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91. 发明专利

JP2006160635A Method for producing 2-trifluoromethyl-5-fluorobenzaldehyde and its derivative 有权
标题翻译：生产2-三氟甲基-5-氟代甲醛及其衍生物的方法
公开(公告)号：JP2006160635A
公开(公告)日：2006-06-22
申请号：JP2004351728
申请日：2004-12-03
申请人： Central Glass Co Ltd , セントラル硝子株式会社
发明人： NISHINOMIYA TAKAYUKI , FUKUI AKIHIRO
IPC分类号： C07C45/43 , C07B61/00 , C07C29/141 , C07C33/46 , C07C47/55 , C07C51/235 , C07C51/58 , C07C63/70 , C07C209/40 , C07C211/29
摘要： PROBLEM TO BE SOLVED: To provide an advantageous method for producing 2-fluoromethyl-5-fluorobenzaldehyde and its derivative useful for intermediates of drugs and agricultural chemicals and the like on an industrial scale. SOLUTION: The method for producing 2-fluoromethyl-5-fluorobenzaldehyde comprises chlorinating 3,4-dimethylfluorobenzene with chlorine (Cl 2 ) to form an isomer mixture (a chlorinated reaction mixture) of 2-trichloromethyl-5-fluorobenzal chloride and 2-trichloromethyl-4-fluorobenzal chloride, bringing the obtained isomer mixture into contact with hydrogen fluoride (HF) to obtain a fluorinated reaction mixture, subjecting the fluorinated reaction mixture to distillation to efficiently isolate 2-fluoromethyl-5-fluorobenzal chloride, and hydrolyzing the obtained 2-fluoromethyl-5-fluorobenzal chloride to obtain 2-fluoromethyl-5-fluorobenzaldehyde. The 2-fluoromethyl-5-fluorobenzaldehyde can be thereafter converted into various derivatives. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为工业规模提供可用于药物和农药等中间体的2-氟甲基-5-氟苯甲醛及其衍生物的有利方法。解决方案：2-氟甲基-5-氟苯甲醛的制备方法包括用氯（Cl 2 ）氯化3,4-二甲基氟苯，以形成2-氟甲基-5-氟苯甲醛的异构体混合物（氯化反应混合物）三氯甲基-5-氟苯甲酰氯和2-三氯甲基-4-氟亚苄基氯，使得到的异构体混合物与氟化氢（HF）接触，得到氟化反应混合物，使氟化反应混合物蒸馏，有效地分离出2-氟甲基 - 并将得到的2-氟甲基-5-氟苯甲醛水解，得到2-氟甲基-5-氟苯甲醛。然后可以将2-氟甲基-5-氟苯甲醛转化成各种衍生物。版权所有（C）2006，JPO＆NCIPI

92. 发明专利

JP2002275131A METHOD FOR PRODUCING OPTICALLY ACTIVE 2-AMINOTETRALIN DERIVATIVE 失效
公开(公告)号：JP2002275131A
公开(公告)日：2002-09-25
申请号：JP2001080300
申请日：2001-03-21
申请人： NIPPON KASEI CHEM
发明人： YAMAURA MAKIKO
IPC分类号： C07C209/40 , C07B55/00 , C07B57/00 , C07B61/00 , C07C209/88 , C07C211/42 , C07C213/10 , C07C217/74
摘要： PROBLEM TO BE SOLVED: To provide a method for producing an optically active 2-aminotetralin derivative, involving converting the unnecessary isomer after optical resolution to the racemic form to put it to recycling use as the raw material for the optical resolution. SOLUTION: This method comprises the steps of making an optical resolution of a 2-aminotetralin derivative of the general formula 1(* denotes R-form or S-form; and R to R are each H, a 1-5C straight-chain or branched alkyl, 1-5C straight-chain or branched alkoxy or halogen atom) followed by separation into the necessary isomer and unnecessary isomer, chlorinating the amino group of the 2-aminotetralin derivative as the unnecessary isomer followed by making a dehydrochlorination and hydrolysis successively to form a 2-tetralone derivative, then reducing the 2-tetralone derivative to effect conversion to the racemic form of the 2-aminotetralin derivative, which is used as the raw material for the optical resolution.

94. 发明专利

JPH1087593A PRIMARY DIOXIME 失效
公开(公告)号：JPH1087593A
公开(公告)日：1998-04-07
申请号：JP24060796
申请日：1996-09-11
申请人： KURARAY CO
发明人： NAGAREDA KATSUSHI , SUZUKI SHIGEAKI
IPC分类号： C07C209/40 , C07B61/00 , C07C211/09 , C07C251/38 , C07C251/42
摘要： PROBLEM TO BE SOLVED: To obtain a primary dioxime usable in the synthesis of a diamine under a low pressure without using ammonia. SOLUTION: The objective compound is expressed by formula I (R is a 5-10C aliphatic or alicyclic hydrocarbon group), preferably 1,9-nonanedialdioxime, 2-methyl-1,8-octanedialdioxime and tricyclo [5.2.1.0]decane-3(4),8(9)- dicarbaldehydedioxime. The compound is produced e.g. by the condensation reaction of a primary dialdehyde of the formula II with hydroxylamine in a solvent such as methanol at a temp. of 0-100 deg.C.

95. 发明专利

JPH0665107A HYDROGENATING REDUCTION OF NITROGEN-CONTAINING COMPOUND 失效
公开(公告)号：JPH0665107A
公开(公告)日：1994-03-08
申请号：JP30715691
申请日：1991-10-28
申请人： SNOW BRAND MILK PROD CO LTD
发明人： KAWASAKI ISAHIRO , MORITA MINORU , KONISHI HIROAKI , KAWANARI MASAMI , DOSEMARI SHUNICHI , SHUKKE SAKANORI
IPC分类号： B01J23/755 , B01J23/74 , B01J23/78 , C07B31/00 , C07B43/02 , C07B43/04 , C07B61/00 , C07C209/32 , C07C209/38 , C07C209/40 , C07C209/42 , C07C209/48 , C07C211/13 , C07C211/39 , C07C211/53 , C07C213/02 , C07C215/44 , C07C221/00 , C07C225/22 , C07C229/44 , C07C229/48 , C07C239/08 , C07C255/24 , C07D333/76
摘要： PURPOSE:To perform safe hydrogenation at a low cost under low pressure in high reduction rate using a highly reactive hydrogen storage alloy in reducing a nitrogen-atom-contg. compound such as nitro group-contg. compound, nitrile group-contg. compound, nitroso group-contg. compound, aldoxime or ketoxime. CONSTITUTION:A nitrogen-atom-contg. compound is reduced by catalytic hydrogenation with hydrogen released from a hydrogen storage alloy having, as the main phase, compounds with hexagonal CaCu5-type crystal structure containing rare earth element or Ca plus Ni as the essential elements. The compounds are e.g. (A) as the essential constituents, CaNi5, LaNi5, LaNi4.2, Al0.8, etc., containing >=50wt.% of the CaCu5-type crystal phase. With this method, using, as starting material, RNO2, RCN, RCHNOH, RNO, RNHNH2, etc., (R is atomic group), RNH2, RNHOH, RCH2NH2, RCH, etc., can be obtained. This process can be effected in high efficiency under highly safe conditions of a hydrogen gas pressure of without requiring any catalyst.

96. 发明专利

JPH05339214A 失效
公开(公告)号：JPH05339214A
公开(公告)日：1993-12-21
申请号：JP14393992
申请日：1992-06-04
申请人： MITSUI TOATSU CHEMICALS
发明人： KAMEOKA TAIJI , TAKAGI MASATOSHI , KATO TOSHIO , HASEYAMA RYUJI
IPC分类号： C07C209/40 , C07C211/49
摘要： PURPOSE:To produce the subject compound in a high yield and in a high purity by catalytically reducing nitroacetophenone oxime readily producible from nitroacetophenone as a raw material in the presence of a reducing catalyst under CO2. CONSTITUTION:Nitroacetophenone oxime of formula I (nitro group is o-position, m-position or p-position) is catalytically reduced in the presence of carbon dioxide in an organic solvent to obtain alpha-(aminophenyl)ethylamine of formula II. In the reaction the product can be obtained as the carbonate salt of alpha-(aminophenyl)ethylamine in a stable form, because the carbon dioxide turns into carbonic acid in the presence of water. Various intermediates such as amines or imines produced in the reduction reaction are stabilized as carbonate salts only by introducing the carbon dioxide into the reaction system, whereby the decompositions of the products and side reactions are suppressed. alpha-(Aminophenyl)ethylamine is useful as a curing agent for epoxy resins, polyurethane resins or polyurea resins, as a raw material for polyamides or polyimides, etc.

97. 发明专利

JPH0481580B2 失效
公开(公告)号：JPH0481580B2
公开(公告)日：1992-12-24
申请号：JP3137184
申请日：1984-02-23
申请人： MITSUI TOATSU CHEMICALS
发明人： YAMAGUCHI KEISABURO , SUGIMOTO KENICHI , TANABE YOSHIMITSU , YAMAZAKI MIDORI , YAMAGUCHI TERUHIRO
IPC分类号： C07C211/49 , B01J31/02 , B01J31/04 , C07B61/00 , C07C67/00 , C07C209/00 , C07C209/36 , C07C209/40

98. 发明专利

JPH029445A METHOD FOR MANUFACTURING A CATALYST COMPOSITION CONTAINING NICKEL, ALUMINIUM OXIDE AND ZIRCONIUM DIOXIDE, A CATALYST COMPOSITION AND METHOD FOR HYDROGENATION OF NITRILE, AROMATIC HYDROCARBON, NITRO COMPOUND AND OLEFIN 失效
公开(公告)号：JPH029445A
公开(公告)日：1990-01-12
申请号：JP7688689
申请日：1989-03-30
申请人： HOECHST AG
发明人： KAARU DEIITAA FUROONINGU , GERUHARUTO HORUN
IPC分类号： B01J23/74 , B01J23/755 , B01J37/03 , C07B31/00 , C07B35/02 , C07B43/04 , C07B61/00 , C07C1/00 , C07C5/03 , C07C5/05 , C07C5/10 , C07C67/00 , C07C209/00 , C07C209/36 , C07C209/40 , C07C209/42 , C07C209/48 , C07C209/50 , C07C211/02 , C07C211/20 , C07C211/46 , C10G45/48
摘要： PURPOSE: To coprecipitate three kinds of metal compounds and to produce the catalyst having an excellent characteristic by adding a basic precipitating agent to a Ni-Al-Zr mixed salt aq. soln. in stoichiometric excess at a specified temp. to subject the metal compounds to precipitation deposition on a carrier. CONSTITUTION: The free acid such as nitric acid is added in excess to the mixed salt aq. soln. in which 10-100 g/L Ni, 1-30 pts.wt. Al and 0.5-20 pts.wt. Zr per 100 pts.wt. Ni are incorporated so that H :Zr may be equal to or more than (2-40):1. Then the precipitating agent such as an alkali carbonate aq. soln. is added to the mixed salt aq. soln. in 5-100% stoichiometric excess to an amount required for precipitation of Ni, Al and Zr to subject simultaneously nickel, aluminum oxide and zirconium dioxide to the precipitation deposition on the carrier at 60-120 deg.C and pH 7-10. The catalyst obtained by this way has an extremely high stability.

99. 发明专利

JPS6345662B2 失效
公开(公告)号：JPS6345662B2
公开(公告)日：1988-09-12
申请号：JP12254583
申请日：1983-07-06
申请人： TOYO STAUFFER CHEM CO
发明人： YAMAMOTO TAKASHI
IPC分类号： C07D223/16 , B01J31/14 , C07B31/00 , C07B43/04 , C07C67/00 , C07C209/00 , C07C209/30 , C07C209/40 , C07C209/52 , C07C211/03 , C07C211/27 , C07C211/45 , C07C211/48 , C07C213/00 , C07C213/02 , C07C217/84 , C07D225/02 , C07D295/02

100. 发明专利

JPS6315259B2 失效
公开(公告)号：JPS6315259B2
公开(公告)日：1988-04-04
申请号：JP13366779
申请日：1979-10-18
申请人： CIBA GEIGY
发明人： JOZEFU PAAIFUAA , DEIITERU RAINAA
IPC分类号： C08G59/00 , C07C67/00 , C07C209/00 , C07C209/40 , C07C209/42 , C07C209/52 , C07C209/62 , C07C211/09 , C07C211/17 , C07C211/25 , C07C211/27 , C07C211/29 , C07C239/00 , C07C241/00 , C07C251/04 , C07C251/16 , C07C251/34 , C07C251/52 , C07C251/78 , C07C251/80 , C07C251/82 , C07C281/06 , C07C281/08 , C07D225/00 , C07D225/02 , C07D225/04 , C07D307/52 , C07D333/06 , C07D333/20 , C08G59/50 , C08G69/26

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