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21. 发明申请

US20100130835A1 METHODS FOR SCREENING AND TREATING PATIENTS WITH COMPROMISED CARDIOPULMONARY FUNCTION 审中-公开
标题翻译：用于筛选和治疗患有严重心脏功能的患者的方法
公开(公告)号：US20100130835A1
公开(公告)日：2010-05-27
申请号：US12570506
申请日：2009-09-30
申请人： Rodney Brenneman , Brad Kellerman , J. Christopher Flaherty
发明人： Rodney Brenneman , Brad Kellerman , J. Christopher Flaherty
IPC分类号： A61B5/02 , A61B5/00 , A61B17/00
CPC分类号： A61B5/222 , A61B5/083 , A61M16/12 , A61M16/125 , A61M2202/0208 , A61M2230/202 , A61M2230/205
摘要： Methods are described for screening patients suffering from compromised cardiopulmonary function to determine if they will benefit from arteriovenous fistula therapy. Performance of an exercise regimen by the patients both in the presence and absence of supplemental oxygen is measured. Those patients whose performance improves in the presence of supplemental oxygen are considered likely candidates for benefitting from arteriovenous therapy.
摘要翻译：描述了用于筛选患有心肺功能受损的患者的方法，以确定它们是否将受益于动静脉瘘治疗。测量患者在存在和不存在补充氧气的情况下对运动方案的表现。在补充氧气的情况下，其性能改善的那些患者被认为是可以从动静脉治疗中受益的候选者。

22. 发明申请

US20100016836A1 Methods and Apparatus for Acute or Chronic Delivery or Substances or Apparatus to Extravascular Treatment Sites 有权
标题翻译：用于急性或慢性输送的方法和装置，或用于血管外治疗部位的物质或装置
公开(公告)号：US20100016836A1
公开(公告)日：2010-01-21
申请号：US12567915
申请日：2009-09-28
申请人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
发明人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
IPC分类号： A61M25/06 , A61K35/12
CPC分类号： A61M25/065 , A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2018/00392 , A61M25/0069 , A61M25/0084 , A61M25/0102 , A61M2025/018
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
摘要翻译：用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品从目标网站。或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

23. 发明授权

US07606615B2 Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
标题翻译：将物质或器械急性或慢性传播至血管外治疗部位的方法和装置
公开(公告)号：US07606615B2
公开(公告)日：2009-10-20
申请号：US10458153
申请日：2003-06-10
申请人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
发明人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
IPC分类号： A61M25/00
CPC分类号： A61M25/065 , A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2018/00392 , A61M25/0069 , A61M25/0084 , A61M25/0102 , A61M2025/018
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
摘要翻译：用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品从目标网站。或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

24. 发明申请

US20080097470A1 SYSTEMS FOR PERFORMING GYNECOLOGICAL PROCEDURES WITH MECHANICAL DISTENSION 有权
标题翻译：用于执行机械分配的妇科手术的系统
公开(公告)号：US20080097470A1
公开(公告)日：2008-04-24
申请号：US11852151
申请日：2007-09-07
申请人： William H. Gruber , Ronald D. Adams , Kevin G. Connors , Geoffrey B. Pardo , James Daniel Cole , J. Christopher Flaherty
发明人： William H. Gruber , Ronald D. Adams , Kevin G. Connors , Geoffrey B. Pardo , James Daniel Cole , J. Christopher Flaherty
IPC分类号： A61B17/42
CPC分类号： A61B17/42 , A61B17/0218 , A61B17/12045 , A61B17/12099 , A61B17/12136 , A61B17/32002 , A61B18/02 , A61B18/1485 , A61B18/22 , A61B90/02 , A61B2017/00026 , A61B2017/00867 , A61B2017/320024 , A61B2017/320028 , A61B2017/4216 , A61B2017/4225 , A61B2017/4233 , A61B2090/3614 , A61B2090/378 , A61B2217/005 , A61B2217/007 , A61N5/1016
摘要： Systems, methods, apparatus and devices for performing improved gynecologic and urologic procedures are disclosed. The system and devices provide simplified use and reduced risk of adverse events. Patient benefit is achieved through improved outcomes, reduced pain, especially peri-procedural pain, and reduced recovery times. The various embodiments enable procedures to be performed outside the hospital setting, such as in a doctor's office or clinic. An intrauterine access end procedure system includes a mechanical distension element, to eliminate the need for liquid distension media at pressure sufficient to create a risk of intravasation.
摘要翻译：公开了用于执行改善的妇科和泌尿系统程序的系统，方法，装置和装置。系统和设备提供简单的使用和降低不良事件的风险。通过改善结果，减轻疼痛，特别是围手术期疼痛，减少恢复时间，实现患者收益。各种实施例使得在医院设置之外执行程序，例如在医生的办公室或诊所中。子宫内进入结束程序系统包括机械膨胀元件，以在足以产生渗透风险的压力下消除对液体膨胀介质的需要。

25. 发明授权

US07357794B2 Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
标题翻译：用于急性或慢性传播物质或器械至血管外治疗部位的装置，系统和方法
公开(公告)号：US07357794B2
公开(公告)日：2008-04-15
申请号：US10466622
申请日：2002-01-17
申请人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
发明人： Joshua Makower , Theodore C. Lamson , J. Christopher Flaherty , John A. Reggie , John Y. Chang , Joseph Catanese, III , David R. Tholfsen
IPC分类号： A61M31/00
CPC分类号： A61M25/0108 , A61B6/12 , A61M5/007 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2210/12
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
摘要翻译：用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品从目标网站。或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

26. 发明授权

US07144384B2 Dispenser components and methods for patient infusion device 失效
标题翻译：用于患者输液装置的分配器组件和方法
公开(公告)号：US07144384B2
公开(公告)日：2006-12-05
申请号：US10261003
申请日：2002-09-30
申请人： William Gorman , John T. Garibotto , J. Christopher Flaherty , John R. Bussiere , Gaurav Rohatgi
发明人： William Gorman , John T. Garibotto , J. Christopher Flaherty , John R. Bussiere , Gaurav Rohatgi
IPC分类号： A61M37/00
CPC分类号： A61M5/14276 , A61M5/1452 , A61M2005/14208 , A61M2005/14573 , A61M2205/0266 , A61M2205/3365 , A61M2205/3523
摘要： A device for delivering fluid to a patient including an exit port assembly, a reservoir including a side wall extending towards an outlet connected to the exit port assembly, a threaded lead screw received at least partly in the reservoir and longitudinally extending towards the outlet, and a plunger secured to the lead screw and having an outer periphery linearly slideable along the side wall of the reservoir. A tube is coaxially received on the lead screw and includes a longitudinal slot, a pin extending through the lead screw and the slot of the tube, and a gear is secured to the tube for rotation therewith.
摘要翻译：一种用于将流体输送到患者的装置，包括出口端口组件，储存器，包括朝向连接到出口端口组件的出口延伸的侧壁;至少部分地容纳在储存器中并且朝向出口纵向延伸的螺纹导螺杆;以及柱塞，其固定到所述导螺杆上，并且具有沿所述储存器的侧壁可直线滑动的外周。管被同轴地容纳在导螺杆上，并且包括纵向狭槽，延伸穿过导螺杆的销和管的狭槽，齿轮固定到管上以与其一起旋转。

27. 发明授权

US07094230B2 Systems and methods for delivering drugs to selected locations within the body 有权
标题翻译：将药物运送到身体内的选定位置的系统和方法
公开(公告)号：US07094230B2
公开(公告)日：2006-08-22
申请号：US10738226
申请日：2003-12-16
申请人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
发明人： J. Christopher Flaherty , Joshua Makower , Philip C. Evard , Patrick E. MacAulay , Jason B. Whitt , Robert C. Colloton , K. Angela Macfarlane
IPC分类号： A61K9/22 , A61M37/00 , A61F2/00
CPC分类号： A61M25/0084 , A61B8/12 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/12172 , A61B17/22 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22077 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61F2002/30079 , A61F2210/009 , A61M5/007 , A61M5/46 , A61M25/0068 , A61M25/0069 , A61M25/007 , A61M25/0108 , A61M39/0208 , A61M39/04 , A61M2025/0037 , A61M2025/0076 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2025/0096 , A61M2025/1052
摘要： An implantable reservoir device (400) including an enclosed membrane (408) on an expandable frame (402) that defines a reservoir (410) and includes a porous region (418). The reservoir device (400) may be deployed and expanded within a blood vessel, and may be filled in situ or prefilled with a drug that passes through the porous region (418). Alternatively, a pair of expandable endovascular blockers (500) may be used to isolate a section of a blood vessel which may be filled with a drug that may be absorbed by the surrounding tissue.
摘要翻译：一种可植入储存器装置（400），其包括限定储存器（410）并且包括多孔区域（418）的可扩张框架（402）上的封闭膜（408）。储存装置（400）可以在血管内展开和扩张，并且可以在原位填充或预填充穿过多孔区域的药物（418）。或者，一对可扩张血管内阻滞剂（500）可以用于分离可以被可被周围组织吸收的药物填充的血管的一部分。

28. 发明授权

US07059330B1 Methods and apparatus for bypassing arterial obstructions and/or performing other transvascular procedures 失效
标题翻译：旁路动脉阻塞和/或执行其他血管内手术的方法和装置
公开(公告)号：US07059330B1
公开(公告)日：2006-06-13
申请号：US09708923
申请日：2000-11-08
申请人： Joshua Makower , J. Christopher Flaherty , Timothy R. Machold , Jason Brian Whitt , Philip Christopher Evard , Patrick Edward Macaulay , John Thomas Garibotto , Claude A. Vidal , Russell J. Redmond , Thomas Banks
发明人： Joshua Makower , J. Christopher Flaherty , Timothy R. Machold , Jason Brian Whitt , Philip Christopher Evard , Patrick Edward Macaulay , John Thomas Garibotto , Claude A. Vidal , Russell J. Redmond , Thomas Banks
IPC分类号： A61B19/00 , A61M25/00
CPC分类号： A61B1/3137 , A61B17/00234 , A61B17/00491 , A61B17/0057 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B17/320725 , A61B17/3417 , A61B17/3496 , A61B18/00 , A61B18/1445 , A61B18/1477 , A61B18/1492 , A61B18/24 , A61B90/361 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/003 , A61B2017/00331 , A61B2017/00504 , A61B2017/00637 , A61B2017/00668 , A61B2017/0641 , A61B2017/1107 , A61B2017/1139 , A61B2017/12127 , A61B2017/22038 , A61B2017/22077 , A61B2017/22095 , A61B2017/306 , A61B2017/347 , A61B2017/3488 , A61B2018/00392 , A61B2018/00404 , A61B2018/00869 , A61B2018/1425 , A61B2018/1475 , A61B2090/378 , A61B2090/3925 , A61B2090/3929 , A61B2090/3958 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/95 , A61F2002/30079 , A61F2002/8486 , A61F2210/009 , A61M2025/0076 , A61M2025/0096 , A61M2025/018 , A61M2025/1052
摘要： Methods, devices, and systems for a) revascularization and/or b) performing other medical procedures at vascular or non-vascular intracorporeal locations within a mammalian body. The methods generally comprise the formation of at least one extravascular passageway from a blood vessel to a vascular or non-vascular target location. In the revascularization methods the extravascular passageway is utilized for blood flow. In the medical procedure methods the extravascular passageway is utilized as a conduit for accessing or performing procedures at the vascular or non-vascular target location. Also disclosed are catheter devices and systems which are useable to form the extravascular passageways of the invention, as well as apparatus for modifying, maintaining and/or closing such extravascular passageways.
摘要翻译：方法，装置和系统，用于a）血管重建和/或b）在哺乳动物体内的血管或非血管体内位置执行其他医学程序。所述方法通常包括从血管到血管或非血管目标位置形成至少一个血管内通道。在血运重建方法中，血管外通路用于血流。在医疗程序方法中，血管外通路被用作在血管或非血管目标位置处进入或执行手术的导管。还公开了可用于形成本发明的血管外通道的导管装置和系统，以及用于修改，维持和/或关闭这种血管外通道的装置。

29. 发明授权

US06746426B1 Transluminally deliverable vascular blockers and methods for facilitating retrograde flow of arterial blood through veins 失效
标题翻译：可口服递送的血管阻滞剂和促进动脉血通过静脉逆行流动的方法
公开(公告)号：US06746426B1
公开(公告)日：2004-06-08
申请号：US09613675
申请日：2000-07-11
申请人： J. Christopher Flaherty , Theodore C. Lamson
发明人： J. Christopher Flaherty , Theodore C. Lamson
IPC分类号： A61M2900
CPC分类号： A61B17/12109 , A61B17/12022 , A61B17/12172 , A61B2017/1205 , A61F2/07 , A61F2/82 , A61F2/86
摘要： Transluminal methods and apparatus for causing arterial blood to flow through a vein of a mammalian patient, in a direction opposite normal venous blood flow, after an arterial blood containing conduit has been purposely or inadvertently connected to the vein. The method includes the use of a transluminally inserted vessel lumen occluding apparatus to at least partially block (e.g., occlude, embolize or close) the lumen of the vein at a location that is proximal to the location at which the arterial blood containing conduit is connected to the vein. The apparatus comprises a radially expandable lumen blocking device that is implantable in the vein lumen and catheters and other apparatus for implanting the radially expandable lumen blocking device into the lumen of the vein.
摘要翻译：在动脉血液导管之间导致动脉血液以与正常静脉血流相反的方向流过哺乳动物患者的静脉的手术方法和装置已经有意或无意地连接到静脉。该方法包括使用平滑插入的血管内腔封闭装置，以在至少部分地阻塞（例如闭塞，栓塞或闭合）静脉内腔的位置处，该位置靠近所述动脉血液导管连接的位置到静脉该装置包括可植入在静脉腔内的可径向扩张的管腔阻断装置，以及用于将可径向扩张的管腔阻塞装置植入静脉内腔的其它装置。

30. 发明授权

US06740059B2 Devices, systems and methods for patient infusion 失效
标题翻译：用于患者输液的装置，系统和方法
公开(公告)号：US06740059B2
公开(公告)日：2004-05-25
申请号：US09943992
申请日：2001-08-31
申请人： J. Christopher Flaherty
发明人： J. Christopher Flaherty
IPC分类号： A61M3100
CPC分类号： A61M5/14248 , A61M5/16809 , A61M5/16813 , A61M37/00 , A61M2005/1403 , A61M2005/1405 , A61M2005/14268 , A61M2205/35 , A61M2205/3569 , A61M2205/50 , A61M2205/6072 , A61M2209/01 , G06F19/00
摘要： A device for delivering a fluid to a patient, including an exit port, a dispenser for causing fluid from a reservoir to flow to the exit port, a local processor programmed to cause a flow of fluid to the exit port based on flow instructions from a separate, remote control device, and a wireless receiver connected to the local processor for receiving the flow instructions. The device also includes a housing free of user input components for providing flow instructions to the local processor, in order to reduce the complexity and costs of the device so that the device lends itself to being disposable in nature. A system and a kit are also described that include the fluid delivery device, a separate, remote control device, and accessories for transcutaneous delivery of fluid medications. Methods of utilizing the fluid delivery device to infuse fluid medications are additionally disclosed.
摘要翻译：一种用于将流体输送到患者的装置，包括出口，用于使流体从储存器流出到出口的分配器，被编程为基于来自流出口的流动指令使流体流入出口的本地处理器单独的遥控设备和连接到本地处理器的无线接收器，用于接收流指令。该装置还包括一个没有用户输入组件的壳体，用于向本地处理器提供流量指令，以便降低设备的复杂性和成本，从而使得设备本身就具有一次性的功能。还描述了包括流体输送装置，单独的远程控制装置和用于经皮输送流体药物的附件的系统和试剂盒。另外公开了利用流体输送装置注入流体药物的方法。

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