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1. 发明公开

US20240288452A1 DETECTION OF OXYTOCIN IN A BIOLOGICAL SAMPLE 审中-公开
公开(公告)号：US20240288452A1
公开(公告)日：2024-08-29
申请号：US18590417
申请日：2024-02-28
申请人： Giner, Inc.
发明人： Avni A. Argun , Muhit Rana
IPC分类号： G01N33/74 , G01N27/327 , G01N33/53 , G01N33/543
CPC分类号： G01N33/74 , G01N27/3276 , G01N27/3277 , G01N33/5308 , G01N33/5438
摘要： Method and kit for detecting oxytocin in a biological sample. According to one embodiment, the method involves providing a test sample. The test sample is prepared by obtaining a biological sample from one or more subjects and then diluting the biological sample with 1×PBS (phosphate-buffered saline) and 2 mM MgCl2, pH 7.4. The method also involves providing a test cassette. The test cassette includes an electrochemical sensing element and a capture element. The capture element is coupled to the electrochemical sensing element, and the capture element has a binding affinity and specificity for oxytocin. The test sample is then added to the test cassette, whereby at least some of the oxytocin present in the test sample binds to the capture element. Then, the test cassette is electrochemically analyzed for any captured oxytocin,

2. 发明公开

US20240288399A1 METAL NANOPARTICLE-MAGNETIC PARTICLE COMPLEX, METHOD OF PREPARING SAME, AND USE THEREOF 审中-公开
公开(公告)号：US20240288399A1
公开(公告)日：2024-08-29
申请号：US18476812
申请日：2023-09-28
申请人： KOREA ELECTRONICS TECHNOLOGY INSTITUTE
发明人： Seong Eun KIM , Se Eun JEONG , Seo Eun LEE
IPC分类号： G01N27/327 , G01N27/36 , G01N33/543
CPC分类号： G01N27/3278 , G01N27/3277 , G01N27/36 , G01N33/54326 , G01N33/5438 , G01N2446/20 , G01N2446/86
摘要： Disclosed are a metal nanoparticle-magnetic particle complex, comprising a core comprising a magnetic particle, the first shell comprising metal nanoparticles and formed on the surface of the core, and the second shell comprising a response factor and formed on the surface of the first shell, a method of preparing the complex, and a method of measuring the concentration of a biomarker in a sample using the complex.

3. 发明公开

US20240277245A1 DEVICES, SYSTEMS, AND METHODS FOR REAL-TIME MONITORING OF ELECTROPHYSICAL EFFECTS DURING TISSUE TREATMENT 审中-公开
公开(公告)号：US20240277245A1
公开(公告)日：2024-08-22
申请号：US18404473
申请日：2024-01-04
申请人： Virginia Tech Intellectual Properties, Inc.
发明人： Rafael V. Davalos , Mohammad Bonakdar , Eduardo L. Latouche , Roop L. Mahajan , John L. Robertson , Christopher B. Arena , Michael B. Sano
IPC分类号： A61B5/0538 , A61B5/01 , G01N33/543
CPC分类号： A61B5/0538 , A61B5/01 , G01N33/5438
摘要： Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.

4. 发明公开

US20240241105A1 PARALLELIZED PROBING OF A PLURALITY OF SAMPLES IN A SELF-ORGANIZED STRUCTURE 审中-公开
公开(公告)号：US20240241105A1
公开(公告)日：2024-07-18
申请号：US18290283
申请日：2022-05-17
申请人： TECHNISCHE UNIVERSITÄT MÜNCHEN
发明人： Dominik BUCHER , Robin Derek ALLERT , Andreas DEEG
IPC分类号： G01N33/487 , G01N33/543
CPC分类号： G01N33/48707 , G01N33/5438
摘要： Disclosed herein is a method for parallelized probing of a plurality of samples, a sensor chip for parallelized probing of a plurality of samples, a sensing device for parallelized probing of a plurality of samples, and a measurement system for parallelized probing of a plurality of samples. The method comprises providing a sensor chip, the sensor chip comprising a sensing layer arranged in or on a substrate and a measurement volume adjacent to the sensing layer. The sensing layer comprises a plurality of sensing elements, each of which is configured to generate a sensor signal characterizing a physical observable in the vicinity of the respective sensing element. A carrier fluid comprising a plurality of sample objects is provided to the measurement volume, wherein each of the sample objects comprises or forms a respective sample. A number of sample objects in the measurement volume is controlled such that the sample objects form a self-organized structure in the measurement volume. The self-organized structure is a structure in which the arrangement of the sample objects is at least in part defined by interactions between the sample objects themselves. A measurement is performed on one or more of the samples while the sample objects are arranged in the self-organized structure, wherein a measurement on a sample is performed using one or more sensing elements arranged adjacent to the respective sample object in the self-organized structure.

5. 发明授权

US12031981B2 Method for electronic detection and quantification of antibodies 有权
公开(公告)号：US12031981B2
公开(公告)日：2024-07-09
申请号：US17053522
申请日：2019-05-08
申请人： Arizona Board of Regents on behalf of Arizona State University
发明人： Stuart Lindsay , Bintian Zhang
IPC分类号： G01N27/327 , G01N33/487 , G01N33/543 , G01N33/68
CPC分类号： G01N33/5438 , G01N33/48721 , G01N33/6854 , G01N2469/20
摘要： The present disclosure relates to a sensing device and methods for detecting, and quantifying the amount of, a target protein in a sample.

6. 发明公开

US20240219377A1 Sensor and Method for Detecting Target Molecules 审中-公开
公开(公告)号：US20240219377A1
公开(公告)日：2024-07-04
申请号：US18585915
申请日：2024-02-23
申请人： Southern Methodist University
发明人： Ali Beskok , Anil Koklu , Jungchih Chiao
IPC分类号： G01N33/53 , B01L3/00 , B61L3/24 , C08J9/236 , C11D3/384 , G01N27/02 , G01N27/447 , G01N33/487 , G01N33/543
CPC分类号： G01N33/5302 , B01L3/502 , C11D3/3845 , G01N27/028 , G01N27/44726 , G01N33/48721 , G01N33/5438 , B01J2219/00813 , B01L2300/0645 , B01L2300/088 , B01L2300/161 , B61L3/243 , C08J9/236
摘要： An apparatus and method for detecting one or more target molecules includes a hydrophobic substrate, and a sensor. The sensor includes two or more electrodes disposed on the hydrophobic substrate and separated from one another by a gap, a plurality of nanostructures formed on or within an upper surface of each electrode, a plurality of binding molecules attached to the plurality of nanostructures, wherein the plurality of binding molecules are configured to bind with the one or more target molecules, and wherein the upper surface of each electrode and the plurality of nanostructures are hydrophilic, and may further detect two or more analytes with two or more sensors that detect two or more different modalities, such as, electrical, optical fluorescence, optical resonance, magnetic detection, or acoustic waves.

7. 发明公开

US20240215873A1 Aptamer Sensors with Temperature Correction 审中-公开
公开(公告)号：US20240215873A1
公开(公告)日：2024-07-04
申请号：US18684114
申请日：2022-08-22
申请人： University of Cincinnati
发明人： Jason Heikenfeld , Israel Belmonte , Ryan Jeffrey White
IPC分类号： A61B5/145 , A61B5/1459 , A61B5/1473 , G01N27/27 , G01N27/327 , G01N33/53 , G01N33/543
CPC分类号： A61B5/14546 , A61B5/1459 , A61B5/1473 , G01N27/27 , G01N27/3276 , G01N27/3277 , G01N33/5308 , G01N33/5438 , A61B2560/0252
摘要： A device for measuring one or more analytes in a sample fluid is provided. The device includes at least one aptamer sensor comprising a plurality of aptamers. The sensor provides a measurement of at least one of the analytes. In addition, the measurement is affected by changes in temperature (“a temperature-dependent response”). The device also includes a means to establish fluid communication between the at least one aptamer sensor and the sample fluid. Further, the device includes at least one temperature sensor and a means for correcting a measurement error due to the temperature-dependent response.

8. 发明公开

US20240159702A1 METHODS AND APPARATUS FOR MEASURING ANALYTES USING LARGE SCALE FET ARRAYS 审中-公开
公开(公告)号：US20240159702A1
公开(公告)日：2024-05-16
申请号：US18353017
申请日：2023-07-14
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： Jonathan M. ROTHBERG , Wolfgang HINZ , Kim L. JOHNSON , James BUSTILLO
IPC分类号： G01N27/414 , C12Q1/6818 , C12Q1/6874 , G01N33/543 , H01L27/088 , H01L29/78
CPC分类号： G01N27/4148 , C12Q1/6818 , C12Q1/6874 , G01N27/4145 , G01N33/54373 , G01N33/5438 , H01L27/088 , H01L29/78 , H01L29/42324 , H01L2924/01006 , H01L2924/01013 , H01L2924/01015 , H01L2924/01073 , H01L2924/14 , H01L2924/1433 , Y10T436/22
摘要： Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

9. 发明公开

US20240118269A1 High Throughput Stochastic Bio-Molecular Sensor 审中-公开
公开(公告)号：US20240118269A1
公开(公告)日：2024-04-11
申请号：US18476272
申请日：2023-09-27
申请人： Massachusetts Institute of Technology
发明人： Swathi Manda , Ashwin Gopinath
IPC分类号： G01N33/53 , G01N27/447 , G01N33/543
CPC分类号： G01N33/5308 , G01N27/4473 , G01N33/5438
摘要： What is described herein is a device for sensing a target, comprising a planar array of unique stochastic sensors, wherein each sensor is weakly cross-reactive with a unique determinant on the target; a means for capturing electrical signals from each sensor and the temporal duration of each signal; and a means for analyzing the cumulative signals from the array of stochastic sensors, and optionally further comprising a computer system for processing an algorithm for identifying the target based on the electrical signals from the sensors of the device.

10. 发明公开

US20240077444A1 CAPACITIVE SENSOR AND METHOD OF USE 审中-公开
公开(公告)号：US20240077444A1
公开(公告)日：2024-03-07
申请号：US18368983
申请日：2023-09-15
申请人： Altratech Limited
发明人： Timothy Cummins , Brian O'Farrell
IPC分类号： G01N27/22 , C12Q1/6825 , G01N27/327 , G01N33/543 , G01R27/26
CPC分类号： G01N27/221 , C12Q1/6825 , G01N27/223 , G01N27/3276 , G01N33/543 , G01N33/5438 , G01R27/2605 , G01N27/745
摘要： An analyte in a liquid sample is detected using a capacitive sensor having electrodes and a sensor surface, and a signal processor. The sample is dried to reduce its liquid content, and capacitive measurements are made after the drying and preferably also before the drying. The sample may include particles, and the analyte is part of or attached to the particles, and the particles provide a major part of the capacitance change compared to absence of particles. In another example the particles are degenerative and form an integral mass upon application of heat, enhancing the extent of capacitance change.

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