart
IPC分类号： A61B1/07 , A61B1/04 , A61B1/06 , A61B1/307 , A61B1/00
摘要： The instant disclosure provides for medical imaging systems that may be used in conjunction with an intraoperative medical device, such as an endoscope. Generally, the disclosed medical imaging systems include an illumination source configured to generate illuminating photons for illuminating a biological sample. An optical signal modulator is configured to separate one or more of the illuminating photons and photons that have interacted with the biological sample into a first optical signal having first multi-passband wavelengths and a second optical signal having second multi-passband wavelengths. At least one detector is configured to detect one or more of the first optical signal and the second optical signal and generate at least one image data set. A processor is configured to analyze the at least one image data set. In some embodiments, the processor is configured to differentiate between structures of the biological sample, such as between an ureter and surrounding tissue.

3. 发明申请

US20150294076A1 SYSTEM AND METHOD FOR SERUM BASED CANCER DETECTION 审中-公开
标题翻译：基于血清的癌症检测系统及方法
公开(公告)号：US20150294076A1
公开(公告)日：2015-10-15
申请号：US14440987
申请日：2013-11-06
申请人： Patrick TREADO , Shona STEWART , Heather KIRSCHNER , Ryan PRIORE , Alan WILSON , CHEMIMAGE CORPORATION
发明人： Patrick Treado , Shona Stewart , Heather Kirschner , Ryan Priore , Alan Wilson
IPC分类号： G06F19/00 , G06F19/24 , G01N21/65 , G01N33/49
CPC分类号： G16H50/20 , G01J3/1804 , G01J3/44 , G01J3/4406 , G01N21/65 , G01N33/49 , G01N33/57419 , G16B40/00
摘要： A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.
摘要翻译：用于分析诸如干人血清的生物样品以确定诸如结肠直肠癌（CRC）的疾病状态的系统和方法。使用干燥的样品可能具有增强样品组分的局部浓度和/或分割的潜力。该方法可以包括照射生物样品的至少一个位置以产生多个相互作用的光子，收集相互作用的光子并产生代表生物样品的至少一个拉曼数据集。系统可以包括照明源以照亮生物样品的至少一个位置并且生成至少一个多个相互作用的光子，至少一个反射镜，用于将相互作用的光子引导到检测器。检测器可以被配置为产生代表生物样品的至少一个拉曼数据集。该系统和方法可以利用FAST设备进行多点分析，或者可以配置为使用线扫描配置分析样本。

4. 发明授权

US11607136B2 System and method for conformal vision 有权
公开(公告)号：US11607136B2
公开(公告)日：2023-03-21
申请号：US16650310
申请日：2018-07-24
申请人： ChemImage Corporation
发明人： Matthew Nelson , Thomas Voigt , Maxxwell Chatsko , Patrick Treado , Rebecca Schuler , Shona Stewart , James McGlone , Oksana Klueva , Nathaniel Gomer
IPC分类号： A61B5/00 , A61B5/0205 , G01J3/02 , G01J3/26 , G01J3/447 , G01N21/31 , A61B5/026 , A61B5/08 , A61B5/103 , A61B5/1455 , A61B5/16
摘要： Conformal vision with enhanced image processing of the outputted image is incorporated into novel applications. The conformal vision provides enhanced contrast by the combined inclusion of tunable filters and processing of the images that are generated by the detector. Furthermore, novel uses and applications of the conformal vision enable users to make determinations related to their health and wellness utilizing information provided by the conformal vision.

5. 发明授权

US11229400B2 Discrimination of calculi and tissues with molecular chemical imaging 有权
公开(公告)号：US11229400B2
公开(公告)日：2022-01-25
申请号：US16544499
申请日：2019-08-19
申请人： CHEMIMAGE CORPORATION
发明人： Jeffrey Cohen , Patrick Treado , Shona Stewart , Heather Gomer , Arash Samiei , Alyssa Zrimsek , Jihang Wang
IPC分类号： A61B5/00 , A61B1/00 , A61B1/06 , G01N21/25
摘要： Systems and methods for the detection of calculi in the biliary system are disclosed. The systems include an illumination source, one or more filters that filter a first set of illumination photons and a second set of illumination photons, as well as associated processors and detectors. The system is also designed to generates image data sets and generated information related to the location of the calculi.

6. 发明授权

US11980349B2 Time correlated source modulation for endoscopy 有权
公开(公告)号：US11980349B2
公开(公告)日：2024-05-14
申请号：US16244845
申请日：2019-01-10
申请人： CHEMIMAGE CORPORATION
发明人： Patrick Treado , Charles Gardner , Shona Stewart , Aaron Smith
IPC分类号： A61B1/05 , A61B1/00 , A61B1/04 , A61B1/06 , A61B1/07 , H04N23/11 , H04N23/45 , H04N23/55 , H04N23/56 , H04N23/50
CPC分类号： A61B1/051 , A61B1/0005 , A61B1/00096 , A61B1/00167 , A61B1/046 , A61B1/0607 , A61B1/0638 , A61B1/0646 , A61B1/0676 , A61B1/07 , H04N23/11 , H04N23/45 , H04N23/55 , H04N23/56 , A61B1/00009 , H04N23/555
摘要： An endoscope has an improved chip-on-tip configuration that includes both a first configuration of source illumination fibers and a second plurality of source illumination fibers, along with a camera chip. The combination of the camera chip and the source illumination fibers on the tip of the endoscope results in endoscopes with reduced size and weight.

7. 发明授权

US11234584B2 Molecular chemical imaging endoscopic imaging systems 有权
公开(公告)号：US11234584B2
公开(公告)日：2022-02-01
申请号：US15374769
申请日：2016-12-09
申请人： ChemImage Corporation
发明人： Patrick Treado , Shona Stewart , Matthew P. Nelson
IPC分类号： A61B1/07 , A61B1/06 , A61B5/00 , A61B1/04 , A61B1/00
摘要： Medical imaging systems for use in conjunction with an endoscope are described. Generally, the medical imaging system includes an illumination source configured to generate illuminating photons. The illuminating photons are transmitted to one or more filters configured to filter a first plurality of illuminating photons and generate a first plurality of filtered photons comprising a first passband wavelength and a second plurality of filtered photons comprising a second passband wavelength. A sample is then illuminated with the first plurality of filtered photons and the second plurality of filtered photons to generate a first plurality of interacted photons and a second plurality of interacted photons. One or more detectors are configured to detect the first plurality of interacted photons and the second plurality of interacted photons and generate one or more image data sets.

8. 发明授权

US11145411B2 System and method for serum based cancer detection 有权
公开(公告)号：US11145411B2
公开(公告)日：2021-10-12
申请号：US14440987
申请日：2013-11-06
申请人： CHEMIMAGE CORPORATION , Patrick Treado , Shona Stewart , Heather Kirschner , Ryan Priore , Alan Wilson
发明人： Patrick Treado , Shona Stewart , Heather Kirschner , Ryan Priore , Alan Wilson
IPC分类号： G01N21/65 , G01N33/49 , G16H50/20 , G16B40/00 , G01N33/574 , G01J3/44 , G01J3/18
摘要： A system and method for analyzing biological samples, such as dried human blood serum, to determine a disease state such as colorectal cancer (CRC). Using dried samples may hold potential for enhancing localized concentration and/or segmentation of sample components. The method may comprise illuminating at least one location of a biological sample to generate a plurality of interacted photons, collecting the interacted photons and generating at least one Raman data set representative of the biological sample. A system may comprise an illumination source to illuminate at least one location of a biological sample and generate at least one plurality of interacted photons, at least one mirror for directing the interacted photons to a detector. The detector may be configured to generate at least one Raman data set representative of the biological sample. The system and method may utilize a FAST device for multipoint analysis or may be configured to analyze a sample using a line scanning configuration.

9. 发明授权

US09274046B2 System and method for gross anatomic pathology using hyperspectral imaging 有权
标题翻译：使用高光谱成像的大体解剖病理学的系统和方法
公开(公告)号：US09274046B2
公开(公告)日：2016-03-01
申请号：US13998776
申请日：2013-12-03
申请人： ChemImage Corporation
发明人： Shona Stewart , Patrick Treado , Heather Kirschner , Alan Wilson , Ryan Priore , Jeffrey Cohen , Serena Augustine
IPC分类号： G01J3/28 , G01N21/25 , G01J3/02 , G01J3/32 , G01J3/44 , G01N21/31 , G01N21/35 , G02B21/00 , G02B21/16 , G02B21/36 , G01N21/21 , G01N21/33 , G01N21/3581 , G01N21/359 , G01N21/65
CPC分类号： G01N21/255 , G01J3/02 , G01J3/0224 , G01J3/32 , G01J3/44 , G01N21/21 , G01N21/314 , G01N21/33 , G01N21/35 , G01N21/3581 , G01N21/359 , G01N21/65 , G02B21/0092 , G02B21/16 , G02B21/361
摘要： A method for analyzing organ samples using hyperspectral imaging comprising illuminating an organ sample to generate interacted photons, collecting the interacted photons and passing the interacted photons through a tunable filter. The filtered interacted photons are detected to generate a hyperspectral image. A brightfield image is generated and associated with the hyperspectral image. Spectra from locations of interest are extracted and analyzed to assess a characteristic of the organ sample. A system may comprise an illumination source to illuminate an organ sample and generate interacted photons, a collection optics for collecting the interacted photons and a tunable filter to filter the interacted photons. A detector is configured to detect the filtered photons and generate at least one hyperspectral image. The detector may also be configured to generate at least one brightfield image representative of the organ sample.
摘要翻译：一种使用高光谱成像分析器官样品的方法，包括照亮器官样品以产生相互作用的光子，收集相互作用的光子并使相互作用的光子通过可调滤光器。检测过滤的相互作用的光子以产生高光谱图像。生成亮场图像并与高光谱图像相关联。提取并分析来自感兴趣位置的光谱，以评估器官样品的特征。系统可以包括用于照亮器官样本并产生相互作用的光子的照明源，用于收集相互作用的光子的收集光学器件和用于过滤相互作用的光子的可调滤波器。检测器被配置为检测滤波的光子并产生至少一个高光谱图像。检测器还可以被配置为产生代表器官样本的至少一个亮场图像。

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