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1. 发明公开

US20240053268A1 FLUORESCENCE-DETECTED ASSAYS ON MICROFLUIDIC CHIPS 审中-公开
公开(公告)号：US20240053268A1
公开(公告)日：2024-02-15
申请号：US18379289
申请日：2023-10-12
申请人： 1DROP SA
发明人： Luc Gervais , Jörg ZIEGLER , Nicolas DESCHARMES
IPC分类号： G01N21/64 , B01L3/00 , G01N21/77 , G01N33/543
CPC分类号： G01N21/648 , B01L3/502715 , G01N21/7746 , G01N21/7703 , G01N21/6428 , G01N33/54306 , G01N2021/6439 , G01N2021/7786 , B01L2300/0816 , B01L2300/0887 , B01L2300/0654 , B01L2300/0877 , G01N2021/7736 , B01L2300/0627 , G01N2201/08
摘要： An assay unit for carrying-out fluorescence-detected assays having a microfluidic chip with a microfluidic system to convey a sample or analyte solution through one or more microfluidic channels arranged on the chip, and a photonic system with two or more rectangular waveguide structures. The microfluidic channels and the waveguide structures cross each other at a detection site. In an assay area, where a certain microfluidic channel and a certain waveguide structure cross each other, one or more lateral surfaces of the core of the waveguide structure at least partially face an inner volume of the microfluidic channel, such that an evanescent field of light guided within the waveguide structure overlaps with a certain part of the inner volume of the microfluidic channel.

2. 发明授权

US11808704B2 Fluorescence-detected assays on microfluidic chips 有权
公开(公告)号：US11808704B2
公开(公告)日：2023-11-07
申请号：US15123965
申请日：2015-03-05
申请人： ONE DROP DIAGNOSTICS SÀRL
发明人： Luc Gervais , Jörg Ziegler , Nicolas Descharmes
IPC分类号： G01N21/64 , G01N21/77 , B01L3/00 , G01N33/543
CPC分类号： G01N21/648 , B01L3/502715 , G01N21/6428 , G01N21/7703 , G01N21/7746 , G01N33/54306 , B01L2300/0627 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , G01N2021/6439 , G01N2021/7736 , G01N2021/7786 , G01N2201/08
摘要： An assay unit for carrying-out fluorescence-detected assays having a microfluidic chip with a microfluidic system to convey a sample or analyte solution through one or more microfluidic channels arranged on the chip, and a photonic system with two or more rectangular waveguide structures. The microfluidic channels and the waveguide structures cross each other at a detection site. In an assay area, where a certain microfluidic channel and a certain waveguide structure cross each other, one or more lateral surfaces of the core of the waveguide structure at least partially face an inner volume of the microfluidic channel, such that an evanescent field of light guided within the waveguide structure overlaps with a certain part of the inner volume of the microfluidic channel.

3. 发明申请

US20180331237A1 In-Plane Resonant Cavity Infrared Photodetectors with Fully Depleted Absorbers 审中-公开
公开(公告)号：US20180331237A1
公开(公告)日：2018-11-15
申请号：US16030883
申请日：2018-07-10
申请人： The Government of the United States of America, as represented by the Secretary of the Navy
发明人： Jerry R. Meyer , Igor Vurgaftman , Chadwick Lawrence Canedy , William W. Bewley , Chul Soo Kim , Charles D. Merritt , Michael V. Warren , Mijin Kim , Eric Stanton
IPC分类号： H01L31/0232 , H01L31/0304 , H01L31/105 , H01L31/109 , G02B6/124 , G02B6/12
CPC分类号： H01L31/02327 , G01N21/00 , G01N21/3504 , G01N21/552 , G01N21/7746 , G02B6/12004 , G02B6/124 , G02B2006/12061 , G02B2006/12078 , G02B2006/12123 , G02B2006/12138 , H01L31/03046 , H01L31/105 , H01L31/109
摘要： Resonant-cavity infrared photodetector (RCID) devices that include a thin absorber layer contained entirely within the resonant cavity. In some embodiments, the absorber is a single type-II InAs—GaSb interface situated between an AlSb/InAs superlattice n-type region and a p-type AlSb/GaSb region. In other embodiments, the absorber region comprises quantum wells formed on an upper surface of the n-type region. In other embodiments, the absorber region comprises a “W”-structured quantum well situated between two barrier layers, the “W”-structured quantum well comprising a hole quantum well sandwiched between two electron quantum wells. In other embodiments, the RCID includes a thin absorber region and an nBn or pBp active core within a resonant cavity. In some embodiments, the RCID is configured to absorb incident light propagating in the direction of the epitaxial growth of the RCID structure, while in other embodiments, it absorbs light propagating in the epitaxial plane of the structure.

4. 发明申请

US20180231462A1 METHOD FOR DETECTING A LOCAL CHANGE IN REFRACTIVE INDEX OF A DIELECTRIC MEDIUM LOCATED ON THE SURFACE OF AN OPTICAL SENSOR 审中-公开
公开(公告)号：US20180231462A1
公开(公告)日：2018-08-16
申请号：US15897362
申请日：2018-02-15
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
发明人： Karim VINDAS , Elodie ENGEL , Loic LEROY , Thierry LIVACHE , Arnaud BUHOT
IPC分类号： G01N21/45 , G01N21/552
CPC分类号： G01N21/45 , G01N21/431 , G01N21/554 , G01N21/7703 , G01N21/7746 , G01N2021/432 , G01N2021/434 , G01N2021/458 , G01N2021/772
摘要： The invention relates to a method for detecting a local change in refractive index of a dielectric medium located on the surface of an optical sensor, said optical sensor comprising for this purpose a waveguide comprising a region, called the active region, covered with at least one metallic layer in contact with the dielectric medium, said method comprising the following steps: a) emitting a light beam at the input of the waveguide so that this light beam can be propagated, within the waveguide, according to at least N propagation modes, where N is a natural integer such that N≥2; b) measuring the intensity of at least one zone of the spatial distribution of the intensity of the light beam reflected by said active region of the optical sensor; and c) detecting the local change in the refractive index of the dielectric medium by means of a database supplying the link between the intensity of said at least one zone of the spatial distribution of the intensity of the light beam reflected by the active region of the optical sensor and a change in refractive index of a reference medium.

5. 发明授权

US09951269B2 Apparatus, method and system for generating optical radiation from biological gain media 有权
公开(公告)号：US09951269B2
公开(公告)日：2018-04-24
申请号：US14683985
申请日：2015-04-10
申请人： The General Hospital Corporation
发明人： Seok-Hyun Yun , Malte C. Gather
IPC分类号： H01S3/16 , C09K11/06 , G01N21/64 , G02B6/138 , H01S3/213 , H01S3/20 , G01N21/77 , G02B6/293 , H01S3/08 , H01S3/094 , H01S3/083
CPC分类号： C09K11/06 , C09K2211/10 , C09K2211/14 , G01N21/645 , G01N21/7746 , G02B6/138 , G02B6/29341 , H01S3/08022 , H01S3/08059 , H01S3/083 , H01S3/094034 , H01S3/094076 , H01S3/168 , H01S3/20 , H01S3/213
摘要： In one exemplary embodiment, an apparatus can be provided which includes at least one biological medium that causes gain. According to another exemplary embodiment, an arrangement can be provided which is configured to be provided in an anatomical structure. This exemplary arrangement can include at least one emitter having a cross-sectional area of at most 10 microns within the anatomical structure, and which is configured to generate at least one laser radiation. In a further exemplary embodiment, an apparatus can be provided which can include at least one medium which is configured to cause gain; and at least one optical biological resonator which is configured to provide an optical feedback to the medium. In still another exemplary embodiment, a process can be whereas, a solution of an optical medium can be applied to a substrate. Further, it is possible to generate a wave guide having a shape that is defined by (i) at least one property of the solution of the optical medium, or (ii) drying properties thereof.

6. 发明授权

US09846060B2 Optical sensor arrangement and method for measuring an observable 有权
公开(公告)号：US09846060B2
公开(公告)日：2017-12-19
申请号：US14780552
申请日：2013-03-28
申请人： Fraunhofer-Gesellschaft zur Foerderung der Angewandten Forschung e.V.
发明人： Helmut Heidrich , Peter Lützow , Daniel Pergande
IPC分类号： G02B6/293 , G01D5/26 , G01N21/77 , G02B6/12
CPC分类号： G01D5/266 , G01N21/7746 , G02B6/12007 , G02B6/29343
摘要： An optical sensor arrangement for measuring an observable, the arrangement including an optical resonance circuit including at least a first and a second optical resonator, each of the optical resonators including an entry port for coupling light into the optical resonator and a drop port for decoupling light from the optical resonator. The first and second resonator are configured such that only a portion of the first and second resonator detects the presence of the observable, a size of the portion of the first resonator being different from a size of the portion of the second resonator. The optical resonance circuit further configured to be coupled to a light generation circuit and to a detector unit for detecting light.

7. 发明申请

US20170336562A1 PHOTONIC DEVICE FOR ULTRAVIOLET AND VISIBLE WAVELENGTH RANGE 审中-公开
公开(公告)号：US20170336562A1
公开(公告)日：2017-11-23
申请号：US15468583
申请日：2017-03-24
申请人： Raytheon BBN Technologies Corporation
发明人： Mohammad Soltani
IPC分类号： G02B6/122 , G01N21/59 , G02B6/293 , G01N21/03 , G02B6/136 , G02B6/132 , G02B6/12
CPC分类号： G02B6/122 , G01N21/0303 , G01N21/59 , G01N21/7746 , G01N2201/0873 , G02B6/102 , G02B6/1223 , G02B6/132 , G02B6/136 , G02B6/29338 , G02B2006/12038 , G02B2006/12133 , G02B2006/12135 , G02B2006/12138
摘要： In one aspect, a photonic device includes a substrate layer comprising magnesium fluoride and an optical guiding layer disposed on the substrate layer. The optical guide layer includes silicon dioxide. The substrate layer and the optical guide layer are transparent at an ultraviolet and visible wavelength range. In another aspect, a method includes oxidizing silicon to form a silicon dioxide layer, bonding the silicon dioxide layer to magnesium fluoride, removing the silicon and performing lithography and etching of the silicon dioxide to form a photonic device.

8. 发明授权

US09678276B1 All-glass on-chip high quality-factor optical microresonator 有权
公开(公告)号：US09678276B1
公开(公告)日：2017-06-13
申请号：US14990296
申请日：2016-01-07
申请人： Wisconsin Alumni Research Foundation
发明人： Randall Howard Goldsmith , Kassandra Ann Knapper , Kevin Daniel Heylman
IPC分类号： G02B6/10 , G02B6/293 , G01N21/77 , G02B6/12 , G02B6/13
CPC分类号： G02B6/29341 , G01N21/7746 , G01N2201/08 , G02B6/12004 , G02B6/13 , G02B2006/12038 , G02B2006/12169
摘要： Optical microresonator platforms are provided comprising a substrate having a surface, a plurality of SiO2 pillars, and a plurality of SiO2 whispering gallery mode (WGM) optical microresonators, each SiO2 pillar extending from the surface of the substrate and terminating in a corresponding SiO2 WGM optical microresonator of the plurality of SiO2 WGM optical microresonators, wherein the substrate, the plurality of SiO2 pillars and the plurality of SiO2 WGM optical microresonators form a monolithic structure, and further wherein the substrate is substantially transparent to visible light. The substrate may be a SiO2 substrate and the SiO2 WGM optical microresonator may be a SiO2 optical microtoroid.

9. 发明授权

US09448181B2 Optical biosensor and biosensing system with resonant feedback controls 有权
标题翻译：具有谐振反馈控制的光学生物传感器和生物传感系统
公开(公告)号：US09448181B2
公开(公告)日：2016-09-20
申请号：US14192926
申请日：2014-02-28
申请人： SAMSUNG ELECTRONICS CO., LTD.
发明人： Kwang-hyun Lee , Seok-yong Hong
IPC分类号： G01N21/77 , G01N1/00
CPC分类号： G01N21/7746 , G01N1/00
摘要： An optical biosensor is provided. The optical biosensor includes a biosensing unit, a detection unit, and a feedback circuit. The biosensing unit is configured to receive an input optical signal, sense a biomaterial, and generate a sensed optical signal. The detecting unit is configured to convert the sensed optical signal into an electrical signal and output the electrical signal as a detection signal. The feedback circuit is configured to output a feedback signal. The feedback signal is generated based on the detection signal and is changed according to a changed amount of a resonant wavelength of the biosensing unit.
摘要翻译：提供光学生物传感器。光学生物传感器包括生物传感单元，检测单元和反馈电路。生物传感单元被配置为接收输入光信号，感测生物材料，并产生检测到的光信号。检测单元被配置为将感测到的光信号转换为电信号并输出电信号作为检测信号。反馈电路被配置为输出反馈信号。基于检测信号产生反馈信号，并且根据生物传感单元的谐振波长的变化量而改变反馈信号。

10. 发明申请

US20160018331A1 BIOSENSORS INCLUDING METALLIC NANOCAVITIES 审中-公开
标题翻译：生物传感器包括金属纳米尺度
公开(公告)号：US20160018331A1
公开(公告)日：2016-01-21
申请号：US14691495
申请日：2015-04-20
申请人： University of Utah Research Foundation
发明人： Steven M. Blair , Farhad Mahdavi , Yongdong Liu , James N. Herron , Ajay Nahata
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , B82Y15/00 , B82Y20/00 , B82Y30/00 , G01N21/6428 , G01N21/7746 , G01N33/54373 , G01N2021/6439 , G02B5/008 , G02B2207/101
摘要： A biomolecular assay includes a substrate with a metallic layer on at least one surface thereof. The metallic film includes nanocavities. The nanocavities are configured to enhance signals that are representative of the presence or amount of one or more analytes in a sample or sample solution, and may be configured to enhance the signal by a factor of about two or more or by a factor of about three or more. Such signal enhancement may be achieved with nanocavities that are organized in an array, randomly positioned nanocavities, or nanocavities that are surrounded by increased surface area features, such as corrugation or patterning, or nanocavities that have quadrilateral or triangular shapes with tailored edge lengths, or with a plurality of nanoparticles. Methods for fabricating biomolecular substrates and assay techniques in which such bimolecular substrates are used are also disclosed.
摘要翻译：生物分子测定包括在其至少一个表面上具有金属层的基底。金属膜包括纳米孔。纳米结构被配置为增强代表样品或样品溶液中一种或多种分析物的存在或量的信号，并且可以被配置为将信号增强约两个或更多个因子或约三分之一或者更多。这种信号增强可以通过以阵列，随机定位的纳米空间或纳米空间组织的纳米腔实现，纳米空间被增加的表面积特征（例如波纹或图案化）或具有具有定制的边缘长度的四边形或三角形形状的纳米腔包围，或与多个纳米颗粒。还公开了制备生物分子底物的方法和其中使用这种双分子底物的测定技术。

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