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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
121	DISINFECTING AND CLEANSING SYSTEM FOR CONTACT LENSES	EP02794578.1	2002-08-07	EP1416975B1	2005-01-26	MOWREY-McKEE, Mary Flowers; SILLS, Marzenna, Alicja

122	INHIBITION OF TWO-COMPONENT SIGNAL TRANSDUCTION SYSTEMS	EP00986856	2000-12-18	EP1248611A4	2003-05-21	ENGLAND DACRE; KJELLEBERG STAFFAN

123	一种隐形眼镜清洗器及电泳解离除蛋白灭菌方法	PCT/CN2021/109100	2021-07-29	WO2022022603A1	2022-02-03	孙碧霞
一种隐形眼镜清洗器及电泳解离除蛋白灭菌方法。隐形眼镜清洗器包括镜片清洗槽（10），镜片清洗槽（10）内相对设置有两个电泳解离探针（20），电泳解离探针（20）与电路电源电连接。于镜片清洗槽（10）内填充电解质溶液，将待清洗镜片置入镜片清洗槽（10）内，启动开关，镜片清洗槽（10）内的两个电泳解离探针（20）形成阳极和阴极，待清洗镜片表面具有泪蛋白，泪蛋白在溶液中带电荷，带电荷的泪蛋白在清洗槽（10）内根据电泳现象向与其电性相反的电极移动，电解质溶液在清洗槽（10）内发生化学反应生成具有强氧化性的次氯酸根，次氯酸根不仅可以降解泪蛋白，还能杀菌消毒。
124	PROGRAMMABLE OPHTHALMIC LENS DISINFECTING BASE UNIT	PCT/US2011/063721	2011-12-07	WO2012078744A1	2012-06-14	PUGH, Randall, B.; KERNICK, Edward, R.; NEELEY, William, Chester; ABOUHALKAH, Dwight; RIALL, James, Daniel
The present invention provides for a programmable processor in a disinfecting radiation base unit for working in conjunction with a storage case for an ophthalmic lens. The processor is operative via executable software to provide disinfecting radiation base radiation for disinfecting an ophthalmic lens. A disinfecting radiation base unit and storage case may also include sensors for providing data and a digital storage for storing the data.
125	L-HISTIDINE IN OPHTHALMIC SOLUTIONS	PCT/US2001/046762	2001-11-08	WO02038077A3	2002-07-25
The invention relates to an aqueous ophthalmic solution comprising 0.01 to about 1.0 percent by weight L-histidine; 0.01 to 0.0001 percent by weight hydrogen peroxide; 0.1 to 500 parts per million of a cationic polymeric preservative that provides superior preservative efficacy especially as against fungal microbes. These solutions may be employed in various ways including cleaning contact lenses, rinsing lenses while in the eye, storing lenses and in delivering active pharmaceutical agents to the eye.
126	INHIBITION OF TWO-COMPONENT SIGNAL TRANSDUCTION SYSTEMS	PCT/AU2000/001553	2000-12-18	WO01043739A1	2001-06-21
The present invention provides compositions and methods for inhibition activities and actions of microorganisms, particularly bacteria. The compositions and methods are based primarily on the inhibition of two-component signal transduction systems with hologenated furanones and related 3-haloalkenones.
127	Compositions and methods for disinfecting contact lenses and preserving contact lens care products	PCT/US9713582	1997-07-31	WO9805365A3	1998-04-30	PARK JOHN Y; PENG LIN; CAFARO DANIEL P; DZIABO ANTHONY J
Compositions for disinfecting contact lenses include a liquid medium containing a chlorite component, preferably a water soluble chlorite component, in a contact lens disinfecting amount, and a polyanionic component, preferably a water soluble polyanionic component, in an amount effective to do at least one of the following: inhibit formation of protein deposit material on a contact lens immersed in the composition; reduce the toxicity of the composition to the human eye, and reduce the damage to a contact lens caused by immersing the contact lens in the composition. The composition has a viscosity of less than 50 cps at 25 °C, an osmolality of at least about 200 mOsmol/kg, and preferably a pH in the range of about 6 to about 9.
128	Compositions, methods and kits for treating a contact lens	US16096603	2017-04-28	US11529309B2	2022-12-20	Guoting Qin; Chengzhi Cai
Provided herein are fluorinated compounds having chemical structures: (I) where n is 0 or greater, or (II) where m and n are 0 or greater, or an amino acid, a soluble polymer, an oligo(ethylene glycol), a poly(ethylene glycol), or a carbohydrate each fluorinated with perfluorocarbons having the chemical structure (III) where n is 0 or greater. These fluorinated compounds are utilized in contact lenses to impart lipid-resistant, protein-resistant and biofouling-resistant properties, thus reducing discomfort and infection caused by contact lens wear without changing its transmission characteristics. Also provided is an ophthalmic drug delivery system comprising at least one of the compounds described above embedded in the contact lens and a kit to incorporate the ophthalmic into a contact lens. Methods for incorporating these compounds onto a contact lens without affecting transparency and for use in treating an ophthalmologic-associated condition are provided.
129	Ophthalmic solution	US14914066	2014-08-05	US10471171B2	2019-11-12	Shunsuke Sakurai; Koji Miyamoto; Yohei Takada; Yoshihisa Shimamura; Mao Maruhashi; Nobuyuki Sakamoto
Provided is an ophthalmic solution of which preservative component, hexamethylene biguanide, contained therein is inhibited from being adsorbed on soft contact lenses and eye droppers. The ophthalmic solution contains, at a specific ratio, (A) hydroxypropyl methylcellulose having 28.0 to 30.0 mass % methoxy groups and 7.0 to 12.0 mass % hydroxypropoxy groups, both with respect to the total amount of the hydroxypropyl methylcellulose, at a methoxy group/hydroxypropoxy group ratio of 2.5 to 4.0 by mass, wherein a 2 mass % aqueous solution of the hydroxypropyl methylcellulose at 20° C. has a viscosity of 50 to 4000 mPa·s; (B) sodium chloride or potassium chloride; (C) hexamethylene biguanide or a salt thereof; (D) 2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer; and (E) water.
130	System for disinfecting contact lenses	US15300296	2015-03-23	US10398799B2	2019-09-03	Robert Carey Tucker
The present invention is generally directed to a hydrogen peroxide-based lens care system for disinfecting contact lenses. Unlike hydrogen peroxide-based system known in the prior art, a lens care system of the present invention involves electrochemically neutralizing of hydrogen peroxide after any desired period of disinfection time for which contact lenses have been immersed in a hydrogen peroxide-based lens care solution.
131	Compositions	US14183314	2014-02-18	US09271490B2	2016-03-01	Staffan Sandström; Carl-Gustav Millinger
Acidic aqueous compositions for elimination of spores of spore forming bacteria comprise from about 100 to about 2000 ppm dissolved chlorine dioxide and a surfactant system having both a wetting effect and a spore solubilising effect.
132	ANTIMICROBIAL CONTACT LENSES WITH REDUCED HAZE AND PREPARATION THEREOF	US11923708	2007-10-25	US20080100797A1	2008-05-01	Nayiby Alvarez-Carrigan; Osman Rathore
This invention relates to antimicrobial lenses containing metals and methods for their production.
133	Contact lens disinfecting solution containing sodium chlorite and polyvinyl pyrrolidone	US219004	1994-03-29	US5782992A	1998-07-21	Anthony P. Frangione
An ophthalmically acceptable solution and a method useful for disinfecting and/or cleaning a contact lens. The solution comprises an oxidizing agent and a polyvinyl pyrrolidone having a molecular weight ranging from 10,000 to 100,000 daltons and reactive towards a chlorite oxidizing agent. The end groups of the polyvinyl pyrrolidone are preferably aldehydes. The oxidizing agent of this invention preferably is selected from the group comprising chlorine oxides. The solution preferably has a pH ranging from about 6 to about 8.5. The method of the invention comprises the steps of forming this solution and then contacting a contact lens with the solution.
134	Compositions and methods for identifying a solution	US227707	1994-04-14	US5578240A	1996-11-26	John Y. Park; James N. Cook; Anthony J. Dziabo, Jr.
A composition and method useful to quickly and effectively indicate whether a functional component such as catalase has been added to a clear solution such as a hydrogen peroxide solution involves compounding with the functional component an effective amount of vitamin B-12 such that when the compounded composition is added to the clear solution, the clear solution turns rose colored. By observing the rose color, the user can determine that the functional component has been added to the clear solution.
135	Double redox system for disinfecting contact lenses	US107268	1993-08-16	US5462713A	1995-10-31	Ronald L. Schlitzer; N. L. Dassanayake; Rajkumar P. Bhatia
An improved method for rapid disinfection of contact lenses in a convenient and reliable manner is disclosed in which a series of oxidation-reduction reactions are employed. Specifically, dicheoroisocyanurate and potassium iodide react to form iodine species for disinfecting the contact lens. An amount of ascorbate is then added to neutralize the iodine species.
136	One-step contact lens sterilization process	US238533	1994-05-05	US5366694A	1994-11-22	Richard F. Stockel
A one-step process for sterilizing a contact lens using an aqueous solution of a sterilant which may be a peroxygen disinfectant, an inorganic hypochlorite compound or a hypochlorite precursor compound. The process involves the step of contacting the lens with a solution containing a sterilant (e.g. hydrogen peroxide, sodium hypochlorite, etc.) and activated carbon for a period of time to effect sterilization of the lens and to decompose substantially all of any sterilant remaining after sterilization of the lens to ophthalmologically innocuous by-products. The activated carbon has a surface area in excess of about 500 m.sup.2 /g and a pore volume of at least about 0.75 ml/g.
137	Methods, compositions and apparatus to disinfect lenses	US974399	1992-11-10	US5336434A	1994-08-09	John Y. Park; Paul S. Ripley; Anthony J. Dziabo
Methods for disinfecting a lens are disclosed. In one embodiment, the methods comprise contacting a lens, e.g., a contact lens, to be disinfected with a liquid medium containing stabilized chlorine dioxide and an activator component selected from chlorine dioxide reducing agents and mixtures thereof to effect formation of chlorine dioxide from the stabilized chlorine dioxide, thereby disinfecting the lens. Compositions and apparatus useful in the above-noted methods are also disclosed.
138	Process for sterilizing a contact lens	US991335	1992-12-16	US5312586A	1994-05-17	Richard F. Stockel
Process for sterilizing a contact lens using an aqueous solution of a sterilant which may be a peroxygen disinfectant, an inorganic hypochlorite compound or a hypochlorite precursor compound. The process involves the steps of contacting the lens with the aqueous solution for a period of time sufficient to effect sterilization of the lens; and thereafter contacting the resultant aqueous solution and lens with an amount of activated carbon and for a period of time sufficient to decompose substantially all of any residual sterilant to ophthalmologically innocuous by-products.
139	Compositions and methods for disinfecting/cleaning of lenses and for destroying oxidative disinfectants	US690625	1991-04-24	US5281353A	1994-01-25	John Y. Park; James N. Cook
Compositions and methods useful in destroying residual oxidative disinfectant, e.g., used to disinfect a contact lens, are disclosed. In one embodiment, the method comprises contacting an oxidative disinfectant-containing liquid medium with a material selected from glutathione, oxidized glutathione and mixtures thereof, and a co-factor selected from nicotinamide adenine dinucleotide phosphate, nicotinamide adenine dinucleotide and mixtures thereof in the presence of glutathione reductase in an amount effective to promote the oxidation of the co-factor.
140	Overworn lens signaling methodology	US838122	1992-02-19	US5213760A	1993-05-25	Anthony J. Dziabo, Jr.; Paul S. Ripley
A method for signaling a lens user when the user's lenses are overworn. The lenses have applied a handling tint, and the lenses are disinfected in an oxidant solution. The amount of tint added to the lens is such that after soaking the lens for a predetermined period of time in the disinfectant solution, over the expected lifetime of the lens, a noticeable change in the appearance of the handling tint is observed. If the lens is intended to have a fixed lifetime, and the lens is intended to be soaked in a disinfectant solution on a regular basis and for a fixed period of time for the lens lifetime, the amount of the handling tint in the lens can be adjusted such that the handling tint is bleached out or changes color after the lens undergoes regular disinfection within the predetermined lens lifetime.

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