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131. 发明申请

WO2012159043A3 METHOD AND SYSTEM FOR USING CHERENKOV RADIATION TO MONITOR BEAM PROFILES AND RADIATION THERAPY 审中-公开
标题翻译：使用CHERENKOV辐射对监测光束轮廓和辐射治疗的方法和系统
公开(公告)号：WO2012159043A3
公开(公告)日：2013-01-24
申请号：PCT/US2012038609
申请日：2012-05-18
申请人： DARTMOUTH COLLEGE , POGUE BRIAN WILLIAM , GLADSTONE DAVID JOSEPH , DAVIS SCOTT CHRISTIAN , AXELSSON JOHAN JAKOB , GLASER ADAM KENNETH , ZHANG RONGXIAO
发明人： POGUE BRIAN WILLIAM , GLADSTONE DAVID JOSEPH , DAVIS SCOTT CHRISTIAN , AXELSSON JOHAN JAKOB , GLASER ADAM KENNETH , ZHANG RONGXIAO
IPC分类号： A61N5/10 , A61B18/00
CPC分类号： A61N5/1065 , A61B5/0071 , A61B5/1455 , A61N5/1075 , A61N2005/1076 , G01T1/22
摘要： A system for providing monitored radiation therapy has a high energy radiation source, apparatus for excluding uncontrolled ambient light, and apparatus for collecting light emitted from a subject. The system has apparatus for spectrally analyzing the collected light, and a processor for determining oxygenation or other metabolic function of tissue within the subject from spectral analysis of the collected light. The system monitors radiation therapy by providing a beam of high energy radiation; collecting Cherenkov and/or photoluminescent light from the subject, the light generated along the beam; spectrally analyzing the light; and determining oxygenation or metabolic function of tissue from the spectral analysis. Beam profile of the system is calibrated by imaging from multiple angles Cherenkov and/or photoluminescent light emitted by a phantom placed in the beam in lieu of a subject, captured images are analyzed to determine beam profile.
摘要翻译：用于提供监测的放射治疗的系统具有高能量辐射源，用于排除不受控制的环境光的装置，以及用于收集从受试者发射的光的装置。该系统具有用于对收集的光进行光谱分析的装置，以及用于通过所收集的光的光谱分析来确定受试者内组织的氧合或其它代谢功能的处理器。该系统通过提供高能辐射束来监测放射治疗; 从受试者收集切伦科夫和/或光致发光，沿着光束产生的光; 光谱分析光; 并从光谱分析中确定组织的氧合或代谢功能。系统的光束轮廓通过从多个角度成像Cherenkov和/或通过放置在光束中的幻影发射的光致发光来代替被摄体来校准，捕获的图像被分析以确定光束轮廓。

132. 发明申请

WO2012159043A2 METHOD AND SYSTEM FOR USING CHERENKOV RADIATION TO MONITOR BEAM PROFILES AND RADIATION THERAPY 审中-公开
标题翻译：使用CHERENKOV辐射对监测光束轮廓和辐射治疗的方法和系统
公开(公告)号：WO2012159043A2
公开(公告)日：2012-11-22
申请号：PCT/US2012/038609
申请日：2012-05-18
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , POGUE, Brian William , GLADSTONE, David Joseph , DAVIS, Scott Christian , AXELSSON, Johan Jakob , GLASER, Adam Kenneth , ZHANG, Rongxiao
发明人： POGUE, Brian William , GLADSTONE, David Joseph , DAVIS, Scott Christian , AXELSSON, Johan Jakob , GLASER, Adam Kenneth , ZHANG, Rongxiao
CPC分类号： A61N5/1065 , A61B5/0071 , A61B5/1455 , A61N5/1075 , A61N2005/1076 , G01T1/22
摘要： A system for providing monitored radiation therapy has a high energy radiation source, apparatus for excluding uncontrolled ambient light, and apparatus for collecting light emitted from a subject. The system has apparatus for spectrally analyzing the collected light, and a processor for determining oxygenation or other metabolic function of tissue within the subject from spectral analysis of the collected light. The system monitors radiation therapy by providing a beam of high energy radiation; collecting Cherenkov and/or photoluminescent light from the subject, the light generated along the beam; spectrally analyzing the light; and determining oxygenation or metabolic function of tissue from the spectral analysis. Beam profile of the system is calibrated by imaging from multiple angles Cherenkov and/or photoluminescent light emitted by a phantom placed in the beam in lieu of a subject, captured images are analyzed to determine beam profile.
摘要翻译：用于提供监测的放射治疗的系统具有高能量辐射源，用于排除不受控制的环境光的装置，以及用于收集从受试者发射的光的装置。该系统具有用于对收集的光进行光谱分析的装置，以及用于通过所收集的光的光谱分析来确定受试者内组织的氧合或其它代谢功能的处理器。该系统通过提供高能辐射束来监测放射治疗; 从受试者收集切伦科夫和/或光致发光，沿着光束产生的光; 光谱分析光; 并从光谱分析中确定组织的氧合或代谢功能。系统的光束轮廓通过从多个角度成像Cherenkov和/或通过放置在光束中的幻影发射的光致发光来代替被摄体来校准，捕获的图像被分析以确定光束轮廓。

133. 发明申请

WO2012139031A1 SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING A PANORAMIC CONE BEAM COMPUTED TOMOGRAPHY (CBCT) 审中-公开
标题翻译：系统，方法和计算机可访问介质提供全景锥束计算机图（CBCT）
公开(公告)号：WO2012139031A1
公开(公告)日：2012-10-11
申请号：PCT/US2012/032574
申请日：2012-04-06
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , CHANG, Jenghwa , CHAO, K.S., Clifford , LILI, Zhou , SONG, Wang
发明人： CHANG, Jenghwa , CHAO, K.S., Clifford , LILI, Zhou , SONG, Wang
IPC分类号： A61B6/00 , G01N23/00
CPC分类号： G06T11/60 , A61B6/032 , A61B6/4085 , A61B6/4233 , A61B6/5205 , A61B6/5241 , A61B6/582 , A61B6/583 , A61N5/1049 , A61N5/1065 , A61N2005/1061 , G01N23/046 , G01N2223/401 , G01N2223/419 , G01N2223/612 , G06T11/005 , G06T11/008 , G06T2207/10081 , G06T2211/432
摘要： Exemplary devices, procedures and computer-readable mediums for providing a projection image associated with at least one target. The projection image can be formed from a plurality of locations of a source arrangement. At each source location, a plurality of panoramic projection images associated with a target can be acquired. At least two of the panoramic projection images can be obtained at view angles which are different from one another. These panoramic projection images can be stitched together or otherwise combined. A resulting image can then be generated using a computed tomography procedure based on the stitched or combined projection images that are generated at the plurality of location.
摘要翻译：用于提供与至少一个目标相关联的投影图像的示例性设备，过程和计算机可读介质。投影图像可以由源装置的多个位置形成。在每个源位置，可以获取与目标相关联的多个全景投影图像。可以在彼此不同的视角获得全景投影图像中的至少两个。这些全景投影图像可以缝合在一起或以其他方式组合。然后可以使用基于在多个位置处生成的缝合或组合的投影图像的计算机断层摄影过程来生成所得到的图像。

134. 发明申请

WO2012063162A1 MAGNETIC RESONANCE IMAGING AND RADIOTHERAPY APPARATUS WITH AT LEAST TWO-TRANSMIT-AND RECEIVE CHANNELS 审中-公开
标题翻译：磁共振成像和放射治疗装置与至少两个发射和接收通道
公开(公告)号：WO2012063162A1
公开(公告)日：2012-05-18
申请号：PCT/IB2011/054858
申请日：2011-11-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , HARVEY, Paul Royston
发明人： HARVEY, Paul Royston
IPC分类号： G01R33/48 , A61N5/10 , A61B5/055
CPC分类号： A61B5/055 , A61B5/0037 , A61B5/0555 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1055 , A61N2005/1056 , G01R33/3806 , G01R33/4808 , G01R33/4812
摘要： A therapeutic apparatus (500, 600) comprising a radiotherapy apparatus (502) for treating a target zone (318, 536) and a magnetic resonance imaging system (510, 532, 44, 602) for acquiring magnetic resonance imaging data (624). The radiotherapy apparatus comprises a radiotherapy source (300, 302, 304, 504) for directing electromagnetic radiation (310, 312, 314, 508) into the target zone. The radiotherapy apparatus is adapted for rotating the radiotherapy source at least partially around the magnetic resonance magnet. The magnetic resonance imaging system further comprises a radio-frequency transceiver (532) adapted for simultaneously acquiring the magnetic resonance data from at least two transmit- and-receive channels (528, 530). The therapeutic apparatus further comprises a processor (614) and a memory(620) containing machine executable instructions (636, 638, 640, 642, 644) for the processor. Execution of the instructions causes the processor to: calibrate(100, 200) the transmit-and-receive channels; acquire (102, 202) the magnetic resonance data; reconstruct (104, 204) a magnetic resonance image (626); register (106, 206) a location (628) of the target zone in the image; and generate (108, 208) radiotherapy control signals (630) using the registered image.
摘要翻译：一种治疗装置（500,600），包括用于治疗目标区域（318,536）的放射治疗装置（502）和用于获取磁共振成像数据（624）的磁共振成像系统（510,532,44,602）。放射治疗装置包括用于将电磁辐射（310,312,314,508）引导到目标区域中的放射治疗源（300,302,304,504）。放射治疗装置适于至少部分地围绕磁共振磁体旋转放射源。磁共振成像系统还包括适于同时从至少两个发射和接收通道（528,530）获取磁共振数据的射频收发器（532）。治疗装置还包括处理器（614）和包含用于处理器的机器可执行指令（636,638,640,642,644）的存储器（620）。执行指令会导致处理器：校准（100,200）发送和接收通道; 获取磁共振数据（102,202）; 重建（104,204）磁共振图像（626）; 寄存器（106,206）图像中的目标区域的位置（628）; 以及使用所述登记图像生成（108,208）放射治疗控制信号（630）。

135. 发明申请

WO2012025719A1 RADIATION-EMITTING MEDICAL APPARATUS 审中-公开
标题翻译：辐射发射医疗器械
公开(公告)号：WO2012025719A1
公开(公告)日：2012-03-01
申请号：PCT/GB2011/001262
申请日：2011-08-22
申请人： MOULTRIE, Alan
发明人： MOULTRIE, Alan
IPC分类号： A61N5/10
CPC分类号： A61N5/1048 , A61N5/1064 , A61N5/1065 , A61N5/1069 , A61N2005/105
摘要： A radiation-emitting medical apparatus (110) comprising a radiation source (102) and a distance measurement device (105). The distance measurement device (105) is configured to automatically determine a distance between a patient (109a) and the radiation source (102). Further, a method of medically emitting radiation comprising automatically determining a distance between a patient (109a) and a radiation source (102) and emitting radiation.
摘要翻译：一种辐射发射医疗设备（110），包括辐射源（102）和距离测量装置（105）。距离测量装置（105）被配置为自动确定患者（109a）和辐射源（102）之间的距离。此外，医疗发射辐射的方法包括自动确定患者（109a）和辐射源（102）之间的距离并发射辐射。

136. 发明申请

WO2011121037A1 CHARGED PARTICLE IRRADIATION DEVICE AND METHOD 审中-公开
标题翻译：充电颗粒辐照装置和方法
公开(公告)号：WO2011121037A1
公开(公告)日：2011-10-06
申请号：PCT/EP2011/054940
申请日：2011-03-30
申请人： ION BEAM APPLICATIONS , CLAEREBOUDT, Yves , SAIVE, Gregory
发明人： CLAEREBOUDT, Yves , SAIVE, Gregory
IPC分类号： A61N5/10
CPC分类号： A61N5/00 , A61N5/1043 , A61N5/1048 , A61N5/1065 , A61N2005/1074 , A61N2005/1087
摘要： A charged particle irradiation device (10) and method for irradiating a target volume (50), adapted for receiving a treatment plan (70) defining a series of prescribed irradiation points (140) having each a prescribed dose to be delivered, comprising an irradiation unit (40) having at least one scanning magnet (100; 110), and at least one beam position monitor (130) installed in between the said scanning magnet (100; 1 10) and said target volume (50). A controller (80) comprises means for calculating for any said prescribed irradiation point corresponding nominal magnetic settings of the scanning magnet such that a beam (90) is pointing to said prescribed irradiation point when corresponding magnetic settings are applied, and for calculating corresponding expected position at said beam position monitor (130) The controller (80) further comprises a) means for selecting a tuning reference point from said series of prescribed irradiation points; b) means for specifying a prescribed tuning dose to be given to said selected tuning reference point, said prescribed tuning dose being equal or smaller than the said prescribed dose at said selected tuning reference point; c) means for comparing a beam position provided by the beam position monitor (130) and the expected position at said beam position monitor (130) for said selected tuning reference point; d) means for computing a first correction to be applied to said nominal magnetic settings of the scanning magnet (100; 110) in order to align the beam position provided by the beam position monitor to the expected position at said beam position monitor (130) for said selected tuning reference point; e) means for correcting the nominal magnetic settings of the scanning magnet for all said prescribed irradiation points according to said first correction.
摘要翻译：一种带电粒子照射装置（10）和用于照射适于接收限定一系列具有规定的待分配剂量的规定照射点（140）的处理计划（70）的目标体积（50）的方法，包括照射具有至少一个扫描磁体（100; 110）的单元（40）和安装在所述扫描磁体（100,110）和所述目标体积（50）之间的至少一个光束位置监视器（130）。控制器（80）包括用于计算对应于所述扫描磁体的所述规定照射点的相应的标称磁性设置的装置，使得当应用相应的磁性设置时，光束（90）指向所述规定的照射点，并且用于计算相应的预期位置在所述光束位置监视器（130）处，所述控制器（80）还包括：a）用于从所述一系列规定照射点选择调谐参考点的装置; b）用于指定给予所述选择的调谐参考点的规定调谐剂量的装置，所述规定调谐剂量等于或小于所述选定调谐参考点处的所述规定剂量; c）用于将由所述光束位置监视器（130）提供的光束位置与所述光束位置监视器（130）对于所述选定调谐参考点的预期位置进行比较的装置; d）用于计算要应用于所述扫描磁体（100; 110）的所述标称磁性设置的第一校正以便将由所述光束位置监视器提供的光束位置对准所述光束位置监视器（130）处的预期位置的装置，对于所述选择的调谐参考点; e）根据所述第一校正用于校正所有所述规定照射点的扫描磁体的标称磁性设置的装置。

137. 发明申请

WO2011041500A3 SYSTEM AND METHODS PHOTON-BASED RADIOTHERAPY AND RADIOSURGERY DELIVERY 审中-公开
标题翻译：系统和方法基于光子的放射治疗和放射外科递送
公开(公告)号：WO2011041500A3
公开(公告)日：2011-08-18
申请号：PCT/US2010050850
申请日：2010-09-30
申请人： STC UNM , LUAN SHUANG , MA LIJUN , CHEN ZHE
发明人： LUAN SHUANG , MA LIJUN , CHEN ZHE
IPC分类号： A61N5/10 , A61B5/05 , A61B6/00
CPC分类号： A61N5/1084 , A61B6/4085 , A61N5/10 , A61N5/1031 , A61N5/1065 , A61N5/1067 , A61N5/1071 , A61N5/1081 , A61N2005/1074
摘要： Photon-based radiosurgery is widely used for treating local and regional tumors. The key to improving the quality of radiosurgery is to increase the dose falloff rate from high dose regions inside the tumor to low dose regions of nearby healthy tissues and structures. Dynamic photon painting (DPP) further increases dose falloff rate by treating a target by moving a beam source along a dynamic trajectory, where the speed, direction and even dose rate of the beam source change constantly during irradiation. DPP creates dose gradient that rivals proton Bragg Peak and outperforms Gamma Knife® radiosurgery.
摘要翻译：基于光子的放射外科广泛用于治疗局部和区域肿瘤。提高放射外科手术质量的关键是增加肿瘤内高剂量区域的剂量衰减率到附近健康组织和结构的低剂量区域。动态光子喷涂（DPP）通过沿着动态轨迹移动光束源来处理目标，从而进一步提高剂量衰减率，其中在照射期间光源的速度，方向和剂量率恒定不变。 DPP制造的剂量梯度可以与质子布拉格峰相媲美，并且胜过伽玛刀放射外科手术。

138. 发明申请

WO2007014091A3 SYSTEM AND METHOD OF GENERATING CONTOUR STRUCTURES USING A DOSE VOLUME HISTOGRAM 审中-公开
标题翻译：使用剂量组织生成轮廓结构的系统和方法
公开(公告)号：WO2007014091A3
公开(公告)日：2009-04-16
申请号：PCT/US2006028534
申请日：2006-07-21
申请人： TOMOTHERAPY INC , KAPATOES JEFFREY M , OLIVERA GUSTAVO H , SCHNARR ERIC , LU WEIGUO , RUCHALA KENNETH J , RECKWERDT PAUL J , HUGHES JOHN , MACKIE THOMAS R
发明人： KAPATOES JEFFREY M , OLIVERA GUSTAVO H , SCHNARR ERIC , LU WEIGUO , RUCHALA KENNETH J , RECKWERDT PAUL J , HUGHES JOHN , MACKIE THOMAS R
IPC分类号： A61N5/10 , H05G1/28 , H05G1/44
CPC分类号： A61N5/103 , A61N5/1042 , A61N5/1048 , A61N5/1049 , A61N5/1065 , A61N5/1069 , A61N2005/1074
摘要： A system and method of defining a new region of interest for an existing region of interest using a dose volume histogram. The method includes the acts of generating a dose volume histogram of radiation dose for a pre-existing region of interest (200), selecting a subset of the dose volume histogram (204), and defining a new region of interest that corresponds to the selected subset of the dose volume histogram (212).
摘要翻译：使用剂量体积直方图来定义现有感兴趣区域的新感兴趣区域的系统和方法。该方法包括产生用于预先存在的感兴趣区域（200）的辐射剂量的剂量体积直方图的动作，选择剂量体积直方图（204）的子集，以及定义与所选择的对应的新的感兴趣区域剂量体积直方图的子集（212）。

139. 发明申请

WO2007014093A3 METHOD AND SYSTEM FOR PROCESSING DATA RELATING TO A RADIATION THERAPY TREATMENT PLAN 审中-公开
标题翻译：处理有关辐射治疗治疗计划的数据的方法和系统
公开(公告)号：WO2007014093A3
公开(公告)日：2007-12-06
申请号：PCT/US2006028537
申请日：2006-07-21
申请人： TOMOTHERAPY INC , SCHNARR ERIC , RUCHALA KENNETH J , OLIVERA GUSTAVO H , LU WEIGUO , KAPATOES JEFFREY M , HAIMERL JASON , HUGHES JOHN H , MACKIE THOMAS R
发明人： SCHNARR ERIC , RUCHALA KENNETH J , OLIVERA GUSTAVO H , LU WEIGUO , KAPATOES JEFFREY M , HAIMERL JASON , HUGHES JOHN H , MACKIE THOMAS R
IPC分类号： G06K9/36
CPC分类号： A61N5/103 , A61N5/1037 , A61N5/1038 , A61N5/1042 , A61N5/1048 , A61N5/1049 , A61N5/1065 , A61N5/1067 , A61N5/1069 , A61N5/107
摘要： A system and method of automatically processing data relating to a radiation therapy treatment plan. The method includes the acts of acquiring image data of a patient, generating a treatment plan for the patient based at least in part on the image data, the treatment plan including a calculated radiation dose to be delivered to the patient, acquiring an on-line image of the patient in substantially a treatment position, delivering at least a portion of the calculated radiation dose to the patient, and automatically recalculating the radiation dose received by the patient.
摘要翻译：自动处理与放射疗法治疗计划有关的数据的系统和方法。该方法包括获取患者的图像数据的行为，至少部分地基于图像数据生成针对患者的治疗计划，该治疗计划包括计算的要递送给患者的辐射剂量，获取在线基本上处于治疗位置的患者图像，将计算的辐射剂量的至少一部分传递给患者，并自动重新计算患者接收的辐射剂量。

140. 发明申请

WO2007021420A3 METHOD AND APPARATUS FOR TARGETING A TUMOR DURING RADIOTHERAPY USING A VIRTUAL IMAGE 审中-公开
标题翻译：使用虚拟图像在放射治疗期间靶向肿瘤的方法和装置
公开(公告)号：WO2007021420A3
公开(公告)日：2007-11-29
申请号：PCT/US2006027625
申请日：2006-07-14
申请人： ACCURAY INC , WEST JAY B , FU DONGSHAN
发明人： WEST JAY B , FU DONGSHAN
IPC分类号： G21K5/10 , A61B8/00
CPC分类号： A61N5/1049 , A61B6/584 , A61B90/36 , A61B2090/364 , A61N5/1065 , A61N2005/1058 , A61N2005/1061
摘要： A method and apparatus for targeting a cancerous lesion or tumor during radiotherapy or radiosurgery comppsing the steps of pre-operatively scanning the surgery site using one of magnetic resonance imaging, positron emission tomography or computed tomography to identify the tumor and plan the surgery Intra-operatively scanning the site with ultrasound and overlaying the live ultrasound scan on top of the pre-operative scan Registration of the two images is achieved using image deformations and an average arbitrary normal patient image atlas The method allows registration of the multimodal images for the tracking of the target dupng surgery.
摘要翻译：一种用于在放射治疗或放射外科手术期间靶向癌性病变或肿瘤的方法和装置，其使用磁共振成像，正电子发射断层扫描或计算机断层摄影术之一来操纵扫描手术部位的步骤，以识别肿瘤并计划手术术中使用超声波扫描现场，并在术前扫描之上叠加实时超声扫描。使用图像变形和平均任意正常患者图像图谱实现两个图像的配准该方法允许注册多模态图像以跟踪目标重复手术。

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