具有增效作用的杀虫剂组合物

A synergistic insecticidal composition

FIELD

The present invention relates to insecticidal and acaricidal composition having improved properties, particularly to insecticidal and acaricidal compositions comprising a molluscicidal or a salt thereof and avermectin, it belongs to the field of pesticide formulations.

Background technique

Molluscicidal amine (niclosamide) of salicylamide derivatives which insect mechanism of inhibition of mitochondrial oxidative phosphorylation of cellular processes parasites, reduce energy substance ATP generation, the head section and the adjacent segments of the tapeworm deterioration, from worms intestinal shedding excreted with the feces. For eggs invalid. Death decomposition segments susceptible to protease digestion in the intestine, releasing eggs, posing a risk of cysticercosis. In agriculture mainly used to kill snails, snails, beef tapeworm, snails, pork tapeworm, fish tapeworm Diphyllobothrium tapeworm, Hymenolepis short, cercariae.

Avermectin (Abamectin) are a class of 26 - Membered macrolide compounds having insecticidal, acaricidal, nematicidal activity produced by Streptomyces Streptomyces griseus Streptomyces avermitilis fermentation. Avermectin having a stomach and contact action of mites and insects, not ovicidal. Different mechanisms of action and the general interference neurophysiological insecticide activity, stimulate the release of γ- aminobutyric acid, aminobutyric acid and inhibit the nerve conduction arthropods. Mite adults, nymphs and larvae and insects avermectins paralysis after contact occurs, inactive, no feeding, died 2 to 4 days. Because the insects do not cause rapid dehydration, so avermectin lethal effect more slowly.

Studies have shown that now, specific and long-term repeated administration of an active compound for controlling pests in many cases will lead to enhanced resistance of the pest, pest resistance is reduced, the current is usually a mixture of different active compounds for controlling pests. By incorporating the active compounds having different mechanisms of action may be combined, can delay development of resistance, to reduce the amount of administration, the effect to improve the control, prevention and reduce costs.

SUMMARY

Object of the present invention is: for insecticide resistance problem in practical use, the two insecticides selected for different principles of action compound, to enhance the effect of prevention and treatment of, reduce application rate, expand the scope.

To achieve the above object, the present invention provides a insecticidal and acaricidal composition, which composition comprises two active ingredients A and B, component A is active molluscicidal or a salt thereof, as active component B Avi bacteria Su. Preferred amine salts of the compounds molluscicidal molluscicides amine salts of ethanolamine.

The inventors found through experiments that the synergistic insecticidal composition significantly, reduce the amount, can reduce the cost. Different structural classes of compounds containing the component A and component B, different mechanism of action, both the compound to expand the spectrum of action, and may delay the development of insect resistance to some extent, and component A to component B is between no cross-resistance.

The present invention provides the use comprising two active ingredients and methods of preparation A and Control B composition crop pests in agriculture.

Wherein the composition comprises two active components A and B, the weight ratio between the two components is 1: 40 to 40: 1, preferably a weight ratio of 1: 30 to 30: 1, more preferred weight ratio of 1: 20 to 20: 1. In some embodiments, the two active components A and B can be selected 40: 1, 39: 1,38: 1,37: 1,36: 1,35: 1,34: 1,33: 1,32 : 1, 31: 1, 30: 1, 29: 1, 28: 1, 27: 1, 26: 1, 25: 1, 24: 1, 23: 1, 22: 1, 21: 1, 20: 1 , 19: 1, 18: 1, 17: 1,16: 1,15: 1,14: 1,13: 1,12: 1,11: 1,10: 1,9: 1,8: 1,7 : 1,6: 1,5: 1,4: 1,3: 1,2: 1,1: 1,1: 2,1: 3,1: 4,1: 5,1: 6,1: 7 , 1: 8,1: 9,1: 10,1: 11,1: 12,1: 13,1: 14,1: 15,1: 16,1: 17,1: 18,1: 19,1 : 20,1: 21, 1: 22, 1: 23,1: 24,1: 25,1: 26,1: 27, 1: 28,1: 29,1: 30,1: 31,1: 32 , 1: 33,1: 34,1: ​​35,1: 36,1: 37,1: 38,1: 39,1: 40, etc. more specifically, the ratio may be composed of two or more of any ratio selected within a range, to be understood that these proportions are by weight, it may also include a molar ratio.

In the present invention the active ingredient compound to kill spiro amine salts preferably molluscicide amine ethanolamine salt.

The composition further comprises adjuvants, solvents, carrier adjunct ingredients conventionally used in pesticide formulations to make a variety of dosage forms suitable for use in agriculture.

The composition of the present invention may be formed with any dosage form allows agriculturally active ingredient with the carrier accessory ingredients or adjuvants.

The composition of the present invention, the mass content of the active ingredient may be from 2 to 95%, preferably 5 to 80%.

Known methods of the present invention compositions can be prepared into various dosage forms, the active ingredient may be mixed with auxiliary agents, such as solvents, solid carriers, if desired can be uniformly mixed, triturated with a surfactant to prepare a desired formulations.

Suitable adjuvants can be solid or liquid, which is typically used during formulation processing materials, such as natural or regenerated mineral substances, solvents, dispersants, wetting agents, adhesives, thickeners, binders or fertilizers .

Solvent selected from the above-described aromatic hydrocarbons, preferably containing 8-12 carbon atoms, such as xylene mixtures or substituted benzene, phthalic esters, such as dibutyl phthalate or octoate, dibutyl phthalate, aliphatic hydrocarbons, such as loop hexane or paraffins, alcohols and glycols and their ethers and esters, such as ethanol, ethylene glycol, ethylene glycol monomethyl; ketones, such as cyclohexanone, strongly polar solvents, such as N- methyl-2 - pyrrolidone, dimethyl sulfoxide or dimethylformamide, and vegetable oils or vegetable oils such as soybean oil.

The above-mentioned solid carriers such as powders and separable for powders are normally natural mineral fillers such as talc, kaolin, montmorillonite or attapulgite. In order to manage the physical properties of the composition, may be added to highly dispersed silicic acid or highly dispersible adsorbing polymer carrier, e.g. particulate adsorbent carrier or adsorption carrier, suitable granulated adsorptive carriers are porous types, such as pumice, bentonite or bentonite; suitable nonsorbent carriers such as calcite or sand. In addition, a large amount of inorganic nature or organic nature preformed granular material as carrier, especially dolomite.

The chemical nature of the active ingredient composition of the present invention, suitable surfactants are lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, alkaline earth metal or amine salt, alkylaryl sulfonates, alkyl sulfates, alkylsulfonates, fatty alcohol sulfates, fatty acids and sulfated fatty alcohol glycol ethers, furthermore condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensates of naphthalene or naphthalenesulfonic acids with phenol and formaldehyde, condensates, polyoxyethylene octylphenyl ether, ethoxylated isooctylphenol, octylphenol, nonylphenol, alkylaryl polyglycol ethers, tributylphenyl polyglycol ethers benzene, tris tristearylphenyl polyglycol ethers, alkylaryl polyether alcohols, ethoxylated castor oil, polyoxyethylene alkyl ethers, ethylene oxide condensates, ethoxylated polyoxypropylene, polyvinyl laurate glycol ether acetal, sorbitol esters, lignin-sulfite waste liquors and methylcellulose.

Administering a composition of the present invention comprises a composition of the present invention for growing ground parts of plants, including leaves or foliar. Plants may be grown properties, such as wheat, with a wetting liquid formulation composition, or the composition is in solid form to the soil, such as in the form of granules (soil application), the composition can enter the plant through the soil by the plant roots the body (systemic effect).

These compositions may contain only the active ingredient administered, may be mixed with additives, so the compositions of the invention may be prepared in various dosage forms such as wettable powders, suspensions, water dispersible granules, water emulsions . The object of the environmental conditions and the nature and application of the composition of these compositions to be achieved, the composition is applied may be selected in a method of spraying, atomizing, dusting, scattering or pouring the like.

The composition of the present invention of two active ingredients showed a synergistic effect, more significant than the individual activity of the individual compounds. It showed a synergistic effect allows a reduction in the amount of administration, a broader insecticidal spectrum, effective, and longer-lasting control effect by administration only once or a few times better pest control, and possibly widening the interval of administration. These features solve a single dose of insecticide resistance to common problems is very important.

Compositions of the invention may be applied to control crop pests in agriculture, particularly in the prevention and treatment of snails, snails or snail pests. On the other hand, the pesticidal composition of the present invention is applied on a variety of crops of wheat, cotton, corn, soybeans, vegetables, fruit trees and other phytophagous mites harmful Ken have good activity, and the scale sucking mouthparts and Hymenoptera insects, such as fleas, leaf miners, thrips, aphids, also has good activity.

Other features of this product exhibited mainly as: 1, can be applied to spraying, soil mixing spreaders and other possible mode of administration; 2, a large single dose of two chemical structural differences of the present composition, a completely different mechanism of action , there is no cross-resistance, can delay the two single agent resistance problems arising from separately; 3, compounded compositions of the present invention has obvious synergistic effect, crop safety, good control effect. The test proved that the composition of the present invention is chemically stable, significant efficiency of control objects show significant synergism and complementation.

detailed description

To make the objectives, technical solutions and advantages of the present invention will become more apparent hereinafter in conjunction with embodiments of the present invention will be further described in detail. It should be understood that the specific embodiments described herein are merely used to explain the present invention and are not intended to limit the present invention, where the premise of the present invention, under the concept of simple modifications of the present invention prepared are within the scope of the present invention.

EXAMPLES All percentages are weight percent of the formulation below. Processing various formulations compositions of the invention are the prior art, it may vary depending on circumstances.

I. Preparation Formulation Example

(A) suspending agents and processing Example

The active ingredient is abamectin and molluscicides and amine dispersants, stabilizers, antifoam agents and solvents and other components of the formulation mixing proportion, into the autoclave after grinding the sand, fed into the mixing homomixer uniform derived products.

Example 1: 31% molluscicides amine avermectin suspension

Molluscicidal amine 30%, 1% abamectin, 8% of sodium lignin sulfonate, 4% bentonite, xanthan gum 1%, 2% silicone defoamer, soybean oil up to 100%.

Example 2: 31% molluscicides amine avermectin suspension

Molluscicidal amine 1%, 30% avermectin, naphthalenesulfonic acid formaldehyde condensates 7%, 5% of diatomaceous earth, 2% magnesium aluminum silicate, dichloroethane up to 100%.

(B) processing the microemulsion and Example

After the active ingredient is abamectin molluscicides amine was completely dissolved in the solvent, stirring, while adding an emulsifier, antifreeze agents and builders, until the above-described mixing systems, and the aqueous mixture was slowly added to the solution was sufficiently stirred to different levels of microemulsions formulated.

Example 3: 11% avermectin molluscicides amine microemulsion

Molluscicidal amine 10%, 1% abamectin, 23% acetone, alkyl polyoxyethylene ethers and polyoxyethylene nonylphenyl ether 5%, sodium nitrophenolate 2%, 1% propylene glycol, urea, 2%, water up to 100%.

Example 4: 11% avermectin molluscicides amine microemulsion

Molluscicidal amine 1% Avermectin 10%, 22% Azone, polyoxyethylene fatty acid ester, and phenethyl phenol polyoxyethylene ether 3%, 4% glycerol, 13% methanol, water ad 100% .

10% avermectin molluscicidal amine microemulsion: 5 Example

Molluscicidal amine 5%, 5% avermectin, alkylbenzene sulfonates and alkyl naphthalene sulfonate 15%, 1% chlorthalidone, 1% propylene glycol, 11% ethyl acetate, water ad 100%.

(C) processing and WP Example

The active ingredient is avermectin and molluscicides amine solvent, adjuvants uniformly mixed under mechanical stirring, after pulverizing the ultrafine pulverizer to obtain a wettable powder.

Example 6: 21% molluscicides amine salts of ethanolamine WP-avermectin

Amine salts of ethanolamine molluscicidal 20%, 1% abamectin, opened powder 4%, sodium dodecylbenzenesulfonate 5%, 6% diatoms, attapulgite clay up to 100%.

21% avermectin molluscicidal amine Wettable powders: Example 7

Molluscicidal amine 1%, 20% avermectin, butylhydroxyanisole 4%, 5% calcium ligninsulfonate, polyoxyethylene alkyl ether sulphonate 3%, 2% bentonite, white carbon 4 %, up to 100% celite.

Example 8 41% molluscicides · amine salts of ethanolamine avermectin Wettable Powder

Amine salts of ethanolamine molluscicidal 40%, 1% abamectin, 8% of sodium lignin sulfonate, polyoxyethylene octyl phenyl ether 3%, 7% kaolin, diatomaceous earth up to 100%.

Example 9 41% molluscicides · amine salts of ethanolamine avermectin Wettable Powder

Amine salts of ethanolamine molluscicidal 1% Avermectin 40%, 6% sodium lignosulfonate, 2% of white carbon, 5% of sodium dodecylbenzenesulfonate, attapulgite clay up to 100%.

Second, the efficacy verification test

(A) Toxicity activity assay

Example 1 molluscicides amine Complex as abamectin GAS Toxicity Test

1.1 Sample Agent

Molluscicidal amine original drug, Avermectin

1.2 for the test insect

Citrus red mite

1.3 Determination

The mortality was calculated, and corrected mortality in the control, in order to obtain a lethal concentration.

1.4 Data Analysis

Press molluscicidal active ingredient percentage amine: ratio of avermectins: 40: 1,30: 1,20: 1,10: 1,1: 1,1: 10,1: 20,1: 30,1: 40 test, calculated by Sun Yunpei agent exponential law virulence toxicity coefficient (CTC).

Found toxicity index (ATI) = (standard agents LC50 / test agent LC50) * 100

Theoretical toxicity index (TTI) = A * index germicide in mixture A + B is the percentage of drug toxicity index of mixture * percentage of agent B

Toxicity coefficient (CTC) = [Mixtures Found toxicity index (ATI) / agent mixture Theoretical toxicity index (TTI)] * 100

CTC≤80, compositions were antagonistic, 80 <CTC <120, the composition exhibits an additive effect, CTC≥120, the composition showed synergistic action.

Analysis of the Results Table 1 molluscicidal amine, and different ratio of avermectins Complex as apple snails virulence

The results (Table 1) show that the control effect molluscicides amine Complex as abamectin significantly increased GAS, GAS Complex as described both have a significant preventive effect. It was found that, when the required range and killing snails amine avermectin compound not according to the present invention, a synergistic effect is difficult both to GAS.

2 molluscicidal and amine salts of ethanolamine avermectin Complex as snails Toxicity Test Example

Table 2 molluscicidal and amine salts of ethanolamine avermectin Complex as snails toxicity test

The results (Table 2) shows that, molluscicides and amine salts of ethanolamine avermectin Complex as snail control effect significantly increased, indicating that both Complex as snails have a significant preventive effect. It was found that, when the required range molluscicides amine salts and ethanolamine avermectin compound not according to the present invention, both having a synergistic effect is difficult to snails.

(Ii) verification test field efficacy

Field efficacy trials for each treatment was repeated four times, at the peak of the whole plant pests uniform spray occurs. Each treated cell then take 5 points, each calibration point 10 plants, insect population base survey before treatment, according to five days after spraying the residual number of live insects was calculated decrease rate of insect, i.e. control effect. At the same time the survey whether the test crop injury symptoms. Determine the safety of the agent.

Expected control effect (%) = X + Y-XY / 100 (wherein, X, Y is a single dose anti-effect)

Table 3. molluscicidal amine abamectin Complex as melon field control effect test results snail

The measurement results (Table 3) show, molluscicides amine abamectin Control Complex as snail control effect significantly improved, both Complex as described snails significant synergy. Throughout the test, the dose range of formulation of the composition according to the invention, No phytotoxicity phenomenon melon growth, compositions of the present invention on the growth of melon safe.