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91. 发明申请

WO2012080948A1 RADIATION THERAPY PLANNING AND FOLLOW-UP SYSTEM WITH LARGE BORE NUCLEAR AND MAGNETIC RESONANCE IMAGING OR LARGE BORE CT AND MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：辐射治疗计划和以下大型核心和磁共振成像或大面积CT和磁共振成像的后续系统
公开(公告)号：WO2012080948A1
公开(公告)日：2012-06-21
申请号：PCT/IB2011/055637
申请日：2011-12-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , OJHA, Navdeep , MORICH, Michael Andrew
发明人： OJHA, Navdeep , MORICH, Michael Andrew
IPC分类号： A61N5/10 , G01N33/48 , A61B5/055
CPC分类号： A61N5/1039 , A61B5/0035 , A61B5/055 , A61B5/0555 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/5247 , A61N5/1071 , A61N2005/1052 , A61N2005/1055 , A61N2005/1061 , G01R33/4808 , G01R33/481 , G01R33/4812
摘要： A radiation therapy planning and follow-up system(10) includes an MR scanner (12) with a first bore (16) which defines an MR imaging region (18)and a functional scanner (26), e.g.,a nuclear imaging scanner,or a CT scanner with a second bore (30) which defines a nuclear or CT imaging region (36). The first and second bores (16,30) have a diameter of at least 70cm, and preferably 80-85 cm. A radiation therapy type couch (90) moves linearly through the MR imaging region (18) along an MR longitudinal axis and the nuclear or CT imaging region (36) along a nuclear or CT longitudinal axis which is aligned with the MR longitudinal axis. The couch positions a subject sequentially in the MR and nuclear or CT imaging regions (18, 36). A fusion processor combines an image representation generated from data collection in the MR imaging region (18) and an image representation generated from data collection in the nuclear or CT imaging region (36) into a composite image representation and a planning processor (112) generates a radiation therapy treatment plan according to the composite image.
摘要翻译：放射治疗计划和跟踪系统（10）包括具有限定MR成像区域（18）的第一孔（16）和功能扫描器（26）的MR扫描仪（12），例如核成像扫描仪，或具有限定核或CT成像区域（36）的第二孔（30）的CT扫描器。第一和第二孔（16,30）的直径至少为70cm，优选为80-85cm。辐射治疗型沙发（90）沿着MR纵向轴线和核或CT成像区域（36）沿着与MR纵向轴线对准的核或CT纵向轴线线性地移动穿过MR成像区域（18）。躺椅将受试者顺序地置于MR和核或CT成像区域（18,36）中。融合处理器将从MR成像区域（18）中的数据收集产生的图像表示和从核或CT成像区域（36）中的数据收集生成的图像表示组合成合成图像表示，并且规划处理器（112）生成根据合成图像的放射治疗方案。

92. 发明申请

WO2011108601A1 荷電粒子線医療におけるミュオン・モニタリング・システム审中-公开
标题翻译：用于充电粒子辐射治疗的MUON监测系统
公开(公告)号：WO2011108601A1
公开(公告)日：2011-09-09
申请号：PCT/JP2011/054787
申请日：2011-03-02
申请人：大学共同利用機関法人高エネルギー加速器研究機構 , 永嶺謙忠
发明人：永嶺　謙忠
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N5/1048 , A61N2005/1052 , A61N2005/1087 , G01N23/00 , G01T1/29
摘要：陽子線などの荷電粒子線パルスのブラッグピーク位置に静止した粒子線自身がつくる正ミュオンのミュエスアール信号を得て、陽子線などの粒子線治療の放射線効果を正確に把握する。加速器から出射される２３０ＭｅＶの陽子を取り込み、照射装置１１から陽子ビームパルスを出射して、治療対象となる患者（人体２）に照射させる毎に、鉛遮蔽板４、遅延信号を使用して、生体中のブラッグピーク位置で同じ陽子がつくる前方ミュオンの消滅に起因し発生する遅延陽電子のみを位置的、時間的に選択し、第１位置敏感陽電子カウンター板９の各陽電子カウンター、第２位置敏感陽電子カウンター板１０の各陽電子カウンターで、陽電子発生位置と遅延同時信号の時間との情報を測定し、遅延陽電子を測定した後、測定結果を解析し、表示装置８に陽子のブラッグピーク位置近辺の陽電子発生場所毎に区分されたミュエスアール信号を画面表示する。
摘要翻译：提供了一种μ子监测系统，其获得由质子束等带电粒子束脉冲的布拉格峰处静止的粒子束产生的正μS的μSR信号，并准确地掌握质子束等的辐射效应用于粒子放射治疗。引入从加速器输出的230MeV质子，并且从照射装置（11）输出质子束脉冲以暴露正在进行治疗的患者（人体（2）），引线屏蔽（4）使用延迟信号位置和时间上仅选择延迟的正电子，这是由于在体内布拉格峰处由相同质子产生的前导子子消失而发生的，并且在已经测量了关于正电子产生位置和延迟同步信号的时间的信息之后通过第一位置敏感正电子计数器板（9）的正电子计数器和第二位置敏感正电子计数器板（10）的正电子计数器，并且测量了延迟的正电子，测量结果被分析，μSR 在显示器（8）的屏幕上显示在质子的布拉格峰附近的每个正电子生成位置被分段的信号。

93. 发明申请

WO2010115608A3 DETECTOR DEVICE 审中-公开
标题翻译：探测装置
公开(公告)号：WO2010115608A3
公开(公告)日：2011-09-09
申请号：PCT/EP2010002161
申请日：2010-04-06
申请人： GSI HELMHOLTZZENTRUM SCHWERIONENFORSCHUNG GMBH , KRAFT GERHARD
发明人： KRAFT GERHARD
IPC分类号： G01T1/169 , G01T1/29
CPC分类号： G01T1/29 , A61N5/1049 , A61N2005/1052 , A61N2005/1087 , G01T1/169
摘要： The invention relates to a detector device for detecting a penetration depth of a particle beam (22) applied to a target volume (23), comprising at least one detection device (25, 52). The detection device (100, 150) is configured and designed to detect photons, in particular gamma quanta, which are created in the target volume. The invention further relates to a method for determining a penetration depth of a particle beam (22) applied to an object (24), in particular a target volume (23) of the object (24), wherein photons, in particular gamma quanta, which are created by an interaction of the particle beam (22) in the object (24), are detected.
摘要翻译：它是一种用于在目标体积（23）检测的穿透深度的检测装置与所提出的至少一个检测装置（25，52）施加的粒子束（22）。的检测装置（100，150）被配置和设置为在目标体积中出现的光子，特别是检测伽马量子。此外，用于在对象（24）确定一个粒子束（22）的穿透深度的方法，提出了，特别是在所述对象（24）的目标体积（23），所述光子，尤其是伽马量子穿过粒子束的相互作用（22 ）（在对象24）出现时，进行检测。

94. 发明申请

WO2009036174A2 IMAGING POSITIONING SYSTEM HAVING ROBOTICALLY POSITIONED D-ARM 审中-公开
标题翻译：具有机械定位的D-ARM的成像定位系统
公开(公告)号：WO2009036174A2
公开(公告)日：2009-03-19
申请号：PCT/US2008076020
申请日：2008-09-11
申请人： HENDERSON TOBY D , SCHREUDER NIEK
发明人： HENDERSON TOBY D , SCHREUDER NIEK
IPC分类号： A61N5/10 , A61B6/04
CPC分类号： A61B6/4441 , A61B5/0064 , A61B6/037 , A61B6/102 , A61B6/4458 , A61B6/4464 , A61B6/4476 , A61B6/544 , A61N2005/1052 , A61N2005/1061
摘要： An imaging positioning system having a robotically positioned support structure is provided. By utilizing a robotic arm, imaging along multiple planes within a patient treatment room without having to move the patient is provided. Such a configuration allows multiple axis x-ray imaging, cone beam CT acquisitions having a dynamic field of view, and PET imaging within the treatment room. Rotation of the imaging panel on the support structure allows the imaging system to simulate a gantry rotation when a fixed beam is used for treatment. Beam line x-ray imaging is also provided by tilting the imaging panel or by moving the support structure on which the x-ray source is positioned. Laser distance scanning for collision avoidance and force torque sensing movement enhance the safety thereof. The support structure may be in the form of a ring along which the imaging components may move.
摘要翻译：提供了具有机器人定位的支撑结构的成像定位系统。通过利用机器人手臂，提供了在患者治疗室内的多个平面成像，而不必移动患者。这种配置允许多轴x射线成像，具有动态视场的锥形束CT采集和处理室内的PET成像。成像面板在支撑结构上的旋转允许成像系统在固定光束用于治疗时模拟台架旋转。通过倾斜成像面板或通过移动其上放置有X射线源的支撑结构也提供了射线X射线成像。激光距离扫描避免碰撞和力矩转矩检测运动增强了其安全性。支撑结构可以是成像组件可沿其移动的环的形式。

95. 发明申请

WO2008116535A1 DETERMINATION OF CONTROL PARAMETERS FOR IRRADIATION OF A MOVING TARGET VOLUME IN A BODY 审中-公开
标题翻译：确定身体运动目标体积的辐照控制参数
公开(公告)号：WO2008116535A1
公开(公告)日：2008-10-02
申请号：PCT/EP2008/001279
申请日：2008-02-19
申请人： GESELLSCHAFT FÜR SCHWERIONENFORSCHUNG MBH , SIEMENS AG , BERT, Christoph , RIETZEL, Eike , KRAFT, Gerhard
发明人： BERT, Christoph , RIETZEL, Eike , KRAFT, Gerhard
IPC分类号： A61N5/10 , A61B17/00
CPC分类号： A61N5/1049 , A61N5/103 , A61N5/1037 , A61N5/1043 , A61N5/1067 , A61N2005/1052 , A61N2005/1055 , A61N2005/1061 , A61N2005/1087
摘要： A control parameter is determined for a system (10) for irradiating a predetermined target volume in a body (77) with a particle beam (75). The system is constructed to direct the particle beam at a multiplicity of target points (30) in the target volume in succession in order to produce at, each of the target points a predetermined dose distribution (42) in a region around the target point. The control parameter controls the extent of an overlap of the dose distribution of a first target point with the dose distributions of neighbouring target points. For determination of the control parameter, there is first determined (94) a movement parameter which quantitatively characterises the movement of the body at the first target point. The control parameter is determined (95) in dependence on the movement parameter.
摘要翻译：对于用粒子束（75）照射体（77）中的预定目标体积的系统（10），确定控制参数。该系统构造成将粒子束连续地引导到目标体积中的多个目标点（30），以便在每个目标点处在目标点周围的区域中产生预定剂量分布（42）。控制参数控制第一目标点的剂量分布与相邻目标点的剂量分布重叠的程度。为了确定控制参数，首先确定（94）定量表征身体在第一目标点处的运动的运动参数。控制参数根据移动参数确定（95）。

96. 发明申请

WO2006039009A3 DYNAMIC TRACKING OF MOVING TARGETS 审中-公开
标题翻译：动态目标的动态跟踪
公开(公告)号：WO2006039009A3
公开(公告)日：2007-05-18
申请号：PCT/US2005030081
申请日：2005-08-22
申请人： ACCURAY INC , THOMSON EUAN , DOOLEY JOHN ROBINSON , KUDUVALLI GOPINATH , WANG JAMES , EARNST ERIC , RAANES CHRIS
发明人： THOMSON EUAN , DOOLEY JOHN ROBINSON , KUDUVALLI GOPINATH , WANG JAMES , EARNST ERIC , RAANES CHRIS
IPC分类号： A61B5/05
CPC分类号： A61N5/1037 , A61B5/055 , A61B5/113 , A61B6/032 , A61B6/037 , A61B6/12 , A61B6/5217 , A61B34/20 , A61B90/36 , A61B2017/00694 , A61B2034/105 , A61B2034/2065 , A61B2090/101 , A61B2090/367 , A61B2090/3762 , A61N5/1039 , A61N5/1049 , A61N5/1064 , A61N5/1067 , A61N2005/1052 , A61N2005/1055 , A61N2005/1061 , A61N2005/1062
摘要： Treatment targets such as tumors or lesions, located within an anatomical region that undergoes motion (which may be periodic with cycle P), are dynamically tracked. A 4D mathematical model is established for the non-rigid motion and deformation of the anatomical region, from a set of CT or other 3D images. The 4D mathematical model relates the 3D locations of part(s) of the anatomical region with the targets being tracked, as a function of the position in time within P. Using fiducialless non-rigid image registration between pre-operative DRRs and intra-operative x-ray images, the absolute position of the target and/or other part(s) of the anatomical region is determined. The cycle P is determined using motion sensors such as surface markers. The radiation beams are delivered using: 1) the results of non-rigid image registration; 2) the 4D model; and 3) the position in time within P.
摘要翻译：动态跟踪位于经历运动的解剖区域（可能与周期P周期性）的肿瘤或病变的治疗靶点。建立了一个4D数学模型，用于从一组CT或其他3D图像中解剖区域的非刚性运动和变形。 4D数学模型将解剖区域的部分的3D位置与正在跟踪的目标相关联，作为P内时间位置的函数。使用手术前DRR和手术之间的无基底非刚性图像配准 x射线图像，确定目标和/或解剖区域的其他部分的绝对位置。周期P使用诸如表面标记的运动传感器来确定。使用以下方式传送辐射束：1）非刚性图像配准的结果; 2）4D模型; 和3）在时间内的位置。

97. 发明申请

WO9927839A9 SURGICAL POSITIONING SYSTEM 审中-公开
公开(公告)号：WO9927839A9
公开(公告)日：1999-10-21
申请号：PCT/US9825476
申请日：1998-12-01
申请人： COSMAN ERIC R
发明人： COSMAN ERIC R
IPC分类号： A61B6/04 , A61B6/08 , A61B19/00 , A61N5/10 , G06T3/00
CPC分类号： A61B6/5247 , A61B5/1127 , A61B6/0421 , A61B6/0492 , A61B6/08 , A61B34/20 , A61B90/10 , A61B90/14 , A61B90/16 , A61B90/20 , A61B2034/102 , A61B2034/2055 , A61B2034/2065 , A61B2034/2068 , A61B2034/2072 , A61B2090/363 , A61B2090/364 , A61B2090/371 , A61B2090/378 , A61B2090/3937 , A61B2090/395 , A61B2090/3966 , A61B2090/3983 , A61B2090/502 , A61N5/1049 , A61N5/1064 , A61N5/107 , A61N2005/105 , A61N2005/1051 , A61N2005/1052 , A61N2005/1059 , A61N2005/1061 , G06T7/73 , G06T2207/10081 , G06T2207/30204
摘要： A system for positioning and repositioning of a portion of a patient's body with respect to a treatment or imaging machine includes multiple cameras to view the body and the machine. Index markers, either light-emitting, passive, geometric shapes, or natural landmarks, are identified and located by the cameras in 3D space. In one embodiment, such reference or index markers are in a determinable relationship to analogous markers used during previous image scanning of the patient. Anatomical targets determined from image scanning can be located relative to reference positions associated with the treatment or diagnostic machine. Several forms of camera, index markers, methods and systems accommodate different clinical uses. X-ray imaging of the patient further refines anatomical target positioning relative to the treatment or diagnostic imaging reference point. Movements of the patient based on comparative analysis of imaging determined anatomical targets relativeto reference points on treatment or diagnostic apparatus are controlled by the system and process of the invention.

98. 发明公开

US20240104767A1 METHODS FOR AUTOMATIC TARGET IDENTIFICATION, TRACKING, AND SAFETY EVALUATION FOR RADIOTHERAPY 审中-公开
公开(公告)号：US20240104767A1
公开(公告)日：2024-03-28
申请号：US18456396
申请日：2023-08-25
申请人： RefleXion Medical, Inc.
发明人： Yevgen VORONENKO , Maksat HAYTMYRADOV , Peter Demetri OLCOTT , Lingxiong SHAO , Manoj V. NARAYANAN
IPC分类号： G06T7/73 , A61N5/10 , G06T7/00 , G06T7/11 , G06T7/12 , G06T11/20
CPC分类号： G06T7/73 , A61N5/1039 , A61N5/1049 , G06T7/0012 , G06T7/11 , G06T7/12 , G06T11/203 , A61N2005/1052 , A61N2005/1087 , A61N2005/1089 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/10116 , G06T2207/20076 , G06T2207/30096
摘要： Disclosed herein are methods and systems for identifying the location of a target region using a tumor identification (ID) profile. A tumor ID profile includes identification parameters that characterize the target region. The tumor ID profile may be used to facilitate the identification of multiple target regions and to evaluate whether it is safe to deliver radiation to the target regions at their updated locations. Also disclosed herein are methods for analyzing a dose distribution to a target region by generating a bounded dose volume histogram (bDVH) based on gamma criteria comprising a distance-to-agreement (DTA) criterion and a dose difference (DD) criterion. In one variation, a gamma-derived bDVH is used in a method for selecting gamma criteria values for evaluating a radiotherapy treatment plan.

99. 发明公开

US20230390580A1 SYSTEMS AND METHODS FOR BIOLOGICAL ADAPTIVE RADIOTHERAPY 审中-公开
公开(公告)号：US20230390580A1
公开(公告)日：2023-12-07
申请号：US18295448
申请日：2023-04-04
申请人： RefleXion Medical, Inc.
发明人： Michael Kirk Owens , Rostem BASSALOW , Peter Demetri OLCOTT , Yevgen VORONENKO , David Quentin LARKIN , Samuel MAZIN
IPC分类号： A61N5/10
CPC分类号： A61N5/1031 , A61N5/1067 , A61N5/1049 , A61N5/1039 , A61N5/1064 , A61N5/1068 , A61N5/1037 , A61N5/1036 , A61N2005/1055 , A61N5/1045 , A61N2005/1034 , A61N2005/1052 , A61N2005/1058 , A61N5/1038
摘要： Disclosed herein are systems and methods for adapting and/or updating radiotherapy treatment plans based on biological and/or physiological data and/or anatomical data extracted or calculated from imaging data acquired in real-time (e.g., during a treatment session). Functional imaging data acquired at the time of radiation treatment is used to modify a treatment plan and/or dose delivery instructions to provide a prescribed dose distribution to patient target regions. Also disclosed herein are methods for evaluating treatment plans based on imaging data acquired in real-time.

100. 发明公开

US20230337991A1 METHOD AND APPARATUS FOR EMISSION GUIDED RADIATION THERAPY 审中-公开
公开(公告)号：US20230337991A1
公开(公告)日：2023-10-26
申请号：US18178431
申请日：2023-03-03
申请人： RefleXion Medical, Inc.
发明人： Samuel Mazin
IPC分类号： A61B6/03 , G01T1/29 , A61B6/00 , A61N5/10 , A61B6/04
CPC分类号： A61B6/037 , G01T1/2985 , A61B6/54 , A61N5/1067 , A61N5/1081 , G01T1/2978 , A61B6/0407 , A61B6/469 , A61B6/541 , A61N2005/1074 , A61N2005/1052 , A61N2005/1072 , A61N2005/1087 , A61N2005/1089 , A61N2005/109 , A61N2005/1091
摘要： An apparatus comprising a radiation source, coincident positron emission detectors configured to detect coincident positron annihilation emissions originating within a coordinate system, and a controller coupled to the radiation source and the coincident positron emission detectors, the controller configured to identify coincident positron annihilation emission paths intersecting one or more volumes in the coordinate system and align the radiation source along an identified coincident positron annihilation emission path.

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