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21. 发明申请

US20110201818A1 POLO-LIKE KINASE INHIBITORS 审中-公开
标题翻译： POLO-like激素抑制剂
公开(公告)号：US20110201818A1
公开(公告)日：2011-08-18
申请号：US12680183
申请日：2008-09-24
申请人： Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
发明人： Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
IPC分类号： C07D211/72
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译：提供下式的化合物用于激酶：其中变量如本文所定义。还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。

22. 发明申请

US20110174737A1 ION CHROMATOGRAPHY SYSTEMS WITH FLOW-DELAY ELUENT RECYCLE 有权
标题翻译：离子色谱系统与流延迟回收
公开(公告)号：US20110174737A1
公开(公告)日：2011-07-21
申请号：US13075009
申请日：2011-03-29
申请人： Yan Liu , Kannan Srinivasan , Christopher A. Pohl , Sheetal Bhardwaj , Zhongqing Lu
发明人： Yan Liu , Kannan Srinivasan , Christopher A. Pohl , Sheetal Bhardwaj , Zhongqing Lu
IPC分类号： B01D15/08
CPC分类号： B01D15/10 , G01N30/26 , G01N30/96 , G01N2030/965
摘要： A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods.
摘要翻译：一种色谱方法，包括在洗脱液流中色谱分离样品离子物质，检测分离的样品离子物质，催化结合氢气和氧气，或催化分解催化气体消除室中的过氧化氢，并将来自室的流出物流再循环至色谱分离柱。检测器和腔室之间的停留时间至少约1分钟。此外，使循环物依次流过电解膜抑制器的两个检测器流出物流动通道。此外，在检测器和室之间施加热或UV能量。另外，在室后检测气泡。此外，铂族金属催化剂和离子交换介质在室内。用于执行方法的装置。

23. 发明授权

US07983799B2 System and method for controlling microgrid 失效
标题翻译：控制微电网的系统和方法
公开(公告)号：US07983799B2
公开(公告)日：2011-07-19
申请号：US11611505
申请日：2006-12-15
申请人： Sumit Bose , Alfredo Sebastian Achilles , Yan Liu , Emad Ezzat Ahmed , Luis Jose Garces
发明人： Sumit Bose , Alfredo Sebastian Achilles , Yan Liu , Emad Ezzat Ahmed , Luis Jose Garces
IPC分类号： G05D11/00
CPC分类号： H02J3/06 , H02J3/08 , H02J3/382 , H02J3/383 , H02J3/386 , Y02E10/563 , Y02E10/763 , Y02P80/14
摘要： A system for controlling a microgrid includes microgrid assets and a tieline for coupling the microgrid to a bulk grid; and a tieline controller coupled to the tieline. At least one of the microgrid assets comprises a different type of asset than another one of the microgrid assets. The tieline controller is configured for providing tieline control signals to adjust active and reactive power in respective microgrid assets in response to commands from the bulk grid operating entity, microgrid system conditions, bulk grid conditions, or combinations thereof.
摘要翻译：用于控制微电网的系统包括微电网资产和用于将微电网耦合到散装电网的线路; 和tieline控制器耦合到tieline。至少有一个微电网资产包括与另一个微电网资产不同的资产类型。电梯控制器被配置为响应于来自批量电网运行实体，微电网系统条件，批量电网条件或其组合的命令，提供tieline控制信号来调整相应微电网资产中的有功功率和无功功率。

24. 发明申请

US20110117556A1 HIGH-SENSITIVE FLUORESCENT ENERGY TRANSFER ASSAY USING FLUORESCENT AMINO ACIDS AND FLUORESENT PROTEINS 有权
标题翻译：使用荧光氨基酸和荧光蛋白的高敏感荧光能量转移测定
公开(公告)号：US20110117556A1
公开(公告)日：2011-05-19
申请号：US12933780
申请日：2009-03-21
申请人： Jiayu Liao , Yang Song , Yongfeng Zhao , Yan Liu
发明人： Jiayu Liao , Yang Song , Yongfeng Zhao , Yan Liu
IPC分类号： G01N33/68 , G01N33/53 , C12Q1/68 , C07K2/00 , C07K19/00 , C07K14/00
CPC分类号： G01N33/542 , C07K7/06 , C07K14/00 , C07K14/001
摘要： The disclosure provides method and composition utilizing fluorescent amino acids and endogenous fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of the disclosure are useful in analyzing protein structure and function, and screening molecular inhibitors.
摘要翻译：本公开提供了利用荧光氨基酸和含有能够经历FRET的部分的内源性荧光蛋白的方法和组合。本公开的方法和组合物可用于分析蛋白质结构和功能，并筛选分子抑制剂。

25. 发明申请

US20110112998A1 METHODS AND SYSTEMS FOR VARIABLE GROUP SELECTION AND TEMPORAL CAUSAL MODELING 有权
标题翻译：可变组选择和时间建模的方法和系统
公开(公告)号：US20110112998A1
公开(公告)日：2011-05-12
申请号：US12616534
申请日：2009-11-11
申请人： Naoki Abe , Yan Liu , Aurelie C. Lozano , Saharon Rosset , Grzegorz Swirszcz
发明人： Naoki Abe , Yan Liu , Aurelie C. Lozano , Saharon Rosset , Grzegorz Swirszcz
IPC分类号： G06N3/12 , G06F15/18
CPC分类号： G06N5/003 , G06N7/005
摘要： A “variable group selection” system and method in which constructs are based upon a training data set, a regression modeling module that takes into account information on groups of related predictor variables given as input and outputs a regression model with selected variable groups. Optionally, the method can be employed as a component in methods of temporal causal modeling, which are applied on a time series training data set, and output a model of causal relationships between the multiple times series in the data.
摘要翻译：一种“可变组选择”系统和方法，其中构造基于训练数据集，回归建模模块考虑了作为输入给出的相关预测变量组的信息，并输出具有选定变量组的回归模型。可选地，该方法可以用作时间因果建模方法中的组件，其应用于时间序列训练数据集，并且输出数据中多次序列之间的因果关系模型。

26. 发明申请

US20110111384A1 METHOD AND SYSTEM FOR CONTROLLING SKILL ACQUISITION INTERFACES 有权
标题翻译：控制技术收购界面的方法和系统
公开(公告)号：US20110111384A1
公开(公告)日：2011-05-12
申请号：US12614175
申请日：2009-11-06
申请人： Brenda Dietrich , Jennifer Lai , Yan Liu
发明人： Brenda Dietrich , Jennifer Lai , Yan Liu
IPC分类号： G09B7/00 , G09B19/00
CPC分类号： G09B7/00 , A61B5/16 , A61B5/18 , G09B19/00
摘要： A method and system for capturing expert behavior that the expert is not even necessarily conscious of, such as gaze patterns, that are tied to positive outcomes, and to create a catalog (e.g. database) of these behaviors. The system compares the current behavior of a person, for example a novice, against this catalog of expert behaviors. If the current behavior is significantly different, the system would adapt various aspects of the interface to bring the current behavior closer in line to that of the expert.
摘要翻译：一种捕获专家行为的方法和系统，专家甚至不一定意识到与注视结果相关的凝视模式，以及创建这些行为的目录（例如数据库）。该系统比较一个人的当前行为，例如新手，与该专家行为目录。如果当前的行为显着不同，系统将适应接口的各个方面，使当前行为更接近专家的行为。

27. 发明申请

US20100207283A1 Wafer level chip scale package and method of laser marking the same 有权
标题翻译：晶圆级芯片级封装和激光打标方法相同
公开(公告)号：US20100207283A1
公开(公告)日：2010-08-19
申请号：US12378713
申请日：2009-02-17
申请人： Ruisheng Wu , Yan Liu , Tao Feng
发明人： Ruisheng Wu , Yan Liu , Tao Feng
IPC分类号： H01L21/304 , H01L23/544
CPC分类号： H01L23/544 , H01L21/67282 , H01L2223/54406 , H01L2223/54433 , H01L2223/54473 , H01L2223/54486 , H01L2224/274 , H01L2924/01079 , H01L2924/10158 , H01L2924/10253 , H01L2924/13091
摘要： A wafer level chip scale package and method of laser marking the same are disclosed. The method includes forming a plurality of semiconductor devices on a frontside surface of a wafer, metallizing device contacts on the frontside surface of the wafer, grinding the backside surface of the wafer, silicon etching the backside surface of the wafer, laser marking the backside surface of the wafer following the silicon etch step, oxide etching the backside surface of the wafer following the laser marking step, depositing a metal layer on the backside surface of the wafer following the oxide etch step, and dicing the wafer into wafer level chip scale packages. A wafer level chip scale package includes a mark formed on a backside surface thereof, the mark comprising a plurality of trenches formed in a silicon backside surface and corresponding indentations formed in an overlaying back metal layer
摘要翻译：公开了一种晶片级芯片级封装及其激光标记方法。该方法包括在晶片的前表面上形成多个半导体器件，金属化器件接触晶片的前侧表面，研磨晶片的背面，硅蚀刻晶片的背面，激光标记背面在所述硅蚀刻步骤之后的所述晶片的氧化物，在所述激光标记步骤之后，氧化物蚀刻所述晶片的所述背面，在所述氧化物蚀刻步骤之后，在所述晶片的所述背面表面上沉积金属层，以及将所述晶片切割成晶片级芯片级封装。晶片级芯片级封装包括在其背面形成的标记，标记包括形成在硅背面中的多个沟槽和形成在覆盖背面金属层中的相应凹痕

28. 发明申请

US20100191743A1 Contextual similarity measures for objects and retrieval, classification, and clustering using same 有权
标题翻译：使用相同的对象和检索，分类和聚类的上下文相似性度量
公开(公告)号：US20100191743A1
公开(公告)日：2010-07-29
申请号：US12361157
申请日：2009-01-28
申请人： Florent C. Perronnin , Yan Liu
发明人： Florent C. Perronnin , Yan Liu
IPC分类号： G06F17/30
CPC分类号： G06F17/30253 , G06K9/6215 , G06K9/72
摘要： A method of comparing first and second objects in a context comprises: maximizing or minimizing a quantitative comparison of the first object and a mixture of the second object and the context respective to a weighting parameter that controls the mixture; and outputting a comparison value based on the value of the weighting parameter determined by the maximizing or minimizing.
摘要翻译：在上下文中比较第一和第二对象的方法包括：最大化或最小化第一对象与第二对象与上下文的混合的定量比较，与控制混合的加权参数相对应; 并且基于由最大化或最小化确定的加权参数的值来输出比较值。

29. 发明申请

US20100144051A1 LARGE CAPACITY ACID OR BASE GENERATOR AND METHOD OF USE 有权
标题翻译：大容量酸或基因发生器及其使用方法
公开(公告)号：US20100144051A1
公开(公告)日：2010-06-10
申请号：US12706944
申请日：2010-02-17
申请人： Yan Liu , Hamish Small , Nebojsa Avdalovic
发明人： Yan Liu , Hamish Small , Nebojsa Avdalovic
IPC分类号： G01N30/50 , C25B1/00
CPC分类号： G01N30/96 , C25B1/16 , C25B1/22 , G01N30/02 , G01N30/34 , G01N2030/965 , Y10T436/25 , B01D15/36 , B01D15/426
摘要： Method and apparatus for generating an acid or base, e.g. for chromatographic analysis of anions. For generating a base the method includes the steps of providing a cation source in a cation source reservoir, flowing an aqueous liquid stream through a base generation chamber separated from the cation source reservoir by a barrier (e.g. a charged membrane) substantially preventing liquid flow while providing a cation transport bridge, applying an electric potential between an anode cation source reservoir and a cathode in the base generation chamber to electrolytically generate hydroxide ions therein and to cause cations in the cation source reservoir to electromigrate and to be transported across the barrier toward the cathode to combine with the transported cations to form cation hydroxide, and removing the cation hydroxide in an aqueous liquid stream as an effluent from the first base generation chamber. Suitable cation sources include a salt solution, a cation hydroxide solution or cation exchange resin.
摘要翻译：用于产生酸或碱的方法和设备，例如，用于阴离子的色谱分析。为了产生碱，该方法包括以下步骤：在阳离子源储存器中提供阳离子源，使水性液体流通过基本上防止液体流动的屏障（例如带电膜）与阳离子源储存器分离的碱性产生室流动，提供阳离子输送桥，在基底产生室中的阳极阳离子源储存器和阴极之间施加电位以在其中电解产生氢氧根离子，并使阳离子源储存器中的阳离子电迁移并穿过屏障向着阴极与所运送的阳离子结合以形成阳离子氢氧化物，并且以水溶液流中的阳离子氢氧化物作为来自第一碱基产生室的流出物除去。合适的阳离子源包括盐溶液，阳离子氢氧化物溶液或阳离子交换树脂。

30. 发明申请

US20100069431A1 IMIDAZOPYRIDINE COMPOUNDS 失效
标题翻译：咪唑吡啶化合物
公开(公告)号：US20100069431A1
公开(公告)日：2010-03-18
申请号：US12065607
申请日：2006-09-01
申请人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
发明人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译：提供化合物，药物组合物，试剂盒和方法用于含有选自式（I）的化合物的葡糖激酶，其中变量如本文所定义。

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