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93. 发明专利

JP2004099562A Low-molecular derivative of biomolecule 有权
标题翻译：生物分子的低分子衍生物
公开(公告)号：JP2004099562A
公开(公告)日：2004-04-02
申请号：JP2002265982
申请日：2002-09-11
申请人： Furuuchi Kagaku Kk , National Institute For Materials Science , フルウチ化学株式会社 , 独立行政法人物質・材料研究機構
发明人： TAGUCHI TETSUSHI , KOBAYASHI HISATOSHI , TANAKA JUNZO , SAITO HIROSHI
IPC分类号： C07D285/00 , A61L24/00 , A61L27/00 , C07C233/03 , C07C235/06 , C07C235/80 , C07D207/02 , C07D207/408 , C07D207/46 , C08H1/00 , C07D285/01
CPC分类号： C07D207/02 , C07D207/46
摘要： PROBLEM TO BE SOLVED: To develop a crosslinking agent derived from organisms and solving the problems of conventional crosslinking agent and condensing agent for the treatment of medical devices, etc., composed mainly of an artificially synthesized agent or an agent of non-natural origin and, accordingly, resistant to metabolism in the body sometimes to develop toxicity to the organism and restricting the use and application dose in the case of using at a medical site. SOLUTION: A crosslinked polymer is produced by crosslinking various kinds of polymers and a low-molecular derivative of a biomolecule obtained by modifying the carboxy group of a low-molecular biomolecule with N-hydroxysuccinimide, N-hydroxysulfosuccinimide or their derivatives. COPYRIGHT: (C)2004,JPO
摘要翻译：要解决的问题：为了开发来自生物体的交联剂，并且解决了主要由人造合成剂或非水溶性剂构成的用于医疗器械等的常规交联剂和缩合剂的问题，因此，在身体中有代谢作用，有时会对生物体产生毒性并限制在医疗场所使用的情况下的使用和施用剂量。解决方案：交联聚合物通过交联各种聚合物和通过用N-羟基琥珀酰亚胺，N-羟基磺基琥珀酰亚胺或其衍生物改性低分子生物分子的羧基获得的生物分子的低分子衍生物来制备。版权所有（C）2004，JPO

94. 发明专利

JP3176619B2 失效
公开(公告)号：JP3176619B2
公开(公告)日：2001-06-18
申请号：JP51347091
申请日：1991-09-05
IPC分类号： A61K31/18 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/495 , A61P13/12 , A61P19/02 , A61P29/00 , A61P37/00 , A61P43/00 , C07C311/14 , C07C311/15 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/21 , C07D207/02 , C07D207/16 , C07D207/48 , C07D209/20 , C07D217/22 , C07D295/18 , C07D295/182 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/26 , C07D401/12 , C07D403/12 , C12N9/99

95. 发明专利

JP2564781B2 失效
公开(公告)号：JP2564781B2
公开(公告)日：1996-12-18
申请号：JP11948292
申请日：1992-03-26
申请人： TANABE SEIYAKU CO
发明人： IWASAKI TAMEO , NISHITANI TAKASHI , OOTANI AKIO , INAMASU MASANORI
IPC分类号： A61K31/40 , A61P7/02 , C07D207/02

96. 发明专利

JPH06510017A 失效
公开(公告)号：JPH06510017A
公开(公告)日：1994-11-10
申请号：JP51347091
申请日：1991-09-05
IPC分类号： A61K31/18 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/47 , A61K31/495 , A61P13/12 , A61P19/02 , A61P29/00 , A61P37/00 , A61P43/00 , C07C311/14 , C07C311/15 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/21 , C07D207/02 , C07D207/16 , C07D207/48 , C07D209/20 , C07D217/22 , C07D295/18 , C07D295/182 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/26 , C07D401/12 , C07D403/12 , C12N9/99

97. 发明专利

JPH0686422B2 失效
公开(公告)号：JPH0686422B2
公开(公告)日：1994-11-02
申请号：JP16365089
申请日：1989-06-28
IPC分类号： C07D207/02 , C07B43/06 , C07D207/40 , C07D207/416 , C07D207/44 , C07D209/50 , C07D405/06 , C07D409/06 , C07D491/107 , C07D495/10 , C09K9/02

98. 发明专利

JPH05279324A 失效
公开(公告)号：JPH05279324A
公开(公告)日：1993-10-26
申请号：JP11948392
申请日：1992-03-26
IPC分类号： A61K31/40 , A61K31/44 , A61K31/4427 , A61P7/02 , C07D207/02 , C07D207/46 , C07D207/50 , C07D401/06
摘要： PURPOSE:To provide the subject new compound having excellent anti- thrombogenic activity, usable in either oral and parenteral administration routes, useful as an antithrombotic agent. CONSTITUTION:The objective 2,5-pyrrolidinedione derivative of formula I [ring A is tri-lower alkoxyphenyl; R is (substituted) alkyl, (substituted)alkoxy, (substituted) amino or pyridylcarbonyl], e.g. (3E,4E)-1-methyl-3-benzylidene-4-(3,4,5 trimethoxybenzylidene)-2,5-pyrrolidinedione. The compound of the formula I can be obtained by intramolecular ring closure of a compound of formula II (R and R are such that one of them is alkoxy and the other is NHR ), or by reaction of a compound of formula III with a compound of formula IV (X is reactive residue). This compound, serving as an antithrombotic agent, is useful as a preventive or therapeutic agent for angiopathy such as cerebral apoploxy, stenocardia, or septicemia and diabetic complications, being also useful as a preventive agent for the reobstruction after percutaneous coronary plastic operations or thrombolytic therapies.

99. 发明专利

JPH05279323A 失效
公开(公告)号：JPH05279323A
公开(公告)日：1993-10-26
申请号：JP11948292
申请日：1992-03-26
IPC分类号： A61K31/40 , A61P7/02 , C07D207/02
摘要： PURPOSE:To provide the subject new compound having excellent anti- thrombogenic activity, usable in either of oral and parenteral administration routes, useful as antithrombotic agent. CONSTITUTION:The objective 2,5-pyrrolidinedione derivative of formula I (ring A is tri-lower alkoxyphenyl) or a pharmacologically permissible salt thereof, e.g. 3-[(E)-benzylidene]-4-[(Z)-3,4,5-trimethoxybenzylidene]-2,5-pyrrolidin edione. The compound of the formula I can be obtained by intramolecular ring closure of a carbamoyl compound of formula II (R and R are such that one of them lower alkoxy and the other is amino) followed by, if desired, making the product into a pharmacologically permissible salt. This compound, serving as an antithrombotic agent, is useful as a preventive or therapeutic agent for e.g. angiopathy such as cardiac infarction, cerebral apoploxy, or pulmonary embolism and diabetic complications, being also usable as a preventive agent for the reobstruction after percutaneous coronary plastic operations or thrombolytic therapies.

100. 发明专利

JPH04334379A AMINOALKYL KETONE DERIVATIVE, PREPARATION THEREOF, AND USE THEREOF FOR MEDICAL TREATMENT 失效
公开(公告)号：JPH04334379A
公开(公告)日：1992-11-20
申请号：JP32775291
申请日：1991-12-11
申请人： LAFON LABOR
发明人： LAFON LOUIS
IPC分类号： A61K31/38 , A61K31/381 , A61K31/395 , A61K31/40 , A61P9/08 , C07D207/02 , C07D211/00 , C07D333/06 , C07D333/22 , C07D409/06 , C07D413/06 , C07D521/00

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