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1. 发明授权

US09816926B2 Multiplex suspension assay/array using lifetime coding 有权
公开(公告)号：US09816926B2
公开(公告)日：2017-11-14
申请号：US14410015
申请日：2013-06-21
申请人： Macquarie University
发明人： Dayong Jin , Yiqing Lu , Jiangbo Zhao
IPC分类号： G01N21/64 , C40B70/00 , C09K11/02 , C09K11/06 , C09D11/50 , C09K11/77 , B42D25/382 , B42D25/387 , G01N33/542 , G01N33/58
CPC分类号： G01N21/6408 , B42D25/382 , B42D25/387 , C09D11/50 , C09K11/02 , C09K11/025 , C09K11/06 , C09K11/7773 , C09K2211/182 , C40B70/00 , G01N21/6428 , G01N33/542 , G01N33/582
摘要： A system, device and/or method for multiplex assays. In a particular, but non-limiting, example there is provided a multiplex array, such as a suspension array. Luminescence decay lifetimes are utilized for probes in a suspension array, and coding/decoding the codes from time-resolved spectra. Lifetime populations can be generated at distinct color bands. A novel temporal technique or dimension is applied over conventional spectral and intensity combinations, thereby expanding the multiplexing capacity of a suspension array. In one example form, the multiplexing capacity of a suspension array can be expanded to the order of about 58. This provides a reliable, high-throughput and relatively inexpensive solution for multiplex assays in various areas of application such as life sciences, data storage and security.

2. 发明申请

US20150185149A1 MULTIPLEX SUSPENSION ASSAY/ARRAY USING LIFETIME CODING 有权
标题翻译：多用途悬挂测定/使用寿命编码的阵列
公开(公告)号：US20150185149A1
公开(公告)日：2015-07-02
申请号：US14410015
申请日：2013-06-21
申请人： Macquarie University
发明人： Dayong Jin , Yiqing Lu , Jiangbo Zhao
IPC分类号： G01N21/64
CPC分类号： G01N21/6408 , B42D25/382 , B42D25/387 , C09D11/50 , C09K11/02 , C09K11/025 , C09K11/06 , C09K11/7773 , C09K2211/182 , C40B70/00 , G01N21/6428 , G01N33/542 , G01N33/582
摘要： A system, device and/or method for multiplex assays. In a particular, but non-limiting, example there is provided a multiplex array, such as a suspension array. Luminescence decay lifetimes are utilised for probes in a suspension array, and coding/decoding the codes from time-resolved spectra. Lifetime populations can be generated at distinct colour bands. A novel temporal technique or dimension is applied over conventional spectral and intensity combinations, thereby expanding the multiplexing capacity of a suspension array. In one example form, the multiplexing capacity of a suspension array can be expanded to the order of about 58. This provides a reliable, high-throughput and relatively inexpensive solution for multiplex assays in various areas of application such as life sciences, data storage and security.
摘要翻译：用于多重测定的系统，装置和/或方法。在特定但非限制性的示例中，提供了多路复用阵列，例如悬架阵列。发光衰减寿命用于悬浮阵列中的探针，并对来自时间分辨光谱的代码进行编码/解码。可以在不同的色带上生成终身人口。一种新颖的时间技术或尺寸应用于常规光谱和强度组合，从而扩大了悬架阵列的复用能力。在一个示例形式中，悬挂阵列的复用容量可以扩展到大约58个数量级。这提供了可靠的，高通量的和相对便宜的解决方案，用于在各种应用领域中的多重测定，诸如生命科学，数据存储和安全。

3. 发明申请

US20150144806A1 TWO-DIRECTIONAL SCANNING FOR LUMINESCENCE MICROSCOPY 审中-公开
标题翻译：用于荧光显微镜的双向扫描
公开(公告)号：US20150144806A1
公开(公告)日：2015-05-28
申请号：US14401103
申请日：2013-05-28
申请人： Macquarie University
发明人： Dayong Jin , Yiqing Lu , James Austin Piper
IPC分类号： G01N21/64
CPC分类号： G01N21/6458 , G01N15/1456 , G01N21/6408 , G01N21/6486 , G01N2201/10 , G02B21/16
摘要： In one form, a two-directional scanning method for luminescence microscopy is disclosed. A series of continuous scans are performed by an interrogation wide-field relative to a first direction and a target is identified. A precise position of the target is determined in the first direction. At least one scan by the interrogation wide-field is performed relative to a second direction at or near the precise position of the target in the first direction. The two-directional scanning method produces “on-the-fly” (i.e. ex tempore or impromptu) precise localization of targets. Embodiments open up new applications for background-free or background-reduced luminescence microscopy, for example time-gated or time-resolved luminescence microscopy, in a relatively fast, higher speed or more efficient manner.
摘要翻译：在一种形式中，公开了用于发光显微镜的双向扫描方法。通过相对于第一方向的询问广域来执行一系列连续扫描，并且识别目标。在第一方向上确定目标的精确位置。相对于目标在第一方向的精确位置处或附近的第二方向，通过询问广域进行至少一次扫描。双向扫描方法产生目标的“即时”（即临时或即兴）精确定位。实施例以相对快速，更高速或更有效的方式开辟了无背景或背景减少发光显微镜的新应用，例如时间门控或时间分辨发光显微镜。

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