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91. 发明授权

US10927086B2 Substituted sulfoximine compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors 有权
公开(公告)号：US10927086B2
公开(公告)日：2021-02-23
申请号：US16483957
申请日：2018-02-19
申请人： Merck Sharp & Dohme Corp. , Kun Liu , Dane Clausen , Liangqin Guo , Yongxin Han , Shuwen He , Joseph Kozlowski , Derun Li , Qinglin Pu , Wensheng Yu , Hongjun Zhang
发明人： Kun Liu , Dane Clausen , Liangqin Guo , Yongxin Han , Shuwen He , Joseph Kozlowski , Derun Li , Qinglin Pu , Wensheng Yu , Hongjun Zhang
IPC分类号： C07D271/08 , C07D413/12
摘要： Compounds of Formula I, or a pharmaceutically acceptable salt, solvate or hydrate thereof: (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

92. 发明授权

US09780427B2 Bandpass filter and method of fabricating the same 有权
公开(公告)号：US09780427B2
公开(公告)日：2017-10-03
申请号：US14406211
申请日：2012-06-21
申请人： Bo Zhou , Junyou Chen , Kun Liu
发明人： Bo Zhou , Junyou Chen , Kun Liu
IPC分类号： H01P3/08 , H01P1/203 , H01P11/00 , H01P5/02
CPC分类号： H01P1/20309 , H01P1/20345 , H01P5/028 , H01P11/007
摘要： The invention provides a bandpass filter, comprising: a substrate with a plurality of dielectric layers; a plurality of resonators; and a plurality of ground layers each having one slot arranged on; wherein the plurality of resonators are arrayed vertically each on respective one of the plurality of dielectric layers alternately without any of offsets, and each of the plurality of ground layers is between adjacent dielectric layers. Adjacent slots are arranged in opposite sides of the ground layers. The invention also provides a method of fabricating the bandpass filter.

93. 发明申请

US20170247377A1 DIAZINE-FUSED AMIDINES AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE 有权
公开(公告)号：US20170247377A1
公开(公告)日：2017-08-31
申请号：US15512081
申请日：2015-09-14
申请人： Kun LIU , Shuwen HE , Jared N. CUMMING , Andrew W. STAMFORD , Merck Sharp & Dohme Corp.
发明人： Kun Liu , Shuwen He , Jared N. Cumming , Andrew W. Stamford
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K45/06 , A61P25/00
摘要： In its many embodiments, the present invention provides certain C-6 spirocarbocyclic iminothiadiazine compounds, including compounds Formula (I) or a tautomer thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1A, R1B, R2, RA, ring A, RA, m, L1, RL, ring C, RC, and p are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

94. 发明授权

US09487506B2 Mineralocorticoid receptor antagonists 有权
公开(公告)号：US09487506B2
公开(公告)日：2016-11-08
申请号：US14110441
申请日：2012-04-11
申请人： Ping Lan , Kun Liu , Anthony Ogawa , Hong Shen , Christine Yang , Yuguang Wang , Richard Beresis , Changhe Qi
发明人： Ping Lan , Kun Liu , Anthony Ogawa , Hong Shen , Christine Yang , Yuguang Wang , Richard Beresis , Changhe Qi
IPC分类号： C07D413/06 , A61K31/4245 , C07D401/04 , A61K31/4439 , C07D231/56 , A61K31/416
CPC分类号： C07D413/06 , A61K31/416 , A61K31/4245 , A61K31/4439 , C07D231/56 , C07D401/04
摘要： Compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that may be useful for treating aldosterone-mediated diseases are disclosed. Processes for preparing compounds of the Formula (I), use of the compounds for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and pharmaceutical compositions which comprise compounds of the Formula (I) are disclosed.

95. 发明授权

US09462491B2 Method and device for processing standard version mode of base station, terminal and base station 有权
标题翻译：处理基站，终端和基站标准版本模式的方法和装置
公开(公告)号：US09462491B2
公开(公告)日：2016-10-04
申请号：US14398543
申请日：2012-06-21
申请人： Zhaohua Lu , Xiaodan Zhang , Kun Liu
发明人： Zhaohua Lu , Xiaodan Zhang , Kun Liu
IPC分类号： H04W4/00 , H04W24/02 , H04W88/10 , H04W88/08
CPC分类号： H04W24/02 , H04W88/08 , H04W88/10
摘要： Provided are a method and device for processing a standard version mode of a base station, a terminal and a base station. A base station working in a first standard version mode judges whether a working mode of the base station needs to be adjusted, the first standard version mode is a mode of providing services for a first standard version terminal at least supporting a first standard version. If a judging result is yes, the base station adjusts the first standard version mode to another standard version mode, wherein said another standard version mode is a mode of providing services for other standard version terminals at least supporting another standard version other than the first standard version. Through the solutions, the problem that the system spectrum efficiency is hard to improve effectively and the networking flexibility is low due to the excessive emphasis on backward compatibility can be solved.
摘要翻译：提供一种用于处理基站，终端和基站的标准版本模式的方法和装置。以第一标准版本模式工作的基站判断是否需要调整基站的工作模式，第一标准版本模式是为第一标准版本终端提供至少支持第一标准版本的服务的模式。如果判断结果为是，则基站将第一标准版本模式调整为另一标准版本模式，其中所述另一标准版本模式是为其他标准版本终端提供至少支持除第一标准之外的另一标准版本的服务的模式版。通过解决方案，可以解决系统频谱效率难以有效提高的问题，由于过度强调向后兼容性，网络灵活性较低。

96. 发明授权

US09126957B2 Selective glycosidase inhibitors and uses thereof 有权
标题翻译：选择性糖苷酶抑制剂及其用途
公开(公告)号：US09126957B2
公开(公告)日：2015-09-08
申请号：US14238481
申请日：2012-08-10
申请人： Harold G. Selnick , Kun Liu , Ernest J. McEachern , Yuanxi Zhou , Yongbao Zhu
发明人： Harold G. Selnick , Kun Liu , Ernest J. McEachern , Yuanxi Zhou , Yongbao Zhu
IPC分类号： A61K31/423 , A61K31/428 , C07D263/58 , C07D413/04 , C07D417/04 , C07D277/60 , C07D277/82
CPC分类号： C07D263/58 , A61K31/423 , A61K31/428 , C07D277/60 , C07D277/82 , C07D413/04 , C07D417/04
摘要： The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, and/or accumulation or deficiency of O-GlcNAc.
摘要翻译：本发明涉及用于选择性抑制糖苷酶的化合物，化合物的用途和包含该化合物的药物组合物，以及治疗与O-GlcNAC的缺乏或过度表达有关的疾病和障碍和/或O-GlcNAc的积累或缺陷的方法。

97. 发明授权

US09080096B2 Oil displacement agent and process for preparing the same 有权
标题翻译：排油代理及其制备方法
公开(公告)号：US09080096B2
公开(公告)日：2015-07-14
申请号：US13007549
申请日：2011-01-14
申请人： Huanquan Sun , Zhenquan Li , Xulong Cao , Guangsu Huang , Xinwang Song , Xiaohong Cui , Kun Liu , Jing Zheng , Xiaoyan Chen , Zhiqing Su , Zuming Jiang , Jinrong Wu
发明人： Huanquan Sun , Zhenquan Li , Xulong Cao , Guangsu Huang , Xinwang Song , Xiaohong Cui , Kun Liu , Jing Zheng , Xiaoyan Chen , Zhiqing Su , Zuming Jiang , Jinrong Wu
IPC分类号： C08F220/56 , C08F218/02 , C08F4/40 , C09K8/588 , C02F101/32 , C08F226/02 , C08F220/34 , C10G1/00
CPC分类号： C09K8/588 , C02F2101/32 , C08F4/40 , C08F218/02 , C08F220/34 , C08F220/56 , C08F226/02 , C08F2218/22 , C10G1/00
摘要： The present invention relates to a new type of oil displacement agent and the process for preparing the same. The oil displacement agent is formed of a polyacrylamide-based polymer characterized by a partly crosslinked and partly branched structure, wherein said polyacrylamide-based polymer is obtained by aqueous copolymerization of acrylamide and N,N-dimethylaminoethyl methacrylate as a functional monomer, in the presence of a redox initiator system.
摘要翻译：本发明涉及新型排油剂及其制备方法。排油剂由聚丙烯酰胺类聚合物形成，其特征在于部分交联和部分支化结构，其中所述聚丙烯酰胺类聚合物通过丙烯酰胺和作为官能单体的N，N-二甲基氨基乙基甲基丙烯酸酯的水共聚获得，的氧化还原引发剂体系。

98. 发明申请

US20150131549A1 METHOD AND DEVICE FOR PROCESSING STANDARD VERSION MODE OF BASE STATION, TERMINAL AND BASE STATION 有权
标题翻译：用于处理基站，终端和基站的标准版本模式的方法和装置
公开(公告)号：US20150131549A1
公开(公告)日：2015-05-14
申请号：US14398543
申请日：2012-06-21
申请人： Zhaohua Lu , Xiaodan Zhang , Kun Liu
发明人： Zhaohua Lu , Xiaodan Zhang , Kun Liu
IPC分类号： H04W24/02 , H04W88/08
CPC分类号： H04W24/02 , H04W88/08 , H04W88/10
摘要： Provided are a method and device for processing a standard version mode of a base station, a terminal and a base station. A base station working in a first standard version mode judges whether a working mode of the base station needs to be adjusted, the first standard version mode is a mode of providing services for a first standard version terminal at least supporting a first standard version. If a judging result is yes, the base station adjusts the first standard version mode to another standard version mode, wherein said another standard version mode is a mode of providing services for other standard version terminals at least supporting another standard version other than the first standard version. Through the solutions, the problem that the system spectrum efficiency is hard to improve effectively and the networking flexibility is low due to the excessive emphasis on backward compatibility can be solved.
摘要翻译：提供一种用于处理基站，终端和基站的标准版本模式的方法和装置。以第一标准版本模式工作的基站判断是否需要调整基站的工作模式，第一标准版本模式是为第一标准版本终端提供至少支持第一标准版本的服务的模式。如果判断结果为是，则基站将第一标准版本模式调整为另一标准版本模式，其中所述另一标准版本模式是为其他标准版本终端提供至少支持除第一标准之外的另一标准版本的服务的模式版。通过解决方案，可以解决系统频谱效率难以有效提高的问题，由于过度强调向后兼容性，网络灵活性较低。

99. 发明授权

US08958075B2 Swing-style and high signal-to-noise ratio demodulation devices and corresponding demodulation method for the measurement of low coherence interference displacement 有权
标题翻译：摆动式和高信噪比解调装置及相应的解调方法用于测量低相干干涉位移
公开(公告)号：US08958075B2
公开(公告)日：2015-02-17
申请号：US13880730
申请日：2012-05-28
申请人： Tiegen Liu , Junfeng Jiang , Jinde Yin , Kun Liu , Shaohua Wang
发明人： Tiegen Liu , Junfeng Jiang , Jinde Yin , Kun Liu , Shaohua Wang
IPC分类号： G01B9/02 , G02B6/293 , G02B6/32 , G02B5/30
CPC分类号： G01B9/0209 , G01B9/02057 , G01B9/02065 , G02B5/3083 , G02B6/29302 , G02B6/32 , G02B2207/117
摘要： Swing-style demodulation device for measuring displacement information, including (1) a broadband light source, (2) an optical circulator, (3) GRIN lens, (4) a fixed mirror on an object under test, (5) a collimating device, (6) a rotating mirror, (7) f-θ lens, (8) a polarizer, (9) a narrow strip shaped birefringent wedge, (10) a polarization analyzer, and (11) a signal acquisition system.
摘要翻译：用于测量位移信息的摆动式解调装置，包括（1）宽带光源，（2）光环行器，（3）GRIN透镜，（4）待测物体上的固定镜，（5）准直装置，（6）旋转镜，（7）f-＆thetas; 透镜，（8）偏振片，（9）窄条状双折射楔形物，（10）偏振分析器，以及（11）信号采集系统。

100. 发明授权

US08933040B2 Selective glycosidase inhibitors and uses thereof 有权
标题翻译：选择性糖苷酶抑制剂及其用途
公开(公告)号：US08933040B2
公开(公告)日：2015-01-13
申请号：US13884061
申请日：2011-11-08
申请人： Craig A. Coburn , Kun Liu , Ernest J. McEacher , Changwei Mu , Harold G. Selnick , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou
发明人： Craig A. Coburn , Kun Liu , Ernest J. McEacher , Changwei Mu , Harold G. Selnick , David J. Vocadlo , Yaode Wang , Zhongyong Wei , Yuanxi Zhou
IPC分类号： C08B37/00 , C07D487/02 , A61K31/70 , A61K31/425 , C07D513/14 , C07D513/04 , C07H9/06 , C07H13/04 , C07H13/12 , C07H15/18 , C12Q1/48
CPC分类号： C07D513/14 , C07D513/04 , C07H9/06 , C07H13/04 , C07H13/12 , C07H15/18 , C12Q1/48 , G01N2500/02
摘要： The invention provides compounds for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
摘要翻译：本发明提供了用于选择性抑制糖苷酶，化合物前药和包含化合物的化合物或前药的药物组合物的化合物。本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。

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