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1. 发明申请

US20130040983A1 RAF KINASE INHIBITORS 审中-公开
标题翻译： RAF激酶抑制剂
公开(公告)号：US20130040983A1
公开(公告)日：2013-02-14
申请号：US13520548
申请日：2011-01-07
申请人： Jean-Michel Vernier , Patrick O'Connor , William Ripka , David Matthews , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
发明人： Jean-Michel Vernier , Patrick O'Connor , William Ripka , David Matthews , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
IPC分类号： C07D401/04 , C12N9/99 , A61P35/00 , C07D471/04 , A61K31/437 , A61K31/4439 , C07D401/14
CPC分类号： C07D401/04 , C07D471/04
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinae mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.
摘要翻译：本文描述了用于抑制RAF基因介导的信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人类疾病和病症。

2. 发明申请

US20130012513A1 HEDGEHOG INHIBITORS 有权
标题翻译： HEDGEHOG抑制剂
公开(公告)号：US20130012513A1
公开(公告)日：2013-01-10
申请号：US13520150
申请日：2011-01-06
申请人： Jean-Michel Vernier , John May , Patrick O'Connor , William Ripka , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
发明人： Jean-Michel Vernier , John May , Patrick O'Connor , William Ripka , Anthony Pinkerton , Pierre-Yves Bounaud , Stephanie Hopkins
IPC分类号： C07D277/30 , C12N5/07 , C07D413/12 , A61P35/00 , C07D263/32 , A61K31/421 , C07D417/12 , A61K31/496 , A61K31/426 , A61K31/5377
CPC分类号： C07D277/28 , C07D263/32 , C07D277/24 , C07D277/30
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary disease and disorders.
摘要翻译：本文描述了用于抑制Hedgehog信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人和兽医疾病和病症。

3. 发明授权

US07268139B2 Methods of promoting osteogenesis 有权
标题翻译：促进成骨的方法
公开(公告)号：US07268139B2
公开(公告)日：2007-09-11
申请号：US10651934
申请日：2003-08-29
申请人： Andrew A. Protter , David Y. Liu , Patrick O'Connor
发明人： Andrew A. Protter , David Y. Liu , Patrick O'Connor
IPC分类号： A61K31/497 , A61K31/445 , A61K31/415 , A61K31/38 , A61K31/385
CPC分类号： A61K31/404 , A61K31/4164 , A61K31/4174 , A61K31/4178 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/501 , A61K31/517 , A61K31/53
摘要： The invention is directed to methods of bone healing by administering a p38 MAP kinase inhibitor. The invention is directed to methods of treating bone fractures, bone diseases, bone grafting, especially enhancing bone healing following facial reconstruction, maxillary reconstruction, mandibular reconstruction or tooth extraction, enhancing long bone extension, enhancing prosthetic ingrowth, and increasing bone synostosis by administering a p38 MAP kinase inhibitor.
摘要翻译：本发明涉及通过施用p38MAP激酶抑制剂的骨愈合方法。本发明涉及治疗骨折，骨疾病，骨移植，特别是增强面部重建后的骨愈合，上颌骨重建，下颌骨重建或拔牙，增强长骨延伸，增强假体向内生长以及增加骨愈合的方法，通过施用 p38 MAP激酶抑制剂。

4. 发明授权

US4549364A Apparatus and method for making snow roads 失效
标题翻译：用于制作雪路的装置和方法
公开(公告)号：US4549364A
公开(公告)日：1985-10-29
申请号：US665288
申请日：1984-10-26
申请人： Patrick O'Connor
发明人： Patrick O'Connor
IPC分类号： E01H4/00 , E01H5/00
CPC分类号： E01H4/00
摘要： A method for laying a snow road or an airplane runway on a snow or ice covered surface includes the removal of a predetermined and relatively small portion of the snow or ice surface, which is melted to water and mixed with the snow or ice remaining on the snow surface. The mixture of water and snow or ice is leveled so as to form a road surface when the mixture freezes. Preferably, the snow remaining on the surface is mechanically worked with a rototiller, while the melted snow is injected into the snow being worked. The method is particularly advantageous in that it can be carried out without requiring melting of all the snow necessary to form the snow road, or requiring the addition of any water from an external source, other than the portion of snow removed from the snow surface. An apparatus for performing the method is also described.
摘要翻译：在雪或冰覆盖的表面上铺设雪路或飞机跑道的方法包括去除冰或冰面的预定和相对较小的部分，其被熔化成水并与剩余在其上的雪或冰混合雪面。水和雪或冰的混合物平整，以便当混合物冻结时形成路面。优选地，将残留在表面上的雪与旋转托盘机械加工，同时将熔融的雪注入正在加工的雪中。该方法特别有利的是，可以不需要熔化形成雪路所需的所有积雪，或者除了从雪地表面除去的雪的部分之外，还需要从外部源添加任何水。还描述了一种用于执行该方法的装置。

5. 发明授权

US08915917B2 Intramedullary nails for long bone fracture setting 有权
$Intramedullary nails for long bone fracture setting$
标题翻译：髓内钉用于长骨骨折设置
公开(公告)号：US08915917B2
公开(公告)日：2014-12-23
申请号：US13389130
申请日：2010-08-12
申请人： William Doherty , Patrick O'Connor , James Harty , Hannah Dailey , Charles Daly , Olive O'Driscoll
发明人： William Doherty , Patrick O'Connor , James Harty , Hannah Dailey , Charles Daly , Olive O'Driscoll
IPC分类号： A61B17/56 , A61B17/58 , A61F2/30 , A61B17/72
CPC分类号： A61B17/725 , A61B17/7225 , A61B17/7241
摘要： An intramedullary nail has a proximal part for engagement with a proximal bone fragment and a distal part for engagement with a distal bone fragment. A motion assembly interconnects the parts and allows limited axial relative motion of the proximal and distal parts. This limited axial motion provides micromotion and in some embodiments also dynamization. The nail may comprise a stem for fastening to one bone fragment and an insert within the stem for fastening to the other bone fragment, the insert being adapted to guide insertion of a bone screw through the stem and to prevent relative rotation of the distal and proximal bone fragments. The motion assembly may include spring bias and/or damping means between the parts, possibly including one or more Belleville washers.
摘要翻译：髓内钉具有近端部分，用于与近端骨片段和用于与远侧骨片段接合的远端部分接合。运动组件互连部件并允许近端和远端部分的有限的轴向相对运动。这种有限的轴向运动提供微动作，并且在一些实施例中也是动态化。指甲可以包括用于紧固到一个骨碎片的杆和用于紧固到另一个骨碎片的柄内的插入件，插入件适于引导骨螺钉穿过杆的插入并且防止远端和近端的相对旋转骨碎片。运动组件可以包括在部件之间的弹簧偏压和/或阻尼装置，可能包括一个或多个Belleville垫圈。

6. 发明授权

US08486936B2 Antagonist of smoothened 失效
标题翻译：拮抗剂平滑
公开(公告)号：US08486936B2
公开(公告)日：2013-07-16
申请号：US12773656
申请日：2010-05-04
申请人： Alexander Khvat , Sergey Tkachenko , Ilya Okun , Borys Rogovoy , Nikolay Savchuk , John May , Patrick O'Connor , William Ripka , Jean-Michel Vernier , David Matthews
发明人： Alexander Khvat , Sergey Tkachenko , Ilya Okun , Borys Rogovoy , Nikolay Savchuk , John May , Patrick O'Connor , William Ripka , Jean-Michel Vernier , David Matthews
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/437 , C12N5/02 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of Hedgehog signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human and veterinary diseases and disorders.
摘要翻译：本文描述了用于抑制Hedgehog信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人和兽医疾病和病症。

7. 发明申请

US20130023857A1 TWO WAY ACCUMULATOR PROGRAMMABLE VALVE PUMP 有权
标题翻译：两路蓄能器可编程阀门泵
公开(公告)号：US20130023857A1
公开(公告)日：2013-01-24
申请号：US13608583
申请日：2012-09-10
申请人： Paul F. Burke , Patrick O'Connor
发明人： Paul F. Burke , Patrick O'Connor
IPC分类号： A61M5/142
CPC分类号： G01F11/086 , A61M5/14276 , A61M5/14586 , A61M5/14593 , A61M5/16809 , A61M2005/14513
摘要： An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration.
摘要翻译：公开了一种用于输送药物的改进的可植入阀蓄能器泵。可植入泵包括加压药物储存器。药物计量组件包括位于一对阀之间的固定容积蓄积器。阀交替地打开和关闭，以将药物从储存器进入蓄能器并且将精确的体积脉冲分配给出口导管。为了提高泵的精度和增加泵送量，同时优化泵的总体尺寸和能量使用，使用双向隔膜蓄能器。该单元可以进行外部编程，也可以以固定速率配置使用，从未编程，但在出厂时或当前的可编程配置中设置。

8. 发明申请

US20050069018A1 Molten cryolitic bath probe 有权
标题翻译：熔融冰晶浴液探针
公开(公告)号：US20050069018A1
公开(公告)日：2005-03-31
申请号：US10672462
申请日：2003-09-25
申请人： Robert Hosler , Xiangwen Wang , Jay Bruggeman , Patrick O'Connor
发明人： Robert Hosler , Xiangwen Wang , Jay Bruggeman , Patrick O'Connor
IPC分类号： G01K1/10 , G01K1/12 , G01K13/12 , G01N1/12
CPC分类号： C25C3/20 , G01K1/105 , G01K1/125
摘要： A method and apparatus for accurately measuring superheat, bath ratio and alumina concentration in an aluminum smelting bath. In one embodiment, a reusable probe determines the bath temperature and bath sample superheat. In other embodiments, the probe also determines bath composition including bath cryolite ratio and alumina concentration.
摘要翻译：一种在铝熔炼浴中精确测量过热，浴比和氧化铝浓度的方法和装置。在一个实施例中，可重复使用的探针确定浴温度和浴样品过热。在其它实施方案中，探针还确定浴组成，包括浴冰晶石比和氧化铝浓度。

9. 发明授权

US5557423A Synchronization of digital video with digital audio 失效
标题翻译：数字视频与数字音频同步
公开(公告)号：US5557423A
公开(公告)日：1996-09-17
申请号：US344409
申请日：1994-11-23
申请人： Michael Phillips , Patrick O'Connor , Eric Peters
发明人： Michael Phillips , Patrick O'Connor , Eric Peters
IPC分类号： H04N5/78 , G11B27/00 , G11B27/031 , G11B27/06 , G11B27/10 , G11B27/11 , G11B27/24 , G11B27/32 , H04N5/85 , H04N5/926 , H04N5/928 , H04N5/76
CPC分类号： G11B27/031 , G11B27/002 , G11B27/06 , G11B27/10 , G11B27/11 , G11B27/24 , G11B27/323 , H04N5/926 , H04N5/9267 , G11B2220/20 , G11B2220/90 , H04N5/85 , H04N5/9265
摘要： A method of synchronizing digitized audio information and digitized picture information establishes a reference time base based on timecodes included with the audio and picture information. The reference time base may be used to synchronize output between a digitized source and one which may be digitized or undigitized.
摘要翻译：使数字化音频信息和数字化图像信息同步的方法基于音频和图像信息中包含的时间码来建立参考时基。参考时基可用于同步数字化源与可能被数字化或未编码的源之间的输出。

10. 发明授权

US08273058B2 Two way accumulator programmable valve pump 有权
标题翻译：双向蓄能器可编程阀门泵
公开(公告)号：US08273058B2
公开(公告)日：2012-09-25
申请号：US11906826
申请日：2007-10-04
申请人： Paul F. Burke , Patrick O'Connor
发明人： Paul F. Burke , Patrick O'Connor
IPC分类号： A61M1/00 , A61M5/00
CPC分类号： G01F11/086 , A61M5/14276 , A61M5/14586 , A61M5/14593 , A61M5/16809 , A61M2005/14513
摘要： An improved implantable valve accumulator pump for the delivery of medication is disclosed. The implantable pump comprises a pressurized drug reservoir. The medication metering assembly comprises a fixed volume accumulator positioned between a pair of valves. The valves alternately open and close to admit medication from the reservoir into the accumulator and to dispense a precise volume pulse to an outlet catheter. In order to improve the pump's accuracy and to increase pumping volume while optimizing the pump's overall size and energy usage a two way diaphragm accumulator is used. The unit can be externally programmed or can be used in a fixed rate configuration that is never programmed but set at the factory or in the current programmable configuration.
摘要翻译：公开了一种用于输送药物的改进的可植入阀蓄能器泵。可植入泵包括加压药物储存器。药物计量组件包括位于一对阀之间的固定容积蓄积器。阀交替地打开和关闭，以将药物从储存器进入蓄能器并且将精确的体积脉冲分配给出口导管。为了提高泵的精度和增加泵送量，同时优化泵的总体尺寸和能量使用，使用双向隔膜蓄能器。该单元可以进行外部编程，也可以以固定速率配置使用，从未编程，但在出厂时或当前的可编程配置中设置。

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