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1. 发明申请

WO2019121543A1 SUBSTITUIERTE THIOPHENYLURACILE SOWIE DEREN SALZE UND IHRE VERWENDUNG ALS HERBIZIDE WIRKSTOFFE 审中-公开
公开(公告)号：WO2019121543A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/085262
申请日：2018-12-17
申请人： BAYER AKTIENGESELLSCHAFT , BAYER CROPSCIENCE AKTIENGESELLSCHAFT
发明人： HEINEMANN, Ines , FRACKENPOHL, Jens , WILLMS, Lothar , BEFFA, Roland , DIETRICH, Hansjörg , GATZWEILER, Elmar , MACHETTIRA, Anu Bheemaiah , ROSINGER, Christopher Hugh , LÜMMEN, Peter
IPC分类号： C07D403/12 , A01N43/54 , C07D401/12 , C07D405/12 , C07D239/54 , C07D413/12 , A01P13/00 , A01P21/00
CPC分类号： C07D239/54 , A01N43/54 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Die vorliegende Erfindung betrifft substituierte Thiophenyluracile der allgemeinen Formel (I) oder deren Salze (I) wobei die Reste in der allgemeinen Formel (I) den in der Beschreibung gegebenen Definitionen entsprechen, sowie deren Verwendung als Herbizide, inbesondere zur Bekämpfung von Unkräutern und/oder Ungräsern in Nutzpflanzenkulturen und/oder als Pflanzenwachstumsregulatoren zur Beeinflussung Wachstums von Nutzpflanzenkulturen.

2. 发明申请

WO2017040895A1 ANTI-VIRAL COMPOUNDS 审中-公开
公开(公告)号：WO2017040895A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/050054
申请日：2016-09-02
申请人： ABBVIE INC.
发明人： CHEN, Hui-Ju, J. , DEGOEY, David, A. , KALTHOD, Vikram , KRUEGER, Allan, C. , RANDOLPH, John, T. , WAGNER, Rolf
IPC分类号： A61K31/513 , A61K31/7072 , C07D239/04 , C07D403/04 , C07F9/06 , C07H19/10
CPC分类号： A61K31/7072 , A61K45/06 , C07D239/54 , C07D405/04 , C07F9/65121 , C07F9/65586 , C07H19/10 , A61K2300/00
摘要： The present invention features compounds effective in inhibiting active against Hepatitis C virus ("HCV") polymerase. The invention also features processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.

3. 发明申请

WO2016187303A1 NANO-TO-NANO FE/PPM PD CATALYSIS OF CROSS-COUPLING REACTIONS IN WATER 审中-公开
标题翻译： NANO-TO-NANO FE / PPM PD催化水中交联反应
公开(公告)号：WO2016187303A1
公开(公告)日：2016-11-24
申请号：PCT/US2016/033083
申请日：2016-05-18
申请人： LIPSHUTZ, Bruce, H. , HANDA, Sachin
发明人： LIPSHUTZ, Bruce, H. , HANDA, Sachin
IPC分类号： B01J31/24
CPC分类号： B01J31/2404 , B01J23/8906 , B01J31/0202 , B01J31/0209 , B01J31/068 , B01J31/22 , B01J35/0013 , B01J35/10 , B01J35/12 , B01J37/16 , B01J2231/4211 , B01J2231/4227 , B01J2231/4266 , B01J2231/64 , B01J2531/004 , B01J2531/007 , B01J2531/824 , B01J2531/842 , B01J2531/96 , B01J2531/985 , C07B37/04 , C07C37/18 , C07C41/30 , C07C45/68 , C07C201/12 , C07C205/12 , C07C209/325 , C07C209/68 , C07C211/45 , C07C269/06 , C07C269/08 , C07C319/20 , C07C2603/24 , C07D211/70 , C07D213/30 , C07D213/64 , C07D215/06 , C07D239/26 , C07D239/54 , C07D241/18 , C07D317/22 , C07D317/46 , C07D333/60 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D471/04 , C07F9/12 , C07C271/28 , C07C321/28 , C07C43/215 , C07C43/205 , C07C43/2055 , C07C47/546 , C07C47/575 , C07C39/21
摘要： In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Ir, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt.
摘要翻译：在一个实施方案中，本申请公开了一种催化剂组合物，其包含：a）反应溶剂或反应介质; b）有机金属纳米颗粒，其包含：i）通过在有机溶剂中还原铁盐制备的纳米颗粒（NP）催化剂，其中所述催化剂包含至少一种选自Pd，Pt，Au，Ni ，Co，Cu，Mn，Rh，Ir，Ru和Os或其混合物; c）配体; 和d）表面活性剂; 其中所述金属或其混合物相对于所述铁盐以小于或等于50,000ppm的量存在。

4. 发明申请

WO2015120290A3 THIOL-X CLICK FOLDAMERS FOR POLYMER AFFINITY AND CATALYSIS LIBRARIES 审中-公开
标题翻译：用于聚合物亲和力和催化文库的THIOL-X点击折叠器
公开(公告)号：WO2015120290A3
公开(公告)日：2015-11-19
申请号：PCT/US2015014844
申请日：2015-02-06
申请人： UNIV COLORADO REGENTS
发明人： BOWMAN CHRISTOPHER N , KLOXIN CHRISTOPHER J , XI WEIXIAN , GONG TAO , PATTANAYAK SANKHA
IPC分类号： C12Q1/68 , C07D239/54
CPC分类号： C07D473/34 , C07D239/47 , C07D239/54 , C07D473/18 , C12N15/1048 , C12N15/1093 , C12Q1/6802 , C12Q1/6876
摘要： Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected Michael acceptor moiety; a primary functional side chain and one ore more secondary functional side chains. A clickable sequence controllable monomer, can have the structure: (formula), wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic, amine, carboxyl, and carbonyls, optionally substituted to form hydrophilic, hydrophobic, amphiphilic, or charged (positive or negative or both) side chains; T is an optionally protected thiol; and TCA is an optionally protected thiol-click acceptor. Methods of using such polymers are also disclosed.
摘要翻译：点击硫醇-X单体和含有这些单体的聚合物。可点击的序列可控单体包括任选保护的硫醇部分; 任选保护的迈克尔受体部分; 主要功能性侧链和一种或多种次要功能性侧链。可点击的序列可控单体可以具有以下结构：（式）其中独立地Y和Z是价电子数为3或更大的原子; n是0-10的整数; m是0-10的整数; x是0-10的整数; PFS是一个功能组SFSi; SFS2; 和SFS3独立地为氢，羟基，芳族，胺，羧基和羰基的组合，任选被取代以形成亲水性，疏水性，两亲性或带电荷（正或负或两者）侧链; T是任选保护的硫醇; 并且TCA是任选保护的巯基点击受体。也公开了使用这种聚合物的方法。

5. 发明申请

WO2015149270A1 曲格列汀半琥珀酸盐的晶体及其制备方法和药物组合物审中-公开
公开(公告)号：WO2015149270A1
公开(公告)日：2015-10-08
申请号：PCT/CN2014/074518
申请日：2014-04-01
申请人：杭州普晒医药科技有限公司
发明人：宋小叶 , 盛晓霞 , 盛晓红
IPC分类号： C07D239/54 , C07D401/12 , C07D401/04 , A61K31/56 , A61P3/10 , A61P35/00
CPC分类号： A61K31/56 , C07D239/54 , C07D401/04 , C07D401/12
摘要：一种DPP-IV抑制剂曲格列汀半琥珀酸盐及其晶体、曲格列汀半琥珀酸盐及其晶体的制备方法、其药用组合物及其用于制备治疗糖尿病等疾病的药物中的用途。

6. 发明申请

WO2015142910A1 BICYCLIC CARBOCYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM 审中-公开
标题翻译：双相制备的碳化硅核苷和低聚物化合物
公开(公告)号：WO2015142910A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/021050
申请日：2015-03-17
申请人： ISIS PHARMACEUTICALS, INC.
发明人： SETH, Punit, P. , SWAYZE, Eric, E.
IPC分类号： C07F9/6512 , C07D233/40 , C07D487/04 , A61K31/4166 , A61K33/42 , A61P31/12
CPC分类号： C12N15/113 , C07D239/54 , C07D473/34 , C07F9/6512 , C07F9/65121 , C07H19/06 , C07H19/16 , C07H21/00 , C07H23/00 , C12N15/111 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3235 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2310/3525 , C12N2320/51 , C12N2320/52
摘要： The present invention provides novel bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the bicyclic carbocyclic nucleosides into an oligomeric compound is expected to enhance one or more properties of the oligomeric compound. In certain embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in modulation of normal function of the target RNA. In certain embodiments, bicyclic carbocyclic nucleosides are provided as monomers for use as antivirals.
摘要翻译：本发明提供由其制备的新型双环碳环核苷和低聚化合物。期望将一种或多种双环碳环核苷掺入低聚化合物中以增强寡聚化合物的一种或多种性质。在某些实施方案中，本文提供的寡聚化合物与靶RNA的一部分杂交，导致调节靶RNA的正常功能。在某些实施方案中，提供双环碳环核苷作为用作抗病毒剂的单体。

7. 发明申请

WO2015120290A2 THIOL-X CLICK FOLDAMERS FOR POLYMER AFFINITY AND CATALYSIS LIBRARIES 审中-公开
标题翻译：用于聚合物活性和催化图谱的THIOL-X点击式
公开(公告)号：WO2015120290A2
公开(公告)日：2015-08-13
申请号：PCT/US2015/014844
申请日：2015-02-06
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
发明人： BOWMAN, Christopher, N. , KLOXIN, Christopher, J. , XI, Weixian , GONG, Tao , PATTANAYAK, Sankha
IPC分类号： C40B30/04
CPC分类号： C07D473/34 , C07D239/47 , C07D239/54 , C07D473/18 , C12N15/1048 , C12N15/1093 , C12Q1/68 , C12Q1/6876
摘要： Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected Michael acceptor moiety; a primary functional side chain and one ore more secondary functional side chains. A clickable sequence controllable monomer, can have the structure: (formula), wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic, amine, carboxyl, and carbonyls, optionally substituted to form hydrophilic, hydrophobic, amphiphilic, or charged (positive or negative or both) side chains; T is an optionally protected thiol; and TCA is an optionally protected thiol-click acceptor. Methods of using such polymers are also disclosed.
摘要翻译：公开了含有这些单体的硫醇-X单体和聚合物。可点击的序列可控单体包括任选保护的硫醇部分; 任选受保护的Michael受体部分; 主要功能侧链和一个以上次要功能侧链。可点击的序列可控单体可以具有以下结构：（式），其中独立地Y和Z是具有3或更多价电子的原子; n是0-10的整数; m是0-10的整数; x是0-10的整数; PFS是功能组SFSi; SFS2; 和SFS3独立地是氢，羟基，芳族，胺，羧基和羰基的组合，任选地被取代形成亲水，疏水，两亲或带电（正或负或两个）侧链; T是任选保护的硫醇; 而TCA是任选保护的硫醇点受体。还公开了使用这些聚合物的方法。

8. 发明申请

WO2015067651A1 SUBSTITUIERTE URACILE ALS CHYMASE INHIBITOREN 审中-公开
标题翻译：取代的尿嘧啶ALS糜蛋白酶抑制剂
公开(公告)号：WO2015067651A1
公开(公告)日：2015-05-14
申请号：PCT/EP2014/073800
申请日：2014-11-05
申请人： BAYER PHARMA AKTIENGESELLSCHAFT
发明人： FÜRSTNER, Chantal , ACKERSTAFF, Jens , STRAUB, Alexander , MEIER, Heinrich , TINEL, Hanna , ZIMMERMANN, Katja , ZUBOV, Dmitry , SCHAMBERGER, Jens
IPC分类号： C07D403/04 , C07D413/04 , C07D417/04 , C07D239/54 , C07D403/12 , C07D417/12 , C07D413/12 , C07D403/10 , C07D413/10 , A61K31/513 , A61P9/00
CPC分类号： C07D239/557 , A61K9/0053 , A61K9/08 , A61K9/20 , A61K31/513 , A61K45/06 , C07D239/54 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Die vorliegende Anmeldung betrifft neue substituierte Uracil-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung allein oder in Kombinationen zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten.
摘要翻译：本申请涉及新的取代的尿嘧啶衍生物，其制备方法，它们的用途单独使用或用于疾病的治疗和/或预防和它们用于制备用于治疗和/或预防疾病的药物组合使用。

9. 发明申请

WO2015058160A1 BROMODOMAIN INHIBITORS 审中-公开
标题翻译： BROMODOMAIN抑制剂
公开(公告)号：WO2015058160A1
公开(公告)日：2015-04-23
申请号：PCT/US2014/061261
申请日：2014-10-17
申请人： QUANTICEL PHARMACEUTICALS, INC.
发明人： BENNETT, Michael, John , BETANCORT, Juan, Manuel , BOLOOR, Amogh , KALDOR, Stephen, W. , STAFFORD, Jeffrey, Alan , VEAL, James, Marvin
IPC分类号： A61K31/472 , A61K31/497 , A61K31/501
CPC分类号： C07D498/04 , C07D211/94 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D217/24 , C07D237/14 , C07D239/54 , C07D239/56 , C07D241/20 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D413/04 , C07D413/06 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04
摘要： The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.
摘要翻译：本发明涉及取代的杂环衍生物化合物，包含所述化合物的组合物，以及所述化合物和组合物通过抑制溴结构域介导的对蛋白质的乙酰赖氨酸区域的识别（例如组蛋白）的表观遗传调节的用途。所述组合物和方法可用于治疗癌症和肿瘤性疾病。

10. 发明申请

WO2014169206A3 DIVALENT NUCLEOBASE COMPOUNDS AND USES THEREFOR 审中-公开
标题翻译：多种核苷酸化合物及其用途
公开(公告)号：WO2014169206A3
公开(公告)日：2015-01-22
申请号：PCT/US2014033793
申请日：2014-04-11
申请人： UNIV CARNEGIE MELLON
发明人： LY DANITH H , GOPALSAMY SURESH KUMAR , MANNA ARUNAVA
IPC分类号： C07H19/22
CPC分类号： C07K14/003 , C07D239/47 , C07D239/54 , C07D251/16 , C07D471/04 , C07D475/08 , C07D487/04 , C07D487/16 , C07H1/06 , C07H21/04 , G01N33/5308
摘要： Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.
摘要翻译：这里描述的是新颖的二价核碱基，其各自结合两个核酸链，当掺入核酸或核酸模拟主链（遗传识别试剂或遗传识别试剂）时匹配或错配）。在一个实施方案中，遗传识别试剂是肽核酸（PNA）或γPNA（λPNA）寡聚体。还提供了含有二价核碱基的二价核碱基和单体和遗传识别试剂的用途。

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