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1. 发明公开

US20240101584A1 TARGETED DELIVERY OF 1,2,4,5 TETRAOXANE COMPOUNDS AND THEIR USES 审中-公开
公开(公告)号：US20240101584A1
公开(公告)日：2024-03-28
申请号：US18266936
申请日：2022-01-29
申请人： Westlake University
发明人： Dan YANG , Ming Kwan WONG
IPC分类号： C07F9/655 , A61K45/06 , A61P35/00 , C07D323/04 , C07D405/12 , C07D407/12 , C07H13/12
CPC分类号： C07F9/65522 , A61K45/06 , A61P35/00 , C07D323/04 , C07D405/12 , C07D407/12 , C07H13/12
摘要： 1, 2, 4, 5-tetraoxane compounds and derivatives thereof that have anticancer properties are disclosed. Pharmaceutical compositions and pharmaceutical formulations in unit dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical compositions or formulations may include one or more active agents in addition to the compounds, such as one or more additional anticancer agents. Methods for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer in a subject are also disclosed. The methods include (i) administering to a subject in need thereof an effective amount of the compound (s). The compound (s) can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. The compound can selectively kill cancer cells and/or cancer stem cells over non-cancerous cells by triggering ferroptosis in the cancer cells and/or cancer stem cells.

2. 发明授权

US09365537B2 Process for recycling polyacetals 有权
标题翻译：聚缩醛回收方法
公开(公告)号：US09365537B2
公开(公告)日：2016-06-14
申请号：US14359333
申请日：2012-11-23
申请人： Ticona GMBH
发明人： Michael Haubs , Jurgen Lingnau , Klaus Kurz
IPC分类号： C07D323/06 , C08G65/16 , C07D323/04
CPC分类号： C07D323/06 , C07C47/04 , C07D323/04 , C08G2/10 , C08G2/36 , C08G65/06 , C08G65/16 , C08G65/30 , C08G2650/62 , C08J11/16 , C08J11/28 , C08J2359/02 , Y02P20/125
摘要： A process for recycling polyoxymethylene polymers is disclosed. A polyoxymethylene polymer is at least partially dissolved in an aprotic compound. The resulting solution or suspension (liquid mixture) is then contacted with a catalyst which causes the polyoxymethylene polymer to be converted into a cyclic acetal. The cyclic acetal can be separated, collected and used in other processes. In one embodiment, the cyclic acetal may be used to produce a polyoxymethylene polymer.
摘要翻译：公开了一种再循环聚甲醛聚合物的方法。聚甲醛聚合物至少部分溶解在非质子传递化合物中。然后将所得溶液或悬浮液（液体混合物）与催化剂接触，催化剂使聚甲醛聚合物转化为环状缩醛。环状缩醛可以分离，收集并用于其他工艺。在一个实施方案中，环状缩醛可以用于制备聚甲醛聚合物。

3. 发明授权

US08871954B2 Process for the preparation of alditol acetals 有权
标题翻译：醛缩醛缩醛的制备方法
公开(公告)号：US08871954B2
公开(公告)日：2014-10-28
申请号：US13936436
申请日：2013-07-08
申请人： Reliance Industries Limited
发明人： Pavankumar Aduri , Parasu Veera Uppara
IPC分类号： C07D323/04 , C07D493/04
CPC分类号： C07D493/04
摘要： The present invention is directed to a process for the preparation of 1,3:2,4-bis (4-methylbenzylidene) sorbitol (MDBS) and 1,3:2,4-bis (4-dimethylbenzylidene) sorbitol (DMDBS) by dehydrocondensating an aldehyde and an alditol using a hydrophobic ionic liquid as an acid catalyst. The ionic liquid used in the accordance with the process of the present invention is a phosphonium ion based ionic liquid.
摘要翻译：本发明涉及通过以下方法制备1,3：2,4-双（4-甲基亚苄基）山梨醇（MDBS）和1,3：2,4-双（4-二甲基亚苄基）山梨糖醇（DMDBS）的方法使用疏水性离子液体作为酸催化剂使醛和糖醇脱水缩合。根据本发明方法使用的离子液体是基于鏻离子的离子液体。

4. 发明授权

US08729257B2 Hybrid lipid compounds based on pentaerythritol, intermediates, preparation methods and use thereof 有权
标题翻译：基于季戊四醇的混合脂质化合物，其中间体，其制备方法和用途
公开(公告)号：US08729257B2
公开(公告)日：2014-05-20
申请号：US13384032
申请日：2010-07-19
申请人： Zhifei Dai , Xiaolong Liang , Xiuli Yue
发明人： Zhifei Dai , Xiaolong Liang , Xiuli Yue
IPC分类号： C07D487/22 , C07D323/04 , C07J51/00
CPC分类号： C07D487/22 , A61K9/1272 , C07D319/06 , C07F7/1804
摘要： This invention relates to a novel class of hybrid lipid compound based on pentaerythritol, their intermediates, preparation methods and uses thereof. Different kinds of functional groups such as alkyl chain, siloxane group, azobenzene, porphyrins, cholesterol, benzene ring and carboxyl were introduced into the four hydroxyl groups of pentaerythritol through chemical reaction to obtain the final hybrid lipid compounds based on pentaerythritol. Cerasomes prepared from such lipids have uniform size, silicate network surface, good stability and biocompatibility, and the leakage of drugs is not easy. The present liposome can be used as functional materials such as drugs or drug carriers, or used for optical storage and molecular devices, simulation, design and synthesis of artificial systems, nano-composite membrane materials and the removal of organic pollutants, etc., in addition, the preparation method of the present invention is simple, and it is easy for industrial production.
摘要翻译：本发明涉及一种基于季戊四醇的新型混合脂质化合物及其中间体，其制备方法和用途。通过化学反应将不同种类的官能团如烷基链，硅氧烷基，偶氮苯，卟啉，胆固醇，苯环和羧基引入季戊四醇的四个羟基中，得到基于季戊四醇的最终杂化脂质化合物。由这种脂质制备的Cerasomes具有均匀的大小，硅酸盐网络表面，稳定性和生物相容性好，药物渗漏不容易。本发明的脂质体可用作药物或药物载体等功能材料，或用于光学储存和分子装置，人造系统的模拟，设计和合成，纳米复合膜材料和有机污染物的去除等此外，本发明的制备方法简单，工业生产容易。

5. 发明申请

US20120226031A1 PALMARUMYCIN BASED INHIBITORS OF THIOREDOXIN AND METHODS OF USING SAME 审中-公开
标题翻译：基于PALMARUMYCIN的三羟甲基纤维素抑制剂及其使用方法
公开(公告)号：US20120226031A1
公开(公告)日：2012-09-06
申请号：US13364499
申请日：2012-02-02
申请人： GARTH POWIS , PETER WIPF
发明人： GARTH POWIS , PETER WIPF
IPC分类号： C07D323/04 , C07D413/10 , C07H15/24 , C07D405/10
CPC分类号： C07D319/08 , A61K31/357 , A61K31/7048
摘要： Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer.
摘要翻译：本发明的实施方案涉及硫氧还蛋白的抑制剂。某些实施方案涉及基于棕榈霉素的化合物及其使用方法。这些化合物可用于抑制硫氧还蛋白的过量表达，抑制肿瘤生长和治疗癌症。

6. 发明申请

US20070259917A1 Processes for the synthesis of 3-isobutylglutaric acid 审中-公开
标题翻译：合成3-异丁基戊二酸的方法
公开(公告)号：US20070259917A1
公开(公告)日：2007-11-08
申请号：US11789662
申请日：2007-04-24
申请人： Vinod Kansal , Brijnath Chaurasia , Hitesh Patel , Shivaji Shelke , Yogesh More
发明人： Vinod Kansal , Brijnath Chaurasia , Hitesh Patel , Shivaji Shelke , Yogesh More
IPC分类号： A61K31/445 , C07D211/54 , C07D323/04
CPC分类号： C07D407/06 , C07D211/88 , C07D319/06
摘要： Provided are processes for the synthesis of 3-isobutylglutaric acid, an intermediate in the synthesis of (S)-Pregabalin.
摘要翻译：提供合成3-异丁基戊二酸的方法，（S） - 普瑞巴林的合成中间体。

7. 发明申请

US20070231300A1 COVALENT CONJUGATES BETWEEN ENDOPEROXIDES AND TRANSFERRIN AND LACTOFERRIN RECEPTOR-BINDING AGENTS 审中-公开
标题翻译：内酯与转铁蛋白和LACTOFERRIN受体结合剂之间的共价结合
公开(公告)号：US20070231300A1
公开(公告)日：2007-10-04
申请号：US11692866
申请日：2007-03-28
申请人： Tomikazu Sasaki , Henry Chiu-Yuen Lai , Narendra Pal Singh , Steve J. Oh
发明人： Tomikazu Sasaki , Henry Chiu-Yuen Lai , Narendra Pal Singh , Steve J. Oh
IPC分类号： A61K38/20 , A61K38/28 , A61K38/18 , C07D323/04
CPC分类号： C07K7/08 , A61K38/00 , A61K47/64 , A61K47/66 , B82Y5/00 , C07D493/18 , C07D493/20 , C07D519/00 , C07K7/06 , Y02A50/411
摘要： The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections.
摘要翻译：本发明涉及内过氧化物与结合于转铁蛋白或乳铁蛋白受体上的分子腔的小肽和有机化合物之间的共价缀合物，以及包含这些缀合物的组合物用于治疗癌症，过度增殖性疾病，炎性疾病和感染的共价缀合物。

8. 发明授权

US06949569B2 Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof 失效
公开(公告)号：US06949569B2
公开(公告)日：2005-09-27
申请号：US10240929
申请日：2001-04-04
申请人： Bernard Meunier , Anne Robert , Odile Dechy-Cabaret , Francoise Benoit-Vical
发明人： Bernard Meunier , Anne Robert , Odile Dechy-Cabaret , Francoise Benoit-Vical
IPC分类号： A61K20060101 , A61K9/08 , A61K9/10 , A61K9/20 , A61K9/48 , A61K31/397 , A61K31/435 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/513 , A61P20060101 , A61P33/06 , C07D20060101 , C07D215/00 , C07D323/04 , C07D405/12 , C07D407/12 , C07D453/04 , C07D471/02 , C07D471/04
CPC分类号： C07D405/12 , C07D323/04 , C07D471/04
摘要： The invention relates to dual molecules formed from coupling products complying with the formula wherein A represents a residue of molecule with anti-malarial activity, Y1 and Y2, represent a linear or ramified alkylene chain at C1 to C5, with the possibility of either Y1 or Y2 being absent, U is an amine, amide, sulphonamide, carboxyl, ether or thioether function, said function linking Y1 and Y2, Z1 and Z2, represent a linear arylene or alkylene, with the possibility of either Z1 or Z2 being absent, or Z1+Z2 together represent a polycyclic structure including the junction carbons Ci and Cj, R1 and R2, represent a hydrogen atom or a functional group capable of increasing the hydrosolubility of the dual molecule, Rx and Ry form a cyclic peroxide with 4 to 8 chain links, Cj being one of the peaks of said cyclic peroxide, or Rx or Ry is a cyclic peroxide with 4 to 8 chain links, which may comprise 1 or 2 additional oxygen atoms in the cyclic structure, and one or more substituents R3, identical or different, at least one representing a halogen atom, an —OH group, a —CF3 group, an aryl, an alkyl or alkoxy at C1 to C5, —NO2, the other substituent(s) having one of these correspondences or a hydrogen, and their addition salts with pharmacological acceptable acids. Application as medicinal products with anti-malarial activity.

9. 发明授权

US06894176B2 Reaction product mixtures including both symmetric compounds and asymmetric dipolar multi-substituted alditol derivatives 失效
标题翻译：反应产物混合物包括对称化合物和不对称偶极多取代的糖醇衍生物
公开(公告)号：US06894176B2
公开(公告)日：2005-05-17
申请号：US10286217
申请日：2002-11-01
申请人： Darin L. Dotson , Brian M. Burkhart , John D. Anderson , Jeffrey R. Jones , Shawn R. Sheppard
发明人： Darin L. Dotson , Brian M. Burkhart , John D. Anderson , Jeffrey R. Jones , Shawn R. Sheppard
IPC分类号： A61K8/49 , A61Q15/00 , C07D493/04 , C08G18/18 , C08J9/00 , C08L23/10 , C07D323/04 , C07D319/14 , C08K5/1575 , C08K5/159
CPC分类号： A61K8/042 , A61K8/498 , A61Q15/00 , C07D493/04 , C08G18/1825 , C08J9/0023 , C08J2375/04 , C08L23/10
摘要： Certain multi-substituted dibenzylidene sorbitol acetals having electron withdrawing groups as constituents and electron donating groups on the other such that the compounds are asymmetric in structure and are dipolar in nature are provided. Polymer compositions comprising such compounds, are also contemplated which may be utilized within, as merely examples, food or cosmetic containers and packaging. These inventive asymmetric dipolar dibenzylidene sorbitol acetals are also useful as gelling agents for water and organic solvents, particularly those used in the preparation of antiperspirant gel sticks.
摘要翻译：提供了一些具有吸电子基团作为组分和给电子基团的多取代二亚苄基山梨糖醇缩醛，使得化合物在结构上是不对称的并且在本质上是偶极性的。包含这些化合物的聚合物组合物也被设想为仅作为例子使用的食品或化妆品容器和包装。这些本发明的不对称偶极二亚苄基山梨糖醇缩醛也可用作水和有机溶剂的胶凝剂，特别是用于制备止汗凝胶棒的那些。

10. 发明授权

US6107496A Process for the preparation of cyclic esters 失效
标题翻译：环酯的制备方法
公开(公告)号：US6107496A
公开(公告)日：2000-08-22
申请号：US261132
申请日：1999-03-03
申请人： Clemens Osterholt , Josef Metz , Guenther Koehler
发明人： Clemens Osterholt , Josef Metz , Guenther Koehler
IPC分类号： C07B61/00 , C07D321/00 , C07D323/04 , C07D407/00
CPC分类号： C07D321/00 , Y02P20/582
摘要： A process for the preparation of cyclic esters of the general formula: ##STR1## in which m is an integer from 6-14 and n is an integer from 2-6, which comprises heating a dicarboxylic acid bis(glycol) ester of the general formula:HO--(CH.sub.2).sub.n --O--CO--(CH.sub.2).sub.m --CO--O--(CH.sub.2).sub.n --OH, formula IIin which m and n are as defined above,(b) optionally, up to 100% by weight, based on the weight of ester II, of esters of the general formula:H[O--(CH.sub.2).sub.n --O--CO--(CH.sub.2).sub.m --CO--].sub.x --O--(CH.sub.2).sub.n --OH, formula IIIH[O--(CH.sub.2).sub.n --O--CO--(CH.sub.2).sub.m CO--]X--OH and/orformula IVHO--CO--(CH.sub.2).sub.m --CO--[--O--(CH.sub.2).sub.n O--CO--(CH.sub.2).sub.m --CO--].sub.x --OH, formula Vin which m and n are as defined previously and x is an integer >1, and(c) a glycol of the general formula:HO--(CH.sub.2).sub.n --OH, formula VIin which n has the same numerical value as in formula I-V,(d) an inert high-boiling reaction medium, and(e) a catalyst.
摘要翻译：一种制备通式的环酯的方法：其中m是6-14的整数，n是2-6的整数，其包括加热通式为HO的二羧酸双（二醇）酯 - （CH 2）n O-CO-（CH 2）m -CO-O-（CH 2）n -OH，其中m和n如上所定义的式IIin，（b）任选地，至多100重量％酯II的通式为H [O-（CH 2）n O-CO-（CH 2）m -CO-] x O - （CH 2）n -OH的酯，式IIIH [O-（CH 2）n O- CO-（CH 2）m CO-] X-OH和/或式IVHO-CO-（CH 2）m -CO- [-O-（CH 2）n O-CO-（CH 2）m -CO-] x-OH，式Vin 其中m和n如前定义，x是> 1的整数，和（c）通式为HO-（CH 2）n -OH的二醇，其中n具有与式IV相同的数值，（d）惰性高沸点反应介质，和（e）催化剂。

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