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91. 发明申请

US20030152609A1 Devices and methods for reducing scar tissue formation 审中-公开
标题翻译：用于减少瘢痕组织形成的装置和方法
公开(公告)号：US20030152609A1
公开(公告)日：2003-08-14
申请号：US10072177
申请日：2002-02-11
发明人： Robert E. Fischell , David R. Fischell , Tim A. Fischell
IPC分类号： A61L015/00
CPC分类号： A61B17/06166 , A61B17/064 , A61B2017/00831 , A61F2/0063 , A61F2013/00451 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/424 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2300/626
摘要： Disclosed is a cytostatic drug attached to a sterile sheet that is designed to be placed between internal body tissues to prevent the formation of post-operative adhesions, which adhesions are really scar tissue formation. This sheet onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. By impregnating an existing product such as the Johnson & Johnson SURGICELnull absorbable hemostat gauze-like sheet with an anti-proliferative drug such as sirolimus, the biodegradable, drug impregnated mesh would act as a barrier to cell proliferation and hence be a deterrent to the formation of adhesions or scar tissue. Another embodiment of this invention is a cytostatic drug attached to a sheet that is placed at the site of an anastamosis to decrease scar tissue formation from within the vessel at the site of the anastomosis.
摘要翻译：公开了附着在无菌片上的细胞生长抑制药物，其被设计为放置在体内组织之间以防止术后粘连的形成，这些粘连真的是瘢痕组织形成。药物放置在药物上或其中的片材可以是永久植入物，也可以是可生物降解的。通过用诸如西罗莫司之类的抗增殖药物浸渍诸如Johnson＆Johnson SURGICEL TM可吸收止血纱布片之类的现有产品，可生物降解的药物浸渍网将作为细胞增殖的障碍，因此成为威慑形成粘连或瘢痕组织。本发明的另一个实施方案是连接到片材上的细胞生长抑制药物，其被放置在吻合部位以减少在吻合部位的血管内的瘢痕组织形成。

92. 发明申请

US20020055701A1 Surgically implanted devices having reduced scar tissue formation 有权
标题翻译：具有减少瘢痕组织形成的手术植入装置
公开(公告)号：US20020055701A1
公开(公告)日：2002-05-09
申请号：US09772693
申请日：2001-01-31
发明人： Robert E. Fischell , David R. Fischell , Tim A. Fischell , Scott J.S. Fischell
IPC分类号： A61F013/00
CPC分类号： A61L27/54 , A61B17/06166 , A61B17/064 , A61B2017/00831 , A61F2/0063 , A61F2013/00451 , A61L15/44 , A61L31/16 , A61L2300/416 , A61L2300/424 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2300/626
摘要： This invention is an anti-proliferative drug placed onto or within a sterile sheet or mesh that is designed to be placed between internal body tissues to prevent the formation of post-operative adhesions, which adhesions are really scar tissue formation. This mesh or gauze onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. By impregnating an existing product such as the Johnson & Johnson SURGICELnull absorbable hemostat gauze-like sheet with an anti-proliferative drug such as Rapamycin or Taxol, the biodegradable, drug impregnated mesh would act as a barrier to cell proliferation and hence be a deterrent to the formation of adhesions. Another embodiment of this invention is an anti-proliferative drug attached to a bandage that is placed onto a cut in the skin to decrease scar tissue formation. Still another embodiment of the invention is an anti-proliferative drug that is attached to a surgical suture or coated onto a surgical staple both of which are used for connecting human tissues. The suture or staple then being more capable for decreasing cellular proliferation where the suture or staple material passes through the human tissue.
摘要翻译：本发明是一种抗增殖药物，其放置在无菌片或网上或设计成放置在内部身体组织之间或之内，以防止形成术后粘连，这些粘连真的是瘢痕组织形成。放置药物的药物或纱布可以是永久植入物，也可以是可生物降解的。通过用抗增殖药物如雷帕霉素或紫杉醇浸渍现有产品如Johnson＆Johnson SURGICEL TM可吸收的止血纱布状片材，可生物降解的药物浸渍网将作为细胞增殖的屏障，因此阻碍形成粘连。本发明的另一个实施方案是附着到绷带上的抗增殖药物，其被放置在皮肤上的切口上以减少瘢痕组织形成。本发明的另一个实施方案是附着于外科缝合线或涂在手术缝合钉上的抗增殖药物，它们都用于连接人体组织。缝合线或缝合线当缝合线或短纤维材料穿过人体组织时更能够减少细胞增殖。

93. 发明申请

US20020009485A1 Drug delivery via therapeutic hydrogels 失效
公开(公告)号：US20020009485A1
公开(公告)日：2002-01-24
申请号：US09818649
申请日：2001-03-28
发明人： Frank DiCosmo , Valerio DiTizio
IPC分类号： A61K009/70
CPC分类号： A61L27/52 , A61K9/127 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/145 , A61L29/16 , A61L2300/406 , A61L2300/414 , A61L2300/42 , A61L2300/43 , A61L2300/436 , A61L2300/626
摘要： The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.

94. 发明申请

US20020001624A1 MEDICINAL PRODUCT FOR THE PROMOTION OF WOUND HEALING 审中-公开
标题翻译：促进创伤治疗的药物产品
公开(公告)号：US20020001624A1
公开(公告)日：2002-01-03
申请号：US09351985
申请日：1999-07-12
发明人： FRIEDRICH BRAUN , HANS-PETER SPANGLER , JOHANN EIBL
IPC分类号： A61K038/00 , A61K035/14 , A61K009/00 , A61K035/18
CPC分类号： A61L24/0005 , A61K35/19 , A61K35/36 , A61K35/54 , A61K38/363 , A61K38/39 , A61K38/4833 , A61L24/0015 , A61L26/0057 , A61L26/0066 , A61L2300/252 , A61L2300/414 , A61L2300/626 , A61L2300/64 , A61K2300/00
摘要： The invention relates to a medicinal product for topical use for the promotion of wound healing, which comprises thrombocytes or thrombocyte fragments, wherein the thrombocytes or thrombocyte fragments contain growth factors and are capable of releasing the same and are present in the lyophilized or deep-frozen state and have been subjected to a process for virus partitioning and/or virus inactivation.
摘要翻译：本发明涉及一种用于促进伤口愈合的局部用药物，其包含凝血细胞或血小板细胞片段，其中血小板或血小板细胞片段含有生长因子并能够释放其并存在于冻干或深冻状态，并且已经进行病毒分解和/或病毒灭活的过程。

95. 发明授权

US5707969A Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor 失效
公开(公告)号：US5707969A
公开(公告)日：1998-01-13
申请号：US480320
申请日：1995-06-07
申请人： Elizabeth G. Nabel , Gary J. Nabel
发明人： Elizabeth G. Nabel , Gary J. Nabel
IPC分类号： A61B17/22 , A61K9/00 , A61K39/00 , A61K47/48 , A61K48/00 , A61L29/16 , C12N15/63 , C12N15/79 , C12N15/09
CPC分类号： A61K39/00 , A61B17/22 , A61K31/70 , A61K47/48992 , A61K48/00 , A61K9/0024 , A61L29/16 , A61B2017/22038 , A61B2017/22054 , A61B2017/22082 , A61B2017/22084 , A61L2300/252 , A61L2300/258 , A61L2300/626 , A61L2300/64
摘要： A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique, provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.

96. 发明授权

US5698531A Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor 失效
标题翻译：通过细胞的位点特异性滴注或细胞的位点特异性转化及其试剂盒来治疗疾病
公开(公告)号：US5698531A
公开(公告)日：1997-12-16
申请号：US376522
申请日：1995-01-23
申请人： Elizabeth G. Nabel , Gary J. Nabel
发明人： Elizabeth G. Nabel , Gary J. Nabel
IPC分类号： A61B17/22 , A61K9/00 , A61K39/00 , A61K47/48 , A61K48/00 , A61L29/16 , C12N15/63 , C12N15/79 , C12N15/09
CPC分类号： A61K39/00 , A61B17/22 , A61K31/70 , A61K47/48992 , A61K48/00 , A61K9/0024 , A61L29/16 , A61B2017/22038 , A61B2017/22054 , A61B2017/22082 , A61B2017/22084 , A61L2300/252 , A61L2300/258 , A61L2300/626 , A61L2300/64
摘要： A method for the direct treatment towards the specific sites of a disease is disclosed. This method is based on the delivery of proteins by catheterization to discrete blood vessel segments using genetically modified or normal cells or other vector systems. Endothelial cells expressing recombinant therapeutic agent or diagnostic proteins are situated on the walls of the blood vessel or in the tissue perfused by the vessel in a patient. This technique, provides for the transfer of cells or vectors and expression of recombinant genes in vivo and allows the introduction of proteins of therapeutic or diagnostic value for the treatment of diseases.
摘要翻译：公开了一种直接治疗疾病特定部位的方法。该方法基于通过导管插入到使用遗传修饰或正常细胞或其他载体系统的离散血管段的蛋白质递送。表达重组治疗剂或诊断性蛋白质的内皮细胞位于血管壁或患者血管灌注的组织中。该技术提供细胞或载体的转移和体内重组基因的表达，并允许引入用于治疗疾病的治疗或诊断价值的蛋白质。

97. 发明授权

EP2437844B1 REJUVENATING CORONARY ARTERY BY IMPROVING BLOOD FLOW WITH THE HELP OF INSERTION OF NANO-BALLS (ENCAPSULATED NANOPARTICLES) CONTAINING THERAPEUTIC AGENTS BY NON IMPLANTABLE DEVICE FOR TISSUES AND THEREBY PROVIDING IN TISSUE RELEASE TO ADDRESS THE REQUIRED CELL CYCLE 有权
标题翻译：使用不可植入的装置对含有治疗剂的纳米球（包封的纳米粒子）进行插入以改善血液流动来重新获得冠状动脉，并且因此在组织中提供释放以解决所需的细胞周期
公开(公告)号：EP2437844B1
公开(公告)日：2018-05-02
申请号：EP10783060.6
申请日：2010-05-21
申请人： Concept Medical Inc.
发明人： DOSHI, Manish , SHERDIWALA, Divyesh , SOJITRA, Prakash , VYAS, Ashwin , GANDHI, Pankaj
IPC分类号： A61M25/04 , A61M25/10 , A61M29/02 , A61K47/14 , A61L29/16
CPC分类号： A61M25/104 , A61K9/5123 , A61K47/24 , A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/42 , A61L2300/624 , A61L2300/626 , A61L2400/12 , A61M25/0045 , A61M25/10 , A61M25/1027 , A61M2025/105 , A61M2025/1088
摘要： A drug-delivering medical device for delivering a drug to a target site in a body lumen is disclosed. The drug-delivering medical device includes a balloon catheter and an inflatable balloon positioned on the balloon catheter. The inflatable balloon has a hydrophilic surface. One or more portions of the hydrophilic surface are coated with two or more nano-carriers. A nano-carrier of the two or more nano-carriers includes a drug surrounded by an encapsulating medium. As the drug is surrounded by the encapsulating medium, the surface of the nano-carrier is devoid of the drug. When the inflatable balloon is inflated upon coming in proximity to a target site in the body lumen, about 30% to 80% of the two or more nano-carriers are released from the hydrophilic surface within 15-90 seconds.

98. 发明授权

EP2370112B1 IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, AND USES THEREOF 有权
标题翻译：随着嵌入式脂质体植入基质组成，其使用
公开(公告)号：EP2370112B1
公开(公告)日：2017-04-05
申请号：EP09828393.0
申请日：2009-11-24
申请人： Bonus Cellora Ltd.
发明人： SCHUBERT, Shai, Yehoshua
IPC分类号： A61L27/18 , A61L27/48 , A61L27/54 , A61L27/24 , A61L27/38 , A61L27/52 , A61K48/00
CPC分类号： A61L27/54 , A61K48/0016 , A61L27/18 , A61L27/222 , A61L27/24 , A61L27/3804 , A61L27/44 , A61L27/48 , A61L27/52 , A61L2300/232 , A61L2300/252 , A61L2300/258 , A61L2300/426 , A61L2300/438 , A61L2300/45 , A61L2300/626 , A61L2400/06 , C08L67/04
摘要： In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to replace lost cells or to restore function to tissue damaged due to disease, injury or genetic defect. In various embodiments, the treatment includes a semisolid hydrogel embedded with liposomes. The liposomes can contain an effector molecule or molecules. When phagocytic cells such as monocytes infiltrate the hydrogel, they encounter the liposomes and incorporate the liposomes carrying the effector molecules into the cells. In some embodiments, the effector molecules can be genetic material encoding the expression of specific proteins such as transcription factors, the expression of which can initiate the reprogramming of the cells. In other embodiments, the effector molecules can induce angiogenesis. In other embodiments, the effector molecules are tumor antigens. The matrix can contain other effector molecules designed to attract specific cells to the matrix. The cells can be released from the matrix as the matrix degrades or by active migration from the matrix. The cells can also remain in the matrix and secret molecules such as proteins and hormones that will diffuse through the matrix material to the surrounding tissue.

99. 发明公开

EP3016637A4 LOW FRICTION HYDROGELS AND HYDROGEL-CONTAINING COMPOSITE MATERIALS 审中-公开
标题翻译：摩擦ARMS和水凝胶HYDROGELHALTIGE复合材料
公开(公告)号：EP3016637A4
公开(公告)日：2017-02-15
申请号：EP14819627
申请日：2014-07-03
申请人： YEDA RES & DEV
发明人： KLEIN JACOB , GOLDBERG RONIT , IUSTER NOA , SORKIN RAYA
IPC分类号： A61K9/127 , A61F2/30 , C08L33/06
CPC分类号： A61L27/52 , A61K9/0019 , A61K9/0024 , A61L27/34 , A61L27/44 , A61L2300/626 , A61L2400/10 , A61L2430/06 , A61L2430/10 , A61L2430/24 , A61L2430/38 , C08F2/10 , C08F2/44 , C09D133/066
摘要： Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.

100. 发明公开

EP3016637A1 LOW FRICTION HYDROGELS AND HYDROGEL-CONTAINING COMPOSITE MATERIALS 审中-公开
标题翻译： REIBUNGSARME HYDROGELE UND HYDRHELHALTIGE VERBUNDWERKSTOFFE
公开(公告)号：EP3016637A1
公开(公告)日：2016-05-11
申请号：EP14819627.2
申请日：2014-07-03
申请人： Yeda Research and Development Co., Ltd.
发明人： KLEIN, Jacob , GOLDBERG, Ronit , IUSTER, Noa , SORKIN, Raya
IPC分类号： A61K9/127 , A61F2/30 , C08L33/06
CPC分类号： A61L27/52 , A61K9/0019 , A61K9/0024 , A61L27/34 , A61L27/44 , A61L2300/626 , A61L2400/10 , A61L2430/06 , A61L2430/10 , A61L2430/24 , A61L2430/38 , C08F2/10 , C08F2/44 , C09D133/066
摘要： Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.
摘要翻译：公开了与纯水凝胶或含有水凝胶的复合材料相比，其中分散有水凝胶和脂质体的水凝胶和复合材料，其表现出降低的摩擦系数，及其制备方法及其使用方法。

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