专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20220409536A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS 有权
公开(公告)号：US20220409536A1
公开(公告)日：2022-12-29
申请号：US17278040
申请日：2019-09-19
申请人： ModernaTX, Inc.
发明人： Kerry E. BENENATO , Mark CORNEBISE , Edward HENNESSY
IPC分类号： A61K9/127 , A61K47/10 , A61K47/28 , A61K47/24 , A61K31/7105 , A61K31/573 , A61K31/519 , A61K31/167 , A61K45/06 , C07C229/12 , C07C229/16 , C07D239/54 , C07D239/47 , C07D473/34 , C07C233/47 , C07C275/14 , C07C335/08 , C07D233/61 , C07C311/05 , C07D473/18 , C07C229/14 , C07C311/64 , C07D249/04 , C07D209/48 , C07D295/13 , C07C279/36 , C07C279/28 , C07C215/08 , C07C235/10 , C07F9/09 , C07C311/14
摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

2. 发明申请

US20150136611A1 REACTION PRODUCTS OF GUANIDINE COMPOUNDS OR SALTS THEREOF, POLYEPOXIDES AND POLYHALOGENS 有权
标题翻译：化合物或其盐，其中多环氧化物和多羟基化合物的反应产物
公开(公告)号：US20150136611A1
公开(公告)日：2015-05-21
申请号：US14086951
申请日：2013-11-21
申请人： Rohm and Haas Electronic Materials LLC
发明人： Julia KOZHUKH , Zuhra I. NIAZIMBETOVA , Maria Anna RZEZNIK
IPC分类号： C07C279/08 , C07C335/24 , C07C311/64 , C25D3/38 , C07C279/18
CPC分类号： C25D3/38 , C07C279/08 , C07C279/18 , C07C311/64 , C07C335/24 , C07D303/10 , C25D3/02 , C25D3/32 , C25D3/56 , C25D3/565 , C25D3/60 , C25D5/02 , C25D5/54 , C25D5/56 , C25D7/123 , H05K3/188 , H05K3/424 , H05K2201/09509 , H05K2201/09563
摘要： Reaction products of guanidine compounds or salts thereof, polyepoxide compounds and polyhalogen compounds may be used as levelers in metal electroplating baths, such as copper electroplating baths, to provide good throwing power. Such reaction products may plate with good surface properties of the metal deposits and good physical reliability.
摘要翻译：胍化合物或其盐，聚环氧化物化合物和多卤素化合物的反应产物可用作金属电镀浴中的均化剂，例如电镀铜浴，以提供良好的投掷力。这样的反应产物可能具有良好的金属沉积物的表面性质并具有良好的物理可靠性。

3. 发明授权

US4317819A Amine derivatives 失效
标题翻译：胺衍生物
公开(公告)号：US4317819A
公开(公告)日：1982-03-02
申请号：US213680
申请日：1980-12-05
申请人： John W. Clitherow , Barry J. Price , John Bradshaw , Michael Martin-Smith
发明人： John W. Clitherow , Barry J. Price , John Bradshaw , Michael Martin-Smith
IPC分类号： A61K31/155 , A61K31/335 , A61K31/38 , A61P1/00 , C07C67/00 , C07C209/00 , C07C211/27 , C07C213/00 , C07C217/48 , C07C239/00 , C07C275/12 , C07C279/04 , C07C279/28 , C07C301/00 , C07C311/64 , C07C325/00 , C07C335/08 , C07D233/64 , C07D295/096 , C07D307/38 , C07D307/42 , C07D307/52 , C07D333/14 , A61K31/17 , C07C127/17 , C07C129/12
CPC分类号： C07D295/096 , C07C279/28 , C07D307/38 , C07D307/42 , C07D307/52 , C07D333/14 , Y10S514/886 , Y10S514/926 , Y10S514/927
摘要： The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, .dbd.CHNO.sub.2 or .dbd.NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.6 ;Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2 and 5 positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1 and 3 or 1 and 4 positions;X represents --CH.sub.2 --, --O-- or --S--;n represents zero or 1;m represents 2, 3 or 4 and Alk represents a straight chain alkylene group of 1 to 3 carbon atoms,andR.sub.2 represents lower alkyl or the group--(CH.sub.2).sub.y E(CH.sub.2).sub.x Gin whichy represents 2, 3 or 4 or can additionally represent zero or 1 when E is a --CH.sub.2 -- group, x represents zero, 1 or 2;E represents --CH.sub.2 --, --O-- or --S--; andG represents a monocyclic 5 or 6 membered carbocyclic or heterocyclic aromatic ring, or G represents the group ##STR3## where Q' represents any of the rings defined for Q; Alk' represents any of the groups defined for Alk; and R.sub.4 ' and R.sub.5 ' which may be the same or different represent any of the groups defined for R.sub.4 or R.sub.5.The compounds of formula (I) have pharmacological activity as selective histamine H.sub.2 -antagonists.
摘要翻译：本发明提供了通式（I）的化合物及其生理上可接受的盐，水合物和生物前体，其中Y和Z可以相同或不同，各自表示氧，硫，= CHNO 2或= NR 3，其中R 3 是氢，硝基，氰基，低级烷基，芳基，烷基磺酰基或芳基磺酰基; p的值为2到12; R 1表示其中可以相同或不同的R 4和R 5各自表示氢，低级烷基，环烷基，低级烯基，芳烷基或被氧原子间隔的低级烷基或基团> N-R6，其中R 6表示氢或低级烷基，或R4和R5与它们所连接的氮原子一起形成可含有另外的氧原子或基团> NR 6的5至7元饱和杂环; Q表示呋喃或噻吩环，其中与分子的其余部分结合通过2和5位的键，或苯环，其中结合到分子的其余部分通过1和3或1的键和 4个职位; X表示-CH 2 - ， - O-或-S-; n表示0或1; m表示2,3或4，Alk表示1〜3个碳原子的直链亚烷基，R2表示低级烷基或 - （CH2）yE（CH2）xG，y表示2,3或4或可以当E是-CH 2 - 基时，x代表0或1; E表示-CH 2 - ， - O-或-S-; 并且G表示单环5或6元碳环或杂环芳环，或G表示基团，其中Q'表示为Q定义的任何环; Alk'代表为Alk定义的任何组; 和可以相同或不同的R 4'和R 5'表示对于R 4或R 5定义的任何基团。式（I）化合物具有作为选择性组胺H2拮抗剂的药理学活性。

4. 发明授权

US4264614A Amine derivatives 失效
标题翻译：胺衍生物
公开(公告)号：US4264614A
公开(公告)日：1981-04-28
申请号：US95065
申请日：1979-11-16
申请人： John W. Clitherow , Barry J. Price , John Bradshaw
发明人： John W. Clitherow , Barry J. Price , John Bradshaw
IPC分类号： A61K31/155 , A61K31/335 , A61K31/38 , A61P1/00 , C07C67/00 , C07C209/00 , C07C211/27 , C07C213/00 , C07C217/48 , C07C239/00 , C07C275/12 , C07C279/04 , C07C279/28 , C07C301/00 , C07C311/64 , C07C325/00 , C07C335/08 , C07D233/64 , C07D295/096 , C07D307/38 , C07D307/42 , C07D307/52 , C07D333/14 , A61K31/34 , C07D307/68 , C07D333/38
CPC分类号： C07D295/096 , C07C279/28 , C07D307/38 , C07D307/42 , C07D307/52 , C07D333/14 , Y10S514/886 , Y10S514/926 , Y10S514/927
摘要： The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichY and Z, which may be the same or different, each represent oxygen, sulphur, =CHNO.sub.2 or =NR.sub.3 where R.sub.3 is hydrogen, nitro, cyano, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl;p has a value from 2 to 12;R.sub.1 represents ##STR2## in which R.sub.4 and R.sub.5 which may be the same or different, each represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group >N-R.sub.6 in which R.sub.6 represents hydrogen or lower alkyl, or R.sub.4 and R.sub.5 together with the nitrogen atom to which they are attached form a 5 to 7-membered saturated heterocyclic ring which may contain an additional oxygen atom or the group >NR.sub.6 ;Q represents a furan or thiophen ring in which incorporation into the rest of the molecule is through bonds at the 2 and 5 positions, or a benzene ring in which incorporation into the rest of the molecule is through bonds at the 1 and 3 or 1 and 4 positions;X represents --CH.sub.2 --, --O-- or --S--;n represents zero or 1;m represents 2, 3 or 4 andAlk represents a straight chain alkylenegroup of 1 to 3 carbon atoms;and R.sub.2 represents lower alkyl or the group--(CH.sub.2).sub.y E(CH.sub.2).sub.x Gin whichY represents 2, 3 or 4 or can additionallyrepresent zero or 1 when E is a --CH.sub.2 -- group;x represents zero, 1 or 2;E represents --CH.sub.2 --, --0-- or --S--; andG represents a monocyclic 5 or 6 membered carbocyclic or heterocyclic aromatic ring, or G represents the group ##STR3## where Q' represents any of the rings defined for Q;Alk' represents any of the groups defined for Alk;and R.sub.4 ' and R.sub.5 ' which may be the same or different represent any of the groups defined for R.sub.4 or R.sub.5.The compounds of formula (I) have pharmacological activity as selective histamine H.sub.2 -antagonists.
摘要翻译：本发明提供了通式（I）的化合物及其生理上可接受的盐，水合物和生物前体，其中Y和Z可以相同或不同，各自表示氧，硫，= CHNO 2或= NR 3，其中R 3 是氢，硝基，氰基，低级烷基，芳基，烷基磺酰基或芳基磺酰基; p的值为2到12; R 1表示其中可以相同或不同的R 4和R 5各自表示氢，低级烷基，环烷基，低级烯基，芳烷基或被氧原子间隔的低级烷基或基团> N-R6，其中R 6表示氢或低级烷基，或R4和R5与它们所连接的氮原子一起形成可含有另外的氧原子或基团> NR 6的5至7元饱和杂环; Q表示呋喃或噻吩环，其中与分子的其余部分结合通过2和5位的键，或苯环，其中结合到分子的其余部分通过1和3或1的键和 4个职位; X表示-CH 2 - ， - O-或-S-; n表示0或1; m表示2,3或4，Alk表示1〜3个碳原子的直链亚烷基; 并且R 2表示低级烷基或基团 - （CH 2）y E（CH 2）x G，其中Y表示2,3或4，或者当E是-CH 2 - 基时，可以另外表示0或1; x表示零，1或2; E表示-CH 2 - ， - O-或-S-; 并且G表示单环5或6元碳环或杂环芳环，或G表示基团，其中Q'表示为Q定义的任何环; Alk'代表为Alk定义的任何组; 和可以相同或不同的R 4'和R 5'表示对于R 4或R 5定义的任何基团。式（I）化合物具有作为选择性组胺H2拮抗剂的药理学活性。

5. 发明授权

US4098900A N,N'-Diphenyl-guanidine derivatives 失效
标题翻译： N，N“ - 二苯胺衍生物
公开(公告)号：US4098900A
公开(公告)日：1978-07-04
申请号：US663414
申请日：1976-03-03
申请人： Volker Dittrich , Werner Topfl , Odd Kristiansen
发明人： Volker Dittrich , Werner Topfl , Odd Kristiansen
IPC分类号： A01N47/44 , A01P7/04 , C07C67/00 , C07C301/00 , C07C303/40 , C07C311/64 , C07C143/75 , A61K31/18 , C07C143/79
CPC分类号： C07C311/64
摘要： N,N'-Diphenyl-guanidine derivative of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each represent hydrogen, halogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 -halogenalkyl, C.sub.1 -C.sub.5 -alkoxy, (C.sub.1 -C.sub.5 -alkyl)-carbonyl, (C.sub.1 -C.sub.5 -alkoxy)-carbonyl, cyano and/or nitro and R.sub.6 represents C.sub.1 -C.sub.5 -alkylsulfonyl or optionally substituted phenylsulphonyl, processes for their production, and their use in pest control.

6. 发明授权

US3950524A Hypoglycemic benzenesulfonamido pyrimidines 失效
标题翻译：低血糖苯磺酰胺嘧啶
公开(公告)号：US3950524A
公开(公告)日：1976-04-13
申请号：US540964
申请日：1975-01-14
申请人： Volker Hitzel , Rudi Weyer , Walter Aumuller
发明人： Volker Hitzel , Rudi Weyer , Walter Aumuller
IPC分类号： C07D239/42 , C07C67/00 , C07C301/00 , C07C303/08 , C07C311/64 , C07D239/46 , C07D239/69 , C07D401/12 , A61K31/505 , C07D239/00
CPC分类号： C07D239/69 , Y10S514/866
摘要： Sulfonamidopyrimidines of the formula ##SPC1##In which X is a 6-membered heteroaromatic ring including 1 to 2 nitrogen atoms which may be substituted with 1 or 2 methyl groups and/or fused with benzene and is linked in vicinal position with regard to the nitrogen atom to the rest of the molecule,R is alkyl or alkoxy, having 1 to 4 carbon atoms each, their manufacture and their use as hypoglycemic agents.
摘要翻译：磺酰胺亚胺嘧啶类，其中X是含有1至2个氮原子的6元杂芳环，其可以被1或2个甲基取代和/或与苯稠合并且相对于氮原子连接在邻位分子的其余部分，R为烷基或烷氧基，各自具有1至4个碳原子，其制备及其作为降血糖剂的用途。

7. 发明授权

US2508930A Removal of water from p-acetylsulfanilylchloride with ketones 失效
标题翻译：用酮除去对乙酰基硫代酰氯的水
公开(公告)号：US2508930A
公开(公告)日：1950-05-23
申请号：US8921849
申请日：1949-04-23
申请人： US RUBBER CO
发明人： RICHMOND HENRY H
IPC分类号： C07C311/64
CPC分类号： C07C311/64

8. 发明授权

US2233569A P-acylamino benzene sulphonyl guanidines and process for making them 失效
标题翻译：对酰氨基苯磺酰胍及其制备方法
公开(公告)号：US2233569A
公开(公告)日：1941-03-04
申请号：US35750040
申请日：1940-09-19
申请人： AMERICAN CYANAMID CO
发明人： STANLEY WINNEK PHILIP
IPC分类号： C07C311/64
CPC分类号： C07C311/64

9. 发明授权

US5968978A Biphenylsulfonylcyanamides, process for their preparation, and their use as medicament 有权
标题翻译：联苯磺酰氰胺，其制备方法及其作为药物的用途
公开(公告)号：US5968978A
公开(公告)日：1999-10-19
申请号：US157589
申请日：1998-09-21
申请人： Heinz-Werner Kleemann , Jan-Robert Schwark , Sabine Faber , Hans Jochen Lang , Andreas Weichert , Hans-Willi Jansen
发明人： Heinz-Werner Kleemann , Jan-Robert Schwark , Sabine Faber , Hans Jochen Lang , Andreas Weichert , Hans-Willi Jansen
IPC分类号： A61K31/00 , A61K31/18 , A61K31/275 , A61K31/33 , A61P3/00 , A61P3/10 , A61P5/28 , A61P5/36 , A61P11/00 , A61P35/00 , A61P43/00 , C07C311/16 , C07C311/18 , C07C311/64 , C12N11/00 , C07C255/33 , C07C309/29
CPC分类号： C07C311/16 , C07C2101/08 , C07C2101/14 , C07C2101/18
摘要： Compounds of the formula I ##STR1## in which the symbols have the meanings indicated in the claims, have outstanding antiarrhythmic properties. They exhibit a cardioprotective component. They can inhibit or greatly decrease, in a preventive manner, the pathophysiological processes in the formation of ischemically induced damage, in particular in the elicitation of ischemically induced cardiac arrhythmias. Moreover, they have a strong inhibitory action on the proliferation of cells.
摘要翻译：其中符号具有权利要求中所示含义的式I化合物具有突出的抗心律失常性质。它们表现出心脏保护成分。它们可以以预防的方式抑制或大大降低缺血诱导的损伤形成中的病理生理过程，特别是引发缺血诱导的心律不齐。此外，它们对细胞增殖具有强烈的抑制作用。

10. 发明授权

US5942546A Sulfonyl-N-hydroxyguanidine derivatives 失效
标题翻译：磺酰基-N-羟基胍衍生物
公开(公告)号：US5942546A
公开(公告)日：1999-08-24
申请号：US975286
申请日：1997-11-20
申请人： Ji-Wang Chern , Yu-Ling Leu , Shan-Shue Wang , Chin-Fen Lee , Shih-Chung Hsu
发明人： Ji-Wang Chern , Yu-Ling Leu , Shan-Shue Wang , Chin-Fen Lee , Shih-Chung Hsu
IPC分类号： C07C311/64 , C07D285/14 , C07D307/82 , C07D333/62 , C07D409/04 , C07D413/04 , A61K31/18 , A61K31/34 , A61K31/38 , A61K31/42 , A61K31/44 , C07C255/50 , C07D333/34 , C07D333/72 , C07C413/04
CPC分类号： C07D285/14 , C07C311/64 , C07D307/82 , C07D333/62 , C07D409/04 , C07D413/04
摘要： A compound of the formula: ##STR1## wherein X is arylene, heteroarylene, fused arylene, fused heteroarylene, or deleted; Y is sulfonyl, --O--, or deleted; R.sub.1 is aryl, heteroaryl, fused aryl, or fused heteroaryl; R.sub.2 is H, lower alkyl, lower alkoxy, halo, nitro, cyano, haloalkyl, hydroxyl, carboxyl, amido, amino, or aminoalkyl; or a salt thereof are disclosed. Also disclosed are a pharmaceutical composition which contains an excipient and an effective amount of a compound of the above formula and a method of treating cancer which involves the administration of an effective amount of such a compound to a patient in need thereof.
摘要翻译：下式的化合物：其中X是亚芳基，亚杂芳基，稠合亚芳基，稠合亚杂芳基或缺失的; Y是磺酰基，-O-或缺失; R1是芳基，杂芳基，稠合芳基或稠合杂芳基; R2是H，低级烷基，低级烷氧基，卤素，硝基，氰基，卤代烷基，羟基，羧基，酰氨基，氨基或氨基烷基; 或其盐。还公开了含有赋形剂和有效量的上述化合物的药物组合物和涉及向有需要的患者施用有效量的这种化合物的癌症治疗方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式