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91. 发明授权

US2073207A Manufacture of ascorbic acid and its analogues 失效
标题翻译：抗坏血酸及其类似物的制造
公开(公告)号：US2073207A
公开(公告)日：1937-03-09
申请号：US3832435
申请日：1935-08-28
申请人： BRITISH DRUG HOUSES LTD
发明人： NORMAN HAWORTH WALTER , LANGLEY HIRST EDMUND , NETHERTON JONES JOHN KENYON , FRED SMITH
IPC分类号： C07D307/62
CPC分类号： C07D307/62

92. 发明授权

US1692697A Process for the manufacture of benzamine borate 失效
标题翻译：硼酸苄胺的制备方法
公开(公告)号：US1692697A
公开(公告)日：1928-11-20
申请号：US15321326
申请日：1926-12-07
申请人： BRITISH DRUG HOUSES LTD
发明人： JACKSON POPE WILLIAM
IPC分类号： C07D211/46
CPC分类号： C07D211/46

93. 发明授权

US1667249A Apparatus for comparing the color of liquids by reflected and transmitted light 失效
标题翻译：用于通过反射和透射的光比较液体的颜色的装置
公开(公告)号：US1667249A
公开(公告)日：1928-04-24
申请号：US1145125
申请日：1925-02-25
申请人： BRITISH DRUG HOUSES LTD
发明人： AUGUSTUS ELLIS HENRY
IPC分类号： G01N21/29
CPC分类号： G01N21/293

94. 发明专利

DE1618088B2 未知
公开(公告)号：DE1618088B2
公开(公告)日：1976-01-02
申请号：DE1618088
申请日：1967-02-01
申请人： THE BRITISH DRUG HOUSES LTD., LONDON
发明人： FEATHER, PETER , PETROW, VLADIMIR
IPC分类号： C07J1/00 , C07J75/00
摘要： Substituted 17alpha-buta-1',3'-diynyl-17beta-alkoxy steroids containing a group as shown in formula (I): R' = H- or C1-5 alkyl- R = C1-5 alkyl-, C1-5 hydroxyalkyl-, C1-5 alkenyl-, C1-7 alkynyl-, C1-9 aryl- Birth control An ethynyl cpd. R"-C triple bond CH is treated with cuprous chloride and a bromoethynyl cpd. R"'-C triple bond CBr in the presence of ethylamine and hydroxylamine. R"-C triple bond CH + R"'-C triple bond CBr R"-C triple bond C-C triple bond C-R"' Either R" or R"' is a steroid group in which the ethynyl- or the bromoethynyl-group is bound to C17, the other being an alkyl-, hydroxyalkyl-, alkenyl-, alkynyl- or aryl-.

95. 发明专利

DE1568115C3 未知
公开(公告)号：DE1568115C3
公开(公告)日：1975-02-20
申请号：DE1568115
申请日：1966-05-17
申请人： THE BRITISH DRUG HOUSES LTD., LONDON
发明人： BURN, DEREK , COOMBS, ROBERT VICTOR , PETROW, VLADIMIR
IPC分类号： C07J1/00 , C07J5/00 , C07J7/00 , C07J71/00 , C07J75/00
摘要： 6 - Halomethyl - D 4,6 - 3 - oxo - steroids wherein the halogen is chlorine, bromine or iodine are prepared from the corresponding 6-methylene - D 4 - 3 - oxo steroids and a hypohalous acid, preferably generated in situ from an N-halo-amide or -imide and a strong acid. Examples describe the preparation of the novel 17b - acetoxy - 6 - iodomethylandrosta-4,6 - dien - 3 - one and 21 - acetoxy - 6 - bromomethyl - 17a - hydroxypregna - 4,6 - dien-3,11,20-trione and other 6-halomethyl-D 4,6- 3-oxo-steroids which may contain hydroxy, alkoxy and acyloxy groups in rings C and D and the 17-side chain, the hydroxy groups preferably being protected by acylation or conversion to, for example, a 17a ,20 :20,21-bismethylenedioxy group; carbonyl, carbalkoxy, cyano, alkyl, methylene, halomethylene and ethylidene groups at various positions of the steroid nucleus or 17-side chain; halogen atoms; 17-spirolactone rings; and spiroketal side chains attached to ring D.

96. 发明专利

NO129855B 未知
公开(公告)号：NO129855B
公开(公告)日：1974-06-04
申请号：NO16467766
申请日：1966-09-12
申请人： BRITISH DRUG HOUSES LTD
发明人： FEATHER P , PETROW V
IPC分类号： C07C169/10

97. 发明专利

BR6680929D0 未知
公开(公告)号：BR6680929D0
公开(公告)日：1973-12-26
申请号：BR18092966
申请日：1966-07-01
申请人： BRITISH DRUG HOUSES LTD
发明人： THE BRITSH DRUG HOUSES LTD
IPC分类号： C07J1/00 , C07J75/00

98. 发明专利

BR6570119D0 未知
公开(公告)号：BR6570119D0
公开(公告)日：1973-08-02
申请号：BR17011965
申请日：1965-06-02
申请人： BRITISH DRUG HOUSES LTD
发明人： THE BRITISH DRUG HOUSES LTD
IPC分类号： A61K31/568 , A61K31/569 , A61K31/57 , A61K31/573 , A61K31/575 , A61K31/58 , C07J1/00 , C07J5/00 , C07J13/00 , C07J71/00 , C07J75/00
摘要： The invention comprises 6-hydroxymethyl-3oxo-D 4,6-steroids and their acylates; and their preparation by treatment of 3-enol ethers of 6hydroxymethyl - 3 - oxo - D 4 - steroids or their acylates (the etherifying group being an alkyl, chloralkyl, hydroxyalkyl, cycloalkyl or aralkyl radical) with dehydrogenating reagents; or by reaction of 3-enol alkyl ethers of 6-hydroxymethyl-3-oxo-D 4-steroids or their acylates with acids of at most 6 carbon atoms with an equivalent amount of a halogen in an inert solvent and in the presence of at least an equivalent amount of a strong proton acceptor; and the preparation of the 6-acyloxy compounds wherein the acyl group contains at most 10 carbon atoms by treatment of the 6-hydroxymethyl compounds with acylating reagents. The steroids which may be used as starting materials are those described in Specification 929,984 (including derivatives of testololactone) or the 6-acylates thereof, prepared by acylation. Quinones are suitable dehydrogenating reagents. Examples are given and the preparation of some starting materials by the method disclosed in Specification 929,984 is also described, as is hydrolysis of some products containing a 6-acyloxymethyl group to the 6-hydroxymethyl compounds.ALSO:A pharmaceutical preparation comprises a 6-hydroxy- or acyloxy-methyl-3-oxo-4, 6-dienic steroid in admixture with one or more solid or liquid pharmaceutically acceptable inert carriers and, if desired, an oestrogen. These preparations are stated variously to have anabolic, androgenic, gonadotrophin inhibiting, claudagenic, progestational, anti-inflammatory and anti-endotoxic properties and, when they contain an oestrogen, to be of value as oral contraceptives. They may take the form of pills or tablets, an example of the latter containing 17 a -acetoxy-6-hydroxymethylpregna-4, 6-diene-3, 20-dione and ethynyloestradiol being given.

99. 发明专利

BR6568559D0 未知
公开(公告)号：BR6568559D0
公开(公告)日：1973-08-02
申请号：BR16855965
申请日：1965-04-17
申请人： BRITISH DRUG HOUSES LTD
发明人： THE BRITISH DRUG HOUSES LTD
IPC分类号： A61K31/567 , C07J1/00 , C07J75/00

100. 发明专利

DK125173B 未知
公开(公告)号：DK125173B
公开(公告)日：1973-01-08
申请号：DK447266
申请日：1966-08-31
申请人： BRITISH DRUG HOUSES LTD
发明人： FEATHER P , PETROW V
IPC分类号： C07C169/00

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