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    • 4. 发明授权
    • Process for producing N-halogenated hydantoins
    • 生产N-卤代乙内酰脲的方法
    • US09029562B2
    • 2015-05-12
    • US14031251
    • 2013-09-19
    • Albemarle Corporation
    • Hassan Y. Elnagar
    • A01N43/50C07D233/82
    • A01N43/50C07D233/82Y10T428/2982
    • This invention provides a process for the N-halogenation of at least one 5-hydrocarbyl hydantoin and/or at least one 5,5-dihydrocarbyl hydantoin. The process comprises concurrently feeding into a reaction zone (i) water, inorganic base, and 5,5-dimethylhydantoin, these being fed separately and/or in any combination(s), (ii) a separate feed of a brominating agent, and (iii) a separate feed of a chlorinating agent, in proportions such that during all or substantially all of the time the concurrent feeding is occurring halogenation of the 5-hydrocarbyl hydantoin and/or 5,5-dihydrocarbyl hydantoin occurs and resultant halogenated product precipitates in the liquid phase of an aqueous reaction mixture, and in which the pH of the liquid phase is continuously or substantially continuously maintained in the range of about 2.0 to about 8.0 during all or substantially all of the time the concurrent feeding is occurring. Also provided by this invention is a composition of matter which is a halogenated 5-hydrocarbyl hydantoin or a halogenated 5,5-dihydrocarbyl hydantoin, which is a mixture of the 1,3-dibromo-, 1,3-dichloro-, and/or N,N′-bromochloro-species of the halogenated hydantoin.
    • 本发明提供了至少一种5-烃基乙内酰脲和/或至少一种5,5-二烃基乙内酰脲N-卤化的方法。 该方法同时进料到反应区(i)水,无机碱和5,5-二甲基乙内酰脲,这些分别单独和/或以任何组合进料,(ii)单独的溴化剂进料和 (iii)氯化剂的单独进料,其比例使得在所有或基本上所有时间内同时进料发生5-烃基乙内酰脲和/或5,5-二烃基乙内酰脲的卤化,得到的卤代产物沉淀 在水性反应混合物的液相中,并且其中液相的pH在所有或基本上所有的同时进料期间连续地或基本上连续地保持在约2.0至约8.0的范围内。 本发明还提供了一种物质组合物,其是卤代5-烃基乙内酰脲或卤代的5,5-二烃基乙内酰脲,其是1,3-二溴 - ,1,3-二氯 - 和/ 或卤代乙内酰脲的N,N'-溴氯物质。