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11. 发明授权

US09867902B2 Dense fibrillar collagen matrices for tissue repair and the preparation method thereof 有权
公开(公告)号：US09867902B2
公开(公告)日：2018-01-16
申请号：US13701071
申请日：2011-05-30
申请人： Marie-Madeleine Giraud-Guille , Nadine Nassif , Yan Wang , Christophe Helary , Anne Pelle
发明人： Marie-Madeleine Giraud-Guille , Nadine Nassif , Yan Wang , Christophe Helary , Anne Pelle
IPC分类号： A61L27/24 , A61L27/18
CPC分类号： A61L27/24 , A61L27/18 , A61L2430/40 , C08L71/02
摘要： Method for preparing a homogeneous collagen-based material by concentration of a collagen solution, includes bringing a collagen solution into contact by way of continuous injection and use of the material for tissue repair.

12. 发明申请

US20160184344A1 STIMULI RESPONSIVE COMPOSITIONS FOR IRON CHELATION 有权
标题翻译：用于钢铁焊接的刺激性反应组合物
公开(公告)号：US20160184344A1
公开(公告)日：2016-06-30
申请号：US14876740
申请日：2015-10-06
申请人： May Pang Xiong , Zhi Liu , Yan Wang
发明人： May Pang Xiong , Zhi Liu , Yan Wang
IPC分类号： A61K31/785 , C08F220/28 , C08F230/04
CPC分类号： A61K31/785 , A61K47/58 , A61K47/61 , A61K47/6903 , C08B37/0012 , C08B37/0015 , C08F2220/282 , C08L5/16
摘要： The present technology provides new compositions comprising at least one cross-linked co-polymer. In some embodiments, the polyacrylamide co-polymer comprises water soluble subunits, cross-linking subunits, and iron chelating subunits. In other embodiments, the co-polymer comprises water soluble units, cross-linking subunits, and substituted subunits, which can be conjugated with iron-chelating agents. When these new particles are exposed to certain environments, such the presence of strong acids or oxidation agents, these particles are capable of breaking up so that the iron chelating agents can chelate iron or other metals from their environments. Methods to prepare these new compositions are also provided. These compositions or compositions comprising nanogels of the present technology may be used to treat metal overload conditions such as iron overload resulting from chronic transfusions.
摘要翻译：本技术提供了包含至少一种交联共聚物的新组合物。在一些实施方案中，聚丙烯酰胺共聚物包含水溶性亚基，交联亚基和铁螯合亚基。在其它实施方案中，共聚物包含可与铁螯合剂缀合的水溶性单元，交联亚单元和取代亚单元。当这些新的颗粒暴露于某些环境，如强酸或氧化剂的存在时，这些颗粒能够分解，使得铁螯合剂可以从其环境中螯合铁或其它金属。还提供了制备这些新组合物的方法。包含本技术的纳米凝胶的这些组合物或组合物可用于治疗由慢性输血引起的金属过载状况，例如铁超载。

13. 发明授权

US09243242B2 Methods of making di-tagged DNA libraries from DNA or RNA using double-tagged oligonucleotides 有权
标题翻译：使用双标记寡核苷酸从DNA或RNA制备二标记DNA文库的方法
公开(公告)号：US09243242B2
公开(公告)日：2016-01-26
申请号：US14226321
申请日：2014-03-26
申请人： Yan Wang
发明人： Yan Wang
IPC分类号： C12N15/10 , C12N15/65 , C12N15/66 , C12Q1/68
CPC分类号： C12N15/1065 , C12N15/65 , C12N15/66 , C12Q1/6806 , C12Q1/6855 , C12Q1/6869 , C12Q2525/119 , C12Q2525/131 , C12Q2525/155 , C12Q2525/186 , C12Q2525/191 , C12Q2535/122
摘要： Disclosed are methods, compositions and kits related to making double-tagged DNA libraries from RNA/DNA samples. A double-tagged oligonucleotide (DTO) is employed to efficiently add two different tags to ends of DNAs to make a double-tagged DNA libraries. Also disclosed are methods to make mate pair libraries using the double-tagged oligonucleotide, and methods to make double-tagged single stranded DNA. The double-tagged DNA libraries of the invention are ready to be used on next generation sequencing machines.
摘要翻译：公开了与从RNA / DNA样品制备双标记DNA文库相关的方法，组合物和试剂盒。使用双重标记的寡核苷酸（DTO）来有效地将两个不同的标签添加到DNA的末端以制备双标记的DNA文库。还公开了使用双标记寡核苷酸制备配对文库的方法，以及制备双标记单链DNA的方法。本发明的双标记DNA文库可以在下一代测序机上使用。

14. 发明申请

US20150354006A1 MARKERS FOR ACUTE LYMPHOBLASTIC LEUKEMIA 审中-公开
标题翻译：急性淋巴细胞白血病标志物
公开(公告)号：US20150354006A1
公开(公告)日：2015-12-10
申请号：US14434063
申请日：2013-10-15
申请人： Ho Man CHAN , Nathan P. ENGLUND , Levi GARRAWAY , Min HU , Jacob JAFFE , Gregory KRYUKOV , Jun LIU , Xianghui LIU , Rob MCDONALD , Frank Peter STEGMEIER , Zhaofu WANG , Yan WANG , Haiping WU , Feng YAN
发明人： Ho Man Chan , Nathan P. Englund , Levi Garraway , Min Hu , Jacob Jaffe , Gregory Kryukov , Jun Liu , Xianghui Liu , Rob McDonald , Frank Peter Stegmeier , Zhaofu Wang , Yan Wang , Haiping Wu , Feng Yan
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , G01N33/5011 , G01N33/57426 , G01N2333/91017 , G01N2440/12 , G01N2500/04 , G01N2500/10
摘要： The invention provides methods of detecting a NSD2 mutation in a cancer cell, methods cancer diagnosis and methods of screening for NSD2 inhibitors.
摘要翻译：本发明提供检测癌细胞NSD2突变的方法，方法癌症诊断和筛选NSD2抑制剂的方法。

15. 发明申请

US20150168424A1 IGFBP2 Biomarker 审中-公开
标题翻译： IGFBP2生物标志物
公开(公告)号：US20150168424A1
公开(公告)日：2015-06-18
申请号：US14556402
申请日：2014-12-01
申请人： Yan Wang
发明人： Yan Wang
IPC分类号： G01N33/68 , A61K39/395 , A61K45/06 , C07K16/28
CPC分类号： G01N33/6872 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K2317/56 , C07K2317/565 , C07K2317/76 , G01N2333/65
摘要： The present invention provides method for quickly and conveniently determining if a given treatment regimen of IGF1R inhibitor is sufficient, e.g., to saturate IGF1R receptors in the body of a subject. Several clinically relevant determinations may be made based on this point, including, for example, whether the dosage of the regimen is sufficient or should be increased.
摘要翻译：本发明提供了用于快速和方便地确定给定的IGF1R抑制剂治疗方案是否足够的方法，例如饱和受试者体内的IGF1R受体。可以基于这一点进行若干临床相关的测定，包括例如方案的剂量是否足够或应当增加。

16. 发明申请

US20150033326A1 System and Method for Unlocking Screen 有权
标题翻译：解锁屏幕的系统和方法
公开(公告)号：US20150033326A1
公开(公告)日：2015-01-29
申请号：US14379575
申请日：2012-05-28
申请人： Wen Fang , Yusheng Cao , Yan Wang
发明人： Wen Fang , Yusheng Cao , Yan Wang
IPC分类号： G06F21/60 , G06F3/0488 , G06F3/0484
CPC分类号： G06F21/60 , G06F3/04842 , G06F3/0488 , G06F3/04883 , H04M1/67 , H04M2250/22
摘要： Disclosed are a method for unlocking a screen and a system for installing a screen. It is determined whether to unlock the screen by calculating an angle between a starting position and a current position of a touch point on the screen with the unlocking reference point as a vertex of the angle. With a technical solution of the disclosure, no path or destination position for screen unlocking is defined, with more casual operation, enhanced user experience, and simpler setting, thereby facilitating usage. Moreover, unlocking by mistake can also be prevented by the setting.
摘要翻译：公开了一种用于解锁屏幕的方法和用于安装屏幕的系统。通过使用解锁参考点作为角度的顶点，通过计算屏幕上的触摸点的开始位置和当前位置之间的角度来确定是否解锁屏幕。通过本公开的技术方案，没有定义用于屏幕解锁的路径或目的地位置，具有更多的休闲操作，增强的用户体验和更简单的设置，从而便于使用。此外，也可以通过设定来防止错误解锁。

17. 发明授权

US08765030B2 Preparation of an enteric release system 有权
标题翻译：肠溶释放系统的准备
公开(公告)号：US08765030B2
公开(公告)日：2014-07-01
申请号：US13475645
申请日：2012-05-18
申请人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , Yan Wang , James D. White
发明人： Ahmad Akashe , Anilkumar Ganapati Gaonkar , Les Lawrence , Amado R. Lopez , Ronald L. Meibach , Dana Sebesta , Yan Wang , James D. White
IPC分类号： A61K9/127
CPC分类号： A61K36/48 , A23P10/35 , A61K8/11 , A61K8/645 , A61K8/927 , A61K9/0095 , A61K9/5015 , A61K9/5052 , A61K9/5063 , A61K31/015 , A61K31/045 , A61K31/05 , A61K31/31 , A61K2800/412 , A61Q13/00 , A61K2300/00
摘要： Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents, the process including forming an emulsion of the enteric material and hydrophobic liquid in water, the emulsion titrated with an acid to form a particulate precipitate of the microencapsulated hydrophobic liquid in an enteric matrix.
摘要翻译：疏水性液体在基本上不含有机溶剂的环境中由肠溶基质微胶囊化，该方法包括在肠液中形成肠溶性物质和疏水性液体的乳液，用酸滴定乳液，以形成微胶囊化疏水液体的颗粒状沉淀物肠溶矩阵

18. 发明授权

US08724587B2 Method, apparatus, and system for sending a data packet 有权
标题翻译：用于发送数据包的方法，装置和系统
公开(公告)号：US08724587B2
公开(公告)日：2014-05-13
申请号：US13234911
申请日：2011-09-16
申请人： Yan Wang , Bo Lin , Yuhong Liu
发明人： Yan Wang , Bo Lin , Yuhong Liu
IPC分类号： H04W4/00 , H04W36/18 , H04W52/54 , H04W36/00
CPC分类号： H04W36/18 , H04W36/02 , H04W52/54
摘要： The present invention relates to radio communications technologies and discloses a method, an apparatus, and a system for sending a data packet to avoid repeated forwarding of data when a user equipment hands over between an access point and an evolved NodeB. The method includes: receiving, by an evolved NodeB, a data packet sent by a core network and sending the data packet to a current access point; and keeping caching the data packet on the evolved NodeB before determining that a user equipment has correctly received the data packet from the current access point. The present invention is applicable to data transmission in a network.
摘要翻译：本发明涉及无线电通信技术，并且公开了一种方法，装置和系统，用于当用户设备在接入点和演进节点B之间切换时，发送数据分组以避免数据重复转发。该方法包括：由演进的节点B接收由核心网发送的数据分组，并将数据分组发送到当前接入点; 并且在确定用户设备已经从当前接入点正确地接收到数据分组之前，将数据分组保持缓存在演进的节点B上。本发明适用于网络中的数据传输。

19. 发明授权

US08476045B2 Methods of using improved polymerases 有权
公开(公告)号：US08476045B2
公开(公告)日：2013-07-02
申请号：US13560075
申请日：2012-07-27
申请人： Yan Wang , Peter Vander Horn , Lei Xi
发明人： Yan Wang , Peter Vander Horn , Lei Xi
IPC分类号： C12P19/34
CPC分类号： C12N15/10 , C07K14/195 , C07K2319/00 , C07K2319/80 , C12N9/1252 , C12N15/62 , C12P19/34 , C12Q1/686 , C12Y207/07007
摘要： This invention provides for methods of sequencing and performing polymerase reactions using an improved generation of nucleic acid polymerases. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the processivity of the polymerase.

20. 发明授权

US08453726B2 Corrugated settling cup and a multi-cup uniform flux gas anchor 有权
标题翻译：波纹沉降杯和多杯均匀通量气锚
公开(公告)号：US08453726B2
公开(公告)日：2013-06-04
申请号：US12673064
申请日：2008-08-22
申请人： Demin Wang , Yan Wang , Jun Wan , Shumin Zhang , Rongjie Zhu , Li Li
发明人： Demin Wang , Yan Wang , Jun Wan , Shumin Zhang , Rongjie Zhu , Li Li
IPC分类号： E21B43/38
CPC分类号： E21B43/38 , E21B43/127 , F04B47/02
摘要： A corrugated settling cup (5) is provided, wherein the cup has a cup body, an opening and a location step (52) are provided at the bottom (55) of the cup body, several location holes (53) are formed at the top of the location step (52), location projections (54) corresponding to the location holes (53) are formed at the bottom (55) of the corrugated settling cup (5), wherein the external profile of the corrugated settling cup body rises along the axial direction in a corrugated shape. A multi-cup uniform flux gas anchor is provided, wherein the gas anchor includes a central pipe (7), several corrugated settling cups (5), several settling cups protection bodies (6) and a well-flushing valve (9), wherein the external profile of the corrugated settling cup body rises along the axial direction in a corrugated shape.
摘要翻译：提供了一种波纹沉降杯（5），其中杯体具有杯体，在杯体的底部（55）设有开口和位置台阶（52），多个位置孔（53）形成在在波纹沉降杯（5）的底部（55）形成位置台阶（52）的顶部，对应于定位孔（53）的定位突起（54），其中波纹沉降杯体的外部轮廓上升沿轴向以波纹形状。提供了一种多杯均匀的通量气体锚定器，其中气锚包括中心管（7），多个波纹沉降杯（5），多个沉降杯保护体（6）和井冲洗阀（9），其中波纹沉降杯体的外部轮廓沿轴向方向以波纹形状上升。

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