INCREASING THE STABILITY OF RECOMBINANT ADULT HUMAN APOHEMOGLOBIN

INCREASING THE STABILITY OF RECOMBINANT ADULT HUMAN APOHEMOGLOBIN
申请号	PCT/US2005032627	申请日	2005-09-15	公开(公告)号	WO2006031840A3	公开(公告)日	2006-05-11
申请人	UNIV RICE WILLIAM M; WISCONSIN ALUMNI RES FOUND; OLSON JOHN S; PHILLIPS GEORGE N JR;			发明人	OLSON JOHN S; PHILLIPS GEORGE N JR;
摘要	The disclosure relates to recombinant adult human apohemoglobin (apo-rHb) in which the stability has been increased by replacement of an amino acid with a counterpart from another organsim, such as a deep sea diving mammal. This mutated apo-rHb may be more stable and/or give higher production yields than unmutated adult human apo-rHb. The mutated apo-rHb may be produced in microorganisms, such as E. coli or yeast cells, or animal erythroid cells. Some apo-rHb of the present disclosure may be used as part of a blood substitute.
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