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1. 发明授权

US12043646B2 Methods and systems for solid phase peptide synthesis 有权
公开(公告)号：US12043646B2
公开(公告)日：2024-07-23
申请号：US18068838
申请日：2022-12-20
申请人： Massachusetts Institute of Technology
发明人： Dale Arlington Thomas, III , Alexander James Mijalis , Bradley L. Pentelute , Mark David Simon , Surin Mong
IPC分类号： C07K1/04 , C07K7/06 , C07K14/47 , C07K14/60 , C07K14/61 , C07K14/62 , G01N21/27 , G01N21/33 , G01N21/3577 , G01N21/84 , G01N33/487
CPC分类号： C07K1/045 , C07K7/06 , C07K14/47 , C07K14/60 , C07K14/61 , C07K14/62 , G01N21/33 , G01N33/48707 , G01N21/272 , G01N21/3577 , G01N2021/8416
摘要： Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.

2. 发明授权

US12017195B2 Apparatus and methods for synthesizing biopolymers 有权
公开(公告)号：US12017195B2
公开(公告)日：2024-06-25
申请号：US17257816
申请日：2019-07-01
申请人： Arizona Board of Regents on behalf of Arizona State University
发明人： Quan Qing , Ching-wei Tsao , Peiming Zhang
IPC分类号： B01J19/00 , C07K1/04
CPC分类号： B01J19/0093 , B01J19/0046 , C07K1/045 , B01J2219/00317 , B01J2219/00529 , B01J2219/00596 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01J2219/00722 , B01J2219/00822 , B01J2219/00853 , B01J2219/00855
摘要： The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer. The apparatus comprises (a) a substrate comprising atop surface and a plurality of wells, wherein each of the plurality of wells comprises a first electrode disposed on the bottom of the well and a linker attached to the sides of the well; and (b) a fluidic chamber system disposed on the top surface of the substrate.

3. 发明公开

US20240002431A1 METHODS OF MAKING AND USING PLATFORMS FOR PEPTIDE SYNTHESIS AND COMPOSITIONS THEREOF 审中-公开
公开(公告)号：US20240002431A1
公开(公告)日：2024-01-04
申请号：US18253986
申请日：2021-11-23
申请人： Peptilogics, Inc.
发明人： Francis Lee
IPC分类号： C07K1/04 , B01J19/00
CPC分类号： C07K1/042 , B01J19/0046 , C07K1/045 , B01J2219/00648 , B01J2219/00725
摘要： Methods are disclosed of making and using platforms for peptide synthesis and compositions thereof, such peptide-anchored resins or beads for use in solid-phase peptide synthesis. The platform includes a plurality of platform particles, which particles are insoluble carrier material particles (microparticles/nanoparticles) having a plurality of different linkers coupled to them. The plurality of linkers includes, in various combinations and combinations, (a) Fmoc-2,4-dimethoxy-4′-(carboxymethyloxy)-benzhydrylamine (Rink amide linker); (b) 4-Formyl-3-methoxy-phenoxyacetic acid; (c) 2-Hydroxy-5-dibenzosuberone; (d) 4-Hydroxymethylbenzoic acid (HMBA); (e) 4-Hydroxymethyl-phenoxyacetic acid (HMP linker); (f) 4-(Fmoc-hydrazino)-benzoic acid; (g) 4(4-(1-hydroxyethyl)-2-methoxy-5-nitrophenoxy)-butyric acid; and (h) Fmoc-Suberol (5-Fmoc-amino-2-carboxymethoxy-10,11-dihydro-5H-dibenzo[a,d] cycloheptene). In some embodiments, the insoluble carrier material particles have a plurality of linkers that are each a different type from one another. Such platforms can be used in solid-phase peptide synthesis processes.

4. 发明公开

US20230279045A1 METHODS AND SYSTEMS FOR SOLID PHASE PEPTIDE SYNTHESIS 审中-公开
公开(公告)号：US20230279045A1
公开(公告)日：2023-09-07
申请号：US18068838
申请日：2022-12-20
申请人： Massachusetts Institute of Technology
发明人： Dale Arlington Thomas, III , Alexander James Mijalis , Bradley L. Pentelute , Mark David Simon , Surin Mong
IPC分类号： C07K1/04 , C07K14/60 , C07K7/06 , C07K14/47 , C07K14/61 , C07K14/62 , G01N21/33 , G01N33/487
CPC分类号： C07K1/045 , C07K14/60 , C07K7/06 , C07K14/47 , C07K14/61 , C07K14/62 , G01N21/33 , G01N33/48707 , G01N2021/8416
摘要： Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system. In some embodiments, the methods and systems, described herein, can be used to conduct quality control to determine and correct problems (e.g., aggregation, truncation, deletion) in reactions (e.g., coupling reactions) taking place in the solid phase peptide synthesis system.

5. 发明公开

US20230256410A1 TREATMENT APPARATUS 审中-公开
公开(公告)号：US20230256410A1
公开(公告)日：2023-08-17
申请号：US18295819
申请日：2023-04-04
申请人： Microwave Chemical Co., Ltd.
发明人： Yasunori TSUKAHARA , Satoshi MORIKAWA , Yukari DEGUCHI , Yuka KOTAKE , Hideshi KURIHARA , Hisao WATANABE , Fumihiro KAYAMORI , Kanako KAIHARA
IPC分类号： B01J19/12 , C07H1/00 , C07K1/04
CPC分类号： B01J19/126 , C07H1/00 , C07K1/045 , B01J2219/1224 , B01J2219/1242 , B01J2219/1266
摘要： In order to provide a treatment apparatus that can efficiently perform microwave irradiation, a treatment apparatus includes: a vessel made of a microwave-reflecting material, and having a first end and an irradiation opening portion, which is an emitting portion of microwaves that are emitted into the vessel; a first filter located so as to partition the vessel, and configured to separate solids that are to be separated, from the contents of the vessel; and a first reflecting member located closer to the first end than the emitting portion is and so as to partition the vessel, and configured to allow at least the contents having passed through the first filter to pass through the first reflecting member, and to reflect microwaves.

6. 发明申请

US20190233501A1 METHODS AND COMPOSITIONS RELATING TO COVALENTLY CIRCULARIZED NANODISCS 审中-公开
公开(公告)号：US20190233501A1
公开(公告)日：2019-08-01
申请号：US16317924
申请日：2017-07-17
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Gerhard WAGNER , Mahmoud NASR
IPC分类号： C07K14/775 , C07K14/705 , C07K14/47 , C12N9/48 , C12N9/80 , C07K1/04 , B82Y5/00 , B82Y40/00
CPC分类号： C07K14/775 , A61K39/12 , A61K39/39 , A61K2039/55555 , B82Y5/00 , B82Y40/00 , C07K1/045 , C07K1/047 , C07K14/47 , C07K14/705 , C12N9/48 , C12N9/80 , C12N2740/16134
摘要： Described herein are methods and compositions relating to nanodiscs, e.g., phospholipid bilayers with a proteinaceous belt or border. Further provided herein are loopable membrane scaffold proteins, e.g., for forming nanodiscs.

7. 发明申请

US20190194246A1 SOLID PHASE PEPTIDE SYNTHESIS 审中-公开
公开(公告)号：US20190194246A1
公开(公告)日：2019-06-27
申请号：US16143917
申请日：2018-09-27
申请人： CEM Corporation
发明人： JONATHAN M. COLLINS
IPC分类号： C07K1/04 , C07K1/06 , C07K1/14 , C07K7/08 , C07K7/16 , C07K14/005 , C07K14/46 , C07K14/47 , C07K14/575 , C07K14/59 , C07K14/605 , C07K14/635 , C07K14/645 , C07K14/705 , C07K14/815 , C07K1/107 , C12N7/00 , B01J19/12
CPC分类号： C07K1/045 , B01J19/126 , B01J2204/005 , B01J2219/00058 , B01J2219/0879 , B01J2219/1248 , C07K1/04 , C07K1/063 , C07K1/1075 , C07K1/14 , C07K7/08 , C07K7/16 , C07K14/005 , C07K14/463 , C07K14/4701 , C07K14/4723 , C07K14/575 , C07K14/57572 , C07K14/59 , C07K14/605 , C07K14/635 , C07K14/645 , C07K14/705 , C07K14/815 , C12N7/00 , C12N2740/16322
摘要： An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.

8. 发明申请

US20180169605A1 CHEMICAL REACTION VESSEL AND SYNTHESIS SYSTEMS AND METHODS 审中-公开
公开(公告)号：US20180169605A1
公开(公告)日：2018-06-21
申请号：US15737640
申请日：2016-06-16
申请人： PROTEIN TECHNOLOGIES, INC.
发明人： Alexander S. Waddell , David W. Ribblett , James Cain
IPC分类号： B01J19/08 , B01J19/00 , C07K1/04 , H05B6/06
CPC分类号： B01J19/087 , B01J19/0013 , B01J19/0046 , B01J19/0053 , B01J2219/00211 , B01J2219/00286 , B01J2219/00288 , B01J2219/00484 , B01J2219/00495 , B01J2219/00725 , C07K1/045 , H05B6/065 , H05B6/108
摘要： Apparatus and methods utilizing induction-heat energy for heating reactions associated with chemical synthesis, such as peptide synthesis reactions involving activation, deprotection, coupling, and cleavage. Thorough agitation of the contents of reaction vessels during heating, real-time monitoring and adjustment of temperature and/or reaction duration, independent control of different reaction vessels, and scalability are also described.

9. 发明申请

US20170369524A1 In-situ Solvent Recycling Process for Solid Phase Peptide Synthesis at Elevated Temperatures 审中-公开
公开(公告)号：US20170369524A1
公开(公告)日：2017-12-28
申请号：US15490090
申请日：2017-04-18
申请人： CEM Corporation
发明人： Jonathan M. Collins
IPC分类号： C07K1/04
CPC分类号： C07K1/04 , C07K1/045
摘要： An improvement in of deprotection in solid phase peptide synthesis is disclosed. The method includes the steps of adding the deprotection composition in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated amino acid from the preceding coupling cycle; and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle; and with the coupling solution at a temperature of at least 30° C.

10. 发明授权

US09522380B2 Control apparatus for dispensing small precise amounts of liquid reagents 有权
标题翻译：用于分配小量精确量的液体试剂的控制装置
公开(公告)号：US09522380B2
公开(公告)日：2016-12-20
申请号：US13922628
申请日：2013-06-20
申请人： CEM Corporation
发明人： David L. Herman , Joseph J. Lambert
IPC分类号： B01J19/12 , C07K1/04 , G05D7/06 , B01J19/00 , G01F11/28 , F04F5/24 , B01J4/00 , B01J4/02
CPC分类号： C07K1/045 , B01J4/008 , B01J4/02 , B01J19/0046 , B01J19/126 , B01J2219/00725 , B01J2219/1206 , C07K1/042 , F04F5/24 , G01F11/28 , G05D7/0623 , G05D7/0641 , G05D7/0647 , Y10T137/0379
摘要： A precision volumetric liquid dispensing instrument is disclosed that includes two pressure sensors and a fluid passageway with a defined volume portion in communication with the two sensors for receiving and distributing liquid in relatively small volumes. One of the pressure sensors is positioned to measure pressure at one portion of the defined volume portion of the fluid passageway and the other of the gas pressure sensors is positioned to measure gas pressure at a different portion of the defined volume portion of the passageway. At least one valve is in communication with the passageway for moving fluids into or out of the defined volume portion of the fluid passageway, and a processor carries out a step selected from the group consisting of (i) calculating the volume of the liquid based upon the measured pressure and (ii) metering a liquid into the defined volume portion of the fluid passageway until the measured pressure indicates that a desired volume of fluid is in the fluid passageway.
摘要翻译：公开了一种精密体积液体分配仪器，其包括两个压力传感器和具有与两个传感器连通的限定体积部分的流体通道，用于以相对小的体积接收和分配液体。压力传感器中的一个定位成测量流体通道的限定体积部分的一部分处的压力，并且气体压力传感器中的另一个定位成测量通道的限定体积部分的不同部分处的气体压力。至少一个阀与通道连通，用于将流体移入或流出流体通道的限定容积部分，并且处理器执行从以下组成的组中选择的步骤：（i）计算液体的体积测量的压力和（ii）将液体计量到流体通道的限定的容积部分中，直到测量的压力表明所需体积的流体在流体通道内。

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