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1. 发明授权

US08146587B2 Method for nasal irrigation and drug delivery 有权
标题翻译：鼻灌和药物输送方法
公开(公告)号：US08146587B2
公开(公告)日：2012-04-03
申请号：US12787576
申请日：2010-05-26
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M11/00
CPC分类号： A61M11/06 , A61M11/001 , A61M15/08 , A61M2210/0618
摘要： A method of treating neoplasms of the nasal cavity. Fluid containing corticosteroids held in a canister is atomized via a compressed air supply to create particles sized for penetration and retention in the nasal cavity under pressure that is able to stent open the soft tissues of the nose to deliver the resultant mist into the whole of the nasal passages without the need for the patient to create an airstream through inhalation. The device consists of a main canister with a reservoir to hold the fluid, two air outlets and an insert that is placed over the air outlets, the insert having at least one outlet that is larger than the holes in the air outlet and allows the fluid to be atomized and injected directly into the nasal cavity.
摘要翻译：一种治疗鼻腔肿瘤的方法。保持在罐中的含有皮质类固醇的流体通过压缩空气供应被雾化，以产生尺寸适于在压力下穿透和保持在鼻腔中的颗粒，该压力能够支架打开鼻子的软组织以将所得的雾输送到整个鼻通道，无需患者通过吸入产生气流。该装置包括具有用于保持流体的储存器的主罐，两个空气出口和放置在空气出口上方的插入件，插入件具有比空气出口中的孔大的至少一个出口，并允许流体被雾化并直接注射到鼻腔中。

2. 发明授权

US08162921B2 Method and device for nasal irrigation and drug delivery 有权
标题翻译：用于鼻灌注和药物输送的方法和装置
公开(公告)号：US08162921B2
公开(公告)日：2012-04-24
申请号：US12633269
申请日：2009-12-08
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M11/02
CPC分类号： A61M11/06 , A61M11/001 , A61M15/08
摘要： A method and device for nasal irrigation and drug delivery wherein fluid held in a canister is atomized via a compressed air supply to create particles sized for penetration and retention in the nasal cavity under pressure that is able to stent open the soft tissues of the nose to deliver the resultant mist into the whole of the nasal passages without the need for the patient to create an airstream through inhalation. The device consists of a main canister with a reservoir to hold the fluid, two air outlets and an insert that is placed over the air outlets, the insert having at least one outlet that is larger than the holes in the air outlet and allows the fluid to be atomized and injected directly into the nasal cavity.
摘要翻译：一种用于鼻灌和药物输送的方法和装置，其中保持在罐中的流体经由压缩空气源雾化，以产生尺寸适于在能够支架打开鼻软组织的压力下穿透和保持在鼻腔中的颗粒将所产生的雾输送到整个鼻通道中，而不需要患者通过吸入产生气流。该装置包括具有用于保持流体的储存器的主罐，两个空气出口和放置在空气出口上方的插入件，插入件具有比空气出口中的孔大的至少一个出口，并允许流体被雾化并直接注射到鼻腔中。

3. 发明申请

US20110132354A1 Method for Nasal Irrigation and Drug Delivery 有权
标题翻译：鼻灌注和药物输送方法
公开(公告)号：US20110132354A1
公开(公告)日：2011-06-09
申请号：US12787576
申请日：2010-05-26
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M11/00
CPC分类号： A61M11/06 , A61M11/001 , A61M15/08 , A61M2210/0618
摘要： The present invention provides a method of treating neoplasms of the nasal cavity. Fluid containing corticosteroids held in a canister is atomized via a compressed air supply to create particles sized for penetration and retention in the nasal cavity under pressure that is able to stent open the soft tissues of the nose to deliver the resultant mist into the whole of the nasal passages without the need for the patient to create an airstream through inhalation. The device consists of a main canister with a reservoir to hold the fluid, two air outlets and an insert that is placed over the air outlets, the insert having at least one outlet that is larger than the holes in the air outlet and allows the fluid to be atomized and injected directly into the nasal cavity.
摘要翻译：本发明提供一种治疗鼻腔肿瘤的方法。保持在罐中的含有皮质类固醇的流体通过压缩空气供应被雾化，以产生尺寸适于在压力下穿透和保持在鼻腔中的颗粒，该压力能够支架打开鼻子的软组织以将所得的雾输送到整个鼻通道，无需患者通过吸入产生气流。该装置包括具有用于保持流体的储存器的主罐，两个空气出口和放置在空气出口上方的插入件，插入件具有比空气出口中的孔大的至少一个出口，并允许流体被雾化并直接注射到鼻腔中。

4. 发明授权

US09440020B2 Nasal irrigator 有权
标题翻译：鼻刺激器
公开(公告)号：US09440020B2
公开(公告)日：2016-09-13
申请号：US13404623
申请日：2012-02-24
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M3/02 , A61M11/00 , A61M11/02 , A61M15/08 , A61M11/06
CPC分类号： A61M3/025 , A61M3/0279 , A61M11/001 , A61M11/02 , A61M11/06 , A61M15/08 , A61M2210/0618 , Y10T29/494
摘要： A nasal nebulizer contains a main canister with at least one air exit port and an insert with at least one fluid channel. The fluid channel ends in a common bell housing above a base of the insert, which rests within the canister. The insert and the canister may form one integral unit for single usage, where a cap plugs the air exit port and the fluid channel, allowing for the transport or long-term storage of fluids within the nebulizer device. The insert may include an extension extending out to the canister and a vertical groove may extend down the fluid channel to a hole in the extension, which upon use helps create a vacuum that pulls in deflected fluid for re-use. The nebulizer may also contain a filter surrounding the tube portion near the top of the canister to catch any extraneous matter expelled from the nose during usage.
摘要翻译：鼻喷雾器包含具有至少一个空气出口的主罐和具有至少一个流体通道的插入件。流体通道在插入件的底部上方的公共钟罩中终止，其位于罐内。插入件和罐可以形成一个整体单元，用于单次使用，其中盖子堵塞空气出口和流体通道，允许在雾化器装置内输送或长期储存流体。插入件可以包括延伸到罐的延伸部分，并且垂直的沟槽可以沿着流体通道向下延伸到延伸部中的孔，在使用时，该凹槽有助于产生拉动偏转的流体以供再次使用的真空。喷雾器还可以包含围绕罐顶部的管部分的过滤器，以在使用期间捕获从鼻子排出的任何外来物质。

5. 发明申请

US20120152238A1 Nasal Nebulizer for Transporting and Storing Fluids 有权
标题翻译：用于运输和储存液体的鼻腔喷雾器
公开(公告)号：US20120152238A1
公开(公告)日：2012-06-21
申请号：US13404623
申请日：2012-02-24
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M11/02 , B21D51/16 , A61M15/08
CPC分类号： A61M3/025 , A61M3/0279 , A61M11/001 , A61M11/02 , A61M11/06 , A61M15/08 , A61M2210/0618 , Y10T29/494
摘要： A nasal nebulizer contains a main canister with at least one air exit port and an insert with at least one fluid channel. The fluid channel ends in a common bell housing above a base of the insert, which rests within the canister. The insert and the canister may form one integral unit for single usage, where a cap plugs the air exit port and the fluid channel, allowing for the transport or long-term storage of fluids within the nebulizer device. The insert may include an extension extending out to the canister and a vertical groove may extend down the fluid channel to a hole in the extension, which upon use helps create a vacuum that pulls in deflected fluid for re-use. The nebulizer may also contain a filter surrounding the tube portion near the top of the canister to catch any extraneous matter expelled from the nose during usage.
摘要翻译：鼻喷雾器包含具有至少一个空气出口的主罐和具有至少一个流体通道的插入件。流体通道在插入件的底部上方的公共钟罩中终止，其位于罐内。插入件和罐可以形成一个整体单元，用于单次使用，其中盖子堵塞空气出口和流体通道，允许在雾化器装置内输送或长期储存流体。插入件可以包括延伸到罐的延伸部分，并且垂直的沟槽可以沿着流体通道向下延伸到延伸部中的孔，在使用时，该凹槽有助于产生拉动偏转的流体以供再次使用的真空。喷雾器还可以包含围绕罐顶部的管部分的过滤器，以在使用期间捕获从鼻子排出的任何外来物质。

6. 发明申请

US20110137290A1 Method and Device for Nasal Irrigation and drug delivery 有权
标题翻译：鼻灌注和药物输送的方法和装置
公开(公告)号：US20110137290A1
公开(公告)日：2011-06-09
申请号：US12633269
申请日：2009-12-08
申请人： William J. Flickinger , John Quackenbush
发明人： William J. Flickinger , John Quackenbush
IPC分类号： A61M11/02
CPC分类号： A61M11/06 , A61M11/001 , A61M15/08
摘要： The present invention provides a method and device for nasal irrigation and drug delivery wherein fluid held in a canister is atomized via a compressed air supply to create particles sized for penetration and retention in the nasal cavity under pressure that is able to stent open the soft tissues of the nose to deliver the resultant mist into the whole of the nasal passages without the need for the patient to create an airstream through inhalation. The device consists of a main canister with a reservoir to hold the fluid, two air outlets and an insert that is placed over the air outlets, the insert having at least one outlet that is larger than the holes in the air outlet and allows the fluid to be atomized and injected directly into the nasal cavity.
摘要翻译：本发明提供了一种用于鼻灌和药物输送的方法和装置，其中保持在罐中的流体经由压缩空气供应被雾化以产生尺寸适于在能够支架打开软组织的压力下穿透和保持在鼻腔中的颗粒的鼻子将所产生的雾输送到整个鼻通道中，而不需要患者通过吸入产生气流。该装置包括具有用于保持流体的储存器的主罐，两个空气出口和放置在空气出口上方的插入件，插入件具有比空气出口中的孔大的至少一个出口，并允许流体被雾化并直接注射到鼻腔中。

7. 发明申请

US20120160237A1 Nasal Nebulizer for Transporting and Storing Fluids 有权
标题翻译：用于运输和储存液体的鼻腔喷雾器
公开(公告)号：US20120160237A1
公开(公告)日：2012-06-28
申请号：US13414439
申请日：2012-03-07
申请人： William J. Flickinger
发明人： William J. Flickinger
IPC分类号： A61M11/00
CPC分类号： A61M3/025 , A61M3/0279 , A61M11/001 , A61M11/06 , A61M15/08 , A61M16/0063 , A61M16/06 , A61M16/0666 , A61M16/1065 , A61M2205/8206 , A61M2210/0618
摘要： A nasal nebulizer with a main canister for receiving fluid and an insert with a fluid channel includes a contiguous pressurized air supply source. The fluid channel may be a tapered tube overlapping an air exit port in the canister. The fluid channel may also comprise a common bell housing surrounding the air exit port above a base of the insert, which rests within the canister. The insert may include an extension projecting out to the canister and a vertical groove may extend down the fluid channel to a hole in the extension, which upon use helps create a vacuum that pulls in deflected fluid. The main canister includes a convex top surface around the periphery of an opening for a reservoir that receives fluids. The top surface extends downwardly to a generally rectangular opening that connects to the pressurized air supply source.
摘要翻译：具有用于接收流体的主罐和具有流体通道的插入件的鼻喷雾器包括邻接的加压空气供应源。流体通道可以是与罐中的空气出口重叠的锥形管。流体通道还可以包括围绕插入件的基部上方的空气出口的共同的钟罩壳体，其位于罐内。插入件可以包括向罐伸出的延伸部，并且垂直的沟槽可以沿着流体通道向下延伸到延伸部中的孔，在使用时，该凹槽有助于产生拉动偏转流体的真空。主罐包括围绕用于容纳流体的储存器的开口的周边的凸顶表面。顶表面向下延伸到连接到加压空气供应源的大致矩形的开口。

8. 发明申请

US20210121353A1 PHYSICAL THERAPY DEVICE AND METHOD FOR STRETCHING MUSCLES IN THE FOOT 有权
公开(公告)号：US20210121353A1
公开(公告)日：2021-04-29
申请号：US16667622
申请日：2019-10-29
申请人： William J. Flickinger
发明人： William J. Flickinger
IPC分类号： A61H1/02
摘要： A device and method for engaging the foot distal to the metatarsi that enables a full stretch of the plantar fascia, muscles of the feet and lower leg. The invention has an elongated shaft that has a brace element affixed to the end of the shaft pointed away from a human user and a handle element affixed to the opposite end of the shaft. When the handle element is pulled toward the human user, the brace element engages the foot such that the intended stretch on the plantar and posterior portions of the foot and leg is initiated.

9. 发明授权

US06572612B2 Ablation catheter and method for isolating a pulmonary vein 有权
公开(公告)号：US06572612B2
公开(公告)日：2003-06-03
申请号：US09975789
申请日：2001-10-11
申请人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
发明人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
IPC分类号： A61B1814
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00214 , A61B2018/1407 , A61B2018/1435
摘要： A catheter assembly and method for treatment of cardiac arrhythmia, for example, atrial fibrillation, by electrically isolating a vessel, such as a pulmonary vein, from a chamber, such as the left atrium. The catheter assembly includes a catheter body and at least one electrode. The catheter body includes a proximal portion, an intermediate portion and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a substantially closed loop transverse to the longitudinal axis. The at least one electrode is disposed along the loop. With this configuration, the loop is axially directed into contact with the chamber wall about the vessel ostium. Upon energization, the electrode ablates a continuous lesion pattern about the vessel ostium, thereby electrically isolating the vessel from the chamber.

10. 发明授权

US06325797B1 Ablation catheter and method for isolating a pulmonary vein 有权
标题翻译：消融导管和隔离肺静脉的方法
公开(公告)号：US06325797B1
公开(公告)日：2001-12-04
申请号：US09286048
申请日：1999-04-05
申请人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
发明人： Mark T. Stewart , William J. Flickinger , David E. Francischelli , Rahul Mehra , Xiaoyi Min
IPC分类号： A61B1814
CPC分类号： A61B18/1492 , A61B2017/00044 , A61B2017/00243 , A61B2017/00867 , A61B2018/00214 , A61B2018/1407 , A61B2018/1435
摘要： A catheter assembly and method for treatment of cardiac arrhythmia, for example, atrial fibrillation, by electrically isolating a vessel, such as a pulmonary vein, from a chamber, such as the left atrium. The catheter assembly includes a catheter body and at least one electrode. The catheter body includes a proximal portion, an intermediate portion and a distal portion. The intermediate portion extends from the proximal portion and defines a longitudinal axis. The distal portion extends from the intermediate portion and forms a substantially closed loop transverse to the longitudinal axis. The at least one electrode is disposed along the loop. With this configuration, the loop is axially directed into contact with the chamber wall about the vessel ostium. Upon energization, the electrode ablates a continuous lesion pattern about the vessel ostium, thereby electrically isolating the vessel from the chamber.
摘要翻译：一种用于治疗心律失常（例如心房颤动）的导管组件和方法，通过诸如左心房的腔室电隔离血管（例如肺静脉）。导管组件包括导管主体和至少一个电极。导管主体包括近端部分，中间部分和远端部分。中间部分从近端部分延伸并且限定纵向轴线。远侧部分从中间部分延伸并且形成横向于纵向轴线的基本上闭合的环。沿着环设置至少一个电极。利用这种构造，环路被轴向地指向与容器孔周围的室壁接触。在通电时，电极消除围绕血管口的连续病变图案，从而将容器与腔室电隔离。

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