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1. 发明公开

US20240255518A1 CHARACTERIZATION OF SERINE-LYSINE CROSS-LINK IN ANTIBODY HIGH MOLECULAR WEIGHT SPECIES 审中-公开
公开(公告)号：US20240255518A1
公开(公告)日：2024-08-01
申请号：US18421538
申请日：2024-01-24
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Yuetian Yan , Gaoyuan Liu , Shunhai Wang
IPC分类号： G01N33/68 , C12Q1/37 , G01N30/02 , G01N30/06 , G01N30/16 , G01N30/72
CPC分类号： G01N33/6848 , C12Q1/37 , G01N30/16 , G01N30/7266 , G01N33/6857 , G01N2030/027 , G01N2030/067 , G01N2333/96413 , G01N2333/96416 , G01N2333/96419 , G01N2333/976
摘要： The present invention generally pertains to methods of characterizing of a protein of interest. In particular, the present invention pertains to the use of post-column denaturation, size exclusion chromatography and mass spectrometry for detecting, identifying and characterizing crosslinking amino acid residues in a therapeutic antibody.

2. 发明授权

US12025594B2 Chromatography system 有权
公开(公告)号：US12025594B2
公开(公告)日：2024-07-02
申请号：US17048671
申请日：2019-01-16
申请人： SHIMADZU CORPORATION
发明人： Yusuke Yokoi , Daisuke Kitabayashi
IPC分类号： G01N30/30 , G01N30/16 , G01N30/32 , G01N30/02
CPC分类号： G01N30/30 , G01N30/16 , G01N30/32 , G01N2030/027 , G01N2030/3084 , G01N2030/324 , G01N2030/326
摘要： A chromatography system includes a liquid sending pump for sending a mobile phase in an analysis flow path, a sample injector that injects a sample into the analysis flow path, a separation column for separating the sample into components, a column oven for storing the separation column and adjusting a temperature of the separation column to a preset target temperature, a liquid sending controller configured to control an operation of the liquid sending pump, and a column protection flow rate setter configured to set a column protection flow rate. The liquid sending controller is configured to control the operation of the liquid sending pump such that, when the liquid sending pump starts sending the mobile phase, the flow rate of the mobile phase flowing through the analysis flow path does not exceed the column protection flow rate until a temperature in the column oven reaches the target temperature.

3. 发明公开

US20240200216A1 HYDROGEN GENERATOR FOR GAS CHROMATOGRAPHY APPLICATIONS 审中-公开
公开(公告)号：US20240200216A1
公开(公告)日：2024-06-20
申请号：US18506432
申请日：2023-11-10
申请人： Thermo Finnigan LLC , Thermo Fisher Scientific (Bremen) GmbH
发明人： Edward B. McCauley , Lothar Rottmann , Hans-Juergen Schlueter
IPC分类号： C25B15/08 , B01D53/02 , B01D53/22 , B01D53/26 , B01D71/02 , C25B1/04 , C25B9/19 , G01N30/16
CPC分类号： C25B15/085 , B01D53/025 , B01D53/228 , B01D53/268 , B01D71/02231 , C25B1/04 , C25B9/19 , C25B15/087 , G01N30/16 , G01N2030/025
摘要： The present invention relates to hydrogen generation for use in gas chromatography applications. In particular, the present invention relates to hydrogen generators producing less than 100 standard cubic centimeters per minute of hydrogen and the use of said hydrogen generators in gas chromatography systems and applications.

4. 发明授权

US11913916B2 Needle drive, system and method 有权
公开(公告)号：US11913916B2
公开(公告)日：2024-02-27
申请号：US17203127
申请日：2021-03-16
申请人： Waters Technologies Corporation
发明人： Joshua A. Burnett , Rose Solow , David A. Simpson , Marc E. Lemelin
IPC分类号： G01N30/16 , G01N35/10
CPC分类号： G01N30/16 , G01N35/1079 , G01N35/1095 , G01N2035/1027
摘要： A liquid chromatography sample manager includes a thermal chamber, a sample platter mounted in the thermal chamber, and a needle drive including a base having a shaft configured to rotate about a vertical axis, the base attachable to an interior of a sample manager of a liquid chromatography system. The needle drive further includes a needle assembly attached to the base, the needle assembly including a sample needle, and a drive system attached to the base, the drive system including a sample needle motor configured to impart vertical movement of the sample needle. The liquid chromatography sample manager further includes a sample delivery system configured to transfer a first sample from a first sample vial carrier located in the sample platter into a chromatographic flow stream.

5. 发明公开

US20240036015A1 MOUNTING DEVICE FOR MOUNTING A SAMPLE SEPARATION UNIT 审中-公开
公开(公告)号：US20240036015A1
公开(公告)日：2024-02-01
申请号：US18265932
申请日：2021-12-13
申请人： Agilent Technologies, Inc.
发明人： Johnny Ebsen , Anneke Muehlebach , Dirk Arheidt , Cathrin Sohns
IPC分类号： G01N30/60 , G01N30/16 , B01D15/22
CPC分类号： G01N30/6047 , G01N30/16 , B01D15/22 , G01N2030/027
摘要： An installation device is for installing a sample separating device for separating a liquid sample in a sample separating tool. The installation device includes a first fluid connection for fluidically connecting to a first fluid connection point of the sample separating device, and an actuation device that can be actuated by a user for converting between an access position and a fluid coupling position. The access position makes the sample separating device accessible to the user, and the fluid coupling position fluidically couples the sample separating device. The installation device also includes a fluid coupling mechanism, which forms a force-loaded fluidic connection between the first fluid connection and the first fluid connection point when the sample separating device is converted into the fluid coupling position by the actuation device. The sample separating device may, for example, be configured for chromatography.

6. 发明公开

US20230384269A1 COLUMN DEVICE 审中-公开
公开(公告)号：US20230384269A1
公开(公告)日：2023-11-30
申请号：US18447604
申请日：2023-08-10
申请人： Roche Diagnostics Operations, Inc.
发明人： Peter Kupser , Andreas Leinenbach
IPC分类号： G01N30/16 , G01N30/60 , G01N35/00
CPC分类号： G01N30/16 , G01N30/6078 , G01N30/6047 , G01N35/00732 , G01N2030/167 , G01N2030/027
摘要： A column device for an automatic analyser. The automatic analyzer comprises a high performance liquid chromatography (HPLC) module. The HPLC module comprises a fixation device configured to automatically fix and release a chromatographic column. The column device comprises a column jacket and a capillary. The capillary comprises predetermined dimensions and is disposed within the column jacket. The column device is configured to be installed at the HPLC module using the fixation device. Further, an automatic analyzer is disclosed.

7. 发明公开

US20230266279A1 GAS ANALYSIS THROUGH SNIFFING SEQUENCES 审中-公开
公开(公告)号：US20230266279A1
公开(公告)日：2023-08-24
申请号：US18003818
申请日：2021-07-01
申请人： President and Fellows of Harvard College
发明人： Sören BRANDT , Joanna AIZENBERG , Venkatesh MURTHY , Haritosh PATEL
IPC分类号： G01N30/16 , G01N30/74 , G01N33/497
CPC分类号： G01N30/16 , G01N30/74 , G01N33/497
摘要： A method and device for analyzing a gas are described. A method for analyzing a gas includes introducing the gas into a chamber according to a sniffing recipe, the chamber including a sensor, wherein the sniffing recipe comprises a sequence of actions and the sniffing recipe is either pre-defined, optimized or determined through machine learning, and detecting, over time and by the sensor, a characteristic indicative of a compound or compounds present in the gas. The use of sniffing sequences can provide active, dynamic odor/gas identification with adaptive or self-optimizing capabilities.

8. 发明授权

US11614428B2 Liquid chromatography multi-draw method, system and use for sampling 有权
公开(公告)号：US11614428B2
公开(公告)日：2023-03-28
申请号：US16841369
申请日：2020-04-06
申请人： DIONEX SOFTRON GMBH
发明人： Christoph Hollnagel
IPC分类号： G01N30/24 , G01N30/20 , G01N30/46 , G01N30/16 , G01N30/60 , G01N30/32 , G01N30/02 , G01N30/38 , G01N30/36 , G01N30/22
摘要： A method for collecting a sample for sample analysis includes drawing a first portion of the sample into a sample storage portion of a chromatography system while the chromatography system is in a first configuration. The method further comprising switching the chromatography system to a second configuration; sealing an end of a sample pick-up needle and draining a portion of a liquid from the second tubing; switching the chromatography system to a third configuration; drawing a second portion of the sample into the sample storage portion of the chromatography system; switching the chromatography system to an injection configuration; and fluidly connecting the sample storage portion to the chromatography column and supplying the first portion of the sample and the second portion of the sample from the sample storage portion to the chromatography column.

9. 发明申请

US20220317101A1 PREPARATIVE LIQUID CHROMATOGRAPH 有权
公开(公告)号：US20220317101A1
公开(公告)日：2022-10-06
申请号：US17702849
申请日：2022-03-24
申请人： SHIMADZU CORPORATION
发明人： Shiori UEDA , Tomohiro SHAGAWA , Soichiro TAMAOKI
IPC分类号： G01N30/86 , G01N30/82 , G01N30/16
摘要： A separation column (6), an injector (4) that injects a sample into a mobile phase flowing through a flow path (16) leading to the separation column (6), at least one detector (8;10) that is fluidly connected downstream of the separation column (6), and generates a plurality of detector signals different from each other derived from a component in a sample separated by the separation column (6), a fraction collector (12) for fractionating and collecting a portion containing a component separated by the separation column (6) in an eluate from the separation column (6) into an individual collection container, and a controller (14) that detects a component peak in a plurality of chromatograms based on each of a plurality of the detector signals and controls operation of the fraction collector (12) based on a result of the detection are included. The controller (14) includes a fractionating collection part (26) configured to execute fractionating collection in which a portion detected as a component peak only in one chromatogram of a plurality of the chromatograms and a portion detected as a component peak in all of a plurality of the chromatograms are collected separately in collection containers different from each other.

10. 发明申请

US20220276208A1 VERSATILE TUBE-FREE JET FOR GAS CHROMATOGRAPHY DETECTOR 有权
公开(公告)号：US20220276208A1
公开(公告)日：2022-09-01
申请号：US17749839
申请日：2022-05-20
申请人： AGILENT TECHNOLOGIES, INC.
发明人： Edward D. MROZ , Heng HE
IPC分类号： G01N30/16 , G01N30/68
摘要： A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.

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