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1. 发明公开

US20230264016A1 IMPLANTABLE COCHLEAR SYSTEM WITH INTEGRATED COMPONENTS AND LEAD CHARACTERIZATION 审中-公开
公开(公告)号：US20230264016A1
公开(公告)日：2023-08-24
申请号：US18310307
申请日：2023-05-01
申请人： Envoy Medical Corporation
发明人： Paul R. Mazanec
IPC分类号： A61N1/05 , A61N1/36 , A61N1/04 , A61N1/378 , A61N1/372 , G16H40/67 , H04W4/80 , A61N1/02 , A61N1/08 , H04W12/50
CPC分类号： A61N1/0541 , A61N1/36038 , A61N1/0488 , A61N1/378 , A61N1/37217 , A61N1/36171 , A61N1/37235 , A61N1/37282 , A61N1/36039 , A61N1/37241 , G16H40/67 , H04W4/80 , A61N1/025 , A61N1/08 , A61N1/37247 , A61N1/37258 , H04W12/50
摘要： Cochlear implant systems can include a cochlear electrode, a stimulator in electrical communication with the cochlear electrode, a sensor configured to receive a stimulus signal and generate an input signal based on the received stimulus signal, and a signal processor in communication with the stimulator and the sensor. The signal processor can include an analog filtering stage configured to generate an analog filtered signal from a received input signal and a digital filtering stage configured to generate a digitally filtered signal from the analog filtered signal. The analog filtering stage and digital filtering stage can be used to normalize the frequency response of the digitally filtered signal with respect to the stimulus signal.

2. 发明申请

US20180264191A1 SYSTEMS AND METHODS FOR NEURAL DRUG DELIVERY AND MODULATION OF BRAIN ACTIVITY 审中-公开
公开(公告)号：US20180264191A1
公开(公告)日：2018-09-20
申请号：US15919822
申请日：2018-03-13
申请人： Massachussetts Institute of Technology
发明人： Canan Dagdeviren , Robert Langer , Michael J. Cima
IPC分类号： A61M5/158 , A61M25/00 , A61M5/172 , A61N1/05
CPC分类号： A61M5/158 , A61B5/0084 , A61B5/04001 , A61B5/4064 , A61B5/6868 , A61M5/1723 , A61M5/329 , A61M5/3294 , A61M25/0084 , A61M2005/1588 , A61M2202/04 , A61M2205/02 , A61M2205/051 , A61M2205/054 , A61M2205/3303 , A61M2207/00 , A61M2210/0693 , A61M2230/08 , A61N1/0488 , A61N1/0529
摘要： A neural drug delivery system is disclosed. In an embodiment, the system includes two or more microtubes, each having a distal end, a proximal end, and elongate channel body extending therebetween; an electrode having a distal end, a proximal end, and elongate body extending therebetween; an elongate carrying template supporting the microtubes and the electrode in an aligned stack; and an annular needle having a distal end and a proximal end, and housing the carrying template, the microtubes, and the electrode. The system may include at least one pump fluidically connected to the proximal end(s) of one or more of the microtubes. The pump may be configured to deliver a fluid drug on demand through the elongate channel body and out of the distal end of the microtubes.

3. 发明授权

US09833616B2 System and method for cardiac lead 有权
公开(公告)号：US09833616B2
公开(公告)日：2017-12-05
申请号：US12649197
申请日：2009-12-29
申请人： Nathan Lee Olson
发明人： Nathan Lee Olson
IPC分类号： A61N1/00 , A61N1/05 , A61N1/04 , A61N1/36 , A61N1/39 , A61M25/00 , A61M25/04
CPC分类号： A61N1/056 , A61M25/0013 , A61M25/0032 , A61M25/0054 , A61M25/04 , A61N1/0488 , A61N1/36 , A61N1/3956
摘要： An implantable medical device (IMD) can include implantable pulse generator (IPG) devices, implantable cardioverter-defibrillators (ICD), cardiac resynchronization therapy defibrillator devices, neurostimulators or combinations thereof. In one example, the IMD can include a body assembly, which can provide at least one electrical signal corresponding to a therapy. The IMD can also include a cardiac lead assembly, which can have a proximal portion and a distal portion. The proximal portion of the cardiac lead assembly can be in communication with the body assembly to receive the therapy and the distal portion can be adapted to be coupled to an anatomical structure to transmit the at least one electrical signal to the anatomical structure. The proximal portion of the cardiac lead assembly can have a first stiffness and the distal portion can have a second stiffness. The first stiffness can be greater than the second stiffness.

4. 发明授权

US09457179B2 Systems for monitoring and applying electrical currents in an organ perfusion system 有权
标题翻译：在器官灌注系统中监测和应用电流的系统
公开(公告)号：US09457179B2
公开(公告)日：2016-10-04
申请号：US11822495
申请日：2007-07-06
申请人： Waleed Hassanein , Ahmed Elbetanony , Richard Bringham , Robert Havener , Vincent Lambert, II , Burt Ochs
发明人： Waleed Hassanein , Ahmed Elbetanony , Richard Bringham , Robert Havener , Vincent Lambert, II , Burt Ochs
IPC分类号： A01N1/00 , A01N1/02 , C12M1/36 , C12M1/38 , C12M3/00 , A61F2/00 , A61N1/04
CPC分类号： A01N1/0247 , A01N1/0294 , A61N1/046 , A61N1/0488 , A61N1/0492
摘要： Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
摘要翻译：已经开发了用于灌注系统中的电极系统来测量移植心脏的电活动并根据需要提供除颤能量。灌注系统在正常生理条件下或接近正常生理条件下保持心脏处于跳动状态; 循环氧合，营养丰富的灌注液在生理温度，压力和流速附近或接近心脏。这些系统包括一对电极，心电图放置在右心房和外移心的左心室，以及放置在主动脉血管路中的电极。

5. 发明申请

US20160166803A1 SYSTEMS AND METHODS FOR DELIVERING CHEMICAL AND ELECTRICAL STIMULATION ACROSS ONE OR MORE NEURAL CIRCUITS 审中-公开
标题翻译：通过一个或多个神经电路传递化学和电刺激的系统和方法
公开(公告)号：US20160166803A1
公开(公告)日：2016-06-16
申请号：US14908586
申请日：2014-07-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Byron C. MASI , Patrick L. TIERNEY , Ann M. GRAYBIEL , Michael J. CIMA
IPC分类号： A61M25/00 , A61B5/00 , A61N1/05 , A61B5/04
CPC分类号： A61M25/0043 , A61B5/04001 , A61B5/6877 , A61M2205/054 , A61N1/0488 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0551
摘要： Systems, devices, and methods are provided for delivering chemical and electrical stimulation across one or more neural circuits. The systems, devices, and methods can also be used for sensing and recording specific neural activity. In certain embodiments, a system includes first and second fluid reservoirs, a manifold, and a delivery tube. The manifold may include first and second chambers therein. The first chamber may be in fluid communication with the first reservoir, and the second chamber may be in fluid communication with the second reservoir. The delivery tube may include a first conduit in fluid communication with the first chamber, a second conduit in fluid communication with the second chamber, and a third conduit configured to house an electrode therein. In this manner, a distal tip of the delivery tube is configured to be positionable adjacent to the one or more neural circuits for providing chemical and electrical stimulation thereto.
摘要翻译：提供系统，装置和方法用于在一个或多个神经回路之间传递化学和电刺激。系统，装置和方法也可用于感测和记录特定的神经活动。在某些实施例中，系统包括第一和第二流体储存器，歧管和输送管。歧管可以包括其中的第一和第二腔室。第一室可以与第一储存器流体连通，并且第二室可以与第二储存器流体连通。输送管可以包括与第一腔室流体连通的第一导管，与第二腔室流体连通的第二导管，以及配置成在其中容纳电极的第三导管。以这种方式，输送管的远侧末端被配置为可邻近于一个或多个神经回路定位，以向其提供化学和电刺激。

6. 发明申请

US20160113710A1 AN ELECTRICAL LEAD FOR A CATHETER AND METHOD OF MANUFACTURING 审中-公开
标题翻译：用于导管的电气导线及其制造方法
公开(公告)号：US20160113710A1
公开(公告)日：2016-04-28
申请号：US14894970
申请日：2014-06-06
申请人： CathRx Ltd
发明人： David Ogle , Roman Greifeneder , Warrick Heald
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/00 , A61B2017/00526 , A61B2018/00577 , A61B2218/002 , A61B2218/003 , A61M25/0012 , A61M25/005 , A61N1/0488 , A61N1/05 , A61N1/3752
摘要： An electrical lead for a catheter includes an elongate member of non-conductive material having a proximal end and a distal end and defining a lumen extending from the proximal end to the distal end. The elongate member further includes a tubular member of non-conductive material, a braid of conductive material applied over the tubular member, an intermediate layer of non-conductive material applied over the braid, a plurality of electrical conductors extending from the proximal end to the distal end laid on the intermediate layer, and an outer layer of non-conductive material applied over the electrical conductors to cover the conductors. At least one electrode is arranged on the outer surface of the elongate member in electrical communication with at least one of the plurality of electrical conductors through the outer layer. The braid underlies the at least one electrode but is insulated from the at least one electrode by the intermediate non-conductive layer.
摘要翻译：用于导管的电引线包括具有近端和远端的非导电材料的细长构件，并且限定从近端延伸到远端的内腔。细长构件还包括非导电材料的管状构件，施加在管状构件上的导电材料的编织物，施加在编织物上的非导电材料的中间层，多个电导体，其从近端延伸到远端放置在中间层上，以及涂覆在电导体上以覆盖导体的非导电材料外层。至少一个电极布置在细长构件的外表面上，与多个电导体中的至少一个通过外层电连通。编织物位于至少一个电极的下面，但是通过中间非导电层与至少一个电极绝缘。

7. 发明授权

US09272130B2 Living body stimulating electrode, living body stimulating electrode apparatus, and method for producing living body stimulating electrode 有权
标题翻译：活体刺激电极，活体刺激电极装置及生物体刺激电极的制造方法
公开(公告)号：US09272130B2
公开(公告)日：2016-03-01
申请号：US14529913
申请日：2014-10-31
申请人： Seiko Instruments Inc. , NIHON KOHDEN CORPORATION
发明人： Ryo Sugawara , Tomoo Kobayashi , Jun Motogi
IPC分类号： A61N1/00 , A61N1/04 , A61B5/05 , A61B5/00 , H05K3/30
CPC分类号： A61N1/0456 , A61B5/05 , A61B5/4005 , A61B5/4047 , A61N1/0476 , A61N1/0488 , H05K3/306 , Y10T29/49133
摘要： Provided are a living body stimulating electrode, a living body stimulating electrode apparatus, and a method for producing a living body stimulating electrode. The living body stimulating electrode has a flexible circuit board (FPC) between a living body stimulating electrode and a resin part. The resin part and the FPC are fixed with the living body stimulating electrode. Specifically, the flexible circuit board is disposed between the living body stimulating electrode and the resin part, and one or both of a stimulating electrode and a contact electrode constituting the living body stimulating electrode have an engaging part having a pressing part and a fixing part. The pressing part presses the flexible circuit board onto the resin part. Simultaneously, the fixing part is penetrated through a through hole formed in the flexible circuit board and pressed into a hole formed in the resin part, thereby fixed to and held by the resin part. The engaging part may be subjected to a chamfering process (the edge may be chamfered into an angulated plane or a round plane) to form an inclined plane or a curved (round) plane.
摘要翻译：本发明提供一种活体刺激电极，活体刺激电极装置，以及生物体刺激电极的制造方法。生物体刺激电极在生物体刺激电极和树脂部分之间具有柔性电路板（FPC）。树脂部和FPC与活体刺激电极固定。具体地说，柔性电路板配置在生物体刺激电极和树脂部之间，构成生物体刺激电极的刺激电极和接触电极中的一个或两个具有具有按压部和固定部的卡合部。按压部将柔性电路板按压到树脂部上。同时，固定部分穿过形成在柔性电路板中的通孔，并被压入形成在树脂部分中的孔中，从而固定并保持在树脂部分上。接合部分可以进行倒角处理（边缘可以被倒角成角度平面或圆形平面）以形成倾斜平面或弯曲（圆形）平面。

8. 发明申请

US20160008597A1 WIRELESS ELECTRICAL STIMULATION SYSTEM 审中-公开
公开(公告)号：US20160008597A1
公开(公告)日：2016-01-14
申请号：US14796456
申请日：2015-07-10
申请人： Eric Ye Chen
发明人： Eric Ye Chen
IPC分类号： A61N1/36 , A61N1/04 , A61N1/372
CPC分类号： A61N1/36014 , A61N1/0452 , A61N1/0456 , A61N1/048 , A61N1/0484 , A61N1/0488 , A61N1/322 , A61N1/37217 , A61N1/37247
摘要： A system and method are provided for a wireless electrical stimulation. The system generally includes at least two electrical stimulation units. Each electrical stimulation unit includes electrodes connected to the unit. The system also includes a transmitter for remotely, wirelessly controlling each of the electrical stimulation units to selectively apply a time-varying electric potential to the electrodes to provide an electrical stimulation to tissue in electrical contact with the electrodes.

9. 发明授权

US09234920B2 Electrically identifiable electrode lead and method of electrically identifying an electrode lead 有权
标题翻译：电识别电极引线和电鉴定电极引线的方法
公开(公告)号：US09234920B2
公开(公告)日：2016-01-12
申请号：US14451830
申请日：2014-08-05
申请人： Greatbatch Ltd.
发明人： Norbert Kaula , Jeff A. Weisgarber , Yohannes Iyassu
IPC分类号： A61N1/04 , G01R19/25 , A61N1/08 , A61N1/05
CPC分类号： G01R19/2503 , A61N1/025 , A61N1/04 , A61N1/0488 , A61N1/05 , A61N1/08 , A61N1/3752
摘要： An electrically identifiable medical electrode lead. The lead includes a flexible lead body having a distal end and a connector end. The lead also includes a plurality of electrodes disposed near the distal end of the flexible lead body. The lead further includes a connector disposed at the connector end of the flexible lead body, the connector including a plurality of contacts. The lead additionally includes a plurality of conductors supported by and passing through the flexible lead body, the plurality of conductors including electrical conductors that provide paths for electrical current from the connector to the plurality of electrodes. Finally, the lead includes a memory circuit supported by the flexible lead body and being in electrical communication with a contact of the plurality of contacts in the connector.
摘要翻译：电可识别的医用电极引线。引线包括具有远端和连接器端的柔性引线体。引线还包括设置在柔性引线主体的远端附近的多个电极。引线还包括设置在柔性引线主体的连接器端处的连接器，该连接器包括多个触点。引线还包括由柔性引线主体支撑并穿过柔性引线主体的多个导体，所述多个导体包括提供用于从连接器到多个电极的电流的路径的电导体。最后，引线包括由柔性引线体支撑并与连接器中的多个触点的触点电连通的存储器电路。

10. 发明授权

US09131895B2 Disposable electrode for electro-stimulation 有权
标题翻译：电刺激一次性电极
公开(公告)号：US09131895B2
公开(公告)日：2015-09-15
申请号：US13806278
申请日：2011-06-29
申请人： Timon Rutger Grob , Rudolf Maria Jozef Voncken , Antonius Wilhelmus Maria De Laat , Judith Petra Huurdeman , Ronaldus Mathias Hubertus Steijvers , Lucas Johannes Anna Maria Beckers , Michael Johan Ferdinand Marie Ter Laak , Steven Ernest Franklin , Sean Scott Wheelhouse
发明人： Timon Rutger Grob , Rudolf Maria Jozef Voncken , Antonius Wilhelmus Maria De Laat , Judith Petra Huurdeman , Ronaldus Mathias Hubertus Steijvers , Lucas Johannes Anna Maria Beckers , Michael Johan Ferdinand Marie Ter Laak , Steven Ernest Franklin , Sean Scott Wheelhouse
IPC分类号： A61B5/0408 , A61N1/04 , A61B5/00 , A61B5/04
CPC分类号： A61B5/6832 , A61B5/04 , A61B5/04087 , A61N1/0408 , A61N1/0452 , A61N1/0456 , A61N1/0472 , A61N1/048 , A61N1/0488 , A61N1/0492 , A61N1/0496 , Y10T29/49204
摘要： An electrode configured to provide electrical contact with a subject's skin and includes a conductive layer and a gel layer. The conductive layer spreads current and transmits electrical signals to and/or receives electrical signals from the subject's skin and has a first conductive surface through which electrical signals are transmitted to and/or received from the subject's skin. The first conductive surface is on a side of the conductive layer that faces toward the subject's skin if the electrode is installed on the subject. The gel layer is formed on the same side of the conductive layer as the first conductive surface. The gel layer has a first interface surface that directly contacts the subject's skin if the electrode is installed on the subject, and to conduct electrical signals between the subject's skin and the first conductive surface. The first interface surface has a surface area larger than that of the first conductive surface.
摘要翻译：一种被配置为提供与受试者皮肤的电接触并包括导电层和凝胶层的电极。导电层扩展电流并将电信号传输到和/或接收来自受检者皮肤的电信号，并且具有第一导电表面，电信号通过该第一导电表面传送到和/或从受试者的皮肤接收。如果电极安装在被摄体上，则第一导电表面位于导电层的朝向被摄体的皮肤的一侧。凝胶层形成在导电层的与第一导电表面相同的一侧上。如果电极安装在被检体上，凝胶层具有直接接触被检者皮肤的第一界面表面，并且在被检者的皮肤和第一导电表面之间传导电信号。第一界面表面的表面积大于第一导电表面的表面积。

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