专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明授权

US06410828B1 Regulatory sequences useful for gene expression in plant embryo tissue 有权
标题翻译：用于植物胚胎组织中基因表达的调节序列
公开(公告)号：US06410828B1
公开(公告)日：2002-06-25
申请号：US09443732
申请日：1999-11-19
申请人： Katherine Armstrong , Aaron T. Woosley , Dayakar R. Pareddy , Beth C. Rubin-Wilson , Timothy D. Hey , Kelley A. Smith , Otto Folkerts
发明人： Katherine Armstrong , Aaron T. Woosley , Dayakar R. Pareddy , Beth C. Rubin-Wilson , Timothy D. Hey , Kelley A. Smith , Otto Folkerts
IPC分类号： A01H100
CPC分类号： C12N15/8222 , C07K14/415 , C07K14/825 , C12N15/8234
摘要： This invention relates to compositions and methods useful in the production of transgenic plants. In particular, the invention relates to maize metallothionein gene transcription regulatory sequences which are useful for directing expression of heterologous DNAs in plant embryo tissue. The invention also relates to expression cassettes containing the promoter sequences and to transgenic plants containing the expression cassettes.
摘要翻译：本发明涉及可用于生产转基因植物的组合物和方法。特别地，本发明涉及可用于将异源DNA表达在植物胚胎组织中的玉米金属硫蛋白基因转录调控序列。本发明还涉及含有启动子序列的表达盒和含有表达盒的转基因植物。

92. 发明授权

US06284946B1 Banana DNA associated with fruit development 有权
标题翻译：与果实发育相关的香蕉DNA
公开(公告)号：US06284946B1
公开(公告)日：2001-09-04
申请号：US09160351
申请日：1998-09-25
申请人： Gregory D. May , Stephanie K. Clendennen
发明人： Gregory D. May , Stephanie K. Clendennen
IPC分类号： C12N504
CPC分类号： C12Y302/01073 , C07K14/415 , C07K14/42 , C07K14/825 , C12N9/0065 , C12N9/1051 , C12N9/2442 , C12N9/2448 , C12N15/8249 , C12N15/8257 , C12Y302/01014
摘要： The present invention provides isolated and purified genes which are differentially expressed during banana fruit development, and the protein products of these genes. The present invention further provides DNA regulatory elements which are differentially expressed during banana fruit development, chimeric genes comprising these DNA regulatory elements operably linked to heterologous DNA molecules, and plants transformed with said chimeric genes, providing for controlled expression of said heterologous DNA molecules during the development and ripening of the fruit of said plants, or in response to exogenous ethylene signals in said plants. The present invention also provides a method for expression of a heterologous protein in fruit comprising transforming fruiting plants with one or more chimeric genes according to the present invention, exposing said fruit to an endogenous or exogenous ethylene signal, and harvesting fruit containing said heterologous protein. The method of the present invention may further comprise isolated the proteins produced by said method from the harvested fruit. In a particularly preferred embodiment, the heterologous protein is a therapeutic protein, which may be isolated from the harvested fruit, or consumed directly in the transformed fruit by a patient in need of said therapeutic protein.
摘要翻译：本发明提供了在香蕉果实发育期间差异表达的分离和纯化的基因，以及这些基因的蛋白质产物。本发明还提供了在香蕉果实发育期间差异表达的DNA调节元件，包含与异源DNA分子可操作地连接的这些DNA调节元件的嵌合基因，以及用所述嵌合基因转化的植物，提供所述异源DNA分子在所述植物的果实的开发和成熟，或响应于所述植物中的外源乙烯信号。本发明还提供了一种用于在果实中表达异源蛋白质的方法，包括用根据本发明的一种或多种嵌合基因转化结实植物，将所述果实暴露于内源或外源乙烯信号，以及收获含有所述异源蛋白质的水果。本发明的方法还可以包括从收获的水果中分离由所述方法产生的蛋白质。在特别优选的实施方案中，异源蛋白质是治疗性蛋白质，其可以从收获的果实中分离，或由需要所述治疗性蛋白质的患者直接在转化的果实中消耗。

93. 发明授权

US5137816A Rhizobial diagnostic probes and rhizobium trifolii nifH promoters 失效
标题翻译：根瘤菌诊断探针和根瘤菌trifolii nifH启动子
公开(公告)号：US5137816A
公开(公告)日：1992-08-11
申请号：US701358
申请日：1991-05-10
申请人： Barry G. Rolfe , John Shine , Kieran F. Scott , John M. Watson , Peter Schofield
发明人： Barry G. Rolfe , John Shine , Kieran F. Scott , John M. Watson , Peter Schofield
IPC分类号： C07K14/195 , C07K14/325 , C07K14/825 , C12N9/02 , C12N15/11 , C12N15/74 , C12N15/90 , C12Q1/68
CPC分类号： C12N9/0095 , C07K14/195 , C07K14/325 , C07K14/825 , C12N15/11 , C12N15/743 , C12N15/90 , C12Q1/689 , C12Y118/06001 , Y10S435/878
摘要： This invention provides useful promoters from the R. trifolii nifH gene for the construction of recombinant molecules to regulate foreign genes for expression under desired conditions. In particular, the promoters act to control expression of the foreign genes within root nodules formed by rhizobial bacterial strains in symbiotic combination with host plants.A rhizobium diagnostic segment (RDS) is also provided comprising a DNA segment found at more than one location in rhizobia, the RDS being species-specific, and detectable by DNA hybridization under stringent conditions. A recombinant plasmid comprising a RDS and a bacterial strain containing the plasmid are provided. Methods are provided for identifying species and strains of field isolates of Rhizobium, using RDS's. One RDS exemplified comprises 5' sequences from the R. trifolii nifH gene.
摘要翻译：本发明提供了来自三叶草nifH基因的有用的启动子，用于构建重组分子以调节外来基因以在期望的条件下表达。特别地，启动子用于控制与宿主植物共生组合的由根瘤菌细菌菌株形成的根结节内的外源基因的表达。还提供了根瘤菌诊断片段（RDS），其包含在根瘤菌中多于一个位置处发现的DNA片段，RDS是物种特异性的，并且可以在严格条件下通过DNA杂交检测。提供了包含RDS和含有该质粒的细菌菌株的重组质粒。提供了使用RDS来鉴定根瘤菌的分离株的种类和菌株的方法。一个RDS示例包括来自三叶草nifH基因的5'序列。

94. 发明公开

KR1020140032896A 미토콘드리아 타겟팅 펩타이드 有权
标题翻译： MITOCHONDRIAL TARGETING PEPTIDE
公开(公告)号：KR1020140032896A
公开(公告)日：2014-03-17
申请号：KR1020130104307
申请日：2013-08-30
申请人： 경희대학교 산학협력단
发明人： 김영미 , 강영철 , 김용희
IPC分类号： C07K7/06 , C07K7/08 , C07K19/00 , A61K38/00
CPC分类号： C07K14/005 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/825 , C07K2319/10 , C07K2319/21 , C12N9/0065 , C12N9/0089 , C12N9/1205 , C12N9/93
摘要： The present invention relates to mitochondirial targeting peptide, to fusion protein to which the peptide is combined at carboxy terminal of protein transduction domain and antioxidant is combined at carboxy terminal of the peptide, to a composition for antioxidant which includes the fusion protein to which the antioxidant is combined, to a composition for preventing or treating Parkinson′s disease, to polynucleotide which codes the protein transduction domain, to polynucleotide which codes the peptide, to recombinant polynucleotide to which polynucleotide coding the antioxidant protein are successively combined, to an impression vector which includes the polynucleotide, and to a transformed host cell which includes the impression vector. The mitochondrial targeting peptide according to the present invention is targeted by mitochondria with high efficiency if existing as a single, and is targeted by the mitochondria with high efficiency even when the peptide is combined with the protein transduction domain and/or antioxidant. In addition, the peptide is suitable for a target carrier by having small size, and is processed when entered into mitochondria so that carried drug can be stably delivered.
摘要翻译：本发明涉及线粒体靶向肽，与蛋白质转导结构域的羧基末端肽结合的融合蛋白和抗氧化剂在肽的羧基末端结合成抗氧化剂的组合物，其包含抗氧化剂的融合蛋白与将编码蛋白质转导结构域的多核苷酸，编码该肽的多核苷酸组合成抗体蛋白质连续组合的重组多核苷酸与编码抗体蛋白质的多核苷酸组合，包括多核苷酸，以及包含该印象载体的转化的宿主细胞。本发明的线粒体靶向肽如果以单一方式存在，则以高效率的线粒体靶向，即使当肽与蛋白质转导结构域和/或抗氧化剂结合时，也可以高效率地被线粒体靶向。此外，肽通过小尺寸适用于靶载体，并且在进入线粒体时被加工，从而能够稳定地输送载体药物。

95. 发明授权

KR101196103B1 포유동물 세포용 무？혈청 세포 배양 배지 有权
标题翻译：无血清细胞培养液用于乳清细胞
公开(公告)号：KR101196103B1
公开(公告)日：2012-11-01
申请号：KR1020077008456
申请日：2005-10-28
申请人： 아레스 트레이딩 에스.에이.
发明人： 카사토레스헤르난데즈,죠세 , 마틴피에라,칼로스
IPC分类号： C12N5/02
CPC分类号： C07K14/825 , C07K14/61 , C12N5/0043 , C12N5/005 , C12N2500/12 , C12N2500/20 , C12N2500/22 , C12N2500/24 , C12N2500/32 , C12N2500/36 , C12N2510/02 , C12N2510/04
摘要： 본 발명은 무-혈청 배지에서 배양된 포유동물 세포에서 단백질을 제조하는 방법에 관한 것이다.

96. 发明申请

US20180237321A1 ENGINEERED YEAST AS A METHOD FOR BIOREMEDIATION 审中-公开
公开(公告)号：US20180237321A1
公开(公告)日：2018-08-23
申请号：US15887305
申请日：2018-02-02
申请人： Massachusetts Institute of Technology
发明人： George Le-Le Sun , Angela M. Belcher
IPC分类号： C02F3/34 , C07K14/825 , C12N9/02 , C12N9/10 , C12N9/88 , C12N1/06 , C12N1/16 , E21C41/00 , E21C41/32
CPC分类号： C02F3/342 , C02F3/322 , C02F3/347 , C02F2101/20 , C02F2101/203 , C02F2103/10 , C07K14/825 , C07K2319/03 , C12N1/063 , C12N1/16 , C12N9/0008 , C12N9/1029 , C12N9/1085 , C12N9/88 , C12Y102/01011 , C12Y203/01031 , C12Y205/01047 , C12Y404/01008 , C22B3/18 , C22B3/24 , E21C41/14 , E21C41/32 , Y02P10/234
摘要： Metal bioremediation and metal mining strategies can include compositions and methods.

97. 发明申请

US20160130325A1 METHOD FOR PRODUCING HYPO-METALLATED REDOX-ACTIVE METALLOTHIONEIN PROTEIN AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：用于生产含金属氧化还原活性金属蛋白酶蛋白质的方法和含有它们的药物组合物
公开(公告)号：US20160130325A1
公开(公告)日：2016-05-12
申请号：US14937142
申请日：2015-11-10
申请人： CHRISTOPH MELCHER , TONY RAOUL HENRY , CHUN-HUNG KUO
发明人： CHRISTOPH MELCHER
IPC分类号： C07K14/825
CPC分类号： C07K14/825 , A61K38/00
摘要： The present invention relates to method for producing hypo-metallated redox-active metallothionein (MT) proteins, pharmaceutical compositions containing the proteins, and uses the pharmaceutical compositions for treatment of conditions originating from elevated intracellular oxidative stress and/or dis-balanced intracellular redox-potential and/or redox-potential-dependent imbalance of metal ions.
摘要翻译：本发明涉及生产低金属氧化还原活性金属硫蛋白（MT）蛋白的方法，含有蛋白质的药物组合物，并且使用该药物组合物来治疗源于升高的细胞内氧化应激和/或不平衡的细胞内氧化还原 - 金属离子的潜在和/或氧化还原电位依赖的不平衡。

98. 发明申请

US20150158940A1 USE OF ANTAGONISTS TARGETING METALLOTHIONEIN TO TREAT INTESTINAL INFLAMMATION 有权
标题翻译：使用金属靶向治疗炎症介质的拮抗剂
公开(公告)号：US20150158940A1
公开(公告)日：2015-06-11
申请号：US14581465
申请日：2014-12-23
申请人： UNIVERSITEIT GENT , UNIVERSITY OF CONNECTICUT
发明人： Martine DE VOS , Debby LAUKENS , Lindsey DEVISSCHER , Michael A. LYNES
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A01K67/0275 , A01K67/0276 , A01K2217/052 , A01K2217/075 , A01K2227/105 , A01K2267/0368 , A61K2039/505 , C07K14/825 , C07K2317/24 , C07K2317/76
摘要： Metallothioneins are stress inducible proteins with modulating functions during inflammation. Antagonizing metallothioneins during gut inflammation reduces markers of inflammations and enhances recuperation of intestinal inflammation.
摘要翻译：金属硫蛋白是在炎症期间具有调节功能的应激诱导蛋白。肠道炎症期间拮抗金属硫蛋白降低炎症标志物并增强肠道炎症的恢复。

99. 发明申请

US20140322744A1 CLONABLE TAG FOR CORRELATIVE LIGHT AND ELECTRON MICROSCOPY LABELING 审中-公开
标题翻译：相关灯和电子显微镜标签的可折叠标签
公开(公告)号：US20140322744A1
公开(公告)日：2014-10-30
申请号：US14359947
申请日：2012-11-27
申请人： INSTITUT CURIE , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIQUE
发明人： Nebraska Zambrano , Vincent Semetey , Sergio Marco
IPC分类号： C12Q1/02
CPC分类号： C12Q1/02 , C07K14/825 , C07K2319/00 , C07K2319/02 , G01N33/683
摘要： The present invention relates to a new clonable label for Correlative Light and Electron Microscopy based on the combination of modified metallothionein and lanthanides.
摘要翻译：本发明涉及基于改性金属硫蛋白和镧系元素组合的相关光和电子显微镜的新克隆标签。

100. 发明授权

US08859492B2 Metallodrugs having improved pharmacological properties, and methods of manufacture and use thereof 有权
标题翻译：具有改善的药理学性质的金属药物及其制造和使用方法
公开(公告)号：US08859492B2
公开(公告)日：2014-10-14
申请号：US13470299
申请日：2012-05-12
申请人： James A. Cowan , Ada S. Cowan , Donna T. Palmer
发明人： James A. Cowan , Ada S. Cowan , Donna T. Palmer
IPC分类号： C07K19/00 , C07K7/08 , C07K14/46 , C07K2/00 , A61K38/05 , A61K38/10 , A61K38/17 , A61K38/08 , A61P31/00 , C07K5/068 , C07K1/113 , A61K47/48 , C07K7/06 , C07K5/02 , C07H23/00 , A61K38/00
CPC分类号： C07K14/825 , A61K31/424 , A61K38/00 , A61K38/10 , A61K38/16 , A61K47/547 , C07F17/02 , C07H21/00 , C07H23/00 , C07K5/022 , C07K7/06 , C07K2319/20 , C07K2319/70
摘要： It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target.
摘要翻译：本发明的目的是通过将这些分子连接到金属结合部分来提供与具有低亲和力的靶（以下称为“配体部分”）结合的分子的改善的药理学性质，由此产生组合分子通常称为“金属药物”或“金属治疗剂”。金属药物的金属结合结构域通常催化氧化还原酶化学或作为路易斯酸催化剂，从而导致由于结合而接近的蛋白质和核酸的修饰的配体部分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式