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91. 发明授权

US3732284A Process for the preparation of beta-cycloalkylpropionic esters of dimethyl-aminoethanol 失效
标题翻译：制备二甲基氨基乙醇的β-环丙基丙烯酸酯的方法
公开(公告)号：US3732284A
公开(公告)日：1973-05-08
申请号：US3732284D
申请日：1969-08-12
申请人： ROLLAND A LAB
发明人： VALETTE R
IPC分类号： B01J31/00 , A61K20060101 , C07C20060101 , C07C67/00 , C07C67/02 , C07C69/24 , C07C69/74 , C07C213/00 , C07C219/10 , C07C93/22
CPC分类号： C07C67/08
摘要： THERAPEUTICALLY USEFUL DIMETHYLAMINOPROPANOL B-CYCLOALKYLPROPIONATE ESTERS ARE PREPARED BY REACTING A METHYL, ETHYL, PROPYL OR BUTYL CYCLOALKYLPROPIONATE ESTER WITH DIMETHYLAMINOETHANOL IN A NON-AQUEOUS SOLVENT.

93. 发明授权

EP3160938B1 NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS 有权转让
公开(公告)号：EP3160938B1
公开(公告)日：2020-09-16
申请号：EP15730023.7
申请日：2015-06-05
申请人： Acuitas Therapeutics Inc.
发明人： ANSELL, Steven, M. , DU, Xinyao
IPC分类号： C07C219/06 , C07C219/08 , C07C219/10 , C07C229/16 , C07D295/13 , A61K47/50 , A61K9/127

94. 发明授权

EP1542942B1 COMPOSITIONS CONTENANT DES LIQUIDES IONIQUES ET LEURS UTILISATIONS, NOTAMMENT EN SYNTHESE ORGANIQUE 有权
标题翻译：组合物离子液体含及其VEWENDUNGEN，特别是在有机合成
公开(公告)号：EP1542942B1
公开(公告)日：2006-12-27
申请号：EP03798215.4
申请日：2003-09-23
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE DE RENNES I
发明人： VAULTIER, Michel , GMOUH, Said
IPC分类号： C07B37/04 , C07B37/12 , C07B37/02 , C07C213/08 , C07C219/10 , C07C219/12 , C07C209/08 , C07C211/63 , C07C213/02 , C07C215/44 , C07C67/03
CPC分类号： B01J31/0281 , B01J31/0224 , B01J31/0239 , B01J31/0288 , B01J31/04 , B01J31/30 , B01J2231/326 , B01J2231/341 , B01J2231/4211 , B01J2231/4261 , B01J2231/4266 , C07B37/02 , C07B37/04 , C07B37/12 , C07C67/03 , C07C67/343 , C07C67/347 , C07C2602/42 , C07C69/732 , C07C69/65 , C07C69/734 , C07C69/753 , C07C69/618 , C07C69/76
摘要： The invention relates to the use of an ionic liquid as a matrix liquid for organic synthesis in a homogeneous phase on a soluble medium, said ionic liquid being present in the form of a liquid or solid at room temperature, having formula A1+X1-, A1+ representing a functional or non-functional cation or a mixture of cations wherein none of said cations are functional or at least one of the cations is functional, and X1- a functional or non-functional anion or a mixture of anions wherein none of the anions are functional or at least one of the anions is functional.

95. 发明公开

EP1641729A2 UTILISATION DE SELS D ONIUM FONCTIONNALISES EN TANT QUE SUPP ORT SOLUBLE POUR LA SYNTHESE ORGANIQUE 有权
标题翻译： VERWENDUNG FUNKTIONALISIERTER ONIUMSALZE ALSLÖSLICHETRÄGERFÜRDIE ORGANISCHE SYNTHESE
公开(公告)号：EP1641729A2
公开(公告)日：2006-04-05
申请号：EP04767564.0
申请日：2004-07-02
申请人： Centre National De La Recherche Scientifique-CNRS , UNIVERSITE DE RENNES I
发明人： VAULTIER, Michel , GMOUH, Said , HASSINE, Fatima
IPC分类号： C07B37/12 , C07B37/04 , C07D211/16 , C07B37/02 , C07C219/10 , C07C209/08 , C07C213/02 , C07C67/03 , C07C213/08 , C07C219/12 , C07C211/63 , C07C215/44
CPC分类号： C07D211/16 , C07B37/02 , C07B37/04 , C07B37/12 , C07B61/00 , C07C67/03 , C07C2602/42 , C07C69/76 , C07C69/618 , C07C69/753 , C07C69/92
摘要： The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula Al+, X1-, wherein A1+ represents a cation and X1- représents an anion.
摘要翻译：本发明涉及通过至少一种有机功能的鎓盐作为可溶性载体在至少一种有机溶剂的存在下，通过至少一种转化在均相中有机合成分子的用途，的有机功能。鎓盐使得合成的分子被释放。鎓盐在室温下以液体或固体形式存在，并且对应于式A的化合物，其中X 1，X 2， SUP>，其中A 1 + O 2表示阳离子，X 1表示阴离子。

97. 发明公开

EP0272576A1 Quaternary ammonium halide salts of cinnamate esters as sunscreen agents and compositions containing same 失效
标题翻译：肉桂酸酯的季铵卤化物的盐，它们作为防晒剂和含有这些制剂使用。
公开(公告)号：EP0272576A1
公开(公告)日：1988-06-29
申请号：EP87118494.1
申请日：1987-12-14
申请人： L. GIVAUDAN & CIE Société Anonyme
发明人： Cohen, Isaac David
IPC分类号： C07C219/10 , A61K7/44 , A61K7/06
CPC分类号： A61Q17/04 , A61K8/416 , D06M13/463 , D06M2200/25
摘要： Higher alkyl quaternary halide salts of cinnamate esters of the general formula I
wherein R¹ is an alkyl group containing from one to four carbon atoms; R² is an alkyl group containing from one to six carbon atoms; R³ is alkylene containing from two to six carbon atoms; R⁴ is an alkyl group containing from sixteen to twenty-two carbon atoms; and X⁻ is a halogen anion
are useful as sunscreen agents. Sunscreen compositions containing same and methods of using are provided.
摘要翻译：较高的烷基卤化物通式的肉桂酸酯的酯季盐I worin - [R <1>是含有一至四个碳原子的烷基; [R <2>是含有一个至六个碳原子的烷基; [R <3>是包含二至六个碳原子的亚烷基; [R <4>是含有从16至22碳原子的烷基; 和X < - >是卤素阴离子如防晒剂是有用的。提供了含有使用的相同和方法防晒组合。

98. 发明授权

KR100911720B1 A PROCESS FOR PREPARING CRYSTAL FOAM OF SARPOGRELATE HCL 有权
标题翻译：一种制备盐酸HCL水晶泡沫的方法
公开(公告)号：KR100911720B1
公开(公告)日：2009-08-10
申请号：KR20090031464
申请日：2009-04-10
申请人： HANSEO CHEMICAL CO LTD
发明人： OH MIN KEUN , KIM KI NAM , SUH KI HYOUNG , KWON HYUK MAN
IPC分类号： C07C213/06 , C07C219/06 , C07C219/10
摘要： A process for preparing crystalline sarpogrelate hydrochloride is provided to shorten operation process and operation time, to reduce generation rate of waste, and to produce type II crystal of sarpogrelate hydrochloride according to addition of methanol. A process for preparing crystalline sarpogrelate hydrochloride comprises the steps of: liberating a compound of chemical formula (III) and hydrochloride by controlling the pH of 2-[(3-dimethylamino-2-hydroxy)-propoxy]-3'-methoxybibenzyl hydrochloride of chemical formula (II) to 10~12 using 10% aqueous sodium hydroxide solution; extracting the compound of chemical formula (III) using any one extraction solvent selected from ethylacetate, dichloromethane and chloroform; reacting the compound of chemical formula (III) among the extraction solvents and succinic anhydride; and injecting chlorine gas in the reactant to obtain type II crystal of sarpogrelate hydrochloride.
摘要翻译：提供了一种制备盐酸沙格列酮盐酸盐的方法，以缩短操作过程和操作时间，降低废物的产生速率，并根据甲醇的添加产生盐酸沙格列酮的II型晶体。制备盐酸沙格列酮盐酸盐的方法包括以下步骤：通过控制2 - [（3-二甲基氨基-2-羟基） - 丙氧基] -3'-甲氧基苄基盐酸盐的pH来释放化学式（III）和盐酸盐的化合物化学式（II）至10〜12，使用10％氢氧化钠水溶液; 使用选自乙酸乙酯，二氯甲烷和氯仿的任何一种萃取溶剂萃取化学式（Ⅲ）化合物; 在萃取溶剂和琥珀酸酐中使化学式（Ⅲ）化合物反应; 并在反应物中注入氯气以获得盐酸沙格雷酯II型晶体。

99. 发明授权

US12043636B2 Method for producing triarylorganoborates 有权
公开(公告)号：US12043636B2
公开(公告)日：2024-07-23
申请号：US16950901
申请日：2020-11-17
申请人： Covestro Deutschland AG
发明人： Thomas Rölle , Horst Berneth , Dennis Hönel , Friedrich-Karl Bruder , Jürgen Kintrup
IPC分类号： C07F5/02 , C07C211/63 , C07C211/64 , C07C217/08 , C07C219/10 , C07C219/28 , C07C219/30 , C07C271/12 , C07C271/16 , C07C271/20 , C07C271/24 , C07C271/28 , C07D213/20 , C07D233/02 , C07D233/58 , C07D247/00 , C07D295/037 , C07D309/34 , C07D335/02 , C07D347/00 , C07D413/06 , C07F5/04 , C07F9/54 , G03F7/00
CPC分类号： C07F5/027 , C07C211/63 , C07C211/64 , C07C217/08 , C07C219/10 , C07C219/28 , C07C219/30 , C07C271/12 , C07C271/16 , C07C271/20 , C07C271/24 , C07C271/28 , C07D213/20 , C07D233/02 , C07D233/58 , C07D247/00 , C07D295/037 , C07D309/34 , C07D335/02 , C07D347/00 , C07D413/06 , C07F5/04 , C07F9/54 , C07F9/5407 , C07F9/5442 , G03F7/001 , C07C2601/14
摘要： The invention relates to a process for preparing triaryl organo borates proceeding from organoboronic esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous workup of the reaction mixture and the use of the triaryl organoborates obtained as co-initiator in photopolymer formulations, holographic media and holograms.

100. 发明公开

US20230202966A1 ACYCLIC LIPIDS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20230202966A1
公开(公告)日：2023-06-29
申请号：US17972395
申请日：2022-10-24
申请人： Renagade Therapeutics Management Inc.
发明人： Muthusamy Jayaraman , Stephen Scully
IPC分类号： C07C219/06 , C07C219/08 , C07C219/10
CPC分类号： C07C219/06 , C07C219/08 , C07C219/10
摘要： The present disclosure details various lipids, compositions, and/or methods of optimized systems and delivery vehicles for the delivery of nucleic acid sequences, polypeptides or peptides for use in vaccinating against infectious agents.

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