专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US10501393B2 Processes for preparing vinylidene dimer derivatives 有权
公开(公告)号：US10501393B2
公开(公告)日：2019-12-10
申请号：US15685172
申请日：2017-08-24
申请人： ExxonMobil Research and Engineering Company
发明人： Abhimanyu O. Patil , Satish Bodige
IPC分类号： C07C29/38 , C07C33/025 , C07C69/24 , C10M105/34 , C07C29/44 , C07C67/08 , C10M105/12 , C10M105/14
CPC分类号： C07C29/38 , C07C29/44 , C07C33/025 , C07C67/08 , C07C69/24 , C10M105/12 , C10M105/14 , C10M105/34 , C10M2207/0215 , C10M2207/0225 , C10M2207/2815 , C10M2207/2855 , C07C29/44 , C07C33/025 , C07C67/08 , C07C69/78 , C07C67/08 , C07C69/24 , C10M2207/0215 , C10N2220/028 , C10M2207/2855 , C10N2220/028
摘要： This disclosure provides a process for producing vinylidene dimer derivatives by subjecting one or more vinylidene dimers and one or more carbonyl-containing compounds to a carbonyl-ene reaction, optionally in the presence of a catalyst, to produce one or more vinylidene dimer derived alcohols. This disclosure also provides a process for producing vinylidene dimer derivatives by reacting one or more vinylidene dimers with one or more carbonyl-containing compounds, optionally in the presence of a catalyst, to produce one or more vinylidene dimer derived alcohols. This disclosure further provides vinylidene dimer derivatives (e.g., vinylidene dimer derived alcohols and esters) produced by these processes. This disclosure still further provides for hydrogenating/reacting the vinylidene dimer derived alcohols with acids or anhydrides to produce vinylidene dimer derived esters. This disclosure yet further relates to lubricating ester oil base stocks, and lubricating oils containing the lubricating ester oil base stocks.

2. 发明申请

US20180086682A1 PROCESSES FOR PREPARING VINYLIDENE DIMER DERIVATIVES 审中-公开
公开(公告)号：US20180086682A1
公开(公告)日：2018-03-29
申请号：US15685172
申请日：2017-08-24
申请人： ExxonMobil Research and Engineering Company
发明人： Abhimanyu O. PATIL , Satish BODIGE
IPC分类号： C07C29/38 , C07C33/025 , C10M105/34 , C07C69/24
CPC分类号： C07C29/38 , C07C29/44 , C07C33/025 , C07C67/08 , C07C69/24 , C10M105/12 , C10M105/14 , C10M105/34 , C10M2207/0215 , C10M2207/0225 , C10M2207/2815 , C10M2207/2855 , C07C69/78 , C10N2220/028
摘要： This disclosure provides a process for producing vinylidene dimer derivatives by subjecting one or more vinylidene dimers and one or more carbonyl-containing compounds to a carbonyl-ene reaction, optionally in the presence of a catalyst, to produce one or more vinylidene dimer derived alcohols. This disclosure also provides a process for producing vinylidene dimer derivatives by reacting one or more vinylidene dimers with one or more carbonyl-containing compounds, optionally in the presence of a catalyst, to produce one or more vinylidene dimer derived alcohols. This disclosure further provides vinylidene dimer derivatives (e.g., vinylidene dimer derived alcohols and esters) produced by these processes. This disclosure still further provides for hydrogenating/reacting the vinylidene dimer derived alcohols with acids or anhydrides to produce vinylidene dimer derived esters. This disclosure yet further relates to lubricating ester oil base stocks, and lubricating oils containing the lubricating ester oil base stocks.

3. 发明授权

US09394218B2 Manufacture of methylolalkanes 有权
标题翻译：羟甲基烷烃的制造
公开(公告)号：US09394218B2
公开(公告)日：2016-07-19
申请号：US14903619
申请日：2014-07-23
申请人： Oxea Bishop LLC
发明人： Heinz Strutz , Donald K. Raff , Guido D. Frey , Norman Nowotny , Marcos Schroeder , Fred Gaytan , Tracy Kevin Hung , William E. Slinkard
IPC分类号： C07C29/38 , C07C31/22 , B01J19/00 , B01J19/24 , B01F5/06
CPC分类号： C07C29/38 , B01F5/0615 , B01F2005/0633 , B01F2005/0637 , B01J19/006 , B01J19/2405 , B01J19/242 , B01J2219/0004 , B01J2219/0006 , B01J2219/00094 , B01J2219/00159 , B01J2219/00204 , B01J2219/00238 , B01J2219/00772 , B01J2219/00777 , B01J2219/24 , C07C31/22
摘要： A multistage tubular reaction system and method for preparing methylol derivatives of an aldehyde includes a tubular reaction system with a plurality of successive reactor stages provided with a formaldehyde containing feed stream. The system includes multiple feed ports for the staged addition of C2 or higher condensible aldehyde and/or base to the formaldehyde containing stream at a plurality of successive feed points to provide a production stream, which is progressively provided with additional reactants as the production stream advances through the successive reaction stages. Advantages include better temperature control and reduced byproduct formation.
摘要翻译：用于制备醛的羟甲基衍生物的多级管状反应体系和方法包括具有多个连续的反应器级的管状反应体系，其提供含甲醛的进料流。该系统包括多个进料口，用于在多个连续的进料点分阶段加入C2或更高的可缩合醛和/或碱至含甲醛的料流，以提供生产流，随着生产流的进展，其逐渐提供有额外的反应物通过连续的反应阶段。优点包括更好的温度控制和副产物的形成。

4. 发明授权

US09328061B2 Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols 有权
标题翻译：简单的有机分子作为实际和有效的对映选择性合成胺和醇的催化剂
公开(公告)号：US09328061B2
公开(公告)日：2016-05-03
申请号：US14382053
申请日：2013-03-01
申请人： Trustees of Boston College
发明人： Amir H. Hoveyda , Daniel L. Silverio , Tatiana Pilyugina , Sebastian Torker , Daniel Robbins
IPC分类号： C07C237/06 , C07C229/04 , C07D295/185 , C07C227/10 , C07C229/14 , C07C251/24 , C07F9/6539 , C07F9/36 , C07C41/30 , C07C29/38 , C07C67/343 , C07F7/08 , C07C229/08 , C07D207/06 , C07F9/50
CPC分类号： C07C237/06 , C07B2200/07 , C07C29/38 , C07C41/30 , C07C67/343 , C07C227/10 , C07C229/04 , C07C229/08 , C07C229/14 , C07C251/24 , C07D207/06 , C07D295/185 , C07F7/081 , C07F7/0812 , C07F9/36 , C07F9/5022 , C07F9/6539 , C07C229/30 , C07C43/23 , C07C33/30 , C07C33/28 , C07C33/483 , C07C69/76
摘要： The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.
摘要翻译：本发明提供有机分子及其有机硼试剂和双键之间的反应的方法，例如亚胺或羰基，以立体选择性提供包括胺和醇的手性产物，可用于制备生物活性分子的实体。

5. 发明授权

US08975447B2 Process for asymetric methylallylation in the presence of a 2,2′-substituted 1,1′-BI-2-naphthol catalyst 有权
标题翻译：在2,2'-取代的1,1'-二-2-萘酚催化剂的存在下进行不对称甲基化反应的方法
公开(公告)号：US08975447B2
公开(公告)日：2015-03-10
申请号：US14003248
申请日：2012-03-06
申请人： Wenjie Li , Zhi-Hui Lu , Chris Hugh Senanayake , Yongda Zhang
发明人： Wenjie Li , Zhi-Hui Lu , Chris Hugh Senanayake , Yongda Zhang
IPC分类号： C07C33/48 , C07C39/38 , C07C29/38 , C07C29/40 , C07C39/14 , C07C37/055 , C07C41/48 , C07C29/143 , C07C37/62
CPC分类号： C07C39/14 , C07B2200/07 , C07C29/143 , C07C29/38 , C07C37/055 , C07C37/62 , C07C39/38 , C07C41/48 , C07C43/313 , C07C33/483
摘要： Disclosed are a process and catalysts useful for carrying out asymmetric methlyallylations. The catalysts used in the invention have the formula (IV): wherein X1, X2, R3 and R4 are as defined herein. Compounds made by the process of the invention can be used to prepare pharmaceutically active compounds such as 11-β-hydroxysteroid hydrogenase type 1 (11-β-HSD1) inhibitors including 1,3-disubstituted oxazinan-2-ones.
摘要翻译：公开了用于进行不对称甲基化反应的方法和催化剂。用于本发明的催化剂具有式（Ⅳ）：其中X 1，X 2，R 3和R 4如本文所定义。通过本发明的方法制备的化合物可用于制备药物活性化合物，例如11-＆bgr-羟基类固醇氢化酶1型（11-＆amp; bgr-HSD1）抑制剂，包括1,3-二取代的恶嗪烷-2-酮。

6. 发明申请

US20150057451A1 SIMPLE ORGANIC MOLECULES AS CATALYSTS FOR PRACTICAL AND EFFICIENT ENANTIOSELECTIVE SYNTHESIS OF AMINES AND ALCOHOLS 有权
标题翻译：简单的有机分子作为催化剂用于实际和有效的选择性合成胺和醇
公开(公告)号：US20150057451A1
公开(公告)日：2015-02-26
申请号：US14382053
申请日：2013-03-01
申请人： Trustees of Boston College
发明人： Amir H. Hoveyda , Daniel L. Silverio , Tatiana Pilyugina , Sebastian Torker , Daniel Robbins
IPC分类号： C07C237/06 , C07F9/6539 , C07F9/50 , C07D207/06 , C07C229/08
CPC分类号： C07C237/06 , C07B2200/07 , C07C29/38 , C07C41/30 , C07C67/343 , C07C227/10 , C07C229/04 , C07C229/08 , C07C229/14 , C07C251/24 , C07D207/06 , C07D295/185 , C07F7/081 , C07F7/0812 , C07F9/36 , C07F9/5022 , C07F9/6539 , C07C229/30 , C07C43/23 , C07C33/30 , C07C33/28 , C07C33/483 , C07C69/76
摘要： The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.
摘要翻译：本发明提供有机分子及其有机硼试剂和双键之间的反应的方法，例如亚胺或羰基，以立体选择性提供包括胺和醇的手性产物，可用于制备生物活性分子的实体。

7. 发明申请

US20140135536A1 PROCESS FOR PRODUCTION OF DITRIMETHYLOLPROPANE 有权
标题翻译：二氯丙醇生产工艺
公开(公告)号：US20140135536A1
公开(公告)日：2014-05-15
申请号：US14129471
申请日：2012-06-28
申请人： Masafumi Watanabe , Takeru Nishida
发明人： Masafumi Watanabe , Takeru Nishida
IPC分类号： C07C41/06
CPC分类号： C07C41/06 , C07C29/38 , C07C45/75 , C07C47/02 , C07C31/22
摘要： Provided is a method for producing di-TMP by reacting n-butyl aldehyde (NBD), formaldehyde and a base, said method including a first step of reacting the NBD, formaldehyde (1) and a base (I) to obtain a reaction mixture solution containing trimethylolpropane (TMP), di-TMP and 2-ethyl-2-propenal (ECR); a second step of distilling the reaction mixture solution to recover the ECR therefrom; and a third step of sequentially adding the ECR recovered by distillation, and adding at least one of a base (II) and formaldehyde (2), to the reaction mixture solution from which the ECR has been recovered by distillation, and thereby allowing a reaction for production of the di-TMP to proceed gradually, in which TMP is added in any one of the first to third steps or in plural steps of the first to third steps.
摘要翻译：本发明提供了通过使正丁醛（NBD），甲醛和碱反应生成二-TMP的方法，所述方法包括使NBD，甲醛（1）和碱（I）反应得到反应混合物的第一步骤含有三羟甲基丙烷（TMP），二-TMP和2-乙基-2-丙烯醛（ECR）的溶液; 蒸馏反应混合物溶液以从其中回收ECR的第二步骤; 和依次加入通过蒸馏回收的ECR，并将至少一种碱（II）和甲醛（2）加入到通过蒸馏回收ECR的反应混合物溶液中，从而进行反应的第三步骤用于生产di-TMP逐渐进行，其中在第一至第三步骤中的任一个或第一至第三步骤的多个步骤中添加TMP。

8. 发明授权

US08492596B2 Process for production of ditrimethylolpropane 有权
标题翻译：二羟甲基丙烷生产工艺
公开(公告)号：US08492596B2
公开(公告)日：2013-07-23
申请号：US12739019
申请日：2008-10-17
申请人： Masafumi Watanabe
发明人： Masafumi Watanabe
IPC分类号： C07C41/01
CPC分类号： C07C29/38 , C07C29/80 , C07C41/01 , C07C43/132 , C07C31/22
摘要： The present invention provides a method for producing ditrimethylolpropane including reacting n-butyraldehyde with formaldehyde in the presence of a base catalyst to thereby produce trimethylolpropane and ditrimethylolpropane, wherein the method includes (I) a step of reacting n-butyraldehyde with formaldehyde (1) in the presence of a base catalyst (1), to thereby produce a reaction mixture containing trimethylolpropane, ditrimethylolpropane, and 2-ethyl-2-propenal; (II) a step of recovering 2-ethyl-2-propenal through distillation of the produced reaction mixture; and (III) a step of adding, to a distillation residue obtained through recovery of 2-ethyl-2-propenal, the recovered 2-ethyl-2-propenal and formaldehyde (2), and optionally a base catalyst (2), to thereby allow reaction for production of ditrimethylolpropane to proceed, wherein the amounts of formaldehyde (I) and the base catalyst (1) supplied in step I and formaldehyde (2) and the base catalyst (2) supplied in step II are controlled to specific amounts, to thereby effectively produce ditrimethylolpropane. According to the present invention, the yield of di-TMP is considerably increased, and the amount of bis-TMP by-produced can be considerably reduced with respect to the amount of di-TMP (i.e., a product of interest) produced; that is, di-TMP can be effectively produced in an industrially advantageous manner.
摘要翻译：本发明提供二羟甲基丙烷的制造方法，其包括在碱催化剂的存在下使正丁醛与甲醛反应，由此制得三羟甲基丙烷和二羟甲基丙烷，其中所述方法包括（I）使正丁醛与甲醛（1）反应的步骤碱催化剂（1）的存在，从而产生含有三羟甲基丙烷，二三羟甲基丙烷和2-乙基-2-丙烯醛的反应混合物; （II）通过蒸馏生成的反应混合物回收2-乙基-2-丙烯醛的步骤; 和（III）将回收的2-乙基-2-丙烯醛和甲醛（2）和任选的碱催化剂（2）加入到通过回收2-乙基-2-丙烯醛获得的蒸馏残余物中的步骤，从而允许进行二羟甲基丙烷的生产反应，其中步骤I中供应的甲醛（I）和碱催化剂（1）和步骤II中提供的甲醛（2）和碱催化剂（2）的量被控制到特定量，从而有效地产生二羟甲基丙烷。根据本发明，di-TMP的产率显着增加，并且相对于所生产的di-TMP（即所关注的产品）的量，可以显着降低副产的双TMP的量; 也就是说，di-TMP可以以工业上有利的方式有效地产生。

9. 发明申请

US20090062575A1 PROCESS FOR PRODUCING MONOPENTAERYTHRITOL OF HIGH PURITY AND MONOPENTAERYTHRITOL PRODUCED BY THE PROCESS 有权
标题翻译：生产过程中生产的高纯度和单硬脂酸单硬脂酸酯的方法
公开(公告)号：US20090062575A1
公开(公告)日：2009-03-05
申请号：US12162423
申请日：2007-02-05
申请人： Hans-Ake Bengtsson , Lars-Henrik Nyman
发明人： Hans-Ake Bengtsson , Lars-Henrik Nyman
IPC分类号： C07C29/38 , C07C29/74
CPC分类号： C07C29/38 , C07C29/78 , C07C31/245
摘要： The invention relates to a process for producing monopentaerythritol of high purity and monopentaerythritol produced by the process. Formaldehyde is reacted with acetaldehyde in an aqueous solution in the presence of a strongly basic hydroxide in a conventional way. The obtained reaction mixture is evaporated to a dryness of 50-70% by weight and is thereafter cooled. Crystals of pentaerythritol thereby formed are separated off. The crystals are dissolved in water or in a water-containing mother liquor containing pentaerythritol to a dryness of 35-55% by weight. The solution is treated in a purification step whereupon monopentaerythritol of high purity is crystallized at a temperature of 40-90° C. and separated from the remaining mother liquor which is recirculated to the above mentioned step.
摘要翻译：本发明涉及通过该方法制备的高纯度单季戊四醇和单季戊四醇的制备方法。在常规方法中，在强碱性氢氧化物的存在下，甲醛与乙醛在水溶液中反应。将所得反应混合物蒸发至50-70重量％的干燥，然后冷却。由此形成的季戊四醇晶体被分离出来。将晶体溶于水或含有季戊四醇的含水母液中至35-55重量％的干燥度。在纯化步骤中处理该溶液，然后将高纯度的单季戊四醇在40-90℃的温度下结晶，并与再循环到上述步骤的剩余母液分离。

10. 发明申请

US20080033171A1 Ligands for Metals and Improved Metal-Catalyzed Processes Based Thereon 有权
标题翻译：金属配体和改进的金属催化工艺
公开(公告)号：US20080033171A1
公开(公告)日：2008-02-07
申请号：US11781651
申请日：2007-07-23
申请人： Stephen Buchwald , David Old , John Wolfe , Michael Palucki , Ken Kamikawa
发明人： Stephen Buchwald , David Old , John Wolfe , Michael Palucki , Ken Kamikawa
IPC分类号： C07D295/00 , C07D211/70 , C07F7/04 , C07F9/02
CPC分类号： C07C1/26 , C07C1/321 , C07C17/16 , C07C17/263 , C07C29/32 , C07C29/38 , C07C37/18 , C07C41/30 , C07C45/68 , C07C45/71 , C07C49/675 , C07C67/31 , C07C201/12 , C07C209/10 , C07C209/18 , C07C211/59 , C07C213/02 , C07C213/08 , C07C221/00 , C07C225/12 , C07C227/08 , C07C227/18 , C07C231/08 , C07C231/12 , C07C249/02 , C07C249/16 , C07C251/24 , C07C253/30 , C07C2531/24 , C07C2531/26 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07C2602/10 , C07D209/08 , C07D213/50 , C07D213/72 , C07D213/74 , C07D295/023 , C07D295/033 , C07D295/096 , C07D295/112 , C07D295/13 , C07D295/155 , C07D307/33 , C07D317/22 , C07D317/26 , C07D317/66 , C07D333/08 , C07D333/66 , C07D401/04 , C07F7/1892 , C07F9/4875 , C07F9/5022 , C07F9/5027 , C07F9/5728 , C07F9/653 , C07F9/6547 , C07F9/65719 , C07F15/0066 , C07C25/18 , C07C49/255 , C07C49/213 , C07C49/657 , C07C49/67 , C07C49/84 , C07C49/245 , C07C49/755 , C07C49/215 , C07C49/683 , C07C47/575 , C07C49/782 , C07C69/92 , C07C211/48 , C07C211/55 , C07C217/40 , C07C217/84 , C07C217/92 , C07C225/22 , C07C229/36 , C07C229/60 , C07C233/07 , C07C235/46 , C07C251/86 , C07C255/33 , C07C255/50 , C07C255/54 , C07C255/56 , C07C255/58 , C07C15/14 , C07C35/21 , C07C33/24 , C07C205/04 , C07C205/06 , C07C43/205 , C07C43/225 , C07C39/15 , C07C35/08
摘要： One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.
摘要翻译：本发明的一个方面涉及用于过渡金属的新配体。本发明的第二方面涉及包含这些配体的催化剂在过渡金属催化的碳 - 杂原子和碳 - 碳键形成反应中的用途。本发明方法提供了过渡金属催化反应的许多特征的改进，包括合适底物的范围，反应条件和效率。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式