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1. 发明授权

US11773043B2 Systems and methods for producing coenzyme Q10 有权
公开(公告)号：US11773043B2
公开(公告)日：2023-10-03
申请号：US16690305
申请日：2019-11-21
申请人： INNER MONGOLIA KINGDOMWAY PHARMACEUTICAL CO., LTD. , XIAMEN KINGDOMWAY GROUP COMPANY
发明人： Weicheng Liao , Bingrong Wang , Dan Li , Luming Xu , Sifu Jiang
IPC分类号： C07C46/10 , G01N30/02 , G01N30/06 , G01N30/08
CPC分类号： C07C46/10 , G01N30/02 , G01N2030/027 , G01N2030/065 , G01N2030/085
摘要： A system and method for purifying coenzyme Q10 are provided. The method includes: passing a CoQ10-containing crude product through a first chromatographic column to obtain a first CoQ10-containing intermediate product. The method further includes preparing, based on the first CoQ10-containing intermediate product, a second CoQ10-containing intermediate product. The method further includes passing the second CoQ10-containing intermediate product through a second chromatographic column to obtain a third CoQ10-containing intermediate product. The method further includes obtaining purified CoQ10 product by purifying the third CoQ10-containing intermediate product.

2. 发明申请

US20180172650A1 ADSORPTION DEVICE FOR TRACE DETECTORS 审中-公开
公开(公告)号：US20180172650A1
公开(公告)日：2018-06-21
申请号：US15380585
申请日：2016-12-15
申请人： Morpho Detection, LLC
发明人： Wilhelm P. Platow , Hanh T. Lai , Evan V. Lane , Bradley D. Shaw
IPC分类号： G01N31/22 , G01V11/00
CPC分类号： B01D53/0407 , B01D53/0454 , B01D53/261 , B01D2253/102 , B01D2253/106 , B01D2253/108 , B01D2258/06 , B01D2259/40084 , B01D2259/40088 , B01D2259/4541 , G01N1/405 , G01N30/08 , G01N30/30 , G01N30/50 , G01N30/72 , G01N30/74 , G01N30/88 , G01N2001/022 , G01N2030/085
摘要： The present disclosure is directed to adsorption devices for use in substance detection systems and methods of using same. In particular, the present disclosure is directed to adsorption devices that allow for both the optional refilling of adsorption material and the optional regeneration of a dryer.

3. 发明授权

US09804133B1 Method to enable the use of larger injection volumes and to reduce extra-column effects in chromatographic separations 有权
公开(公告)号：US09804133B1
公开(公告)日：2017-10-31
申请号：US14838070
申请日：2015-08-27
申请人： Mark A. Stone
发明人： Mark A. Stone
IPC分类号： G01N30/02 , G01N30/16 , B01D15/40 , B01D15/26
CPC分类号： G01N30/16 , B01D15/265 , B01D15/40 , G01N30/08 , G01N2030/027 , G01N2030/085
摘要： A method and apparatus for enabling larger injection volumes and for reducing extra column effects in chromatographic separations using focusing pre-columns placed upstream of the analytical, or preparative, column with applications in any chromatographic system where the requirement is that the focusing pre-column, placed upstream of the analytical column, allows larger injection volumes to be utilized and, by enabling efficient focusing of solutes onto the analytical column, results in a significant reduction of band broadening due to extra-column effects which act upstream of the analytical column.

4. 发明申请

US20170234782A1 ANALYTE CONCENTRATOR SYSTEM AND METHODS OF USE 审中-公开
公开(公告)号：US20170234782A1
公开(公告)日：2017-08-17
申请号：US15043332
申请日：2016-02-12
申请人： DIONEX CORPORATION
发明人： Kannan SRINIVASAN
IPC分类号： G01N1/40 , G01N27/40 , B01D15/36 , G01N27/413
CPC分类号： G01N1/405 , B01D15/361 , G01N27/40 , G01N27/413 , G01N30/08 , G01N30/38 , G01N30/40 , G01N30/96 , G01N2030/085 , G01N2030/405
摘要： Systems and methods for concentrating an analyte preparatory to analysis thereof include processing the effluent of an analyte concentrator to produce an eluent for eluting an analyte retained in the same or separate concentrator, and systems implementing the same. The analyte concentrator system connects the effluent outlet of an analyte concentrator column to an eluent generation module such that the substantially analyte-free effluent discharged from the analyte concentrator column passes fluidly into the eluent generation module. Eluent generated from the substantially analyte-free effluent in the eluent generation module is likewise substantially free of the analyte. The systems and methods can minimize and/or (substantially) eliminate background signal during analysis of the concentrated analyte.

5. 发明申请

US20170097325A1 DEVICE AND METHOD FOR EXTRACTION OF COMPOUNDS WITH AROMATIC CYCLES CONTAINED IN A LIQUID SAMPLE 审中-公开
公开(公告)号：US20170097325A1
公开(公告)日：2017-04-06
申请号：US15280227
申请日：2016-09-29
申请人： Commissariat a L'Energie Atomique et aux Energies Alternatives
发明人： Louise FOAN , Severine VIGNOUD , Florence RICOUL
IPC分类号： B01J20/281 , C01B31/30 , B01J20/02 , G01N30/06 , B01J20/28 , B01J20/32 , C07C7/10 , G01N30/60 , B01D15/22 , B01J20/282
CPC分类号： G01N30/482 , B01D15/22 , B01J20/02 , B01J20/10 , B01J20/2808 , B01J20/28083 , B01J20/282 , B01J20/283 , B01J20/286 , B01J20/3214 , B01J20/3234 , B01J20/3257 , B01J2220/54 , C01B32/907 , C07C7/10 , G01N1/405 , G01N30/06 , G01N30/08 , G01N30/6095 , G01N2030/027 , G01N2030/085 , G01N30/6069
摘要： A device for extraction of analytes with aromatic cycles, preferably analytes with aromatic cycles for which the octanol-water partition coefficient is more than 103, the analytes being contained in a liquid phase, the extraction device including a support and an adsorption layer at least partially covering the support, the adsorption layer being porous SiOxCyHz.

6. 发明授权

US09588088B2 Gas sample introduction device 有权
标题翻译：气体样品引入装置
公开(公告)号：US09588088B2
公开(公告)日：2017-03-07
申请号：US13966765
申请日：2013-08-14
申请人： SHIMADZU CORPORATION
发明人： Akira Aono
IPC分类号： G01N1/22 , G01N30/20 , G01N30/02 , G01N30/08
CPC分类号： G01N30/20 , G01N1/2214 , G01N2030/025 , G01N2030/085 , G01N2030/207
摘要： In a gas sample analysis device including a metering tube, sample gas supply channel, carrier gas supply channel, evacuation channel and collection tube, there is provided a first channel switching valve which switches between a load state in which the metering tube is interposed between said sample gas supply channel and the evacuation channel and an injection state in which the metering tube is interposed between the sample gas supply channel and gas analysis device; and a second channel switching valve which, in the load state or injection state, switches between a collection tube interposition state in which the collection tube is interposed between the sample gas supply channel and the metering tube or between the metering tube and the gas analysis device, and a collection tube shunt state in which the collection tube is not interposed.
摘要翻译：在包括计量管，样品气体供给通道，载气供给通道，排气通道和收集管的气体样品分析装置中，设置有第一通道切换阀，其在计量管介于所述样品气体供给通道和排气通道以及计量管插入在样品气体供给通道和气体分析装置之间的注入状态; 以及第二通道切换阀，所述第二流路切换阀在所述负荷状态或注入状态下，在收集管插入状态之间切换，在所述收集管插入状态中，所述收集管插入在所述样品气体供给流路和所述计量管之间，或者在所述计量管与所述气体分析装置，收集管未插入收集管分流状态。

7. 发明授权

US09285348B2 Automated system for handling components of a chromatographic system 有权
标题翻译：用于处理色谱系统组件的自动化系统
公开(公告)号：US09285348B2
公开(公告)日：2016-03-15
申请号：US14068104
申请日：2013-10-31
申请人： Proxeon Biosystems A/S
发明人： Soeren Theodorsen
IPC分类号： G01N30/08 , G01N30/24 , G01N35/00 , G01N35/10
CPC分类号： G01N30/08 , G01N30/24 , G01N35/0099 , G01N2030/085 , G01N2035/1013
摘要： An automated system for handling components of a chromatographic system, comprising: one or more trap columns each having sorbent material therein; a robotic system for moving a trap column from a storage position to an operating position where the trap column is connected in a liquid pathway along which solvent is flowed in operation to a liquid chromatography (LC) column; and an optical sensor for sensing one or more parameters of the trap column. Sensed parameters can include: a presence or absence of a trap column in the operating position, a position or orientation of the trap column, a fluid level in the trap column, the presence and position of a sorbent material in the trap column, the condition of the trap column and/or whether the trap column is new or used.
摘要翻译：一种用于处理色谱系统组分的自动化系统，包括：一个或多个各自在其中具有吸附剂材料的捕集塔; 用于将捕集塔从储存位置移动到操作位置的机器人系统，其中所述捕集塔在液体通路中连接，所述液体通路在所述液体通路中使溶剂在操作中流动到液相色谱（LC）柱; 以及用于感测陷阱柱的一个或多个参数的光学传感器。感测参数可以包括：在操作位置存在或不存在捕集塔，捕集塔的位置或取向，捕集塔中的液位，捕集塔中吸附剂材料的存在和位置，条件的陷阱列和/或陷阱列是新的还是使用的。

8. 发明申请

US20160003784A1 SOLUTE EXTRACTING APPARATUS 审中-公开
标题翻译：溶剂萃取装置
公开(公告)号：US20160003784A1
公开(公告)日：2016-01-07
申请号：US14768355
申请日：2013-08-23
申请人： MIURA CO., LTD.
发明人： Hiroyuki FUJITA , Hirofumi NAKAMURA
IPC分类号： G01N30/08 , B01D15/10
CPC分类号： G01N30/08 , B01D15/10 , G01N2001/4061 , G01N2030/009 , G01N2030/085
摘要： A solute trapping column including two trapping agent layers has a first branched pathway extending from an upper part of a main body part thereof, and a second branched pathway extending from between two trapping agent layers, and with its upper part a purification column is connected. By injection of solution of dioxins and supply of solvent into the purification column, dioxins are trapped by the trapping agent layers. An extraction solvent supplied from the lower end side of the solute trapping column while keeping both the purification column and the first branched pathway blocked extracts the dioxins trapped by the second trapping agent layer and flows into the second branched pathway. An extraction solvent supplied in a similar manner while keeping both the purification column and the second branched pathway blocked extracts the dioxins trapped by the first trapping agent layer and flows into the first branched pathway.
摘要翻译：包括两个捕集剂层的溶质捕集塔具有从其主体部分的上部延伸的第一分支路径和从两个捕集剂层之间延伸的第二分支路径，并且其上部具有纯化塔。通过注入二恶英溶液并将溶剂供应到净化塔中，二恶英被捕获剂层捕获。同时保持纯化塔和第一分支途径同时保留从溶质捕集塔的下端侧提取的萃取溶剂提取被第二捕集剂层捕获的二氧diox类物质并流入第二分支途径。同时保持纯化塔和第二支链路径同时保持的提取溶剂提取被第一捕获剂层捕获的二氧diox类物质并流入第一分支途径。

9. 发明申请

US20150198611A1 Microfluidic Glycan Analysis 审中-公开
标题翻译：微流控糖分析
公开(公告)号：US20150198611A1
公开(公告)日：2015-07-16
申请号：US14664709
申请日：2015-03-20
申请人： Agilent Technologies, Inc.
发明人： Magdalena Anna Ostrowski , Rudolf Grimm , Kevin P. Killeen , Karla M. Robotti
IPC分类号： G01N33/68 , G01N27/447 , G01N30/72 , G01N30/60 , G01N30/46 , B01D15/08 , B01L3/00
CPC分类号： G01N33/6842 , B01D15/08 , B01L3/502738 , B01L3/502753 , B01L3/502761 , B01L2200/10 , B01L2300/0627 , B01L2300/0874 , B01L2300/0887 , B01L2400/0406 , B01L2400/0421 , B01L2400/0487 , B01L2400/0644 , F16K99/0001 , G01N1/405 , G01N27/44791 , G01N30/465 , G01N30/6095 , G01N30/7266 , G01N2030/085 , G01N2400/00 , H01J49/00
摘要： Microfluidic devices and methods for analyzing glycan profiles of glycoproteins are provided. Some embodiments of the devices comprise a deglycosylation column for cleaving glycans, an optional cleaning column for removing proteins, a trapping column for enriching glycans, and a separation column for resolving glycans. The devices and methods significantly improve the speed and sensitivity of glycan analysis.
摘要翻译：提供了用于分析糖蛋白聚糖谱的微流体装置和方法。装置的一些实施方案包括用于切割聚糖的去糖基化柱，用于去除蛋白质的可选清洁柱，用于富集聚糖的捕集塔，以及用于分解聚糖的分离柱。装置和方法显着提高了聚糖分析的速度和灵敏度。

10. 发明申请

US20140338430A1 AUTOMATED SYSTEM FOR HANDLING COMPONENTS OF A CHROMATOGRAPHIC SYSTEM 有权
标题翻译：用于处理色谱系统的组件的自动化系统
公开(公告)号：US20140338430A1
公开(公告)日：2014-11-20
申请号：US14068104
申请日：2013-10-31
申请人： Proxeon Biosystems A/S
发明人： Soeren THEODORSEN
IPC分类号： G01N30/74 , G01N30/02
CPC分类号： G01N30/08 , G01N30/24 , G01N35/0099 , G01N2030/085 , G01N2035/1013
摘要： An automated system for handling components of a chromatographic system, comprising: one or more trap columns each having sorbent material therein; a robotic system for moving a trap column from a storage position to an operating position where the trap column is connected in a liquid pathway along which solvent is flowed in operation to a liquid chromatography (LC) column; and an optical sensor for sensing one or more parameters of the trap column. Sensed parameters can include: a presence or absence of a trap column in the operating position, a position or orientation of the trap column, a fluid level in the trap column, the presence and position of a sorbent material in the trap column, the condition of the trap column and/or whether the trap column is new or used.
摘要翻译：一种用于处理色谱系统组分的自动化系统，包括：一个或多个各自在其中具有吸附剂材料的捕集塔; 用于将捕集塔从储存位置移动到操作位置的机器人系统，其中所述捕集塔在液体通路中连接，所述液体通路在所述液体通路中使溶剂在操作中流动到液相色谱（LC）柱; 以及用于感测陷阱柱的一个或多个参数的光学传感器。感测参数可以包括：在操作位置存在或不存在捕集塔，捕集塔的位置或取向，捕集塔中的液位，捕集塔中吸附剂材料的存在和位置，条件的陷阱列和/或陷阱列是新的还是使用的。

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