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21. 发明授权

US09533071B2 Wound healing compositions including cyanoacrylate monomers and phenytoin 有权
标题翻译：伤口愈合组合物包括氰基丙烯酸酯单体和苯妥英
公开(公告)号：US09533071B2
公开(公告)日：2017-01-03
申请号：US14806734
申请日：2015-07-23
申请人： Adhezion Biomedical, LLC
发明人： Sheng Zhang , Rafael Ruiz, Sr.
IPC分类号： A61L24/10 , A61K31/4166 , A61K31/785 , C08F22/32 , A61L24/00 , A61L24/06 , A61L26/00 , A61L24/02
CPC分类号： A61L26/0066 , A61K31/4166 , A61K31/785 , A61L24/0015 , A61L24/0021 , A61L24/02 , A61L24/06 , A61L26/0004 , A61L26/0014 , A61L26/0071 , A61L2300/404 , A61L2300/412 , C08F22/32 , C08L35/04
摘要： A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.
摘要翻译：单体粘合剂组合物包括稳定的可聚合单体，例如包括氰基丙烯酸酯的1,1-二取代单体和伤口愈合剂，其中伤口愈合剂是5,5-二取代的乙内酰脲，包括苯妥英; 和制备所述组合物的方法。

22. 外观设计

USD771250S1 Liquid dispenser with an extended tip 有权
标题翻译：具有延长尖端的液体分配器
公开(公告)号：USD771250S1
公开(公告)日：2016-11-08
申请号：US29549452
申请日：2015-12-22
申请人： Adhezion Biomedical, LLC
设计人： Sheng Zhang , Rafael Ruiz, Sr. , Amanda Guido

23. 发明申请

US20150320905A1 WOUND HEALING COMPOSITIONS INCLUDING CYANOACRYLATE MONOMERS AND PHENYTOIN 有权
公开(公告)号：US20150320905A1
公开(公告)日：2015-11-12
申请号：US14806734
申请日：2015-07-23
申请人： Adhezion Biomedical, LLC
发明人： Sheng Zhang , Rafael Ruiz, SR.
IPC分类号： A61L26/00 , A61L24/06 , A61L24/02 , A61L24/00
CPC分类号： A61L26/0066 , A61K31/4166 , A61K31/785 , A61L24/0015 , A61L24/0021 , A61L24/02 , A61L24/06 , A61L26/0004 , A61L26/0014 , A61L26/0071 , A61L2300/404 , A61L2300/412 , C08F22/32 , C08L35/04
摘要： A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.

24. 发明授权

US09101683B2 Wound healing compositions including cyanoacrylate monomers and phenytoin 有权
标题翻译：伤口愈合组合物包括氰基丙烯酸酯单体和苯妥英
公开(公告)号：US09101683B2
公开(公告)日：2015-08-11
申请号：US14542741
申请日：2014-11-17
申请人： Adhezion Biomedical, LLC
发明人： Sheng Zhang , Rafael Ruiz, Sr.
IPC分类号： A61L24/06 , A61K31/4166 , C08F22/32 , A61K31/785 , A61L24/00
CPC分类号： A61L26/0066 , A61K31/4166 , A61K31/785 , A61L24/0015 , A61L24/0021 , A61L24/02 , A61L24/06 , A61L26/0004 , A61L26/0014 , A61L26/0071 , A61L2300/404 , A61L2300/412 , C08F22/32 , C08L35/04
摘要： A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.
摘要翻译：单体粘合剂组合物包括稳定的可聚合单体，例如包括氰基丙烯酸酯的1,1-二取代单体和伤口愈合剂，其中伤口愈合剂是5,5-二取代的乙内酰脲，包括苯妥英; 和制备所述组合物的方法。

25. 外观设计

USD725264S1 Blistered dispenser 有权
标题翻译：吹气机
公开(公告)号：USD725264S1
公开(公告)日：2015-03-24
申请号：US29459600
申请日：2013-07-02
申请人： Adhezion Biomedical, LLC
设计人： Sheng Zhang , Rafael Ruiz, Sr. , Martin Krauss

26. 发明授权

US08980947B2 Curing accelerator and method of making 有权
标题翻译：固化加速剂和制作方法
公开(公告)号：US08980947B2
公开(公告)日：2015-03-17
申请号：US14230351
申请日：2014-03-31
申请人： Adhezion Biomedical, LLC
发明人： Sheng Zhang , Rafael Ruiz, Sr. , Max Azevedo
IPC分类号： A61K31/275 , A61L24/06 , A61L24/00
CPC分类号： A61L24/06 , A61L24/0015 , A61L26/0014 , A61L26/0066 , A61L2300/602 , A61L2300/624 , C08L35/06
摘要： A sterilized cyanoacrylate adhesive composition including a cyanoacrylate composition and a cure speed enhancer, wherein the sterilized cyanoacrylate adhesive composition does not cure upon sterilization. A kit for applying the sterilized cyanoacrylate adhesive composition, including the cyanoacrylate adhesive composition and an applicator. A method of making the sterilized cyanoacrylate adhesive composition, by adding a cure speed enhancer to a cyanoacrylate adhesive composition and sterilizing the composition. A method of applying the sterilized cyanoacrylate adhesive composition to tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid, and quickly curing the sterilized cyanoacrylate adhesive composition. A method of sealing tissue by applying the sterilized cyanoacrylate adhesive composition as a liquid to tissue to be sealed, quickly curing the sterilized cyanoacrylate adhesive composition, and sealing the tissue.
摘要翻译：一种灭菌的氰基丙烯酸酯粘合剂组合物，其包含氰基丙烯酸酯组合物和固化速度增强剂，其中灭菌的氰基丙烯酸酯粘合剂组合物在灭菌时不固化。一种用于施用灭菌的氰基丙烯酸酯粘合剂组合物的试剂盒，包括氰基丙烯酸酯粘合剂组合物和涂布器。通过向氰基丙烯酸酯粘合剂组合物中加入固化速度增强剂并对组合物进行灭菌来制备灭菌的氰基丙烯酸酯粘合剂组合物的方法。通过将灭菌的氰基丙烯酸酯粘合剂组合物作为液体施用灭菌的氰基丙烯酸酯粘合剂组合物并快速固化灭菌的氰基丙烯酸酯粘合剂组合物的方法。通过将灭菌的氰基丙烯酸酯粘合剂组合物作为液体施加到待密封的组织上，快速固化灭菌的氰基丙烯酸酯粘合剂组合物并密封组织来密封组织的方法。

27. 外观设计

USD686366S1 Dispensing applicator with a foam tip 有权
标题翻译：点胶涂抹器带泡沫头
公开(公告)号：USD686366S1
公开(公告)日：2013-07-16
申请号：US29436182
申请日：2012-11-02
申请人： Adhezion Biomedical, LLC
设计人： Rafael Ruiz, Sr. , Sheng Zhang , Martin Krauss

28. 发明授权

US09717699B2 Sterilized compositions of cyanoacrylate monomers and naphthoquinone 2,3-oxides 有权
公开(公告)号：US09717699B2
公开(公告)日：2017-08-01
申请号：US15220922
申请日：2016-07-27
申请人： Adhezion Biomedical, LLC
发明人： Sheng Zhang , Rafael Ruiz, Sr. , Shannon Phelps
IPC分类号： A61L24/06 , A61L24/02 , A61L2/08 , C08L35/04 , A61K47/20 , A61K47/02 , A61K31/122 , A61L24/00 , A61K47/10 , A61K47/16 , A61L26/00
CPC分类号： A61K31/122 , A61K47/02 , A61K47/10 , A61K47/16 , A61L2/081 , A61L24/0015 , A61L24/0021 , A61L24/02 , A61L24/06 , A61L26/0066 , A61L2300/412 , A61L2300/428 , C08L35/04
摘要： Sterilized wound healing compositions comprise stabilized cyanoacrylate monomers homogenously mixed together with a naphthoquinone 2,3-oxide, including vitamin K oxides. The compositions are sterilized by irradiation, and the sterilized compositions are shelf stable such that their viscosity does not substantially increase following at least two years of shelf storage. The compositions may be used for closure of open wounds, and the compositions enhance the rate of wound healing relative to wounds not closed with the compositions.

29. 外观设计

USD772407S1 Liquid dispenser having a tapered tip 有权
标题翻译：具有锥形尖端的液体分配器
公开(公告)号：USD772407S1
公开(公告)日：2016-11-22
申请号：US29549451
申请日：2015-12-22
申请人： Adhezion Biomedical, LLC
设计人： Sheng Zhang , Rafael Ruiz, Sr. , Amanda Guido

30. 外观设计

USD771248S1 Dispensing applicator having a curved elongated nozzle 有权
标题翻译：具有弯曲细长喷嘴的点胶涂抹器
公开(公告)号：USD771248S1
公开(公告)日：2016-11-08
申请号：US29503972
申请日：2014-10-01
申请人： Adhezion Biomedical, LLC
设计人： Rafael Ruiz, Sr. , Sheng Zhang , Melissa Brent Hill

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