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91. 发明授权

US09309252B2 Pyrrolopyrimidine compounds as inhibitors of CDK4/6 有权
标题翻译：吡咯并嘧啶化合物作为CDK4 / 6的抑制剂
公开(公告)号：US09309252B2
公开(公告)日：2016-04-12
申请号：US14568410
申请日：2014-12-12
申请人： Christopher Thomas Brain , Young Shin Cho , John William Giraldes , Bharat Lagu , Julian Roy Levell , Michael Joseph Luzzio , Lawrence Blas Perez , Yaping Wang , Fan Yang
发明人： Christopher Thomas Brain , Young Shin Cho , John William Giraldes , Bharat Lagu , Julian Roy Levell , Michael Joseph Luzzio , Lawrence Blas Perez , Yaping Wang , Fan Yang
IPC分类号： A01N43/90 , A61K31/519 , C07D487/04 , C07D519/00 , C07D471/08 , C07D471/10 , C07D487/08 , C07D498/08 , C07D498/20 , C07D487/10 , C07D498/10
CPC分类号： C07D487/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , C07D498/08 , C07D498/10 , C07D498/20 , C07D519/00
摘要： The invention is directed to novel pyrrolopyrimidine compounds of formula (1) wherein R1, R2y, R4, R8-R11, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译：本发明涉及式（1）的新颖的吡咯并嘧啶化合物，其中R 1，R 2y，R 4，R 8 -R 11，A和L在本文中定义，并且包括其药学上可接受的盐。本发明的化合物是CDK4 / 6抑制剂，可用于治疗由CDK4 / 6介导的疾病和病症，如癌症，包括外套细胞淋巴瘤，脂肪肉瘤，非小细胞肺癌，黑素瘤，鳞状细胞食管癌癌症和乳腺癌。本发明还涉及包含本发明化合物的药物组合物。本发明还涉及抑制CDK4 / 6活性的方法以及使用本发明化合物或包含本发明化合物的药物组合物治疗与之相关的病症。

92. 发明申请

US20150344897A1 MONOCOTYLEDON TRANSGENIC METHOD FOR INVADING GROWING POINTS OF SEED BUDS MINIMALLY AND FULLY 审中-公开
标题翻译：用于将种子的生长点投入到最小和完全的单烯基转移方法
公开(公告)号：US20150344897A1
公开(公告)日：2015-12-03
申请号：US14422661
申请日：2012-09-14
申请人： Haibo Wang , Fushuang Dong , Mengyu Lv , Yanmin Zhang , Zhiheng Ren , Fan Yang , Xinchao Liang , Wenbo Zuo , Xueping Shi , Huanhuan Zhang , Yiping Gao , He Zhao , Xian Xu , Guozhong Sun , Jianfang Chai , Yongwei Liu , Jinyong Zhu , Qiufen Han , Qiang Zhang , Huijie Ma , Zhanwu Wang , Junfeng Guan
发明人： Haibo Wang , Fushuang Dong , Mengyu Lv , Yanmin Zhang , Zhiheng Ren , Fan Yang , Xinchao Liang , Wenbo Zuo , Xueping Shi , Huanhuan Zhang , Yiping Gao , He Zhao , Xian Xu , Guozhong Sun , Jianfang Chai , Yongwei Liu , Jinyong Zhu , Qiufen Han , Qiang Zhang , Huijie Ma , Zhanwu Wang , Junfeng Guan
IPC分类号： C12N15/82
CPC分类号： C12N15/8205 , C12N15/8207
摘要： The present invention is a method of shoot apical meristem transformation for monocot plant via sufficient and micro wounding (SMW). The technical process includes: expose the apical meristem by removing the coleoptile away when the shoot grows to 0.2-2 cm after 1-2 days of seed germination; make sufficient and micro wounding transformation to the apical meristem by stabbing and brushing for 2-3 times using the SMW brush having 100-5000 bristles which is 4-20 μm in diameter for each one and 0.5-3 mm in exposed length, and dipped with the Agrobacterium tumefaciens containing binary vector harboring exogenous genes; develop the treated meristems directly to normal plants after co-cultivation; promote the plants to develop big spikes and set more seeds; harvest the seeds of T0 plants separately; detect and identify the transformation results in T1 generation which is bred from each individual T0 plant. The advantages of the invention are independent of tissue culture, unlimited in genotype, unnecessary to carry resistant marker, simple and large scale to perform, and applicable to all monocot plants which can set seeds. The transformation efficiencies for wheat, rice and maize using this method are 49%, 66.3%, and 100%, respectively.
摘要翻译：本发明是通过足够和微伤（SMW）的单子叶植物的茎顶分生组织转化的方法。技术过程包括：通过在种子发芽1-2天后枝条生长至0.2-2厘米时，通过去除胚芽鞘来揭开顶端分生组织; 使用具有直径为4-20μm，暴露长度为0.5-3mm的直径为4-20μm的100-5000个刷毛的SMW刷，通过刺入和刷刷2-3次来对顶端分生组织进行充分和微小的伤口转化，并浸渍含有包含外源基因的二元载体的根癌农杆菌; 共培养后将经处理的分生组织直接发育至正常植物; 促进植物发展大穗，种植更多种子; 分别收获T0植物的种子; 检测和识别从每个T0植物繁殖的T1代转化结果。本发明的优点独立于组织培养，基因型无限，不需携带抗性标记，简单大规模进行，适用于可以设置种子的所有单子叶植物。使用该方法对小麦，水稻和玉米的转化效率分别为49％，66.3％和100％。

93. 发明授权

US09141779B2 Usable security of online password management with sensor-based authentication 有权
标题翻译：使用基于传感器身份验证的在线密码管理的可用安全性
公开(公告)号：US09141779B2
公开(公告)日：2015-09-22
申请号：US13110939
申请日：2011-05-19
申请人： Guobin Shen , Fan Yang , Lidong Zhou
发明人： Guobin Shen , Fan Yang , Lidong Zhou
IPC分类号： G06F21/00 , G06F21/32 , H04L9/32 , H04L9/08 , H04L29/06
CPC分类号： G06F21/32 , H04L9/0866 , H04L9/32 , H04L9/3231 , H04L9/3271 , H04L63/0815 , H04L63/0861 , H04L2209/805 , H04L2463/082
摘要： A multi-party security protocol that incorporates biometric-based authentication and withstands attacks against any single party (e.g., mobile phone, cloud, or the user). The protocol involves the function split between mobile and cloud and the mechanisms to chain-hold the secrets. A key generation mechanisms binds secrets to a specific device or URL (uniform resource locator) by adding salt to a master credential. An inline CAPTCHA (Completely Automated Public Turing test to tell Computers and Humans Apart) handling mechanism uses the same sensor modality as the authentication process, which not only improves the usability, but also facilitates the authentication process. This architecture further enhances existing overall system security (e.g., handling untrusted or compromised cloud service, phone being lost, impersonation, etc.) and also improves the usability by automatically handling the CAPTCHA.
摘要翻译：一种多方安全协议，其包含基于生物特征的身份验证，并且可以对任何一方（例如手机，云端或用户）进行攻击。协议涉及移动和云之间的功能分割以及链接保密机制。密钥生成机制通过向主凭证添加salt来将秘密绑定到特定设备或URL（统一资源定位符）。内部人机识别（全面自动化公众图灵测试，告诉计算机和人员）处理机制采用与认证过程相同的传感器模式，这不仅提高了可用性，而且有助于认证过程。该架构进一步增强了现有的整体系统安全性（例如，处理不受信任或受到损害的云服务，电话丢失，冒充等），并且还通过自动处理CAPTCHA来提高可用性。

94. 发明申请

US20150167049A1 DETECTION AND DISTINCTION OF TRICHOMONAS AND CANDIDA 审中-公开
标题翻译：三叉戟和坎迪达的检测和分类
公开(公告)号：US20150167049A1
公开(公告)日：2015-06-18
申请号：US14594581
申请日：2015-01-12
申请人： Zeyu Wang , Hongyun Yang , Guangyu Fu , Xuewei Wu , Chaojie Feng , Yang Yang , Jingjing Yang , Yuanyuan Xie , Yehuan Zheng , Guilin Li , Fan Yang
发明人： Zeyu Wang , Hongyun Yang , Guangyu Fu , Xuewei Wu , Chaojie Feng , Yang Yang , Jingjing Yang , Yuanyuan Xie , Yehuan Zheng , Guilin Li , Fan Yang
IPC分类号： C12Q1/40
CPC分类号： C12Q1/40 , C12Q1/04 , C12Q1/34 , G01N2333/40 , G01N2333/44 , G01N2333/924
摘要： A method and a kit for the detection of Trichomonas infection by detecting N-acetyl-β-D-hexosaminidase activity in a sample, and a method and a kit for the detection of Trichomonas or Candida infection by detecting N-acetyl-β-D-hexosaminidase activity in a sample. The presence of a Trichomonas or a Candida infection can be distinguished by a pH of the sample.
摘要翻译：通过检测样品中的N-乙酰基-β-D-氨基己糖苷酶活性来检测毛滴虫感染的方法和试剂盒，以及通过检测N-乙酰基 - bgr检测毛滴虫或念珠菌感染的方法和试剂盒; -D-己糖胺酶活性。可以通过样品的pH来区分毛滴虫或念珠菌感染的存在。

95. 发明申请

US20140219972A1 TISSUE ENGINEERING USING PROGENITOR CELLS TO CATALYZE TISSUE FORMATION BY PRIMARY CELLS 审中-公开
标题翻译：组织工程使用原核细胞催化原代细胞组织形成
公开(公告)号：US20140219972A1
公开(公告)日：2014-08-07
申请号：US14173628
申请日：2014-02-05
申请人： Janice Lai , William Maloney , R. Lane Smith , Fan Yang
发明人： Janice Lai , William Maloney , R. Lane Smith , Fan Yang
IPC分类号： A61K35/12 , A61K35/32
CPC分类号： A61K35/35 , A61K35/28 , A61K35/32 , A61K35/34 , A61K35/51 , A61K35/545
摘要： Methods of regenerating tissue using progenitor cells in combination with primary cells from a target tissue are disclosed. In particular, progenitor cells catalyze proliferation and tissue production by primary cells allowing the use of fewer primary cells from a target tissue for effective tissue regeneration. Cell-based therapies combining progenitor cells and primary cells can be used for repair and regeneration of damaged tissue and organs for treating bodily injuries and degenerative diseases. For example, adipose-derived stem cells and neonatal articular chondrocytes, co-encapsulated in mixed or bilayered cultures in a hydrogel comprising chondroitin sulfate methacrylate and poly(ethylene)glycol diacrylate, generated cartilage that could be used for treatment of traumatic injuries or diseases involving cartilage degeneration. Moreover, the inventors showed that progenitor cells could be used to stimulate cartilage formation with a minimal number of primary cells, as few as 1% or less, in mixed cultures containing primary cells and progenitor cells.
摘要翻译：公开了使用祖细胞与来自靶组织的原代细胞组合再生组织的方法。特别地，祖细胞催化原代细胞的增殖和组织产生，从而允许使用较少的来自靶组织的原代细胞用于有效的组织再生。结合祖细胞和原代细胞的基于细胞的疗法可用于损伤组织和器官的修复和再生，用于治疗身体损伤和退行性疾病。例如，由包含硫酸软骨素甲基丙烯酸酯和聚（乙二醇）二丙烯酸酯的水凝胶共混包封在混合或双层培养物中的脂肪来源的干细胞和新生儿关节软骨细胞产生的软骨可用于治疗创伤性损伤或涉及软骨变性。此外，发明人显示，在含有原代细胞和祖细胞的混合培养物中，祖细胞可用于刺激在最少数量的原代细胞中形成软骨，少至1％或更少。

96. 发明申请

US20140084137A1 SWITCHABLE SUBSTRATES FOR PHOTOGRAPHY AND VIDEO ENHANCEMENT APPLICATIONS 审中-公开
标题翻译：用于摄影和视频增强应用的可切换基板
公开(公告)号：US20140084137A1
公开(公告)日：2014-03-27
申请号：US13629189
申请日：2012-09-27
申请人： Wilhelmus A. de Groot , Nicholas I. Buchan , Fan Yang , Philip D. Floyd , Russel A. Martin
发明人： Wilhelmus A. de Groot , Nicholas I. Buchan , Fan Yang , Philip D. Floyd , Russel A. Martin
IPC分类号： H01L27/146
CPC分类号： H01L27/14625 , G01J3/0229 , G01J2003/2826 , G02B26/001 , G02B26/007 , G03B19/12 , H01L27/14685 , H04N5/2254 , H04N5/2355 , H04N5/238 , H04N5/332
摘要： This disclosure provides systems, methods and apparatus relating to implementations of a switchable substrate that can be used in an imaging device. In one aspect, the switchable substrate includes a plurality of pixels, with each pixel having at least one switchable element. The switchable element can be switched between a first optical state and a second optical state. In the first optical state, a first spectral band of broadband light is reflected from the switchable element while a second spectral band is transmitted through the switchable element. In the second optical state, the first spectral band of the broadband light is transmitted through the switchable element while the second spectral band is reflected from the switchable element.
摘要翻译：本公开提供了可用于成像装置中的可切换基板的实现的系统，方法和装置。在一个方面，可切换基板包括多个像素，每个像素具有至少一个可切换元件。可切换元件可以在第一光学状态和第二光学状态之间切换。在第一光学状态中，宽带光的第一光谱带从可切换元件反射，而第二光谱带透过可切换元件。在第二光学状态下，宽带光的第一光谱带通过可切换元件传输，而第二光谱带从可切换元件反射。

97. 发明授权

US08546336B2 SMAC peptidometics useful as IAP inhibitors 有权
标题翻译： SMAC肽酶用作IAP抑制剂
公开(公告)号：US08546336B2
公开(公告)日：2013-10-01
申请号：US13606676
申请日：2012-09-07
申请人： Zhuoliang Chen , Mark G. Charest , Christine Hiu-Tung Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
发明人： Zhuoliang Chen , Mark G. Charest , Christine Hiu-Tung Chen , Miao Dai , Feng He , Huangshu Lei , Ly Luu Pham , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming David Wang , Fan Yang , Leigh Zawel
IPC分类号： A61K38/00
CPC分类号： C07D417/04 , A61K31/427 , A61K45/06 , C07K5/06191
摘要： The present invention is directed to a compound of the formula: or pharmaceutically acceptable salts thereof and use of such compounds for treating proliferative diseases such as cancer, in mammals.
摘要翻译：本发明涉及下式的化合物或其药学上可接受的盐，以及在哺乳动物中用于治疗增殖性疾病例如癌症的用途。

98. 发明申请

US20130249293A1 FUNCTIONAL BACK GLASS FOR A SOLAR PANEL 审中-公开
标题翻译：太阳能面板功能背玻璃
公开(公告)号：US20130249293A1
公开(公告)日：2013-09-26
申请号：US13430533
申请日：2012-03-26
申请人： Fan Yang , Gaurav Sethi , Evgeni Petrovich Gousev , Patrick Forrest Brinkley , Ravindra V. Shenoy , Sijin Han
发明人： Fan Yang , Gaurav Sethi , Evgeni Petrovich Gousev , Patrick Forrest Brinkley , Ravindra V. Shenoy , Sijin Han
IPC分类号： H02J1/10 , H01L31/18 , H02M7/5387
CPC分类号： H01L31/02021 , H02S40/32 , Y02E10/50 , Y10T307/50
摘要： A photovoltaic solar panel includes a front glass, a back glass, and a photovoltaic (PV) power generating layer encapsulated between the front glass and the back glass. The PV power generating layer is configured to convert ambient electromagnetic energy, received through the front glass, to a direct current (DC) power output. The PV solar panel also includes at least one component, disposed behind the PV power generating layer, selected from the group consisting of: a direct current to alternating current (DC-AC) inverter configured to convert the DC power output from the PV power generator to an alternating current (AC) power output, a battery, and an antenna.
摘要翻译：光伏太阳能电池板包括前玻璃，后玻璃和封装在前玻璃和后玻璃之间的光伏（PV）发电层。 PV发电层被配置为将通过前玻璃接收的环境电磁能转换成直流（DC）功率输出。 PV太阳能电池板还包括设置在PV发电层后面的至少一个部件，该组件选自以下的组：直流到交流（DC-AC）逆变器，被配置为转换从光伏发电机输出的直流电力交流电（AC）电力输出，电池和天线。

99. 发明授权

US08499612B2 Hydrogen gas detection using single palladium nanowires 有权
标题翻译：使用单一钯纳米线进行氢气检测
公开(公告)号：US08499612B2
公开(公告)日：2013-08-06
申请号：US12766743
申请日：2010-04-23
申请人： Fan Yang , Reginald M. Penner
发明人： Fan Yang , Reginald M. Penner
IPC分类号： G01N7/00
CPC分类号： G01N33/005 , G01N27/127
摘要： Devices and methods for fast, sensitive hydrogen gas detection using a single palladium nanowire. In one embodiment, a hydrogen sensor comprises a palladium nanowire extending between metal contacts. The palladium nanowire is not subject to fracturing when exposed to hydrogen. The nanowire is able to rapidly and reversibly detect hydrogen as a resistance increase down to 2 ppm with excellent reproducibility and baseline stability at room temperature.
摘要翻译：使用单一钯纳米线进行快速灵敏氢气检测的装置和方法。在一个实施例中，氢传感器包括在金属触点之间延伸的钯纳米线。钯纳米线在暴露于氢气时不会发生断裂。纳米线能够快速和可逆地检测氢，作为电阻增加低至2ppm，具有优异的再现性和室温下的基线稳定性。

100. 发明申请

US20130185054A1 TECHNIQUES FOR INSERTING DIACRITICAL MARKS TO TEXT INPUT VIA A USER DEVICE 有权
标题翻译：通过用户设备将双向标记插入文本输入的技术
公开(公告)号：US20130185054A1
公开(公告)日：2013-07-18
申请号：US13565056
申请日：2012-08-02
申请人： Xiangye Xiao , Yuanbo Zhang , Vincent Ngo Bao Khoi , Fan Yang , Baohua Liao , Hanping Feng
发明人： Xiangye Xiao , Yuanbo Zhang , Vincent Ngo Bao Khoi , Fan Yang , Baohua Liao , Hanping Feng
IPC分类号： G06F17/27
CPC分类号： G06F17/214 , G06F3/018 , G06F17/2223 , G06F17/276
摘要： A computer-implemented method for assisting a user to input Vietnamese text to a user device lacking a subset of characters in a Vietnamese alphabet includes receiving a character input by a user, determining three words previously input by the user, the three words having already had diacritical marks inserted, transmitting the three words and the character to a server via a network, receiving first and second information corresponding to the character from the server via the network, the first and second information generated at the server based on a context of the three words, the context determined at the server using a language model, the first and second information indicating whether the character requires a diacritical mark and a specific diacritical mark, respectively, generating a modified character comprising a character in the Vietnamese alphabet based on the character and the first and second information, and displaying the modified character.
摘要翻译：用于辅助用户将越南语文本输入到越南字母中缺少字符子集的用户设备的计算机实现的方法包括：接收用户输入的字符，确定用户先前输入的三个字，已经有三个字插入的变音标记，经由网络将三个字和字符发送到服务器，经由网络从服务器接收对应于该字符的第一和第二信息，基于三个上下文的服务器生成的第一和第二信息单词，使用语言模型在服务器处确定的上下文，分别指示角色是否需要变音标记和特定变音符号的第一和第二信息，生成包括基于字符的越南字母表中的字符的修改字符;以及第一和第二信息，并显示修改的字符。

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