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1. 发明申请

US20210325332A1 ELECTROCHEMICAL SENSOR FOR HUMORAL DETECTION AND DETECTION DEVICE 有权
公开(公告)号：US20210325332A1
公开(公告)日：2021-10-21
申请号：US16605021
申请日：2018-09-29
申请人： BOE TECHNOLOGY GROUP CO.,LTD.
发明人： Zheng WU
IPC分类号： G01N27/30 , G01N33/543 , G01N27/401
摘要： An electrochemical sensor for humoral detection and a detection device. The electrochemical sensor for humoral detection includes a material layer including at least one hydrophilic region; and at least one detection unit, located in the hydrophilic region. The hydrophilic region includes a sampling port configured to be in contact with a liquid sample (for example, saliva) to be detected, the detection unit includes a working electrode and an opposed electrode disposed apart from each other, the working electrode comprises a reaction surface containing a substance configured to have a reaction with an analyte in the liquid sample, and the working electrode and the opposed electrode are configured to detect an electrical signal generated by the reaction so as to detect the analyte.

2. 发明申请

US20200064300A1 DISPOSABLE ELECTROCHEMICAL SENSING STRIPS AND ASSOCIATED METHODS 审中-公开
公开(公告)号：US20200064300A1
公开(公告)日：2020-02-27
申请号：US16609695
申请日：2018-04-30
申请人： DEVICARE, S.L.
发明人： Julian ALONSO CHAMARRO , Maria Mar PUYOL BOSCH , Antonio CALVO LOPEZ
IPC分类号： G01N27/333 , G01N27/401 , G01N27/30 , G01N27/327
摘要： Electrochemical sensing device (S) for measuring the content of ions in biological fluid samples (D) comprising two membrane half cells, a salt bridge (3) connecting them, means for bringing a biological fluid sample (D) in contact with the measuring cell, wherein the first and second membranes (11, 21) of the half-cells are selective to the same ions, the first volume (13) and second volume (23) adjacent to the membranes are filled with known concentrations (C1, C2) of the ions to which the membranes (11, 21) are selective, these known concentrations being different such that a voltage can be measured between the first electrode (12) and the second electrode (22) that allows calibrating the sensing device (S) and then measuring the ion-content of the sample. The invention also refers to a method using such sensing devices. The sensing devices are useful especially in the area of so-called home monitoring.

3. 发明申请

US20190187088A1 REFERENCE ELECTRODE 审中-公开
公开(公告)号：US20190187088A1
公开(公告)日：2019-06-20
申请号：US16226203
申请日：2018-12-19
申请人： LAPIS Semiconductor Co., Ltd.
发明人： Masao OKIHARA
IPC分类号： G01N27/30 , G01N27/401 , G01N27/414
CPC分类号： G01N27/301 , G01N27/302 , G01N27/401 , G01N27/414
摘要： A reference electrode is provided with an accommodation portion that is provided with a tube-shaped lead-out portion that can guide an accommodated internal liquid; a liquid junction portion that is connected to an end of the lead-out portion, and that allows the internal liquid to seep out; a liquid dripping portion that has a first end connected to the liquid junction portion, that has a second end that protrudes into the accommodation portion, and that guides the internal liquid to the liquid junction portion; and an internal electrode having at least a portion that is positioned further towards the first end side than the second end of the liquid dripping portion.

4. 发明授权

US09696273B2 Reference half-cell and electrochemical sensor with the reference half-cell 有权
公开(公告)号：US09696273B2
公开(公告)日：2017-07-04
申请号：US13719363
申请日：2012-12-19
申请人： Endress + Hauser Conducta Gesellschaft für Mess-und Regeltechnik mbH + Co. KG
发明人： Thomas Wilhelm , Thomas Schroter , Michael Hanko , Wolfram Nowak , Thilo Trapp
IPC分类号： G01N27/30 , G01N27/31 , G01N27/333 , G01N27/401 , G01N27/414 , G01N27/416
CPC分类号： G01N27/31 , G01N27/301 , G01N27/333 , G01N27/401 , G01N27/414 , G01N27/416 , Y10T29/417
摘要： A reference half-cell for application in an electrochemical sensor, comprising a housing, in which a chamber containing a reference electrolyte is formed, wherein the reference electrolyte (5, 105) is in contact with a medium surrounding the housing via a liquid junction arranged in a wall of the housing, wherein the liquid junction comprises a porous diaphragm, especially a porous ceramic diaphragm, and wherein the diaphragm has, at least partially, a coating, which comprises at least one metal.

5. 发明授权

US08911604B2 Reference electrode having a flowing liquid junction and filter members 有权
标题翻译：参考电极具有流动的液体接合点和过滤器部件
公开(公告)号：US08911604B2
公开(公告)日：2014-12-16
申请号：US13284051
申请日：2011-10-28
申请人： Scott T. Broadley , Herbert P. Silverman , Ta-Yung Chen , Steven R. Ragsdale
发明人： Scott T. Broadley , Herbert P. Silverman , Ta-Yung Chen , Steven R. Ragsdale
IPC分类号： G01N27/401 , G01N27/30
CPC分类号： C25B15/00 , C25F7/00 , G01N27/30 , G01N27/301 , G01N27/401
摘要： A flowing junction reference electrode comprising a liquid junction member matched with a filter. The junction member and the filter are situated between a reference electrolyte solution and a sample solution. An array of nanochannels spans the junction member and provides fluid communication between the electrolyte solution and the sample solution. The filter is configured to allow a greater flux of electrolyte than that associated with the junction member. Preferably, the number of pores is greater than the number of nanochannels. The filter is preferably configured to have pores with an inner diameter that is the same or less than the inner diameter of the nanochannels. In some embodiment, the resistance of the filter is made lower relative to the resistance of the junction member by selecting suitable length, number, and inner diameter size for the pores of the filter relative to the nanochannels of the junction member.
摘要翻译：一种流动接合参考电极，包括与过滤器配合的液体接合部件。接合构件和过滤器位于参考电解质溶液和样品溶液之间。纳米通道阵列跨越接合部件并提供电解质溶液和样品溶液之间的流体连通。过滤器被配置为允许比与接合部件相关联的更大的电解质通量。优选地，孔的数量大于纳米通道的数量。过滤器优选地构造成具有内径等于或小于纳米通道的内径的孔。在一些实施例中，通过相对于接合部件的纳米通道选择合适的过滤器的孔的长度，数量和内径尺寸，使得过滤器的电阻相对于连接部件的电阻较低。

6. 发明授权

US08268148B2 Reference electrode, manufacturing method and battery comprising same 有权
标题翻译：参考电极，制造方法和包含该电极的电池
公开(公告)号：US08268148B2
公开(公告)日：2012-09-18
申请号：US12448623
申请日：2007-06-25
申请人： Angel Zhivkov Kirchev
发明人： Angel Zhivkov Kirchev
IPC分类号： G01N27/30 , G01N27/36 , G01N27/401
CPC分类号： H01M4/54 , G01N27/301 , H01M4/58 , H01M6/28 , Y10T29/49108 , Y10T29/53204
摘要： A reference electrode having a casing with an inner cavity successively filled with a paste constituting an active material and a porous material impregnated with an electrolyte solution. The projecting end of a silver wire is embedded in the paste at the bottom of the inner cavity. The paste is constituted of a powder of a silver compound and of the alkaline electrolyte solution. The silver compound is any insoluble silver salt or oxide containing the negative ion of the electrolyte solution. The impregnated porous material is preferably constituted by a plurality of mat separator pieces mechanically and compressed by a closing plug, closing the inner cavity and forming a porous liquid junction.
摘要翻译：一种参考电极，其具有连续填充有构成活性物质的糊料的内腔和浸渍有电解质溶液的多孔材料的壳体。银线的突出端嵌入内腔底部的糊状物中。该糊状物由银化合物和碱性电解质溶液的粉末构成。银化合物是包含电解质溶液的负离子的任何不溶性银盐或氧化物。浸渍的多孔材料优选由多个垫片分离器片构成，机械地由封闭塞子压缩，封闭内腔并形成多孔液体接合部。

7. 发明申请

US20100140110A1 MICROFLUIDIC-BASED LAB-ON-A-TEST CARD FOR A POINT-OF-CARE ANALYZER 有权
标题翻译：一个点分析仪的基于微流体的实验卡
公开(公告)号：US20100140110A1
公开(公告)日：2010-06-10
申请号：US12632661
申请日：2009-12-07
申请人： Sunnie Park KIM , Young Shik SHIN , Changgeng LIU , Rory KELLY , Becky CHAN
发明人： Sunnie Park KIM , Young Shik SHIN , Changgeng LIU , Rory KELLY , Becky CHAN
IPC分类号： G01N27/07 , B81B7/00 , G01N27/00 , G01N27/02 , G01N27/401 , C12M1/00 , C12N5/00 , C07K16/00 , C07K1/22 , C07H21/00
CPC分类号： G01N33/5044 , B01L3/502761 , B01L9/527 , B01L2200/04 , B01L2200/0636 , B01L2200/0668 , B01L2300/0645 , B01L2300/0654 , B01L2300/0681 , B01L2300/0864 , B01L2300/0883 , B01L2300/0887 , B01L2400/0475 , B01L2400/0487 , B82Y10/00 , B82Y15/00 , G01N1/405 , G01N33/54313 , G01N33/5438 , G01N2001/4088 , G01N2035/00158 , H01L29/0665 , H01L29/0673
摘要： A microfluidic-based lab-on-a-test card is described. The test card is used with a point-of-care (POC) analyzer. The test card is designed to receive a sample and then, with the use of the POC analyzer, quantify or count a particular substance in the sample. The test card may be comprised of multiple layers. In one embodiment, the test card includes a primary separation chamber with a filtration surface, a trapping channel, and a particle detector. The test card may also include a nanowire sensor.
摘要翻译：描述了基于微流体的实验室实验卡。测试卡与点对点（POC）分析仪一起使用。测试卡设计用于接收样品，然后使用POC分析仪对样品中的特定物质进行定量或计数。测试卡可以由多层组成。在一个实施例中，测试卡包括具有过滤表面的主分离室，捕集通道和颗粒检测器。测试卡还可以包括纳米线传感器。

8. 发明授权

US07459066B2 Reference electrode having a microfluidic flowing liquid junction 有权
标题翻译：具有微流体流动液体接头的参比电极
公开(公告)号：US07459066B2
公开(公告)日：2008-12-02
申请号：US10621010
申请日：2003-07-15
申请人： Scott T. Broadley , Steven R. Ragsdale , Herbert P. Silverman
发明人： Scott T. Broadley , Steven R. Ragsdale , Herbert P. Silverman
IPC分类号： G01N27/333 , G01N27/401
CPC分类号： G01N27/401 , G01N27/30
摘要： A flowing junction reference electrode comprises a microfluidic liquid junction member situated between a pressurized reference electrolyte solution and a sample solution. The liquid junction member has an array of nanochannels spanning the member and physically connecting the electrolyte and the sample. The number of nanochannels in the array can be between 10 and 108. Preferably, the nanochannels are substantially straight and parallel to one another. The nanochannels can be coated to facilitate the flow of the electrolyte solution through the junction member. The nanochannels can have widths of between 1 and 500 nanometers, and the width of any one nanochannel is substantially equal to the width of any other nanochannel. The member can be manufactured out a polymer such as polycarbonate and polyimide, and may also be made of silicon, glass, or ceramic. In one embodiment, the reference electrode includes means for pressurizing the electrolyte solution.
摘要翻译：流动接合参考电极包括位于加压参考电解质溶液和样品溶液之间的微流体液体接合构件。液体接合构件具有跨越构件的纳米通道的阵列并物理连接电解质和样品。阵列中的纳米通道的数量可以在10和108之间。优选地，纳米通道基本上是直的并且彼此平行。可以涂覆纳米通道以促进电解质溶液通过接合部件的流动。纳米通道可以具有1至500纳米的宽度，并且任何一个纳米通道的宽度基本上等于任何其它纳米通道的宽度。该构件可以由诸如聚碳酸酯和聚酰亚胺的聚合物制成，并且还可以由硅，玻璃或陶瓷制成。在一个实施例中，参考电极包括用于加压电解质溶液的装置。

9. 发明授权

US06896793B2 Liquid junction reference electrode and methods of use thereof 有权
标题翻译：液结参考电极及其使用方法
公开(公告)号：US06896793B2
公开(公告)日：2005-05-24
申请号：US10094566
申请日：2002-03-07
申请人： Miklos Erdosy , Vasile V. Cosofret
发明人： Miklos Erdosy , Vasile V. Cosofret
IPC分类号： G01N27/30 , G01N27/28 , G01N27/401 , G01N33/487 , G01N33/49
CPC分类号： G01N27/401 , G01N33/4915
摘要： The invention relates to a durable and reliable miniature liquid junction reference electrode for use with at least one electrode (e.g., an electrochemical sensor cartridge) for measuring certain characteristics of a fluid sample such as blood or other body fluid.
摘要翻译：本发明涉及一种用于与至少一个电极（例如，电化学传感器盒）一起使用以测量诸如血液或其它体液的流体样品的某些特性的耐久且可靠的微型液接基准电极。

10. 发明授权

US06894502B2 pH sensor with internal solution ground 失效
标题翻译： pH传感器内部溶液接地
公开(公告)号：US06894502B2
公开(公告)日：2005-05-17
申请号：US10319430
申请日：2002-12-13
申请人： Chang-Dong Feng , Joe N. Covey , Beth Meinhard Covey , Richard N. Baril , Roland H. Koluvek
发明人： Chang-Dong Feng , Joe N. Covey , Beth Meinhard Covey , Richard N. Baril , Roland H. Koluvek
IPC分类号： G01N27/401 , G01N27/403 , G01N27/416 , G01N27/02
CPC分类号： G01N27/401 , G01N27/4035
摘要： The invention relates to an internal solution ground for primary use with a pH sensor, and preferably with a multi-sensing instrument monitoring a pH sensor and one or more additional secondary sensors having non-isolated circuits. In one aspect, a pH sensor assembly includes a pH electrode, a reference electrode, and an internal solution ground wire. The internal solution ground wire shares a liquid junction with the reference electrode but is protected by the reference fill solution. In one embodiment, the internal solution ground can be electrically isolated through a capacitor or, alternately, a capacitor and resistor in parallel.
摘要翻译：本发明涉及一种用于主要用于pH传感器的内部溶液，并且优选地具有监测pH传感器的多感测仪器和具有非隔离电路的一个或多个另外的次级传感器。一方面，pH传感器组件包括pH电极，参比电极和内部溶液接地线。内部溶液接地线与参比电极共享液体接头，但受到参考填充溶液的保护。在一个实施例中，内部溶液接地可以通过电容器或电容器和电阻器并联地电隔离。

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