专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20090286754A1 Method of Treating Cancer and Other Conditions or Disease States Using L-Cytosine Nucleoside Analogs 有权
标题翻译：使用L-胞嘧啶核苷类似物治疗癌症和其他病症或疾病状态的方法
公开(公告)号：US20090286754A1
公开(公告)日：2009-11-19
申请号：US11992044
申请日：2006-11-22
申请人： Yung-Chi Cheng
发明人： Yung-Chi Cheng
IPC分类号： A61K31/7068
CPC分类号： A61K31/513 , A61K47/549 , A61K47/55
摘要： The present invention relates to the use of the compound according to formula (I) Where S is (A) or (B); X is H or F; R1 is H, an acyl group, a C1-C20 alkyl or ether group, a phosphate, diphosphate, triphosphate or a phosphodiester group, a (C) or (D) group; Where Nu is a radical of a biologically active compound such as an anticancer, antihyperproliferative or antiviral compound such that an amino group or hydroxyl group from said biologically active agent forms a phosphate, phosphoramidate, carbonate or urethane group with the adjacent moiety; Each R8 is independently H, or a C1-C20 alkyl or ether group, preferably H or a C1-C2 alkyl group; k is 0-12, preferably, 0-2; R2 is H, an acyl group or a C1-C20 alkyl or ether group; and pharmaceutically acceptable salts, solvates or polymorphs thereof for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease states.
摘要翻译：本发明涉及式（I）化合物的用途，其中S为（A）或（B）; X为H或F; R1是H，酰基，C1-C20烷基或醚基，磷酸酯，二磷酸酯，三磷酸酯或磷酸二酯基，（C）或（D）基团; 其中Nu是生物活性化合物如抗癌，抗增白或抗病毒化合物的基团，使得所述生物活性剂的氨基或羟基与相邻部分形成磷酸酯，氨基磷酸酯，碳酸酯或氨基甲酸酯基团; 每个R 8独立地是H或C 1 -C 20烷基或醚基，优选H或C 1 -C 2烷基; k为0-12，优选为0-2; R2是H，酰基或C1-C20烷基或醚基; 和其药学上可接受的盐，溶剂合物或多晶型物，用于治疗肿瘤，癌症和过度增殖性疾病等疾病状态。

12. 发明授权

US07534455B2 Herbal composition PHY906 and its use in chemotherapy 有权
标题翻译：草药组合物PHY906及其在化疗中的应用
公开(公告)号：US07534455B2
公开(公告)日：2009-05-19
申请号：US11100433
申请日：2005-04-07
申请人： Yung-Chi Cheng , Shwu-Huey Liu
发明人： Yung-Chi Cheng , Shwu-Huey Liu
IPC分类号： A61K36/484 , A61K36/725 , A61K36/539 , A61K36/65
CPC分类号： A61K36/484 , A61K31/454 , A61K31/4745 , A61K31/704 , A61K31/7072 , A61K36/539 , A61K36/65 , A61K36/725 , A61K2300/00
摘要： This invention provides herbal compositions useful for increasing the therapeutic index of drugs, including those used in the treatment of disease, especially viral infections and neoplasms of cancer. This invention provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a person undergoing such chemotherapy.
摘要翻译：本发明提供了可用于增加药物治疗指数（包括用于治疗疾病，特别是病毒感染和癌症肿瘤）的药物组合物的草药组合物。本发明提供了有助于改善接受化疗的个体的生活质量的方法。此外，本发明通过将药草组合物PHY906施用于经历这种化疗的人，通过增加化疗药物的治疗指数来改善疾病的治疗。

13. 发明授权

US07262213B2 Compounds and methods for the treatment of cancer 有权
标题翻译：化合物和治疗癌症的方法
公开(公告)号：US07262213B2
公开(公告)日：2007-08-28
申请号：US10646980
申请日：2003-08-22
申请人： Chung K. Chu , Yung-Chi Cheng
发明人： Chung K. Chu , Yung-Chi Cheng
IPC分类号： A01N43/48 , A61K31/13
CPC分类号： C07D405/04 , C07H17/00
摘要： (−)-(2S,4S)-1-(2-Hydroxymethyl-1,3-dioxolan-4-yl)cytosine (also referred to as (−)-OddC) or its derivative and its use to treat cancer in animals, including humans.
摘要翻译：（ - ） - （2S，4S）-1-（2-羟甲基-1,3-二氧戊环-4-基）胞嘧啶（也称为（ - ） - OddC）或其衍生物及其用于治疗动物癌症，包括人类。

14. 发明授权

US06653318B1 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use 失效
标题翻译： 5-（E） - 溴乙烯基尿嘧啶类似物和相关的嘧啶核苷作为抗病毒剂和使用方法
公开(公告)号：US06653318B1
公开(公告)日：2003-11-25
申请号：US09358028
申请日：1999-07-21
申请人： Yung-Chi Cheng , Chung K. Chu , Ling Li , Yongseok Chai
发明人： Yung-Chi Cheng , Chung K. Chu , Ling Li , Yongseok Chai
IPC分类号： A61K31505
CPC分类号： C07H19/06
摘要： The present invention relates to pyrimidine nucleoside compounds and their use to treat viral infections of Varicella Zoster virus and Epstein Barr Virus, as well as cancers which are complications of Epstein Barr virus.
摘要翻译：本发明涉及嘧啶核苷化合物及其用于治疗水痘带状疱疹病毒和爱泼斯坦巴尔病毒的病毒感染以及作为爱泼斯坦巴尔病毒并发症的癌症的用途。

15. 发明授权

US5792773A L-.beta.-dioxolane uridine analog administration for treating Epstein-Barr virus infection 失效
标题翻译：用于治疗爱泼斯坦 - 巴尔病毒感染的L-二氧戊环尿苷类似物给药
公开(公告)号：US5792773A
公开(公告)日：1998-08-11
申请号：US749263
申请日：1996-11-15
申请人： Chung K. Chu , Yung-Chi Cheng , Fucheng Qu
发明人： Chung K. Chu , Yung-Chi Cheng , Fucheng Qu
IPC分类号： C07D405/04 , A61K31/505 , A61K31/70 , C07D473/00 , C07H19/10
CPC分类号： C07D405/04
摘要： The present invention relates to the discovery that certain .beta.-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5-halosubstituted uracil base, exhibit unexpectedly high activity against Epstein-Barr virus (EBV). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus (viral growth) in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds are useful for treating EBV infections in humans.
摘要翻译：本发明涉及发现含有尿嘧啶碱基，优选5-卤代尿嘧啶碱基的某些β-L-二氧戊环核苷类似物对EB病毒（EBV）表现出意想不到的高活性。特别地，根据本发明的化合物显示出对宿主细胞（即动物或人体组织）的非常低毒性的组合对病毒（病毒生长）的复制的有效抑制。化合物可用于治疗人类的EBV感染。

16. 发明授权

US5728684A Determination of prodrugs metabolizable by the liver and therapeutic use thereof 失效
标题翻译：肝脏可代谢的前体药物的测定及其治疗用途
公开(公告)号：US5728684A
公开(公告)日：1998-03-17
申请号：US146164
申请日：1994-04-19
申请人： Yung-Chi Cheng , Chien-Neng Chang
发明人： Yung-Chi Cheng , Chien-Neng Chang
IPC分类号： A61K31/505 , A61K31/513 , A61K31/52 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7076 , A61K45/00 , A61P35/00 , A61P43/00 , C07D239/22 , C07D239/34 , C07D239/42 , C07D405/04 , C07D473/32 , C07H19/04 , C07H19/06 , G01N33/50 , A01N43/04
CPC分类号： G01N33/5067 , A61K31/505 , A61K31/52 , A61K31/70 , C07H19/04 , G01N33/5008 , G01N33/5011 , G01N33/5091
摘要： A method of ascertaining if a prodrug is useful for treating a disease is disclosed. The prodrug is acceptable if it is metabolized in liver cells by aldehyde oxidase to produce an active drug or metabolite. Prodrugs are shown equally effective in treating diseases as the active drug itself with many benefits and without as many associated side effects. Methods for treating cancers with 5-iodo-2-pyrimidinone-deoxyribose and 5-fluoro-2-pyrimidinone are also described.
摘要翻译： PCT No.PCT / US92 / 04142 Sec。 371日期1994年04月19日 102（e）1994年4月19日PCT PCT日期为1992年5月15日公开了确定前药是否可用于治疗疾病的方法。如果在肝细胞中通过醛氧化酶代谢以产生活性药物或代谢物，则前药是可接受的。前药在治疗疾病方面同样有效，作为活性药物本身具有许多益处，并且没有多少相关的副作用。还描述了用5-碘-2-嘧啶酮脱氧核糖和5-氟-2-嘧啶酮治疗癌症的方法。

17. 发明授权

US07025993B2 Herbal composition PHY906 and its use in chemotherapy 有权
公开(公告)号：US07025993B2
公开(公告)日：2006-04-11
申请号：US10220876
申请日：2001-03-08
申请人： Yung-Chi Cheng , Shwu-Huey Liu
发明人： Yung-Chi Cheng , Shwu-Huey Liu
IPC分类号： A01K35/78
CPC分类号： A61K36/48 , A61K36/484 , A61K36/539 , A61K36/65 , A61K36/725 , A61K2300/00
摘要： This invention provides herbal compositions useful for increasing the therapeutic index of drugs, including those used in the treatment of disease, especially viral infections and neoplasms of cancer. This invention provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a person undergoing such chemotherapy.

18. 发明申请

US20050261320A1 Compounds and methods for the treatment of cancer 有权
标题翻译：化合物和治疗癌症的方法
公开(公告)号：US20050261320A1
公开(公告)日：2005-11-24
申请号：US10646980
申请日：2003-08-22
申请人： Chung Chu , Yung-Chi Cheng
发明人： Chung Chu , Yung-Chi Cheng
IPC分类号： A61K31/506 , A61K20060101 , A61K31/505 , A61K31/513 , A61P35/00 , C07D20060101 , C07D405/04 , C07F20060101 , C07H17/00 , C07D45/04
CPC分类号： C07D405/04 , C07H17/00
摘要： (−)-(2S,4S)-1-(2-Hydroxymethyl-1,3-dioxolan-4-yl)cytosine (also referred to as (−)-OddC) or its derivative and its use to treat cancer in animals, including humans.
摘要翻译：（ - ） - （2S，4S）-1-（2-羟甲基-1,3-二氧戊环-4-基）胞嘧啶（也称为（ - ） - OddC）或其衍生物及其用于治疗动物癌症的用途，包括人类。

19. 发明申请

US20050222418A1 Novel tyloindicines and related processes, pharmaceutical compositions and methods 审中-公开
标题翻译：新型的酪氨酸和相关过程，药物组合物和方法
公开(公告)号：US20050222418A1
公开(公告)日：2005-10-06
申请号：US10502074
申请日：2003-02-12
申请人： David Baker , Yung-Chi Cheng , Sanbao Zhong
发明人： David Baker , Yung-Chi Cheng , Sanbao Zhong
IPC分类号： A61K31/437 , A61K31/4745 , A61P1/04 , A61P3/10 , A61P7/02 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/06 , A61P11/16 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B61/00 , C07D455/02 , C07D455/03 , C07D471/04 , C07F7/02 , C07F7/18
CPC分类号： C07D455/00 , C07D471/04 , C07F7/1804
摘要： The invention provides novel tyloindicines analogues and related processes, pharmaceutical compositions, and methods. The novel tyloindicines are useful in a wide variety of antiviral, antineoplastic, antibacterial, and anti-inflammatory applications. Preferred embodiments of the instant invention include the novel tyloindicine designated herein as compound IT-3 (NSC-716802). Compounds of the instant invention have exhibited potent antiviral and anticancer activity in vitro. The invention further provides novel methods of treating neoplastic, bacterial, viral, and anti-inflammatory disorders using tyloindicines including the novel tyloindicine analogues of the instant invention. The invention also provides novel syntheses of tyloindicines including the novel tyloindicines analogues of the instant invention.
摘要翻译：本发明提供新型的Tyloindicines类似物和相关方法，药物组合物和方法。新颖的噻吩类可用于各种抗病毒，抗肿瘤，抗菌和抗炎应用。本发明的优选实施方案包括本文称为化合物IT-3（NSC-716802）的新型噻吗啉。本发明的化合物在体外表现出有效的抗病毒和抗癌活性。本发明进一步提供了使用包括本发明的新型噻吗啉类似物的甲状腺素治疗肿瘤，细菌，病毒和抗炎症疾病的新方法。本发明还提供了包括本发明的新型Tyloindicines类似物的tyloindicine的新合成。

20. 发明申请

US20050196473A1 Herbal composition PHY906 and its use in chemotherapy 有权
标题翻译：草药组合物PHY906及其在化疗中的应用
公开(公告)号：US20050196473A1
公开(公告)日：2005-09-08
申请号：US11100433
申请日：2005-04-07
申请人： Yung-Chi Cheng , Shwu-Huey Liu
发明人： Yung-Chi Cheng , Shwu-Huey Liu
IPC分类号： A61K31/454 , A61K31/4745 , A61K31/704 , A61K31/7072 , A61K36/484 , A61K36/539 , A61K36/65 , A61K36/725 , A61K35/78
CPC分类号： A61K36/484 , A61K31/454 , A61K31/4745 , A61K31/704 , A61K31/7072 , A61K36/539 , A61K36/65 , A61K36/725 , A61K2300/00
摘要： This invention provides herbal compositions useful for increasing the therapeutic index of drugs, including those used in the treatment of disease, especially viral infections and neoplasms of cancer. This invention provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a person undergoing such chemotherapy.
摘要翻译：本发明提供了可用于增加药物治疗指数（包括用于治疗疾病，特别是病毒感染和癌症肿瘤）的药物组合物的草药组合物。本发明提供了有助于改善接受化疗的个体的生活质量的方法。此外，本发明通过将药草组合物PHY906施用于经历这种化疗的人，通过增加化疗药物的治疗指数来改善疾病的治疗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式