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11. 发明申请

US20130281502A1 POST-TREATMENT BREAST CANCER PROGNOSIS 审中-公开
标题翻译：治疗后乳腺癌预后
公开(公告)号：US20130281502A1
公开(公告)日：2013-10-24
申请号：US13914617
申请日：2013-06-10
申请人： Dennis Sgroi , Mark G. Erlander , Yi Zhang , Catherine A. Schnabel
发明人： Dennis Sgroi , Mark G. Erlander , Yi Zhang , Catherine A. Schnabel
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to extended treatment and cancer-free survival in a patient. In particular, the disclosure includes the identities of genes that are expressed in correlation with benefit in a switch in endocrine therapy used to treat a patient. The levels of gene expression are disclosed as a molecular index for predicting clinical outcome, and so prognosis, for the patient. The disclosure further includes methods for predicting cancer recurrence, and/or predicting occurrence of metastatic cancer, after initial treatment with an anti-estrogen agent. The disclosure further includes methods for determining or selecting the treatment of a subject based upon the likelihood of life expectancy, cancer recurrence, and/or cancer metastasis.
摘要翻译：该公开内容包括鉴定和使用基因表达谱或模式，其与患者中延长的治疗和无癌生存具有临床相关性。具体地，本公开包括与用于治疗患者的内分泌治疗的转换中的益处相关表达的基因的身份。公开了基因表达水平作为预测临床结果的分子指标，并为患者预后。本发明还包括在用抗雌激素剂初次治疗后预测癌症复发和/或预测转移性癌症的发生的方法。本公开还包括基于预期寿命，癌症复发和/或癌症转移的可能性来确定或选择受试者的治疗的方法。

12. 发明授权

US07930105B2 Grading of breast cancer 有权
标题翻译：乳腺癌分级
公开(公告)号：US07930105B2
公开(公告)日：2011-04-19
申请号：US11946835
申请日：2007-11-28
申请人： Xiao-Jun Ma , Dennis C. Sgroi , Mark G. Erlander
发明人： Xiao-Jun Ma , Dennis C. Sgroi , Mark G. Erlander
IPC分类号： G06F7/00
CPC分类号： C12Q1/6886 , A61K31/138 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57415 , G01N33/57496
摘要： Methods and compositions for the identification of breast cancer grade signatures are provided. The signature profiles are identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for identification of cells as being in one or more particular stages and/or grades of breast cancer.
摘要翻译：提供了确定乳腺癌分级标记的方法和组成。基于来自乳腺癌独立情况的参考乳腺组织样品的多次取样来识别特征谱，并且提供用于鉴定细胞在乳腺癌的一个或多个特定阶段和/或等级中的可靠的一组分子标准。

13. 发明申请

US20110034346A1 GENE EXPRESSION PROFILING FROM FFPE SAMPLES 有权
标题翻译：来自FFPE样品的基因表达谱
公开(公告)号：US20110034346A1
公开(公告)日：2011-02-10
申请号：US12855577
申请日：2010-08-12
申请人： Mark G. Erlander , Ranelle C. Salunga
发明人： Mark G. Erlander , Ranelle C. Salunga
IPC分类号： C40B30/04
CPC分类号： C12Q1/6806 , C12N15/1096 , C12Q1/6809 , C12Q1/6837 , C12Q1/6886 , C12Q2600/158 , G06F19/20 , C12Q2527/125
摘要： Methods and compositions relating to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can electronically stored and implemented as well as used to augment diagnosis and treatment of diseases.
摘要翻译：提供了与已经固定和嵌入的组织样品的基因表达数据的产生和使用相关的方法和组合物。数据可以电子存储和实现，并用于增加疾病的诊断和治疗。

14. 发明授权

US07879555B2 Gene expression profiling from FFPE samples 有权
标题翻译： FFPE样品的基因表达谱
公开(公告)号：US07879555B2
公开(公告)日：2011-02-01
申请号：US12616103
申请日：2009-11-10
申请人： Mark G. Erlander , Ranelle C. Salunga
发明人： Mark G. Erlander , Ranelle C. Salunga
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12N15/1096 , C12Q1/6809 , C12Q1/6837 , C12Q1/6886 , C12Q2600/158 , G06F19/20 , C12Q2527/125
摘要： Method and compositions related to the generation and use of gene expression data from tissue samples that have been fixed and embedded are provided. The data can be electronically stored and implemented as well as used to augment diagnosis and treatment of diseases.
摘要翻译：提供了与已经固定和嵌入的组织样品的基因表达数据的产生和使用有关的方法和组合物。数据可以电子存储和实现，并用于增加疾病的诊断和治疗。

15. 发明申请

US20090092973A1 Grading of Breast Cancer 有权
标题翻译：乳腺癌分级
公开(公告)号：US20090092973A1
公开(公告)日：2009-04-09
申请号：US11946835
申请日：2007-11-28
申请人： Mark G. Erlander , Xiao-Jun Ma , Dennis C. Sgroi
发明人： Mark G. Erlander , Xiao-Jun Ma , Dennis C. Sgroi
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/138 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G01N33/57415 , G01N33/57496
摘要： Methods and compositions for the identification of breast cancer grade signatures are provided. The signature profiles are identified based upon multiple sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for identification of cells as being in one or more particular stages and/or grades of breast cancer.
摘要翻译：提供了确定乳腺癌分级标记的方法和组成。基于来自乳腺癌独立情况的参考乳腺组织样品的多次取样来识别特征谱，并且提供用于鉴定细胞在乳腺癌的一个或多个特定阶段和/或等级中的可靠的一组分子标准。

16. 发明授权

US07186803B2 Human vanilloid receptor VR3 protein 有权
标题翻译：人类香草素受体VR3蛋白
公开(公告)号：US07186803B2
公开(公告)日：2007-03-06
申请号：US10985156
申请日：2004-11-10
申请人： Adrienne Elizabeth Dubin , Arne Huvar , Charles A. Glass , Mark G. Erlander
发明人： Adrienne Elizabeth Dubin , Arne Huvar , Charles A. Glass , Mark G. Erlander
IPC分类号： C07K14/705 , C07K14/435 , A61K38/17 , C12P21/02
CPC分类号： C07K14/705 , A61K38/00
摘要： DNA encoding human VR1 receptor has been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant protein. The recombinant protein is also purified from the recombinant host cells. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
摘要翻译：编码人VR1受体的DNA已被克隆和表征。重组蛋白能够形成生物活性蛋白。 cDNA已经在产生活性重组蛋白的重组宿主细胞中表达。重组蛋白也从重组宿主细胞中纯化。此外，重组宿主细胞用于建立识别受体活性调节剂的方法，并鉴定受体调节剂。

17. 发明授权

US06682906B1 Cloned glutamic acid decarboxylase 失效
标题翻译：克隆谷氨酸脱羧酶
公开(公告)号：US06682906B1
公开(公告)日：2004-01-27
申请号：US07586536
申请日：1990-09-21
申请人： Allan J. Tobin , Mark G. Erlander , Daniel L. Kaufman
发明人： Allan J. Tobin , Mark G. Erlander , Daniel L. Kaufman
IPC分类号： C12N100
CPC分类号： C12Y401/01015 , A61K38/00 , C12N9/88 , G01N33/564 , G01N2800/042
摘要： cDNA molecules coding for GAD65 polypeptide are disclosed. The invention provides cDNA molecules comprising a part of the cDNA sequence of GAD65 which encode at least one epitope for autoantibodies to GAD65. The invention also provides cloning vehicles capable of replication and expression comprising cDNA molecules coding for GAD65. The invention further provides for hosts transformed with a vehicle having a cDNA molecule coding for GAD65. In another embodiment, the invention provides for the detection of autoantibodies to GAD65 using the GAD65 polypeptides coded for by the cDNA molecules of the invention.
摘要翻译：公开了编码GAD65多肽的cDNA分子。本发明提供了包含编码至少一个表位用于GAD65的自身抗体的GAD65的cDNA序列的cDNA分子。本发明还提供能够复制和表达的克隆载体，其包含编码GAD65的cDNA分子。本发明还提供了用载体转化的宿主，其具有编码GAD65的cDNA分子。在另一个实施方案中，本发明提供使用由本发明的cDNA分子编码的GAD65多肽来检测GAD65的自身抗体。

18. 发明授权

US06596484B1 Method for simultaneous sequence-specific identification and display of mRNA's 失效
标题翻译：同时序列特异性鉴定和mRNA显示的方法
公开(公告)号：US06596484B1
公开(公告)日：2003-07-22
申请号：US09650229
申请日：2000-08-29
申请人： J. Gregor Sutcliffe , Mark G. Erlander , Karl W. Hasel
发明人： J. Gregor Sutcliffe , Mark G. Erlander , Karl W. Hasel
IPC分类号： C12Q168
CPC分类号： C12Q1/6853 , C12N15/1096 , C12Q1/6809 , C12Q2535/138 , C12Q2525/185 , C12Q2525/173 , C12Q2525/131
摘要： An improved method for the simultaneous sequence-specific identification of mRNAs in a mRNA population allows the visualization of nearly every mRNA expressed by a tissue as a distinct band on a gel whose intensity corresponds roughly to the concentration of the mRNA. In general, the method comprises the formation of cDNA using anchor primers to fix a 3′-endpoint, producing cloned inserts from the cDNA in a vector containing a bacteriophage-specific promoter for subsequent RNA synthesis, generating linearized fragments of the cloned inserts, preparing cRNA, transcribing cDNA from the cRNA using a set of primers, and performing PCR using a 3′-primer whose sequence is derived from the vector and a set of 5′-primers that is derived from the primers used for transcription of cDNA from cRNA. The method can identify changes in expression of mRNA associated with the administration of drugs or with physiological or pathological conditions.
摘要翻译：用于mRNA同种序列特异性鉴定mRNA群体的改进方法允许将组织表达的几乎每个mRNA作为凝胶上的不同条带进行可视化，其强度大致对应于mRNA的浓度。通常，该方法包括使用锚定引物形成cDNA以固定3'端点，在含有噬菌体特异性启动子的载体中从cDNA产生克隆的插入片段用于随后的RNA合成，产生克隆插入物的线性化片段，制备 cRNA，使用一组引物从cRNA转录cDNA，并使用序列衍生自载体的3'-引物进行PCR，以及从用于从cRNA转录cDNA的引物衍生的一组5'-引物。该方法可以鉴定与给药药物或生理或病理状况相关的mRNA的表达变化。

19. 发明授权

US6110680A Method for simultaneous identification of differentially expressed mRNAs and measurement of relative concentrations 失效
公开(公告)号：US6110680A
公开(公告)日：2000-08-29
申请号：US108100
申请日：1998-06-30
申请人： J. Gregor Sutcliffe , Mark G. Erlander , Karl W. Hasel
发明人： J. Gregor Sutcliffe , Mark G. Erlander , Karl W. Hasel
IPC分类号： G01N33/50 , C12N15/09 , C12N15/10 , C12P19/34 , C12Q1/68 , C12Q1/70 , G01N33/15 , G01N33/48 , G06F17/30
CPC分类号： C12Q1/6853 , C12N15/1096 , C12Q1/6809
摘要： An improved method for the simultaneous sequence-specific identification of mRNAs in a mRNA population allows the visualization of nearly every mRNA expressed by a tissue as a distinct band on a gel whose intensity corresponds roughly to the concentration of the mRNA. In general, the method comprises the formation of cDNA using anchor primers to fix a 3'-endpoint, producing cloned inserts from the cDNA in a vector containing a bacteriophage-specific promoter for subsequent RNA synthesis, generating linearized fragments of the cloned inserts, preparing cRNA, transcribing cDNA from the cRNA using a set of primers, and performing PCR using a 3'-primer whose sequence is derived from the vector and a set of 5'-primers that is derived from the primers used for transcription of cDNA from cRNA. The method can identify changes in expression of mRNA associated with the administration of drugs or with physiological or pathological conditions.

20. 发明授权

US5475086A Cloned glutamic acid decarboxylase peptides 失效
标题翻译：克隆的谷氨酸脱羧酶
公开(公告)号：US5475086A
公开(公告)日：1995-12-12
申请号：US135849
申请日：1993-10-13
申请人： Allan J. Tobin , Mark G. Erlander , Daniel L. Kaufman , Michael J. Clare-Salzler
发明人： Allan J. Tobin , Mark G. Erlander , Daniel L. Kaufman , Michael J. Clare-Salzler
IPC分类号： A61K38/00 , A61K39/00 , C12N9/88 , G01N33/564 , C07K7/04 , C07K14/00
CPC分类号： G01N33/564 , C12N9/88 , C12Y401/01015 , A61K38/00 , A61K39/00 , G01N2800/042 , G01N2800/24
摘要： Isolated polypeptides useful in ameliorating autoimmune disease.
摘要翻译：用于改善自身免疫性疾病的分离的多肽。

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