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    • 94. 发明申请
    • Apparatus and method for needle filling and laser resealing
    • 针刺和激光重新密封的装置和方法
    • US20060283522A1
    • 2006-12-21
    • US11510961
    • 2006-08-28
    • Daniel Py
    • Daniel Py
    • B67C3/00
    • B65B7/161B65B3/003B65B7/00B65B37/06B65B43/54B65B51/22B65B55/04B65B55/08B65B57/00B65B65/02
    • An apparatus is provided for needle filling and thermally resealing containers having stoppers that are needle penetrable for filling the containers with a substance, and are thermally resealable for thermally sealing a needle hole in the stopper upon withdrawal of a needle therefrom. A container support of the apparatus supports at least one container having a resealable stopper in a substantially fixed position during needle filling and thermally resealing a needle hole in the stopper upon withdrawal of a needle therefrom. A manifold is drivingly mounted over the container support and comprises (1) a needle cartridge including a needle for penetrating the resealable stopper and introducing a substance through the needle and into the container, a needle mount for mounting the needle cartridge on the manifold, and a needle cover releasably coupled to the needle mount for covering the needle during transportation, installation and/or removal of the needle cartridge from the manifold, and that is removable from the needle cartridge upon mounting the needle cartridge to the manifold. The manifold further includes a thermal source for heating a needle penetrated region of the stopper and, in turn, sealing a needle hole in the stopper.
    • 提供了一种用于针头填充和热重新密封容器的装置,其具有用于针对物品填充容器的可穿刺的塞子,并且在从其中取出针时,可热再密封用于热封塞塞中的针孔。 装置的容器支撑件支撑至少一个具有可重新封闭的塞子的容器,该容器在针填充期间处于基本上固定的位置,并且在从针头中​​取出针时,在塞子中对针孔进行热再密封。 歧管被驱动地安装在容器支架上方,并且包括(1)针筒,其包括用于穿透可再密封塞子并将物质通过针引入容器的针,用于将针筒安装在歧管上的针座,以及 可拆卸地联接到针座的针罩,用于在从歧管运输,安装和/或移除针筒期间覆盖针头,并且当将针筒安装到歧管上时可从针筒上移除。 歧管还包括用于加热塞子的针穿入区域的热源,并且进而密封塞子中的针孔。
    • 97. 发明授权
    • Capsules
    • 胶囊
    • US06755010B2
    • 2004-06-29
    • US10220805
    • 2002-09-06
    • Allan Draisey
    • Allan Draisey
    • B65B4702
    • B29C65/7435A61J3/07B29C65/04B29C66/1122B29C66/43B29C66/71B29C66/73143B29C66/73793B29C66/83411B29C66/83413B29C66/83513B29C66/849B65B51/22B29K2001/00
    • Capsules, for example for the delivery of pharmaceuticals, are produced from two films (18) of a water-soluble polymeric material, by deforming the films to form a multiplicity of recesses, and filling the recesses with a flowable filling material. This is performed using two adjacent rotary dies (14, 15), with recesses (16) into which the films (18) are deformed. The dies (14, 15) also act as electrodes for welding the films together by dielectric welding to form filled capsules (30). The capsules (30) can readily be separated from the resulting web. The polymeric material may be gelatin, or a water-soluble cellulose derivative such as hydroxypropyl methyl cellulose, and may also contain a plasticizer.
    • 例如用于输送药物的胶囊由两种水溶性聚合物材料薄膜(18)制成,通过使膜变形以形成多个凹部,并用可流动的填充材料填充凹部。 这是使用两个相邻的旋转模具(14,15)执行的,其中薄膜(18)变形成凹部(16)。 模具(14,15)还用作通过电介质焊接将膜焊接在一起以形成填充胶囊(30)的电极。 胶囊(30)可以容易地从所得到的纤维网分离。 聚合物材料可以是明胶,或水溶性纤维素衍生物如羟丙基甲基纤维素,也可以含有增塑剂。