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    • 8. 发明申请
    • HIGH-THROUGHPUT METHODS AND SYSTEMS FOR PROCESSING BIOLOGICAL MATERIALS
    • 用于加工生物材料的高通量方法和系统
    • US20150233803A1
    • 2015-08-20
    • US14702263
    • 2015-05-01
    • General Electric Company
    • Weston Blaine GriffinJaydeep RoyPhillip Alexander ShoemakerWilliam Patrick Waters
    • G01N1/40
    • A61M1/0209A61M1/0218A61M1/34A61M2205/3306A61M2205/3334B01D21/26B03D3/00
    • A high-throughput system for processing biological material that comprises: a tray that supports a functionally-closed fluid path subsystem comprising, a vessel for containing and enabling the biological material to separate into two or more distinct submaterials; one or more receptacles to receive one or more of the submaterials from the vessel; a filtration device; a conduit through which one or more submaterials are transported between at least the vessel and the filtration device; and a first engagement structure; a processing unit comprising, a pumping device for moving one or more of the submaterials between at least the vessel and the filtration device via the conduit; a second engagement structure corresponding to the first engagement structure; a locking mechanism for at least temporarily holding the tray in a fixed position relative to the processing unit; a control device that automatically starts and stops the pumping device in response to one or more commands.
    • 一种用于处理生物材料的高通量系统,包括:托盘,其支撑功能封闭的流体路径子系统,包括:用于容纳和使所述生物材料分离成两个或更多个不同的子材料的容器; 从容器接收一个或多个子材料的一个或多个容器; 过滤装置; 导管,至少在所述容器和所述过滤装置之间运送一个或多个副材料; 和第一接合结构; 处理单元,包括:泵送装置,用于经由所述导管在至少所述容器和所述过滤装置之间移动所述副材料中的一种或多种; 对应于第一接合结构的第二接合结构; 用于至少临时将所述托盘相对于所述处理单元暂时保持在固定位置的锁定机构; 响应于一个或多个命令自动启动和停止泵送装置的控制装置。
    • 10. 发明申请
    • METHOD AND APPARATUS FOR CONTINUOUSLY FRACTIONATING PARTICLES CONTAINED WITHIN A VISCOPLASTIC FLUID
    • 用于连续分离在粘度流体中的颗粒的方法和装置
    • US20140296052A1
    • 2014-10-02
    • US14129820
    • 2012-06-29
    • Dominic Mark MartinezJames Allen OlsonArio MadaniIan Alistair FrigaardDavood FarajisarirJames Lockhart
    • Dominic Mark MartinezJames Allen OlsonArio MadaniIan Alistair FrigaardDavood FarajisarirJames Lockhart
    • B04B7/08B04B11/02
    • B04B7/08B03B5/32B03D3/00B04B1/00B04B11/02B04B11/06
    • Particles are separated from a source viscoplastic fluid by flowing streams of the viscoplastic fluid and a destination fluid in parallel streamed relationship inside a rotating cylindrical annulus (FIG. 16 (106, 102b) by using baffles (112, 114) to introduce each fluid independently at an inlet lower end of the annulus and for separating the upper streams consisting of an un-yielded source and destination flow proximate the radially innermost side of the annulus, a bulk axial flow in a more central region and a yielded layer destination flow adjacent the radial outermost side of the annulus which contains the particles that have separated. Inlet and outlet baffles are provided at each end of the vertically oriented device to maintain the flows discrete on entry and to maintain the separated flows discrete on exit so as to facilitate removal of the component flows from the fractionator. The flow is maintained as laminar Poiseuille flow by adjusting the flow rates of the source and destination fluids. Supporting theory is provided with derived parameters for controlling the flow and predicting results. Two major embodiments are presented the first based on axial inlet flows (FIG. 17) and the second based on radial inlet flows (FIG. 8). Pump blades (170), (176) (FIG. 17) may be provided for the axial inlet/outlet embodiment in the region of the separated flow channels. Modular construction is shown in FIGS. 1-3.
    • 通过使用挡板(112,114)独立地引入每个流体,在旋转的圆柱形环(图16(106,102b))内流动粘性塑料流体和平行流动关系的目的流体,将颗粒与源粘塑性流体分离 在环形空间的入口下端处,并且用于分离由邻近环形空间的径向最内侧的未产生的源和目的地流组成的上部流,在更中心区域中的体积轴向流和邻近 包含已经分离的颗粒的环的径向最外侧。在垂直取向的装置的每个端部处设置入口和出口挡板,以保持流入离开的流动并且使离开的流体保持在出口处离散,以便于移除 组分从分馏器流出,流量通过调节源和dest的流量而保持为层流Poiseuille流 输液 为支持理论提供了用于控制流量和预测结果的派生参数。 基于轴向入口流(图17)和基于径向入口流(图8)的第二实施例呈现出两个主要实施例。 可以在分离的流动通道的区域中为轴向入口/出口实施例提供泵叶片(170),(176)(图17)。 模块化结构示于图1和图2。 1-3。