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91. 发明专利

TW201142292A 利用以血液為主之樣品的質譜分析進行治療劑投藥之癌症病患選擇 CANCER PATIENT SELECTION FOR ADMINISTRATION OF THERAPEUTIC AGENTS USING MASS SPECTRAL ANALYSIS OF BLOOD-BASED SAMPLES 审中-公开
简体标题：利用以血液为主之样品的质谱分析进行治疗剂投药之癌症病患选择 CANCER PATIENT SELECTION FOR ADMINISTRATION OF THERAPEUTIC AGENTS USING MASS SPECTRAL ANALYSIS OF BLOOD-BASED SAMPLES
公开(公告)号：TW201142292A
公开(公告)日：2011-12-01
申请号：TW100106286
申请日：2011-02-24
申请人：拜歐迪希克斯公司
发明人：葛瑞葛里伊娃茱莉亞 , 羅德海瑞奇 , 斯平麥克斯梅
IPC分类号： G01N
CPC分类号： G01N33/6848 , G01N33/57415 , G01N2800/52 , G06F19/703 , G06F19/707 , G16H10/40 , H01J49/00 , H01J49/40 , Y02A90/22
摘要：本發明揭示一種利用質譜數據分析及分類演算方法，該方法可提供測定實體上皮腫瘤癌症病患是否可能受益於靶向與MAPK路徑(促分裂素原活化蛋白激酶)或位於Akt上游或該處之PKC(蛋白激酶C)路徑或ERK/JNK/p38或PKC有關之受體促效劑、受體或蛋白質之治療劑或治療劑組合(諸如，靶向EGFR及/或HER2之治療劑)的能力。該等方法亦可提供測定癌症病患是否可能受益於靶向EFGR治療劑及靶向COX2治療劑的組合；或癌症病患是否可能受益於NF-κB抑制劑治療之能力。
简体摘要：本发明揭示一种利用质谱数据分析及分类演算方法，该方法可提供测定实体上皮肿瘤癌症病患是否可能受益于靶向与MAPK路径(促分裂素原活化蛋白激酶)或位于Akt上游或该处之PKC(蛋白激酶C)路径或ERK/JNK/p38或PKC有关之受体促效剂、受体或蛋白质之治疗剂或治疗剂组合(诸如，靶向EGFR及/或HER2之治疗剂)的能力。该等方法亦可提供测定癌症病患是否可能受益于靶向EFGR治疗剂及靶向COX2治疗剂的组合；或癌症病患是否可能受益于NF-κB抑制剂治疗之能力。

92. 发明专利

TW201028687A 以標定ＥＧＦＲ路徑之藥物治療大腸直腸癌之病患選擇方法 SELECTION OF COLORECTAL CANCER PATIENTS FOR TREATMENT WITH DRUGS TARGETING EGFR PATHWAY 失效
简体标题：以标定ＥＧＦＲ路径之药物治疗大肠直肠癌之病患选择方法 SELECTION OF COLORECTAL CANCER PATIENTS FOR TREATMENT WITH DRUGS TARGETING EGFR PATHWAY
公开(公告)号：TW201028687A
公开(公告)日：2010-08-01
申请号：TW098143181
申请日：2009-12-16
申请人：拜歐迪希克斯公司
发明人：羅德海瑞奇 , 斯平麥克斯梅 , 葛瑞葛里伊娃茱莉亞
IPC分类号： G01N , G06F
CPC分类号： G01N33/57446 , G01N33/6848 , G01N2800/52 , G06F19/707 , Y02A90/26 , Y10T436/24
摘要：本發明係關於一種利用質譜數據分析及分類演算法提供判斷大腸直腸癌(CRC)之病患是否可能自靶定表皮生長因子受體路徑之藥物(如單株抗體EGFR抑制劑)獲益之方法。
简体摘要：本发明系关于一种利用质谱数据分析及分类算法提供判断大肠直肠癌(CRC)之病患是否可能自靶定表皮生长因子受体路径之药物(如单株抗体EGFR抑制剂)获益之方法。

93. 发明申请

US20180330064A1 APPARATUS AND METHOD FOR PREDICTING DISPERSION OF HAZARDOUS AND NOXIOUS SUBSTANCES 审中-公开
公开(公告)号：US20180330064A1
公开(公告)日：2018-11-15
申请号：US15775929
申请日：2016-10-05
申请人： Korea Institute of Ocean Science & Technology
发明人： Moon Jin LEE , Sang Woo OH , Ho-Jin HWANG
IPC分类号： G06F19/00 , G01W1/00 , G01C13/00 , G01P13/02 , G01P5/00 , G06Q50/26
CPC分类号： G06F19/707 , G01C13/00 , G01K13/00 , G01P5/00 , G01P13/02 , G01W1/00 , G06Q50/26
摘要： The present invention relates to an apparatus and a method for predicting the dispersion of hazardous and noxious substances and, more specifically, provides an apparatus and a method for predicting the dispersion of hazardous and noxious substances, the method: checking the components of the hazardous and noxious substances having leaked into the ocean, so as to classify the hazardous and noxious substances into a corresponding classification set among twelve classification sets by means of at least one of vapor pressure, the degradation in water, or density; dividing the classification sets, in which the hazardous and noxious substances are classified, into one dispersion model among an air dispersion model, a seawater dispersion model, and an air/seawater dispersion model according to the dispersion characteristics thereof; acquiring, from a weather center server, the state information of a sea area, which is set to be different according to the divided dispersion models; and predicting a danger radius for the dispersion of the hazardous and noxious substances by using the acquired state information of the sea area, and outputting the same.

94. 发明授权

US09810673B1 Cannabis cultivation test 有权
公开(公告)号：US09810673B1
公开(公告)日：2017-11-07
申请号：US15491336
申请日：2017-04-19
申请人： James Ehleringer , Lesley Chesson , Rozann Dunn , Joshua Ehleringer , Patrick Shea , Brett Tipple
发明人： James Ehleringer , Lesley Chesson , Rozann Dunn , Joshua Ehleringer , Patrick Shea , Brett Tipple
IPC分类号： G06F17/00 , G06F17/10 , G06F19/00 , G01N33/00 , G01N33/15 , C12M1/34 , G01N33/18 , G01N30/88 , G01N33/94
CPC分类号： G01N33/0098 , G01N33/0036 , G01N33/0047 , G01N33/1846 , G01N33/5097 , G01N33/948 , G01N2333/415 , G01N2458/15 , G01N2560/00 , G06F19/707
摘要： Systems and methods are disclosed to determine that a cannabis plant has been cultivated under desired cultivation conditions. Quantitative processes are disclosed, based on stable carbon isotope ratio analysis, and using modeling constraints and Bayesian approaches to produce a likelihood that a cannabis plant was cultivated under desired conditions (e.g., indoors), and provide a quantitative estimate of the average CO2 concentration in the growth environment.

95. 发明授权

US09792416B2 Peak correlation and clustering in fluidic sample separation 有权
公开(公告)号：US09792416B2
公开(公告)日：2017-10-17
申请号：US13252731
申请日：2011-10-04
申请人： Gerd Heinje , Rainer Jaeger
发明人： Gerd Heinje , Rainer Jaeger
IPC分类号： G06F19/00 , G06T11/20
CPC分类号： G06F19/707 , G06F19/708 , G06T11/206
摘要： A device for analyzing measurement data having a plurality of data sets, each data set being assigned to a respective one of a plurality of measurements, each data set having multiple features being indicative of different fractions of a fluidic sample, the device comprising a cluster determining unit configured for determining feature clusters by clustering features from different data sets presumably relating to the same fraction, a spread determining unit configured for determining for at least a part of the feature clusters a spread of the features within a respective feature cluster, and a display unit configured for displaying at least the part of the feature clusters together with a graphical indication of the corresponding spread.

96. 发明授权

US09536194B2 Method and system for exploring the associations between drug side-effects and therapeutic indications 有权
标题翻译：探讨药物副作用与治疗适应症之间关联的方法和系统
公开(公告)号：US09536194B2
公开(公告)日：2017-01-03
申请号：US13971072
申请日：2013-08-20
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION
发明人： Nan Cao , Jianying Hu , Robert K. Sorrentino , Fei Wang , Ping Zhang
IPC分类号： G06N5/02 , G06F19/00
CPC分类号： G06F19/704 , G06F19/707 , G06F19/708 , G06N5/02 , G06N5/022
摘要： A system and method for analyzing chemical data including a processor and one or more classifiers, stored in memory and coupled to the processor, which further includes an indication predictive module configured to predict whether a given chemical treats a particular indication or not and a side effect predictive module configured to predict whether a given chemical causes a side-effect or not. A correlation engine is configured to determine one or more correlations between one or more indications and one or more side effects for the given chemical and a visualization tool is configured to analyze the one or more correlations and to output results of the analysis.
摘要翻译：一种用于分析化学数据的系统和方法，包括存储在存储器中并耦合到处理器的处理器和一个或多个分类器，其进一步包括指示预测模块，其被配置为预测给定化学品是否处理特定指示和副作用预测模块被配置为预测给定化学品是否导致副作用。相关引擎被配置为确定一个或多个指示与给定化学品的一个或多个副作用之间的一个或多个相关性，并且可视化工具被配置为分析一个或多个相关性并输出分析结果。

97. 发明授权

US09372962B2 Systems and methods for identifying drug targets using biological networks 有权
公开(公告)号：US09372962B2
公开(公告)日：2016-06-21
申请号：US14658341
申请日：2015-03-16
申请人： The Regents of the University of California
发明人： Wei Wang , Rui Chang
IPC分类号： G06N7/00 , G06N99/00 , G06F19/12 , G06F19/00 , G06F19/18 , G06N5/02
CPC分类号： G06F19/707 , G06F19/12 , G06F19/18 , G06N5/02 , G06N7/005 , G06N99/005
摘要： Certain embodiments of the invention may include systems and methods for identifying drug targets using biological networks. According to an example embodiment of the invention, a method is provided for predicting the effects of drug targets on treating a disease. The method can include constructing a structure of a Bayesian network based at least in part on knowledge of drug inhibiting effects on a disease; associating a set of parameters with the constructed Bayesian network; determining values of a joint probability distribution of the Bayesian network via an automatic procedure; deriving a mean Bayesian network with one or more averaged parameters based at least in part on the joint probability values; and calculating a quantitative prediction based at least in part on the mean Bayesian network.

98. 发明授权

US09367812B2 Compound selection in drug discovery 有权
标题翻译：药物发现中的化合物选择
公开(公告)号：US09367812B2
公开(公告)日：2016-06-14
申请号：US13261542
申请日：2010-08-25
申请人： Matthew Segall , Tatsunori Hashimoto
发明人： Matthew Segall , Tatsunori Hashimoto
IPC分类号： G06N99/00 , G06F19/00
CPC分类号： G06N99/005 , G06F19/704 , G06F19/706 , G06F19/707
摘要： Methods and systems for determining the selection criteria that in its embodiments can distinguish compounds that successfully meet an objective from those that do not, determine the importance of selection criterion in selecting test compounds that have a high probability of achieving an objective and automatically apply the selection criteria to select test compounds with a high chance of meeting an objective.
摘要翻译：用于确定选择标准的方法和系统，在其实施方案中可以将成功满足目标的化合物与不能确定选择标准在选择具有高概率实现目标的测试化合物中并且自动应用选择的重要性选择具有很高机会达到目标的化合物的标准。

99. 发明授权

US09317664B2 Method and device for partitioning a molecule 有权
标题翻译：用于分配分子的方法和装置
公开(公告)号：US09317664B2
公开(公告)日：2016-04-19
申请号：US10966041
申请日：2004-10-14
申请人： Sachin Ahuja , David Kita , Eniko Fodor , Adityo Prakash
发明人： Sachin Ahuja , David Kita , Eniko Fodor , Adityo Prakash
IPC分类号： G01N33/48 , G01N33/50 , G06F19/00 , G06F19/24 , G06F19/26 , G06F19/28 , G01N33/68 , G06F19/16 , C40B30/02 , G06F19/18
CPC分类号： G06F19/701 , C40B30/02 , G01N33/6803 , G06F19/16 , G06F19/18 , G06F19/24 , G06F19/26 , G06F19/28 , G06F19/706 , G06F19/707
摘要： A method for partitioning a molecular subset is described. The partitioning method takes into account molecular structure and its manner of storage and transmission, transformations to be applied to the molecular subset and their implementation, and constraints imposed by the implementation of the partitioning method. Using this method, a molecular subset can be stored, transmitted, and processed more efficiently. The resulting efficiency makes it possible to design and run applications which require complex molecular processing, such as rational drug discovery, virtual library design, etc.
摘要翻译：描述了用于分割分子子集的方法。分割方法考虑了分子结构及其存储和传输方式，应用于分子子集的变换及其实现，以及实施分区方法所施加的约束。使用这种方法，可以更有效地存储，传输和处理分子子集。所产生的效率使得可以设计和运行需要复杂的分子处理的应用，例如合理的药物发现，虚拟图书馆设计等。

100. 发明申请

US20150254434A1 Systems and Methods for Identifying Drug Targets Using Biological Networks 有权
标题翻译：使用生物网络识别药物靶点的系统和方法
公开(公告)号：US20150254434A1
公开(公告)日：2015-09-10
申请号：US14658341
申请日：2015-03-16
申请人： The Regents of the University of California
发明人： Wei Wang , Rui Chang
IPC分类号： G06F19/00 , G06N99/00 , G06N7/00
CPC分类号： G06F19/707 , G06F19/12 , G06F19/18 , G06N5/02 , G06N7/005 , G06N99/005
摘要： Certain embodiments of the invention may include systems and methods for identifying drug targets using biological networks. According to an example embodiment of the invention, a method is provided for predicting the effects of drug targets on treating a disease. The method can include constructing a structure of a Bayesian network based at least in part on knowledge of drug inhibiting effects on a disease; associating a set of parameters with the constructed Bayesian network; determining values of a joint probability distribution of the Bayesian network via an automatic procedure; deriving a mean Bayesian network with one or more averaged parameters based at least in part on the joint probability values; and calculating a quantitative prediction based at least in part on the mean Bayesian network.
摘要翻译：本发明的某些实施方案可以包括使用生物网络鉴定药物靶标的系统和方法。根据本发明的示例性实施方案，提供了一种用于预测药物靶标对治疗疾病的影响的方法。该方法可以包括至少部分地基于对疾病的药物抑制作用的知识来构建贝叶斯网络的结构; 将一组参数与构建的贝叶斯网络相关联; 通过自动程序确定贝叶斯网络的联合概率分布的值; 至少部分地基于联合概率值，得到具有一个或多个平均参数的平均贝叶斯网络; 并且至少部分地基于平均贝叶斯网络来计算定量预测。

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