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    • 3. 发明授权
    • Polypeptide of protein p140 and DNAs encoding it
    • 蛋白质p140的多肽和编码它的DNA
    • US5506205A
    • 1996-04-09
    • US348143
    • 1994-11-23
    • Hisao TajimaKoichiro KitagawaHiroyuki Ohno
    • Hisao TajimaKoichiro KitagawaHiroyuki Ohno
    • A61K38/00C07K14/47C12N1/21C12N15/12C12P21/08C07K14/435C12N9/12
    • C07K14/47A61K38/00
    • The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector comprising the DNA; host cells transformed with the vector; antibody against the polypeptide; pharmaceutical compositions containing the peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate protein p140, as active ingredient and screening methods for the prevention and/or treatment agent.Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only to improves the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
    • 本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽, 制备方法 编码所述多肽的DNA; 包含DNA的载体; 宿主细胞用载体转化; 抗多肽抗体; 含有肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法,其特征在于所述蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗糖尿病的药物,其特征在于含有可将酪氨酸磷酸化蛋白质p140的化合物作为活性成分和预防和/或治疗剂的筛选方法。 蛋白质p140的酪氨酸磷酸化是通过葡萄糖摄取诱导低血糖的关键步骤。 基于本发明的蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅可改善糖尿病来源的高血糖病症,而且可用于治疗和/或预防糖尿病,特别是非胰​​岛素依赖性 糖尿病(NIDDM)。
    • 4. 发明申请
    • Handover Parameter Control Apparatus and Method, and Computer Program
    • 切换参数控制装置和方法以及计算机程序
    • US20120176892A1
    • 2012-07-12
    • US13342455
    • 2012-01-03
    • Toshiaki YAMAMOTOKoichiro KitagawaToshihiko Komine
    • Toshiaki YAMAMOTOKoichiro KitagawaToshihiko Komine
    • H04W36/00H04L12/26
    • H04W36/30
    • A handover parameter control apparatus in each cell of a cellular system having a condition in which if power received by a mobile terminal from a neighbor base station and power received from an access base station, to which the mobile terminal is connected, have power difference greater than or equal to a threshold, the mobile terminal executes handover from an access cell belonging to the access base station to a neighbor cell belonging to the neighbor base station. The apparatus includes a threshold control weight computation unit that computes a threshold control weight which indicates a threshold control direction so as to reduce handover failures, by using a frequency of first-type handover failure events which reduces by increasing the threshold; and a frequency of second-type handover failure events which reduces by decreasing the threshold; and a threshold determination unit that determines the threshold based on the threshold control weight.
    • 在蜂窝系统的每个小区中的切换参数控制装置具有如下条件:如果移动终端从邻近基站接收的功率和从接入基站接收到的功率与移动终端连接的功率具有较大的功率差 移动终端执行从属于接入基站的接入小区到属于邻近基站的邻居小区的切换。 该装置包括阈值控制权重计算单元,其通过使用通过增加阈值而减少的第一类型切换失败事件的频率来计算指示阈值控制方向以便减少切换失败的阈值控制权重; 以及通过降低阈值而减少的第二类切换失败事件的频率; 以及阈值确定单元,其基于所述阈值控制权重来确定所述阈值。
    • 5. 发明授权
    • Polypeptide of protein p140 and DNAs encoding it
    • 蛋白质p140的多肽和编码它的DNA
    • US06432913B1
    • 2002-08-13
    • US09558340
    • 2000-04-26
    • Hisao TajimaKoichiro KitagawaHiroyuki Ohno
    • Hisao TajimaKoichiro KitagawaHiroyuki Ohno
    • A01N6100
    • C07K14/47A61K38/00
    • The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment for the currently said the prevention and/or treatment method; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylation of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only improve the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
    • 本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽, 制备方法 编码所述多肽的DNA; 载体衍生所述DNA; 宿主细胞转化所述载体; 所述多肽的抗体; 含有所述肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法,其特征在于所述蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗目前所述的预防和/或治疗方法的药剂; 用于预防和/或治疗糖尿病的药物,其特征在于含有可以作为活性成分的蛋白质p140的酪氨酸磷酸化的化合物和所述预防和/或治疗剂的筛选方法。蛋白质p140的酪氨酸磷酸化是 通过葡萄糖摄取诱导低血糖的关键步骤。 本发明中基于蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅可以改善糖尿病来源的高血糖状况,而且可用于治疗和/或预防糖尿病,特别是非胰​​岛素依赖型糖尿病 (NIDDM)。
    • 6. 发明授权
    • Polypeptide of protein P140 and DNAs encoding it
    • 蛋白P140的多肽和编码它的DNA
    • US06303320B1
    • 2001-10-16
    • US09192435
    • 1998-01-08
    • Hisao TajimaKoichiro KitagawaHiroyuki Ohno
    • Hisao TajimaKoichiro KitagawaHiroyuki Ohno
    • G01N3353
    • C07K14/47A61K38/00
    • The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the polypeptide; vector derived with the DNA; host cells transformed with the vector; antibody of the polypeptide; pharmaceutical composition containing the peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the protein p140; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate protein p140, as active ingredient and the screening methods of the prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention not only improve the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
    • 本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽, 制备方法 编码多肽的DNA; 用DNA衍生的载体; 宿主细胞用载体转化; 多肽的抗体; 含有肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法,其特征在于蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗糖尿病的药物,其特征在于含有可以酪氨酸磷酸化蛋白质p140的化合物作为活性成分和预防和/或治疗剂的筛选方法。 蛋白质p140的酪氨酸磷酸化是通过葡萄糖摄取诱导低血糖的关键步骤。 本发明中基于蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅改善糖尿病衍生的高血糖病症,而且可用于治疗和/或预防糖尿病,特别是非胰​​岛素依赖性糖尿病 (NIDDM)。
    • 7. 发明授权
    • Polypeptide of protein P140 and DNAS encoding it
    • 蛋白质P140的多肽和编码它的DNAS
    • US5804411A
    • 1998-09-08
    • US571785
    • 1995-12-13
    • Hisao TajimaKoichiro KitagawaHiroyuki Ohno
    • Hisao TajimaKoichiro KitagawaHiroyuki Ohno
    • A61K38/00C07K14/47C12N1/21C12N15/12C12P21/08C12P21/02C07H21/04C12N15/63
    • C07K14/47A61K38/00
    • The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment of diabetes, agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only to improve the diabetes-derived hypoglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
    • 本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽, 制备方法 编码所述多肽的DNA; 载体衍生所述DNA; 宿主细胞转化所述载体; 所述多肽的抗体; 含有所述肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法,其特征在于所述蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗糖尿病的药剂,用于预防和/或治疗糖尿病的药剂,其特征在于含有可以将蛋白质p140的酪氨酸磷酸化的化合物作为活性成分,以及所述预防和/ 或治疗剂。 蛋白质p140的酪氨酸磷酸化是通过葡萄糖摄取诱导低血糖的关键步骤。 基于本发明的蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅可改善糖尿病衍生的低血糖状况,而且可用于治疗和/或预防糖尿病,特别是非胰​​岛素依赖性 糖尿病(NIDDM)。