TRANSGENIC UNGULATES CAPABLE OF HUMAN ANTIBODY PRODUCTION

TRANSGENIC UNGULATES CAPABLE OF HUMAN ANTIBODY PRODUCTION
申请号	EP03738939	申请日	2003-05-19	公开(公告)号	EP1513397A4	公开(公告)日	2007-10-24
申请人	HEMATECH LLC; KIRIN BREWERY;			发明人	ROBL JAMES M; COLLAS PHILIPPE; SULLIVAN EDDIE; KASINATHAN P; GOLDSBY RICHARD A; KUROIWA YOSHIMI; TOMIZUKA KAZUMA; ISHIDA ISAO; OSBORNE BARBARA;
摘要	The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.
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