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1. 发明申请

US20180334611A1 WATER SOLUTION, CLEAN FRACTURING FLUID AND METHOD FOR FRACTURING RESERVOIR 审中-公开
公开(公告)号：US20180334611A1
公开(公告)日：2018-11-22
申请号：US15668273
申请日：2017-08-03
申请人： China University of Petroleum(East China) , Research Institute of Petroleum Exploration & Development
发明人： Caili DAI , Mingwei ZHAO , He Liu , Yining Wu , Guang Zhao , Yongpeng Sun , Xuepeng Wu
IPC分类号： C09K8/68 , C07C233/05 , C07C57/145 , C07C57/13 , C07C57/46 , C07C309/04
CPC分类号： C09K8/68 , C07C57/13 , C07C57/145 , C07C57/46 , C07C233/05 , C07C309/04
摘要： The present invention relates to the fracturing field, and discloses a water solution, a clean fracturing fluid, and a method for fracturing reservoir. The water solution contains organic acid amidopropyl dimethylamine, an additive, and water, wherein, the additive is at least one of salicylate, cis-butenedioic acid, o-phthalic acid, dodecyl sulfonate, p-toluene sulfonate, and benzoate. The water solution has high carbon dioxide response performance, a clean fracturing fluid that contains the water solution has superior cyclic utilization performance, and the fracturing fluid can solve the problems of conventional fracturing fluids used in fracturing stimulation of oil and gas reservoirs, including incomplete gel breaking, severe damages to the reservoir, and severe contamination of flow-back fluid, etc.

2. 发明授权

US09439882B2 Compounds and compositions for the treatment of cancer 有权
公开(公告)号：US09439882B2
公开(公告)日：2016-09-13
申请号：US14797957
申请日：2015-07-13
申请人： PROMETIC BIOSCIENCES, INC.
发明人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
IPC分类号： A01N27/00 , A61K31/015 , A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.

3. 发明授权

US08063242B2 2-aryl-propionic acids and pharmaceutical compositions containing them 有权
标题翻译： 2-芳基 - 丙酸和含有它们的药物组合物
公开(公告)号：US08063242B2
公开(公告)日：2011-11-22
申请号：US10495365
申请日：2002-11-19
申请人： Marcello Allegretti , Riccardo Bertini , Cinzia Bizzarri , Maria Candida Cesta , Francesco Colotta
发明人： Marcello Allegretti , Riccardo Bertini , Cinzia Bizzarri , Maria Candida Cesta , Francesco Colotta
IPC分类号： A61K31/192
CPC分类号： A61K31/192 , A61K31/196 , C07C57/30 , C07C57/38 , C07C57/42 , C07C57/46 , C07C57/58 , C07C59/135 , C07C59/48 , C07C229/42 , C07C307/02 , C07C307/10 , C07C309/65 , C07C309/67 , C07C309/73 , C07C311/08 , C07C311/09 , C07C311/21 , C07C317/44
摘要： (R) and (S) 2-Aryl-propionic acids, and pharmaceutical compositions that contain them, are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The acids are used for the prevention and treatment of pathologies deriving from said activation. In particular, the (R) enantiomers of said acids are lacking cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bollous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.
摘要翻译：（S）2-芳基 - 丙酸和含有它们的药物组合物可用于抑制白细胞介素-8（IL-8）与CXCR1和CXCR2相互作用诱导的嗜中性粒细胞（PMN白细胞）的趋化活化膜受体。酸用于预防和治疗由所述活化引起的病理学。特别地，所述酸的（R）对映异构体缺乏环加氧酶抑制活性，并且特别可用于治疗中性粒细胞依赖性病理学如牛皮癣，溃疡性结肠炎，黑素瘤，慢性阻塞性肺疾病（COPD），刺激性呼吸系统，类风湿关节炎，特发性纤维化，肾小球性肾炎，以及预防和治疗由缺血和再灌注引起的损伤。

4. 发明申请

US20030187296A1 Cyclic ketones, their preparation and their use in the synthesis of amino acids 失效
标题翻译：循环酮，其制备及其在氨基酸合成中的应用
公开(公告)号：US20030187296A1
公开(公告)日：2003-10-02
申请号：US10312065
申请日：2003-02-05
发明人： David Clive Blakemore , Justin Stephen Bryans
IPC分类号： C07C229/32 , C07C061/06 , C07C061/16
CPC分类号： C07C229/28 , C07B2200/07 , C07C45/62 , C07C45/676 , C07C45/69 , C07C49/395 , C07C51/09 , C07C51/412 , C07C57/46 , C07C227/04 , C07C2601/08 , C07C49/597
摘要： A method is provided for making an enantiomerically pure of the formula: in which R and Rnull represent C1nullC10 alkyl, C2nullC10 alkenyl or C3nullC10 cycloalkyl and the wedges signify (S)- or (R)-stereochemistry, the substituents in compound (II) being trans. Conjugate addition is carried out between an organometallic nucleophile that provides a group R as defined above and (R)-4-acetoxycyclopent-2-en-1-one, (S)-4-acetoxycyclopent-2-en-1-one or a similar compound in which acetoxy is replaced by another leaving group to give, e.g. in the case of the acetoxy compound, a trans 3,4-disubstituted addition product of formula III or IV; The acetyl group is eliminated from the addition product to give an (R)- or (S)-4-alkyl or 4-alkenyl cyclopent-2-en-1-one the compound of formula is then to be hydrogenated to give a cyclopentanone of formula (I) or conjugate addition of a second organometallic nucleophile that provides a group Rnull as defined above to the compound of the above formula may be carried out to give a trans 3,4-disubstituted addition product of formula (II). One of the above compounds may be converted e.g. via an intermediate (XV)-(XVIII) (in which the substituents R and Rnull and the wedges have the meanings indicated above) to a gabapentin analogue of one of the formulae shown below: in which the substituents R and Rnull and the wedges also have the meanings indicated above. 1 2
摘要翻译：提供了一种制备具有下式的对映异构体纯的方法：其中R和R'代表C 1 -C 10烷基，C 2 -C 10烯基或C 3 -C 10环烷基，楔形表示（S） - 或（R） - 立体化学，化合物（II）中的取代基是反式的。在提供如上所定义的基团R的有机金属亲核试剂和（R）-4-乙酰氧基环戊-2-烯-1-酮，（S）-4-乙酰氧基环戊-2-烯-1-酮或（S）-4-乙酰氧基环戊-2-烯-1-酮之间进行共轭加成类似的化合物，其中乙酰氧基被另一个离去基团取代，例如在乙酰氧基化合物的情况下，式III或IV的反式3,4-二取代的加成产物; 从加成产物中除去乙酰基，得到（R） - 或（S）-4-烷基或4-烯基环戊-2-烯-1-酮，然后氢化得到环戊酮可以进行式（I）化合物的共轭加成或向上述化合物提供如上定义的基团R'的第二有机金属亲核试剂的共轭加成，得到式（II）的反式3,4-二取代的加成产物。上述化合物之一可以被转化为例如。（XV） - （XVIII）（其中取代基R和R'和楔子具有上述含义）与下列通式所示的加巴喷丁类似物反应：其中取代基R和R'和楔子也具有上述含义。＆lt;化学 - cwu id =“CHEM-US-00002”> 2

5. 发明授权

US4522828A Therapeutic agents 失效
公开(公告)号：US4522828A
公开(公告)日：1985-06-11
申请号：US365285
申请日：1982-04-05
申请人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
发明人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
IPC分类号： C07D295/06 , A01N33/02 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/40 , A61K31/435 , A61K31/495 , A61P25/24 , A61P25/26 , C07C29/147 , C07C33/50 , C07C45/00 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07C67/00 , C07C209/00 , C07C209/28 , C07C209/40 , C07C209/48 , C07C209/52 , C07C209/56 , C07C209/58 , C07C211/25 , C07C211/26 , C07C213/00 , C07C217/74 , C07C231/00 , C07C231/02 , C07C231/08 , C07C231/10 , C07C231/12 , C07C233/03 , C07C233/05 , C07C233/13 , C07C233/18 , C07C313/00 , C07C323/32 , C07D207/06 , C07D211/70 , C07D295/073 , C07D295/185
CPC分类号： C07D295/185 , C07C255/00 , C07C29/147 , C07C33/50 , C07C45/004 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07D207/06 , C07D211/70 , C07D295/073 , C07C2101/04
摘要： Compounds of formula I ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, formyl, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.

6. 发明授权

US3880916A Cycloaliphatic acids 失效
标题翻译：环磷酰胺
公开(公告)号：US3880916A
公开(公告)日：1975-04-29
申请号：US35044773
申请日：1973-04-12
申请人： CIBA GEIGY CORP
发明人： DICKEL DANIEL FREDERICK , DE STEVENS GEORGE
IPC分类号： C07C57/46 , C07C63/50 , C07C63/60
CPC分类号： C07C57/46
摘要： R1 H or alk(en)yl R2 cycloalk(en)yl or cycloalk(en)yl-alkyl R3 aliphatic, cycloaliphatic, araliphatic or aromatic radical, CF3, NO2, acyl, free or functionally converted OH, SH, carboxy or sulfo AND FUNCTIONAL ACID DERIVATIVES THEREOF, ARE ANTI-INFLAMMATORY AGENTS.

New Alpha -aryl-cycloaliphatic acids, e.g., those of the formula
摘要翻译：新的α-芳基 - 脂环族酸，例如式R1 = H或烷（烯）基R2 =环烷基（烯）基或环烷基（烯）基 - 烷基R3 =脂族，脂环族，芳脂族或芳族基团，CF3 ，NO 2，酰基，游离或功能转化的OH，SH，羧基或磺基及其功能性酸衍生物，为抗炎剂。

7. 发明授权

US3228831A Compositions and method for treating symptoms of inflammation, pain and fever 失效
标题翻译：用于治疗炎症，疼痛和发烧症状的组合物和方法
公开(公告)号：US3228831A
公开(公告)日：1966-01-11
申请号：US16794162
申请日：1962-01-22
申请人： BOOTS PURE DRUG CO LTD
发明人： STUART NICHOLSON JOHN , SANDERS ADAMS STEWART
IPC分类号： A61K31/19 , C07C29/147 , C07C29/149 , C07C29/36 , C07C33/20 , C07C33/22 , C07C33/30 , C07C33/34 , C07C33/38 , C07C33/50 , C07C51/09 , C07C51/38 , C07C55/02 , C07C57/30 , C07C57/34 , C07C57/42 , C07C57/46 , C07C59/64 , C07C59/68 , C07C59/72 , C07C69/612
CPC分类号： C07C323/00 , C07C29/147 , C07C29/36 , C07C33/20 , C07C33/22 , C07C33/30 , C07C33/34 , C07C33/38 , C07C33/50 , C07C51/09 , C07C51/38 , C07C55/02 , C07C57/30 , C07C57/34 , C07C57/46 , C07C59/64 , C07C59/68 , C07C59/72 , C07C255/00 , C07C2601/14 , C07C2601/18 , C12C11/02 , Y10S514/916 , Y10S514/937 , Y10S514/96

8. 发明申请

US20160280616A1 Production of Biphenyl Compounds 有权
标题翻译：联苯化合物的生产
公开(公告)号：US20160280616A1
公开(公告)日：2016-09-29
申请号：US14976983
申请日：2015-12-21
申请人： ExxonMobil Chemical Patents Inc.
发明人： Michael Salciccioli , Jihad M. Dakka , Neeraj Sangar , Lorenzo C. DeCaul , Ali A. Kheir
IPC分类号： C07C2/74 , C07C5/367 , C07C67/08
CPC分类号： C07C2/74 , C07C5/367 , C07C51/265 , C07C67/08 , C07C2521/08 , C07C2523/42 , C07C2529/74 , C07C69/76 , C07C13/18 , C07C13/28 , C07C15/14 , C07C57/46
摘要： In a process for producing biphenyl compounds, a Cn aromatic hydrocarbon may be hydroalkylated to give C2n cycloalkylaromatic compounds and byproduct Cn saturated cyclic hydrocarbons. The C2n cycloalkylaromatic compounds are dehydrogenated to provide the biphenyl compounds. The Cn saturated cyclic hydrocarbons may also be dehydrogenated back to the corresponding Cn aromatic hydrocarbon, which may be recycled to provide additional feed. Although both the intermediate C2n cycloalkylaromatic compounds and the byproduct Cn saturated cyclic hydrocarbons should be dehydrogenated, at least part of the dehydrogenation of the Cn saturated cyclic hydrocarbons should take place in the absence of C2n or greater hydrocarbons. Thus, dehydrogenation of the byproduct Cn saturated cyclic hydrocarbons should take place at least in part separately from dehydrogenation of the C2n cycloalkylaromatic compounds.
摘要翻译：在制备联苯化合物的方法中，C n芳族烃可以被加氢烷基化以得到C 2n环烷基芳族化合物和副产物C n饱和环状烃。将C2n环烷基芳族化合物脱氢以提供联苯化合物。 Cn饱和环状烃也可以脱氢回到相应的C n芳族烃，其可以再循环以提供额外的进料。虽然中间体C2n环烷基芳族化合物和副产物Cn饱和环状烃都应脱氢，但Cn饱和环状烃的至少部分脱氢应在不存在C2n或更高级烃的情况下进行。因此，副产物Cn饱和环状烃的脱氢应至少部分地与C2n环烷基芳族化合物的脱氢分开发生。

9. 发明申请

US20150313856A1 COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER 有权
标题翻译：化合物和组合物治疗癌症
公开(公告)号：US20150313856A1
公开(公告)日：2015-11-05
申请号：US14797957
申请日：2015-07-13
申请人： PROMETIC BIOSCIENCES, INC.
发明人： Lyne GAGNON , Brigitte GROUIX , Lilianne GEERTS , Pierre LAURIN , Christopher PENNEY , Boulos ZACHARIE
IPC分类号： A61K31/192 , A61K31/196 , A61K31/7068
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
摘要翻译：苯甲酮羧酸酯化合物和式I，式I.1，式I.2，式IA，式IB，式IC和式II的取代芳族化合物及其用于治疗癌症的药学上可接受的盐的新用途。描述了这些化合物中的两种的组合的使用，并且使用这些化合物之一与抗癌剂如脱巴嗪，多柔比星，柔红霉素，环磷酰胺，总胆固醇，白消安，长春花碱，长春新碱，博来霉素，依托泊苷，拓扑替康，伊立替康，泰索帝，紫杉醇，5-氟尿嘧啶，甲氨蝶呤，吉西他滨，顺铂，卡铂和苯丁酸氮芥。

10. 发明授权

US09114118B2 Compounds and compositions for the treatment of cancer 有权
标题翻译：用于治疗癌症的化合物和组合物
公开(公告)号：US09114118B2
公开(公告)日：2015-08-25
申请号：US13882355
申请日：2011-10-26
申请人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
发明人： Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Pierre Laurin , Christopher Penney , Boulos Zacharie
IPC分类号： A01N27/00 , A61K31/015 , A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
CPC分类号： A61K31/192 , A61K31/196 , A61K31/22 , A61K31/513 , A61K31/675 , A61K31/7068 , C07C57/46 , C07C57/48 , C07C59/54 , C07C59/84 , C07C62/20 , C07C229/18 , C07C229/42 , C07C323/52
摘要： New uses for phenylketone carboxylate compounds and substituted aromatic compounds of Formula I, Formula I.1, Formula I.2, Formula IA, Formula IB, Formula IC and Formula II and their pharmaceutical acceptable salts for the treatment of cancer. The use of a combination of two of these compounds is described and the use of the combination of one of these compounds with an anticancer agent such as decarbazine, doxorubicin, daunorubicin, cyclophosphamide, busulfex, busulfan, vinblastine, vincristine, bleomycin, etoposide, topotecan, irinotecan, taxotere, taxol, 5-fluorouracil, methotrexate, gemcitabine, cisplatin, carboplatin and chlorambucil.
摘要翻译：苯甲酮羧酸酯化合物和式I，式I.1，式I.2，式IA，式IB，式IC和式II的取代芳族化合物及其用于治疗癌症的药学上可接受的盐的新用途。描述了这些化合物中的两种的组合的使用，并且使用这些化合物之一与抗癌剂如脱巴嗪，多柔比星，柔红霉素，环磷酰胺，总胆固醇，白消安，长春花碱，长春新碱，博来霉素，依托泊苷，拓扑替康，伊立替康，泰索帝，紫杉醇，5-氟尿嘧啶，甲氨蝶呤，吉西他滨，顺铂，卡铂和苯丁酸氮芥。

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